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Displaying drugs 851 - 875 of 14030 in total

Dostarlimab

Dostarlimab is an IgG4 humanized monoclonal antibody targeted against the human programmed death receptor-1 (PD-1). PD-1 receptors are found on T-cells and, when activated, serve to inhibit immune responses - some cancers leverage this system by overexpressing PD-1 ligands, thereby effectively inhibiting the anti-tumor immune response that would typically attempt...
Approved
Investigational
Matched Description: … resulted in all twelve patients exhibiting a complete clinical response. ... A prospective phase II study in patients with mismatch repair-deficient locally advanced rectal cancer ... in the same month. …

Cefmetazole

A semisynthetic cephamycin antibiotic with a broad spectrum of activity against both gram-positive and gram-negative microorganisms. It has a high rate of efficacy in many types of infection and to date no severe side effects have been noted.
Approved
Investigational
Matched Description: … It has a high rate of efficacy in many types of infection and to date no severe side effects have been ... A semisynthetic cephamycin antibiotic with a broad spectrum of activity against both gram-positive and …
Matched Categories: … Antibacterials for Systemic Use ... Antiinfectives for Systemic Use …

Nilutamide

Nilutamide is an antineoplastic hormonal agent primarily used in the treatment of prostate cancer. Nilutamide is a pure, nonsteroidal anti-androgen with affinity for androgen receptors (but not for progestogen, estrogen, or glucocorticoid receptors). Consequently, Nilutamide blocks the action of androgens of adrenal and testicular origin that stimulate the growth of...
Approved
Investigational
Matched Description: … Nilutamide is a pure, nonsteroidal anti-androgen with affinity for androgen receptors (but not for progestogen ... Nilutamide is an antineoplastic hormonal agent primarily used in the treatment of prostate cancer. …

Grepafloxacin

Grepafloxacin is an oral broad-spectrum quinoline antibacterial agent used to treat bacterial infections. Due to the QTc-prolonging potential, as indicated by the changes in the QT interval on the electrocardiogram, and the risk for cardiovascular adverse events, grepafloxacin was withdrawn in the United States.
Approved
Investigational
Withdrawn
Matched Description: … , and the risk for cardiovascular adverse events, grepafloxacin was withdrawn in the United States. ... Due to the QTc-prolonging potential, as indicated by the changes in the QT interval on the electrocardiogram …
Matched Categories: … Antibacterials for Systemic Use ... Antiinfectives for Systemic Use …

Sitaxentan

Sitaxentan was marketed under the trade name Thelin for the treatment of pulmonary arterial hypertension (PAH) by Encysive Pharmaceuticals until Pfizer purchased Encysive in February 2008. In 2010, Pfizer voluntarily removed sitaxentan from the market over concerns of hepatotoxicity.
Approved
Investigational
Withdrawn
Matched Description: … Sitaxentan was marketed under the trade name Thelin for the treatment of pulmonary arterial hypertension ... (PAH) by Encysive Pharmaceuticals until Pfizer purchased Encysive in February 2008. ... In 2010, Pfizer voluntarily removed sitaxentan from the market over concerns of hepatotoxicity. …
Matched Categories: … Antihypertensives for Pulmonary Arterial Hypertension …

Rupatadine

Rupatadine is a dual histamine H1 receptor and platelet activating factor receptor antagonist that is used for symptomatic relief in seasonal and perennial rhinitis as well as chronic spontaneous urticaria. It was approved for marketing in Canada under the tradename Rupall and comes in tablet formulation for adult use and...
Approved
Matched Description: … It was approved for marketing in Canada under the tradename Rupall and comes in tablet formulation for ... used for symptomatic relief in seasonal and perennial rhinitis as well as chronic spontaneous urticaria ... Rupatadine is a dual histamine H1 receptor and platelet activating factor receptor antagonist that is …
Matched Categories: … Antihistamines for Systemic Use …

Ulobetasol

Ulobetasol is a highly potent corticosteroid. It is structurally related to clobetasol. Due to its high potency, it is mainly prescribed in the treatment of severe plaque psoriasis and corticosteroid responsive dermatoses.[L15047,L15052,L15102] Ulobetasol was granted FDA approval on 17 December 1990.
Approved
Matched Description: … Ulobetasol is a highly potent corticosteroid.[A215597] It is structurally related to [clobetasol]. ... [A215597] Due to its high potency, it is mainly prescribed in the treatment of severe plaque psoriasis …
Matched Categories: … Antipsoriatics for Topical Use …

Cefditoren

Cefditoren is an oral third-generation cephalosporin. It is commonly marketed under the trade name Spectracef by Cornerstone BioPharma.
Approved
Investigational
Matched Categories: … Antibacterials for Systemic Use ... Antiinfectives for Systemic Use …

