Displaying drugs 276 - 300 of 8033 in total
Sorafenib
Sorafenib is a bi-aryl urea and an oral multikinase inhibitor. It targets cell surface tyrosine kinase receptors and downstream intracellular kinases that are implicated in tumour cell proliferation and tumour angiogenesis. First approved by the FDA and European Commission in 2007 for the treatment of hepatocellular carcinoma, sorafenib is also...
Approved
Investigational
Matched Description: … [A255852] First approved by the FDA and European Commission in 2007 for the treatment of hepatocellular …
Olodaterol
Olodaterol is a novel, long-acting beta2-adrenergic agonist (LABA) that exerts its pharmacological effect by binding and activating beta2-adrenergic receptors located primarily in the lungs. Beta2-adrenergic receptors are membrane-bound receptors that are normally activated by endogenous epinephrine whose signalling, via a downstream L-type calcium channel interaction, mediates smooth muscle relaxation and...
Approved
Matched Description: … of COPD or for the treatment of asthma. ... Elevation of these two molecules induces bronchodilation by relaxation of airway smooth muscles. ... (COPD) and the progressive airflow obstruction that is characteristic of it. …
Lorlatinib
Lorlatinib is a third-generation ALK tyrosine kinase inhibitor (TKI) for patients with ALK-positive metastatic non-small cell lung cancer which was first approved by the US FDA in November of 2018. It was subsequently approved by the EMA in 2019 for the treatment of select patients with previously treated advanced ALK-positive...
Approved
Investigational
Matched Description: … It was subsequently approved by the EMA in 2019 for the treatment of select patients with previously ... ALK-positive metastatic non-small cell lung cancer[L39905] which was first approved by the US FDA in November of …
Apixaban
Apixaban is an oral, direct, and highly selective factor Xa (FXa) inhibitor of both free and bound FXa, as well as prothrombinase, independent of antithrombin III for the prevention and treatment of thromboembolic diseases[Label,A6897]. It is marketed under the name Eliquis[Label,L6043]. Apixaban was approved by the FDA on December 28,...
Approved
Matched Description: … , as well as prothrombinase, independent of antithrombin III for the prevention and treatment of thromboembolic ... Apixaban is an oral, direct, and highly selective factor Xa (FXa) inhibitor of both free and bound FXa …
Ancestim
Ancestim is a non-glycosylated recombinant methionyl human stem cell factor. It is a 166 amino acid protein produced by E. coli with an amino acid sequence that is identical to the natural sequence predicted from human DNA sequence analysis, except for the addition of an N-terminal methionine . Ancestim was...
Approved
Investigational
Withdrawn
Matched Description: … It was submitted to the FDA under the status of recommendation for approval with a 10 to 1 votes. ... identical to the natural sequence predicted from human DNA sequence analysis, except for the addition of ... [T68] It was also approved by Health Canada in 1999 but it is currently under the status of canceled …
Brivaracetam
Brivaracetam is a racetam derivative of levetiracetam used in the treatment of partial-onset seizures. Brivaracetam binds SV2A with 20 times higher affinity than levetiracetam . It is available under the brand name Briviact made by UCB. Briviact received FDA approval on February 19, 2016 .
Approved
Investigational
Matched Description: … Brivaracetam is a racetam derivative of levetiracetam used in the treatment of partial-onset seizures …
Olaparib
Olaparib is a selective and potent inhibitor of poly (ADP-ribose) polymerase (PARP) enzymes, PARP1 and PARP2.[L41100, L40908, L43792] PARP inhibitors represent a novel class of anti-cancer therapy and they work by taking advantage of a defect in DNA repair in cancer cells with BRCA mutations and inducing cell death. Olaparib...
Approved
Matched Description: … Olaparib is a selective and potent inhibitor of poly (ADP-ribose) polymerase (PARP) enzymes, PARP1 and ... [L41100, L40908, L43792] PARP inhibitors represent a novel class of anti-cancer therapy and they work ... by taking advantage of a defect in DNA repair in cancer cells with BRCA mutations and inducing cell …
Givinostat
Givinostat is a small molecule histone deacetylase (HDAC) inhibitor. It has been investigated as a treatment for a variety of inflammatory diseases, like Crohn's disease and juvenile idiopathic arthritis, cancers like leukemia and lymphoma, as well as several muscular dystrophies. In the context of muscular dystrophy, inhibitors of HDAC appear...
Approved
Investigational
Matched Description: … In the context of muscular dystrophy, inhibitors of HDAC appear to exert their therapeutic effects by ... 6 years of age with Duchenne muscular dystrophy (DMD). ... It has been investigated as a treatment for a variety of inflammatory diseases, like Crohn's disease …
Ferric pyrophosphate citrate
Ferric pyrophosphate citrate is a soluble iron replacement product. Free iron presents several side effects as it can catalyze free radical formation and lipid peroxidation as well as the presence of interactions of iron in plasma. The ferric ion is strongly complexed by pyrophosphate and citrate. FPC is categorized in...
