Displaying drugs 376 - 400 of 15165 in total
Talazoparib
Talazoparib is an inhibitor of mammalian polyadenosine 5’-diphosphoribose polymerases (PARPs), enzymes responsible for regulating essential cellular functions, such as DNA transcription and DNA repair. Developed by Pfizer, talazoparib was first approved by the FDA in October 2018 and by the EMA in June 2019. It was approved by Health Canada...
Approved
Investigational
Matched Iupac: … (11S,12R)-7-fluoro-11-(4-fluorophenyl)-12-(1-methyl-1H-1,2,4-triazol-5-yl)-2,3,10-triazatricyclo[7.3.1.0 …
Matched Description: … (PARPs), enzymes responsible for regulating essential cellular functions, such as DNA transcription and ... L47236] Developed by Pfizer, talazoparib was first approved by the FDA in October 2018 [A260346] and ... [L47301] Talazoparib is currently used in the treatment of BRCA-mutated breast cancer and HRR-mutated …
Matched Categories: … Antineoplastic and Immunomodulating Agents …
Matched Description: … (PARPs), enzymes responsible for regulating essential cellular functions, such as DNA transcription and ... L47236] Developed by Pfizer, talazoparib was first approved by the FDA in October 2018 [A260346] and ... [L47301] Talazoparib is currently used in the treatment of BRCA-mutated breast cancer and HRR-mutated …
Matched Categories: … Antineoplastic and Immunomodulating Agents …
Sucralfate
Sucralfate is a medication that is widely used to prevent and treat a number of diseases in the gastrointestinal tract such as duodenal ulcers [FDA label], gastro-esophageal reflux disease (GERD), gastritis, peptic ulcer disease, stress ulcer, in addition to dyspepsia . It is considered a cytoprotective agent, protecting cells in...
Approved
Matched Iupac: … 4R,5R)-3,4-bis({[(dihydroxyalumanyl)oxy]sulfonyl}oxy)-2,5-bis[({[(dihydroxyalumanyl)oxy]sulfonyl}oxy)methyl ... -2-yl]oxy}-4,5-bis({[(dihydroxyalumanyl)oxy]sulfonyl}oxy)-2-[({[(dihydroxyalumanyl)oxy]sulfonyl}oxy)methyl …
Matched Description: … It was approved by the FDA 1982 in tablet form, and in 1994 for the suspension form [L6073, L6076]. ... It is sold under many brands and is available in both tablet and suspension forms. ... Sucralfate has been shown to be a well-tolerated and safe drug. …
Matched Categories: … Alimentary Tract and Metabolism ... Drugs for Peptic Ulcer and Gastro-Oesophageal Reflux Disease (Gord) …
Matched Description: … It was approved by the FDA 1982 in tablet form, and in 1994 for the suspension form [L6073, L6076]. ... It is sold under many brands and is available in both tablet and suspension forms. ... Sucralfate has been shown to be a well-tolerated and safe drug. …
Matched Categories: … Alimentary Tract and Metabolism ... Drugs for Peptic Ulcer and Gastro-Oesophageal Reflux Disease (Gord) …
Magnesium citrate
Magnesium citrate is a low volume and osmotic cathartic agent. The cathartic action works primarily through the high osmolarity of the solution which draws large amounts of fluid into space where is used. Magnesium citrate is considered by the FDA as an approved inactive ingredient for approved drug products under...
Approved
Matched Description: … Magnesium citrate is a low volume and osmotic cathartic agent. …
Matched Mixtures name: … Calcium and Magnesium Citrate and Vitamin D 250mg/125mg/200iu ... Calcium and Magnesium Citrate With Vitamin D …
Matched Categories: … Blood and Blood Forming Organs ... Alimentary Tract and Metabolism ... Blood Substitutes and Perfusion Solutions …
Matched Mixtures name: … Calcium and Magnesium Citrate and Vitamin D 250mg/125mg/200iu ... Calcium and Magnesium Citrate With Vitamin D …
Matched Categories: … Blood and Blood Forming Organs ... Alimentary Tract and Metabolism ... Blood Substitutes and Perfusion Solutions …
Bos taurus dander
Bos taurus dander allergenic extract is used in allergenic testing.
