Displaying drugs 10676 - 10700 of 11653 in total
SN-38
7-ethyl-10-hydroxycamptothecin (SN 38) is a liposomal formulation of the active metabolite of Irinotecan DB00762, a chemotherapeutic pro-drug approved for the treatment of advanced colorectal cancer. SN 38 has been used in trials studying the treatment of Cancer, Advanced Solid Tumors, Small Cell Lung Cancer, Metastatic Colorectal Cancer, and Triple Negative...
Investigational
Matched Description: … 7-ethyl-10-hydroxycamptothecin (SN 38) is a liposomal formulation of the active metabolite of Irinotecan ... [DB00762], a chemotherapeutic pro-drug approved for the treatment of advanced colorectal cancer. …
OPC-51803
OPC-51803 is the first nonpeptide vasopressin (AVP) V(2)-receptor-selective agonist. It is a V(2)-selective agonist that produces a significant antidiuretic action after single and multiple oral dosing in AVP-deficient and normal AVP states. It is useful therapeutic drug in the treatment of hypothalamic diabetes insipidus, nocturnal enuresis, and some kinds of...
Investigational
Matched Description: … It is a V(2)-selective agonist that produces a significant antidiuretic action after single and multiple …
Bardoxolone
Bardoxolone has been used in trials studying the treatment of LYMPHOMA and Solid Tumors. It is a synthetic triterpenoid and a highly potent activator of redox-sensitive signaling pathways that induce programmed cell death (apoptosis) in cancer cells that are under high levels of intrinsic oxidative stress. In contrast, Bardoxolone in...
Investigational
Matched Description: … It is a synthetic triterpenoid and a highly potent activator of redox-sensitive signaling pathways that …
Dexchlorpheniramine
Dexchlorpheniramine is a potent S-enantiomer of chlorpheniramine. The salt form dexchlorpheniramine maleate as the active ingredient is available as a prescription drug indicated for adjunctive therapy for allergic and anaphylactic reactions. It is an antihistamine drug with anticholinergic (drying) and sedative actions. It disrupts histamine signaling by competing with histamine...
Experimental
Investigational
Matched Description: … Dexchlorpheniramine is a potent S-enantiomer of chlorpheniramine. ... The salt form dexchlorpheniramine maleate as the active ingredient is available as a prescription drug …
BNT162c2 SARS-CoV-2 Vaccine
BNT162c2 is one of four advanced mRNA-based vaccines being developed through "Project Lightspeed," a joint program between Pfizer and BioNTech.[L15002, L15007] BNT162c2 is a self-amplifying mRNA (saRNA) vaccine formulated in lipid nanoparticles for delivery via intramuscular injection.[L15002, L15007]
BNT162c2 is undergoing evaluation in clinical trials in both the USA (NCT04368728)...
Investigational
Matched Description: … BNT162c2 is one of four advanced mRNA-based vaccines being developed through "Project Lightspeed," a ... [L15002, L15007] BNT162c2 is a self-amplifying mRNA (saRNA) vaccine formulated in lipid nanoparticles …
OAV201
OAV201 is a non-replicating, recombinant adeno-associated virus serotype 9 (AAV9) containing the human Methyl CpG Binding Protein 2B (MECP2B) cDNA under the control of a segment of the murine MECP2 promoter. It was first developed by Novartis and investigated for the treatment of Rett syndrome, but further investigation in clinical...
Investigational
Matched Description: … OAV201 is a non-replicating, recombinant adeno-associated virus serotype 9 (AAV9) containing the human ... Methyl CpG Binding Protein 2B (MECP2B) cDNA under the control of a segment of the murine MECP2 promoter …
Surotomycin
Surotomycin has been used in trials studying the treatment of Diarrhea and Clostridium Difficile Infection. It is a benzenebutanoic acid derivative patented by Cubist Pharmaceuticals, Inc. as antibacterial agents for the treatment of Gram-positive infections. Surotomycin has a fourfold greater in vitro potency than vancomycin against C. Difficile and other...
Investigational
Matched Description: … Surotomycin has a fourfold greater in vitro potency than vancomycin against C. ... It is a benzenebutanoic acid derivative patented by Cubist Pharmaceuticals, Inc. as antibacterial agents ... effective against both initial and relapsing hamster Clostridium difficile-associated diarrhea, with a …
Inhibitor of P38 Kinase
Inhibitor of P38 Kinase is a solid. This compound belongs to the indoles. These are compounds containing an indole moiety, which consists of a pyrrole ring fused to benzene to form 2,3-benzopyrrole. This drug is known to target mitogen-activated protein kinase 14.
Experimental
Matched Description: … Inhibitor of P38 Kinase is a solid. This compound belongs to the indoles. ... These are compounds containing an indole moiety, which consists of a pyrrole ring fused to benzene to …
Zebularine
A chemically stable, cytidine analog that displays anti-tumor properties. It acts as a transition state analog inhibitor of cytidine deaminase by binding to the active site as covalent hydrates. Also shown to inhibit DNA methylation and tumor growth both in vitro and in vivo.
Experimental
Matched Description: … A chemically stable, cytidine analog that displays anti-tumor properties. ... It acts as a transition state analog inhibitor of cytidine deaminase by binding to the active site as …
Virginiamycin S1
One of the components of virginiamycin, a cyclic polypeptide antibiotic complex from streptomyces virginiae, s. Loidensis, s. Mitakaensis, s. Pristina-spiralis, s. Ostreogriseus, and others. It is used to treat infections with gram-positive organisms and as a growth promoter in cattle, swine, and poultry.