Approved
Investigational
Matched Description: … interactions of iron in plasma. ... side effects as it can catalyze free radical formation and lipid peroxidation as well as the presence of …
Nizatidine
A histamine H2 receptor antagonist with low toxicity that inhibits gastric acid secretion. The drug is used for the treatment of duodenal ulcers.
Approved
Matched Description: … The drug is used for the treatment of duodenal ulcers. …
Chromium
Chromium is a transition element with the chemical symbol Cr and atomic number 24 that belongs to Group 6 of the periodic table. It is used in various chemical, industrial and manufacturing applications such as wood preservation and metallurgy. The uses of chromium compounds depend on the valency of chromium,...
Approved
Matched Description: … blood glucose, regulation of insulin resistance and metabolism of lipids. ... The uses of chromium compounds depend on the valency of chromium, where trivalent Cr (III) compounds ... According to the National Institute of Health, the daily dietary reference intake (DRI) of chromium for …
Ingenol mebutate
Ingenol mebutate was approved by the FDA in January 2012, and it is marketed under the name Picato®. Picato gel is indicated for the topical treatment of actinic keratosis. Before approval, ingenol mebutate was called PEP005 as an investigational drug. PEP005 is a selective small molecule activator of protein kinase...
Approved
Matched Description: … Picato gel is indicated for the topical treatment of actinic keratosis. ... peplus, whose sap has been used as a traditional medicine for the treatment of skin conditions including ... PEP005 is a selective small molecule activator of protein kinase C (PKC) extracted from the plant Euphorbia …
Calcium gluconate
Calcium gluconate is used as mineral supplement and medication when there is insufficient calcium in the diet. Supplementation may be done to treat or prevent osteoporosis or rickets, consequences of hypocalcemia. It can also be taken by mouth but is not recommended by injection into a muscle.
Calcium Gluconate Injection,...
Approved
Vet approved
Matched Description: … Calcium saccharate provides 6% of the total calcium and stabilizes the supersaturated solution of calcium ... Each 10 mL of the injection provides 93 mg elemental calcium (Ca++) equivalent to 1 g of calcium gluconate ... Supplementation may be done to treat or prevent osteoporosis or rickets, consequences of hypocalcemia …
Etravirine
Etravirine is an antiretroviral agent more specifically classified as a Non-Nucleoside Reverse Transcriptase Inhibitor (NNRTI). Etraverine is used clinically for the treatment of human immunodeficiency virus type 1 (HIV-1) infection. On January 18, 2007, the FDA granted accelerated approved for the use of etravirine 100mg tablets in the treatment of...
Approved
Matched Description: … of rashes in patients taking etravirine, lead to a modification of etravirine's monograph. ... Common side effects of use include mild to moderate rash within the first 6 weeks of therapy, nausea, ... Etravirine exerts its effects via direct inhibition of the reverse transcriptase enzyme of human immunodeficiency …
Abametapir
Abametapir is a novel pediculicidal metalloproteinase inhibitor used to treat infestations of head lice. The life cycle of head lice (Pediculus capitis) is approximately 30 days, seven to twelve of which are spent as eggs laid on hair shafts near the scalp. Topical pediculicides generally lack adequate ovicidal activity, including...
Approved
Investigational
Matched Description: … to take advantage of this novel target. ... of which are spent as eggs laid on hair shafts near the scalp. ... Abametapir is a novel pediculicidal metalloproteinase inhibitor used to treat infestations of head lice …
Nicoboxil
Nicoboxil has been investigated for the treatment of Acute Low Back Pain, where it is typically considered an effective and safe therapeutic option. Nevertheless, it is predominantly found paired with nonivamide as a combination topical analgesic product where its proposed mechanism of action as a rubefacient is complementary and ultimately...
Approved
Investigational
Matched Description: … Nicoboxil has been investigated for the treatment of Acute Low Back Pain, where it is typically considered ... found paired with nonivamide as a combination topical analgesic product where its proposed mechanism of ... Such combination topical analgesics are only available for purchase and use (for humans) in some parts of …
Avibactam
Avibactam is a non-β-lactam β-lactamase inhibitor that is available in combination with ceftazidime (Avycaz). This combination was approved by the FDA on February 25, 2015 for the treatment of complicated intra-abdominal infections in combination with metronidazole, and the treatment of complicated urinary tract infections, including pyelonephritis caused by antibiotic resistant-pathogens,...
Approved
Matched Description: … infections in combination with metronidazole, and the treatment of complicated urinary tract infections ... This combination was approved by the FDA on February 25, 2015 for the treatment of complicated intra-abdominal …
D-glucose
Glucose is a simple sugar (monosaccharide) generated during phosynthesis involving water, carbon and sunlight in plants. It is produced in humans via hepatic gluconeogenesis and breakdown of polymeric glucose forms (glycogenolysis). It circulates in human circulation as blood glucose and acts as an essential energy source for many organisms through...