Approved
Matched Mixtures name: … Animal Allergens, AP Cattle Hair and Dander ... Animal Allergens, AP Cattle Hair and Dander ... Animal Allergens, AP Cattle Hair and Dander …
Eptifibatide
Synthetic cyclic hexapeptide that binds to platelet receptor glycoprotein and inhibits platelet aggregation. Derived from venom of the Southeastern pygmy rattlesnake (Sistrurus miliarus barbouri), eptifibatide is a cyclic heptapeptide that belongs to the class of arginin-glycin-aspartat-mimetics.
Approved
Investigational
Matched Description: … Synthetic cyclic hexapeptide that binds to platelet receptor glycoprotein and inhibits platelet aggregation …
Matched Categories: … Blood and Blood Forming Organs ... Amino Acids, Peptides, and Proteins …
Matched Categories: … Blood and Blood Forming Organs ... Amino Acids, Peptides, and Proteins …
Sodium metavanadate
Approved
Experimental
Matched Mixtures name: … Multivitamins and Minerals Tablets ... Milltrium Senior Vitamin and Mineral Supplement ... Spectrum Performa Multivitamins and Minerals Tablets …
Anisindione
Anisindione is a synthetic anticoagulant and an indanedione derivative. Its anticoagulant action is mediated through the inhibition of the vitamin K-mediated gamma-carboxylation of precursor proteins that are critical in forming the formation of active procoagulation factors II, VII, IX, and X, as well as the anticoagulant proteins C and S,...
Approved
Matched Description: … Anisindione is a synthetic anticoagulant and an indanedione derivative. ... X, as well as the anticoagulant proteins C and S, in the liver. ... precursor proteins that are critical in forming the formation of active procoagulation factors II, VII, IX, and …
Nickel sulfate
Nickel sulfate is used in allergenic testing.
Approved
Experimental
Matched Mixtures name: … Multivitamins and Minerals Tablets ... Milltrium Senior Vitamin and Mineral Supplement ... Spectrum Performa Multivitamins and Minerals Tablets …
Corynebacterium diphtheriae toxoid antigen (formaldehyde inactivated)
Approved
Investigational
Matched Mixtures name: … Diphtheria and Tetanus Toxoids Adsorbed ... Tetanus and Diphtheria Toxoids Adsorbed ... Tetanus and Diphtheria Toxoids Adsorbed …
Laronidase
Human recombinant alpha-L-iduronidase, 628 residues (mature form), produced by recombinant DNAtechnology in a Chinese hamster ovary cell line. Laronidase is a glycoprotein with a molecular weight of approximately 83 kD. The predicted amino acid sequence of the recombinant form, as well as the nucleotide sequence that encodes it, are identical...
Approved
Matched Description: … it, are identical to a polymorphic form of human a-L-iduronidase. ... Human recombinant alpha-L-iduronidase, 628 residues (mature form), produced by recombinant DNAtechnology ... The predicted amino acid sequence of the recombinant form, as well as the nucleotide sequence that encodes …
Matched Categories: … Enzymes and Coenzymes ... Alimentary Tract and Metabolism …
Matched Categories: … Enzymes and Coenzymes ... Alimentary Tract and Metabolism …
Sebelipase alfa
The lysosomal acid lipase (LAL) enzyme is found in lysosomes and is primarily responsible for the metabolism of lipids, and its absence or deficiency results in the accumulation of lipids in various organs. This lipid accumulation can lead to end-organ damage in the form of liver dysfunction or malabsorption secondary...
Approved
Investigational
Matched Description: … This lipid accumulation can lead to end-organ damage in the form of liver dysfunction or malabsorption ... [L39337]
Sebelipase alfa is a recombinant form LAL approved for the treatment of LAL deficiency. ... It was first approved by both the FDA and EMA in 2015 and is marketed under the brand name Kanuma (Alexion …
Matched Categories: … Enzymes and Coenzymes ... Alimentary Tract and Metabolism …
Matched Categories: … Enzymes and Coenzymes ... Alimentary Tract and Metabolism …
Hydrocortamate
Hydrocortamate is a synthetic glucocorticoid used for its anti-inflammatory or immunosuppressive properties to treat inflammation due to corticosteroid-responsive dermatoses. Glucocorticoids are a class of steroid hormones characterised by an ability to bind with the cortisol receptor and trigger a variety of important cardiovascular, metabolic, immunologic and homeostatic effects.
Approved
Matched Description: … Hydrocortamate is a synthetic glucocorticoid used for its anti-inflammatory or immunosuppressive properties ... trigger a variety of important cardiovascular, metabolic, immunologic and homeostatic effects. ... Glucocorticoids are a class of steroid hormones characterised by an ability to bind with the cortisol receptor and …
Dyclonine
Dyclonine is an oral anaesthetic found in Sucrets, an over the counter throat lozenge. It may also be found in some Cepacol sore throat spray products.