Trofinetide

Trofinetide is a novel synthetic analog of glypromate, also known as glycine–proline–glutamate (GPE), a naturally occurring protein in the brain and the N-terminal tripeptide of insulin-like growth factor 1 (IGF-1). Trofinetide was approved by the FDA on March 10, 2023, for the treatment of Rett syndrome,[L45718,L45748] which is an X-linked...
Approved
Investigational
Matched Description: … ), a naturally occurring protein in the brain and the N-terminal tripeptide of insulin-like growth factor ... [A258438] Trofinetide was approved by the FDA on March 10, 2023, for the treatment of Rett syndrome,[ ... Trofinetide is a novel synthetic analog of [glypromate], also known as glycine–proline–glutamate (GPE …

Influenza B virus B/Massachusetts/2/2012 BX-51B hemagglutinin antigen (formaldehyde inactivated)

A seasonally-specific component of the influenza vaccine. The influenza vaccine, also known as the "flu shot", is a vaccine that protects against infection from the influenza viruses. Vaccines provide protection from influenza by exposing the immune system to the virus (or parts of the virus) which stimulates an immunological defence...
Approved
Matched Description: … Inactivated vaccines contain a virus particle that has been grown in media and then subsequently killed ... A seasonally-specific component of the influenza vaccine. ... The influenza vaccine, also known as the "flu shot", is a vaccine that protects against infection from …
Matched Mixtures name: … FluVaccinol Subunit Tetra Injektionssuspension in einer Fertigspritze …

Rubidium Rb-82

Rubidium chloride Rb-82 injection is a sterile nonpyrogenic solutions of rubidium Rb 82 chloride. It is indicated for Positron Emission Tomography (PET) imaging of the myocardium under rest or pharmacologic stress conditions to evaluate regional myocardial perfusion in adult patients with suspected or existing coronary artery disease.
Approved
Investigational
Matched Description: … Rubidium chloride Rb-82 injection is a sterile nonpyrogenic solutions of rubidium Rb 82 chloride. ... It is indicated for Positron Emission Tomography (PET) imaging of the myocardium under rest or pharmacologic ... stress conditions to evaluate regional myocardial perfusion in adult patients with suspected or existing …

Tiaprofenic acid

Tiaprofenic acid is a non-steroidal anti-inflammatory drug employed in the treatment of pain, particularly arthritis pain. It belongs to the arylpropionic acid (profen) group of nonsteroidal anti-inflammatory drugs (NSAIDs).
Approved
Matched Description: … Tiaprofenic acid is a non-steroidal anti-inflammatory drug employed in the treatment of pain, particularly …

Chlorambucil

A nitrogen mustard alkylating agent used as antineoplastic agent for the treatment of various malignant and nonmalignant diseases. Although it is less toxic than most other nitrogen mustards, it has been listed as a known carcinogen in the Fourth Annual Report on Carcinogens (NTP 85-002, 1985). (Merck Index, 11th ed)
Approved
Matched Description: … A nitrogen mustard alkylating agent used as antineoplastic agent for the treatment of various malignant ... in the Fourth Annual Report on Carcinogens (NTP 85-002, 1985). ... Although it is less toxic than most other nitrogen mustards, it has been listed as a known carcinogen …

Aspergillus fumigatus

Aspergillus fumigatus is a fungus which can provoke allergic reactions. Aspergillus fumigatus extract is used in allergenic testing.
Approved
Matched Description: … Aspergillus fumigatus extract is used in allergenic testing. ... Aspergillus fumigatus is a fungus which can provoke allergic reactions. …
Matched Mixtures name: … A Mold Mixture ... A Mold Mixture ... A Mold Mixture …

Zafirlukast

Zafirlukast is an oral leukotriene receptor antagonist (LTRA) for the maintenance treatment of asthma, often used in conjunction with an inhaled steroid and/or long-acting bronchodilator. It is available as a tablet and is usually dosed twice daily. Another leukotriene receptor antagonist is montelukast (Singulair), which is usually taken just once...
Approved
Investigational
Matched Description: … It is available as a tablet and is usually dosed twice daily. ... Zafirlukast is an oral leukotriene receptor antagonist (LTRA) for the maintenance treatment of asthma ... , often used in conjunction with an inhaled steroid and/or long-acting bronchodilator. …
Matched Categories: … Drugs for Obstructive Airway Diseases …

Bordetella pertussis pertactin antigen (formaldehyde inactivated)

Approved
Matched Mixtures name: … Repevax Injektionssuspension in einer Fertigspritze …

