Displaying drugs 676 - 700 of 784 in total
Trastuzumab
Produced in CHO cell cultures, trastuzumab is a recombinant IgG1 kappa, humanized monoclonal antibody that selectively binds with high affinity in a cell-based assay (Kd = 5 nM) to the extracellular domain of the human epidermal growth factor receptor protein (HER2). It is used as a treatment of human epidermal...
Approved
Investigational
Matched Synonyms: … trastuzumab-anns …
Matched Description: … Trastuzumab binds to HER2 and suppresses cancer cell growth, proliferation, and survival directly and ... that the overexpression or gene amplification of HER2 has been found in about 20–30% of breast cancers and ... KANJINTI (trastuzumab-anns) is another biosimilar approved by the FDA in June 2019. …
Matched Categories: … Amino Acids, Peptides, and Proteins ... Antineoplastic and Immunomodulating Agents ... pertuzumab and trastuzumab ... MONOCLONAL ANTIBODIES AND ANTIBODY DRUG CONJUGATES …
Matched Description: … Trastuzumab binds to HER2 and suppresses cancer cell growth, proliferation, and survival directly and ... that the overexpression or gene amplification of HER2 has been found in about 20–30% of breast cancers and ... KANJINTI (trastuzumab-anns) is another biosimilar approved by the FDA in June 2019. …
Matched Categories: … Amino Acids, Peptides, and Proteins ... Antineoplastic and Immunomodulating Agents ... pertuzumab and trastuzumab ... MONOCLONAL ANTIBODIES AND ANTIBODY DRUG CONJUGATES …
Brodimoprim
Experimental
Matched Synonyms: … 2,4-diamino-5-(4-bromo-3,5-dimethoxybenzyl)pyrimidine …
Matched Iupac: … 5-[(4-bromo-3,5-dimethoxyphenyl)methyl]pyrimidine-2,4-diamine …
Matched Categories: … Sulfonamides and trimethoprim ... Trimethoprim and Derivatives …
Matched Iupac: … 5-[(4-bromo-3,5-dimethoxyphenyl)methyl]pyrimidine-2,4-diamine …
Matched Categories: … Sulfonamides and trimethoprim ... Trimethoprim and Derivatives …
Halofuginone
Halofuginone is a low molecular weight quinazolinone alkaloid, and a potent inhibitor of collagen alpha1(I) and matrix metalloproteinase 2 (MMP-2) gene expression. Halofuginone also effectively suppresses tumor progression and metastasis in mice. Collgard Biopharmaceuticals is developing halofuginone for the treatment of scleroderma and received orphan drug designation from the U.S....
Investigational
Vet approved
Matched Synonyms: … (+/-)-trans-7-bromo-6-chloro-3-(3-(3-hydroxy-2-piperidyl)-acetonyl)-4(3H)-quinazolinone …
Matched Iupac: … 7-bromo-6-chloro-3-{3-[(2R,3S)-3-hydroxypiperidin-2-yl]-2-oxopropyl}-3,4-dihydroquinazolin-4-one …
Matched Description: … (I) and matrix metalloproteinase 2 (MMP-2) gene expression. ... Halofuginone is a low molecular weight quinazolinone alkaloid, and a potent inhibitor of collagen alpha1 ... Food and Drug Administration in March, 2000. …
Matched Iupac: … 7-bromo-6-chloro-3-{3-[(2R,3S)-3-hydroxypiperidin-2-yl]-2-oxopropyl}-3,4-dihydroquinazolin-4-one …
Matched Description: … (I) and matrix metalloproteinase 2 (MMP-2) gene expression. ... Halofuginone is a low molecular weight quinazolinone alkaloid, and a potent inhibitor of collagen alpha1 ... Food and Drug Administration in March, 2000. …
Flubrobenguane F18
Investigational
Matched Synonyms: … N-((3-bromo-4-(3-(fluoro-18f)propoxy)phenyl)methyl)guanidine …
Matched Iupac: … N-({3-bromo-4-[3-(¹⁸F)fluoropropoxy]phenyl}methyl)guanidine …
Matched Iupac: … N-({3-bromo-4-[3-(¹⁸F)fluoropropoxy]phenyl}methyl)guanidine …
Vandetanib
Vandetanib is an oral once-daily kinase inhibitor of tumour angiogenesis and tumour cell proliferation with the potential for use in a broad range of tumour types.