Approved
Matched Mixtures name: … Benzethonium Chloride and Dyclonine Hydrochloride ... Benzethonium chloride and Dyclonine hydrochloride ... Benzethonium Chloride and Dyclonine Hydrochloride …
Carvedilol
Carvedilol is a racemic mixture where the S(-) enantiomer is both a beta and alpha-1 adrenoceptor blocker, and the R(+) enantiomer is an alpha-1 adrenoceptor blocker.[L7889,L7892] It is currently used to treat heart failure, left ventricular dysfunction, and hypertension.[L7889,L7892] The dual action of carvedilol is advantageous in combination therapies as...
Approved
Investigational
Matched Description: … , and the R(+) enantiomer is an alpha-1 adrenoceptor blocker. ... Carvedilol is a racemic mixture where the S(-) enantiomer is both a beta and alpha-1 adrenoceptor blocker ... [L7889,L7892] It is currently used to treat heart failure, left ventricular dysfunction, and hypertension …
Matched Categories: … carvedilol and ivabradine ... Alpha and Beta Blocking Agents ... Calcium-Regulating Hormones and Agents …
Matched Categories: … carvedilol and ivabradine ... Alpha and Beta Blocking Agents ... Calcium-Regulating Hormones and Agents …
Dextrothyroxine
The major hormone derived from the thyroid gland. Thyroxine is synthesized via the iodination of tyrosines (monoiodotyrosine) and the coupling of iodotyrosines (diiodotyrosine) in the thyroglobulin. Thyroxine is released from thyroglobulin by proteolysis and secreted into the blood. Thyroxine is peripherally deiodinated to form triiodothyronine which exerts a broad spectrum...
Approved
Investigational
Matched Description: … Thyroxine is peripherally deiodinated to form triiodothyronine which exerts a broad spectrum of stimulatory ... Thyroxine is released from thyroglobulin by proteolysis and secreted into the blood. ... Thyroxine is synthesized via the iodination of tyrosines (monoiodotyrosine) and the coupling of iodotyrosines …
Matched Categories: … Amino Acids, Peptides, and Proteins ... Hormones, Hormone Substitutes, and Hormone Antagonists …
Matched Categories: … Amino Acids, Peptides, and Proteins ... Hormones, Hormone Substitutes, and Hormone Antagonists …
Diacerein
Diacerein is a prodrug which is metabolized to rhein. It is currently approved in France for the treatment of osteoarthritis although the use of diacerein is restricted due to the side effects including severe diarrhea . Diacerein is under investigation for the treatment of Insulin Resistance, Diabetes Mellitus (Type 2),...
Approved
Investigational
Matched Description: … Diacerein is under investigation for the treatment of Insulin Resistance, Diabetes Mellitus (Type 2), and …
Matched Categories: … Antiinflammatory and Antirheumatic Products ... Antiinflammatory and Antirheumatic Products, Non-Steroids …
Matched Categories: … Antiinflammatory and Antirheumatic Products ... Antiinflammatory and Antirheumatic Products, Non-Steroids …
Niacinamide ascorbate
Approved
Nutraceutical
Matched Mixtures name: … Stress B Complex With C and E Tab ... Stress B Complex With C, E and Iron Tab ... Stress B Complex With C,e, Zinc and Copper …
Matched Categories: … Vitamin C and analogues …
Matched Categories: … Vitamin C and analogues …
Canis lupus familiaris hair
Domestic dog hair is used in allergenic testing.
Approved
Matched Mixtures name: … Dog Hair and Epithelia ... Animal Allergens, Dog Hair and Dander Canis spp. ... Animal Allergens, Dog Hair and Dander Canis spp. …
Venlafaxine
Venlafaxine is an antidepressant and a serotonin and norepinephrine reuptake inhibitor (SNRI). Its active metabolite, desvenlafaxine, works by blocking the reuptake of serotonin and norepinephrine, which are key neurotransmitters in mood regulation. Venlafaxine is officially approved to treat major depressive disorder (MDD), generalized anxiety disorder (GAD), social anxiety disorder, and...