Mobocertinib

Mobocertinib is a kinase inhibitor targeted against human epidermal growth factor receptor (EGFR). It is used specifically in the treatment of non-small cell lung cancer (NSCLC) caused by exon 20 insertion mutations in the EGFR gene, which are typically associated with a poorer prognosis (as compared to "classical" EGFR mutants...
Approved
Investigational
Matched Description: … September 2021 for the treatment of locally advanced or metastatic NSCLC in patients with _EGFR_ exon ... mutations in the _EGFR_ gene,[L38368] which are typically associated with a poorer prognosis (as compared ... Mobocertinib is a kinase inhibitor targeted against human epidermal growth factor receptor (EGFR). …

Zopiclone

Zopiclone is a novel hypnotic agent used in the treatment of insomnia. Its mechanism of action is based on modulating benzodiazepine receptors. In addition to zopiclone's benzodiazepine pharmacological properties it also has some barbiturate-like properties.
Approved
Matched Description: … Zopiclone is a novel hypnotic agent used in the treatment of insomnia. ... In addition to zopiclone's benzodiazepine pharmacological properties it also has some barbiturate-like …

Papaverine

An alkaloid found in opium but not closely related to the other opium alkaloids in its structure or pharmacological actions. It is a direct-acting smooth muscle relaxant used in the treatment of impotence and as a vasodilator, especially for cerebral vasodilation. The mechanism of its pharmacological actions is not clear,...
Approved
Investigational
Matched Description: … It is a direct-acting smooth muscle relaxant used in the treatment of impotence and as a vasodilator, ... especially for cerebral vasodilation. ... An alkaloid found in opium but not closely related to the other opium alkaloids in its structure or pharmacological …
Matched Categories: … Drugs Used in Erectile Dysfunction ... Drugs for Functional Gastrointestinal Disorders …

Casein

Casein allergenic extract is used in allergenic testing.
Approved
Matched Description: … Casein allergenic extract is used in allergenic testing. …
Matched Categories: … Compounds used in a research, industrial, or household setting …

Nilotinib

Nilotinib, also known as AMN107, is a tyrosine kinase inhibitor under investigation as a possible treatment for chronic myelogenous leukemia (CML). A Phase I clinical trial in 2006 showed that this drug was relatively safe and offered significant therapeutic benefits in cases of CML which were found to be resistant...
Approved
Investigational
Matched Description: … tyrosine kinase inhibitor used as a first-line treatment for CML. ... A Phase I clinical trial in 2006 showed that this drug was relatively safe and offered significant therapeutic ... for chronic myelogenous leukemia (CML). …
Matched Categories: … P-glycoprotein substrates with a Narrow Therapeutic Index ... Cytochrome P-450 CYP3A4 Substrates with a Narrow Therapeutic Index …

Ombitasvir

Ombitasvir is a direct acting antiviral medication used as part of combination therapy to treat chronic Hepatitis C, an infectious liver disease caused by infection with Hepatitis C Virus (HCV). HCV is a single-stranded RNA virus that is categorized into nine distinct genotypes, with genotype 1 being the most common...
Approved
Investigational
Matched Description: … In a joint recommendation published in 2016, the American Association for the Study of Liver Diseases ... being the most common in the United States, and affecting 72% of all chronic HCV patients [L852]. ... First approved in July 2015, Technivie is indicated in combination with Ribavirin for the treatment of …
Matched Categories: … Antivirals for Systemic Use ... Treatments for Hepatitis C ... Antiinfectives for Systemic Use ... Antivirals for treatment of HCV infections …

Griseofulvin

An antifungal antibiotic. Griseofulvin may be given by mouth in the treatment of tinea infections.
Approved
Investigational
Vet approved
Matched Description: … Griseofulvin may be given by mouth in the treatment of tinea infections. …
Matched Categories: … Antifungals for Topical Use ... Antifungals for Systemic Use ... Antifungals for Dermatological Use …

Azadirachta indica leaf

Azadirachta indica leaf is a plant/plant extract used in some OTC (over-the-counter) products. It is not an approved drug.
Approved
Experimental
Matched Description: … Azadirachta indica leaf is a plant/plant extract used in some OTC (over-the-counter) products. …

Influenza B virus B/Austria/1359417/2021 live (attenuated) antigen

A seasonally-specific component of the influenza vaccine. The influenza vaccine, also known as the "flu shot", is a vaccine that helps to protect against infection from influenza viruses. These vaccines provide protection from influenza by exposing the immune system to the virus (or parts of the virus) which results in...
Approved
Matched Description: … Inactivated vaccines contain a virus particle that has been grown in media and then subsequently killed ... A seasonally-specific component of the influenza vaccine. ... The influenza vaccine, also known as the "flu shot", is a vaccine that helps to protect against infection …
Displaying drugs 851 - 875 of 14030 in total