Approved
Investigational
Vet approved
Matched Description: … Its aldohexose stereoisomer, dextrose or D-glucose, is the most commonly occurring isomer of glucose ... It is produced in humans via hepatic gluconeogenesis and breakdown of polymeric glucose forms (glycogenolysis ... [T28] The unspecified form of glucose is commonly supplied as an injection for nutritional supplementation …
Matched Mixtures name: … Reveos Select CPD/AS-5 Red Cell Preservative For Collection Of Blood …
Matched Mixtures name: … Reveos Select CPD/AS-5 Red Cell Preservative For Collection Of Blood …
Zavegepant
Zavegepant (BHV-3500) is a calcitonin gene-related peptide (CGRP) receptor antagonist. CGRP is released from sensory nerves and acts as a strong vasodilator, and thanks to these properties, it is involved in pain pathways. CGRP receptors are expressed in the central and peripheral nervous system; however, CGRP does not cross the...
Approved
Investigational
Matched Description: … is beneficial in the treatment of migraine. ... of migraine with or without aura in adults. ... [L45505,L45510] A clinical trial (NCT04804033) is currently investigating the efficacy and safety of …
Carisoprodol
Originally approved by the FDA in 1959 [FDA label], carisoprodol is a centrally acting muscle relaxant used in painful musculoskeletal conditions in conjunction with physical therapy and other medications . This drug is available by itself in an oral tablet or combined with aspirin, or in a fixed-dose combination with...
Approved
Matched Description: … Schedule IV substance under the controlled substances act in several US states due to alarming rates of ... abuse [A176062, A176077] despite having a low potential for abuse in addition to a low risk of dependence …
Sugammadex
Sugammadex is a selective relaxant binding agent indicated for reversal of neuromuscular blockade induced by rocuronium bromide and vecuronium bromide during surgery. Rocuronium bromide and vecuronium bromide are neuromuscular blocking medications that cause temporary paralysis and are especially useful for general anesthesia, ventilation, or tracheal intubation that patients may require...
Approved
Matched Description: … Sugammadex is a selective relaxant binding agent indicated for reversal of neuromuscular blockade induced ... Sugammadex provides a new treatment option to reverse the effects of those medications and possibly help …
Selexipag
Selexipag was approved by the United States FDA on December 22, 2015 for the treatment of pulmonary arterial hypertension (PAH) to delay disease progression and reduce risk of hospitalization. PAH is a relatively rare disease with usually a poor prognosis requiring more treatment options to prolong long-term outcomes. Marketed by...
Approved
Matched Description: … hypertension (PAH) to delay disease progression and reduce risk of hospitalization. ... Selexipag was approved by the United States FDA on December 22, 2015 for the treatment of pulmonary arterial ... under brand name Uptravi, selexipag and its active metabolite, ACT-333679 (MRE-269), act as agonists of …
Nifurtimox
Chagas disease, caused by a parasite known as Trypanosoma cruzi (T.cruzi), is a vector-transmitted disease affecting animals and humans in the Americas. It is commonly known as American Trypanosomiasis. The CDC estimates that approximately 8 million people in Central America, South America, and Mexico are infected with T. cruzi, without...
Approved
Investigational
Matched Description: … L15366]
Nifurtimox, developed by Bayer, is a nitrofuran antiprotozoal drug used in the treatment of ... [L15361] A convenient feature of Bayer's formulation is the ability to divide the scored tablets manually …
Entrectinib
Entrectinib is a tropomyosin receptor tyrosine kinase (TRK) TRKA, TRKB, TRKC, proto-oncogene tyrosine-protein kinase ROS1, and anaplastic lymphoma kinase (ALK) inhibitor. It was approved by the FDA in August 2019 for use in the treatment of ROS1-positive metastatic non-small cell lung cancer and NTRK gene fusion positive solid tumors. Entrectinib's...
Approved
Investigational
Matched Description: … [L8081] It was approved by the FDA in August 2019 for use in the treatment of ROS1-positive metastatic ... [L8207] Entrectinib's approved use is meant as a last line of therapy due to its accelerated approval ... over similar ALK inhibitors such as [alectinib], [ceritinib], and [lorlatinib] due to a wider range of …
Bronopol
Bronopol, or 2-Bromo-2-nitro-1,3-propanediol, is an organic compound with wide-spectrum antimicrobial properties. First synthesized in 1897, bronopol was primarily used as a preservative for pharmaceuticals and was registered in the United States in 1984 for use in industrial bactericides, slimicides and preservatives . Bronopol is used as a microbicide or microbiostat...
Approved
Matched Description: … The agent is largely available commercially as an antibacterial for a variety of industrial purposes ... Nevertheless, ongoing contemporary re-evaluations of bronopol use in large markets such as Canada now ... ] and in other products where it may not primarily be used in the role of a non-medicinal preservative …
Displaying drugs 276 - 300 of 8033 in total