Approved
Matched Description: … Venlafaxine is an antidepressant and a serotonin and norepinephrine reuptake inhibitor (SNRI). ... Its active metabolite, [desvenlafaxine], works by blocking the reuptake of serotonin and norepinephrine ... treat major depressive disorder (MDD), generalized anxiety disorder (GAD), social anxiety disorder, and …
Matched Categories: … Serotonin and Noradrenaline Reuptake Inhibitors …
Matched Categories: … Serotonin and Noradrenaline Reuptake Inhibitors …
Ferric pyrophosphate citrate
Ferric pyrophosphate citrate is a soluble iron replacement product. Free iron presents several side effects as it can catalyze free radical formation and lipid peroxidation as well as the presence of interactions of iron in plasma. The ferric ion is strongly complexed by pyrophosphate and citrate. FPC is categorized in...
Approved
Investigational
Matched Description: … The ferric ion is strongly complexed by pyrophosphate and citrate. ... Free iron presents several side effects as it can catalyze free radical formation and lipid peroxidation …
Matched Categories: … Enzymes and Coenzymes …
Matched Categories: … Enzymes and Coenzymes …
Metyrapone
An inhibitor of the enzyme steroid 11-beta-monooxygenase. It is used as a test of the feedback hypothalamic-pituitary mechanism in the diagnosis of cushing syndrome.
Approved
Investigational
Matched Iupac: … 2-methyl-1,2-bis(pyridin-3-yl)propan-1-one …
Influenza A virus A/Brisbane/59/2007(H1N1) hemagglutinin antigen (UV,formaldehyde inactivated)
A seasonally-specific component of the influenza vaccine. The influenza vaccine, also known as the "flu shot", is a vaccine that protects against infection from the influenza viruses. Vaccines provide protection from influenza by exposing the immune system to the virus (or parts of the virus) which stimulates an immunological defence...
Approved
Matched Description: … Upon re-exposure to infectious influenza virus, the immune system is prepared to identify and destroy ... Inactivated vaccines contain a virus particle that has been grown in media and then subsequently killed ... There are two basic types of vaccines available: inactivated influenza vaccine (IIV) and live attenuated …
Influenza A virus A/Uruguay/716/2007(H3N2) hemagglutinin antigen (UV,formaldehyde inactivated)
A seasonally-specific component of the influenza vaccine. The influenza vaccine, also known as the "flu shot", is a vaccine that protects against infection from the influenza viruses. Vaccines provide protection from influenza by exposing the immune system to the virus (or parts of the virus) which stimulates an immunological defence...
Approved
Matched Description: … Upon re-exposure to infectious influenza virus, the immune system is prepared to identify and destroy ... Inactivated vaccines contain a virus particle that has been grown in media and then subsequently killed ... There are two basic types of vaccines available: inactivated influenza vaccine (IIV) and live attenuated …
Dabigatran
Dabigatran is the active form of the orally bioavailable prodrug dabigatran etexilate.
Approved
Investigational
Matched Iupac: … 3-[1-(2-{[(4-carbamimidoylphenyl)amino]methyl}-1-methyl-1H-1,3-benzodiazol-5-yl)-N-(pyridin-2-yl)formamido …
Matched Description: … Dabigatran is the active form of the orally bioavailable prodrug [dabigatran etexilate]. …
Matched Description: … Dabigatran is the active form of the orally bioavailable prodrug [dabigatran etexilate]. …
Rabeprazole
Rabeprazole is an antiulcer drug in the class of proton pump inhibitors. It is a prodrug - in the acid environment of the parietal cells it turns into active sulphenamide form. Rabeprazole inhibits the H+, K+ATPase of the coating gastric cells and dose-dependent oppresses basal and stimulated gastric acid secretion.
Approved
Investigational
Matched Description: … and stimulated gastric acid secretion. ... It is a prodrug - in the acid environment of the parietal cells it turns into active sulphenamide form ... Rabeprazole inhibits the H+, K+ATPase of the coating gastric cells and dose-dependent oppresses basal …
Matched Categories: … Alimentary Tract and Metabolism ... Antiinflammatory and Antirheumatic Products ... rabeprazole, amoxicillin and metronidazole ... rabeprazole, amoxicillin and clarithromycin ... Topical Products for Joint and Muscular Pain …
Matched Categories: … Alimentary Tract and Metabolism ... Antiinflammatory and Antirheumatic Products ... rabeprazole, amoxicillin and metronidazole ... rabeprazole, amoxicillin and clarithromycin ... Topical Products for Joint and Muscular Pain …
Displaying drugs 376 - 400 of 15165 in total