Experimental
Matched Description: … One of the components of virginiamycin, a cyclic polypeptide antibiotic complex from streptomyces virginiae ... It is used to treat infections with gram-positive organisms and as a growth promoter in cattle, swine …
IR208
IR208 is a synthetic T-Cell receptor peptide
vaccine developed by Immune Response Corporation.
It contains three peptides (BV5S2, BV6S5
and BV13S1) expressed by T-Cells in over 90% of MS
patients. IR208 is currently undergoing Phase II
studies in a 200-patient trial.
Investigational
Matched Description: … IR208 is currently undergoing Phase II
studies in a 200-patient trial. ... IR208 is a synthetic T-Cell receptor peptide
vaccine developed by Immune Response Corporation. …
Idraparinux
Idraparinux, a synthetic pentasaccharide is an antithrombin-dependent inhibitor of activated factor X. It was developed for the treatment and prevention of thromboembolic events. However, clinical trials have revealed that idraparinux had lead to bleeding. As a result, Sanofi stopped the development of the drug.
Investigational
Matched Description: … As a result, Sanofi stopped the development of the drug. ... Idraparinux, a synthetic pentasaccharide is an antithrombin-dependent inhibitor of activated factor X …
Benzoctamine
Benzoctamine is a drug with two main uses. It can be used as a sedative which does not depress the respiratory system, but rather stimulates it. It can also be used as an anxiolytic with the same efficacy as chlordiazepoxide for treating anxiety neurosis.
Experimental
Matched Description: … Benzoctamine is a drug with two main uses. ... It can be used as a sedative which does not depress the respiratory system, but rather stimulates it. …
MDX-018
MDX-018, also known as HuMax-Inflam, is a fully human antibody that is directed to IL-8 (interleukin-8) and may have potential application in oncology and inflammation. Trials will initially focus on studies to treat glioblastoma, a cancer of the central nervous system. Other possible indications include chronic obstructive pulmonary disease (COPD)...
Investigational
Matched Description: … MDX-018, also known as HuMax-Inflam, is a fully human antibody that is directed to IL-8 (interleukin- ... Trials will initially focus on studies to treat glioblastoma, a cancer of the central nervous system. ... HuMax-Inflam was also effective in reducing disease activity in palmoplantar pustulosis patients in a …
D-Phenylalanine
An essential aromatic amino acid that is a precursor of melanin; dopamine; noradrenalin (norepinephrine), and thyroxine. [PubChem]
Experimental
Matched Description: … An essential aromatic amino acid that is a precursor of melanin; dopamine; noradrenalin (norepinephrine …
Uridine 5'-triphosphate
Uridine 5'-(tetrahydrogen triphosphate). A uracil nucleotide containing three phosphate groups esterified to the sugar moiety.
Experimental
Investigational
Matched Description: … A uracil nucleotide containing three phosphate groups esterified to the sugar moiety. …
Tiamulin
Tiamulin is a pleuromutilin antibiotic drug that is used in veterinary medicine particularly for pigs and poultry.
Vet approved
Matched Description: … Tiamulin is a pleuromutilin antibiotic drug that is used in veterinary medicine particularly for pigs …
Lanabecestat
Lanabecestat is under investigation in clinical trial NCT03499041 (A Study of LY3314814 in Participants With Liver Impairment).
Investigational
Matched Description: … Lanabecestat is under investigation in clinical trial NCT03499041 (A Study of LY3314814 in Participants …
SB-1578
SB-1578 is under investigation in clinical trial NCT01235871 (A Single and Multiple-Dose Study of SB1578).
Investigational
Matched Description: … SB-1578 is under investigation in clinical trial NCT01235871 (A Single and Multiple-Dose Study of SB1578 …
Zansecimab
Zansecimab is under investigation in clinical trial NCT04342897 (A Study of LY3127804 in Participants With COVID-19).
Investigational
Matched Description: … Zansecimab is under investigation in clinical trial NCT04342897 (A Study of LY3127804 in Participants …
KB109
KB109 is a prebiotic to feed healthy bacteria for them to to outcompete multi-drug resistance organisms.
Investigational
Matched Description: … KB109 is a prebiotic to feed healthy bacteria for them to to outcompete multi-drug resistance organisms …
SKF-96365 free base
SKF-96365 is a receptor-mediated calcium entry (RMCE) inhibitor structurally different from other calcium antagonists.
Investigational
Matched Description: … SKF-96365 is a receptor-mediated calcium entry (RMCE) inhibitor structurally different from other calcium …
MK-4830
MK-4830 is a monoclonal antibody that targets the myeloid-specific immunoglobulin-like transcript (ILT) 4 receptor.
Investigational
Matched Description: … MK-4830 is a monoclonal antibody that targets the myeloid-specific immunoglobulin-like transcript (ILT …
ETBX-011
ETBX-011 is a cancer vaccine used to treat patients with cancers that express carcinoembryonic antigen (CEA).
Investigational
Matched Description: … ETBX-011 is a cancer vaccine used to treat patients with cancers that express carcinoembryonic antigen …
RTL-1000
RTL-1000 is a recombinant T-Cell receptor ligand being investigated for the treatment of multiple sclerosis.
Investigational
Matched Description: … RTL-1000 is a recombinant T-Cell receptor ligand being investigated for the treatment of multiple sclerosis …
Displaying drugs 10676 - 10700 of 11653 in total