On April 6 2011, vandetanib was approved by the FDA to treat nonresectable, locally advanced, or metastatic medullary thyroid cancer in adult patients.
Approved
Matched Synonyms: … N-(4-Bromo-2-fluorophenyl)-6-methoxy-7-((1-methyl-4-piperidinyl)methoxy)-4-quinazolinamine ... N-(4-Bromo-2-fluorophenyl)-6-methoxy-7-((1-methylpiperidin-4-yl)methoxy)quinazolin-4-amine …
Matched Iupac: … N-(4-bromo-2-fluorophenyl)-6-methoxy-7-[(1-methylpiperidin-4-yl)methoxy]quinazolin-4-amine …
Matched Description: … Vandetanib is an oral once-daily kinase inhibitor of tumour angiogenesis and tumour cell proliferation …
Matched Categories: … Antineoplastic and Immunomodulating Agents …
Matched Iupac: … N-(4-bromo-2-fluorophenyl)-6-methoxy-7-[(1-methylpiperidin-4-yl)methoxy]quinazolin-4-amine …
Matched Description: … Vandetanib is an oral once-daily kinase inhibitor of tumour angiogenesis and tumour cell proliferation …
Matched Categories: … Antineoplastic and Immunomodulating Agents …
WP-1066
WP1066 has been used in trials studying the treatment of Melanoma, Brain Cancer, Solid Tumors, and Central Nervous System Neoplasms.
Investigational
Matched Synonyms: … (E)-3-(6-Bromo-pyridin-2-yl)-2-cyano-N-((S)-1-phenyl-ethyl)-acryl amide ... 2-PROPENAMIDE, 3-(6-BROMO-2-PYRIDINYL)-2-CYANO-N-((1S)-1-PHENYLETHYL)-, (2E)- …
Matched Description: … WP1066 has been used in trials studying the treatment of Melanoma, Brain Cancer, Solid Tumors, and Central …
Matched Description: … WP1066 has been used in trials studying the treatment of Melanoma, Brain Cancer, Solid Tumors, and Central …
Bromopride
Bromopride is a dopamine antagonist used as an antiemetic. Its prokinetic properties are similar to those of metoclopramide. It is unavailable in America or the United Kingdom.
Investigational
Matched Synonyms: … 4-amino-5-bromo-N-[2-(diethylamino)ethyl]-2-methoxybenzamide …
Matched Iupac: … 4-amino-5-bromo-N-[2-(diethylamino)ethyl]-2-methoxybenzamide …
Matched Categories: … Alimentary Tract and Metabolism ... Benzamides and benzamide derivatives …
Matched Iupac: … 4-amino-5-bromo-N-[2-(diethylamino)ethyl]-2-methoxybenzamide …
Matched Categories: … Alimentary Tract and Metabolism ... Benzamides and benzamide derivatives …
Exagamglogene autotemcel
Sickle cell disease (SCD) is a genetic disorder characterized by the production of abnormal sickle-shaped red blood cells (called hemoglobin S, HbS) that initiate a pathophysiology resulting in severe pain, progressive multi-organ damage, and premature death. Treatment options for SCD are largely focused on preventing the production and circulation of...
Approved
Investigational
Matched Synonyms: … blood by positive selection, modified by CRISPR/Cas9 (clustered regularly interspaced short palindromic repeats …
Matched Description: … hemoglobin S, HbS) that initiate a pathophysiology resulting in severe pain, progressive multi-organ damage, and ... [A262691] Treatment options for SCD are largely focused on preventing the production and circulation ... of HbS and inducing the production of normal fetal hemoglobin (HbF),[A262696,A262701] including [hydroxyurea …
Matched Description: … hemoglobin S, HbS) that initiate a pathophysiology resulting in severe pain, progressive multi-organ damage, and ... [A262691] Treatment options for SCD are largely focused on preventing the production and circulation ... of HbS and inducing the production of normal fetal hemoglobin (HbF),[A262696,A262701] including [hydroxyurea …
Fordadistrogene movaparvovec
Investigational
Matched Synonyms: … MUSCLE-SPECIFIC ENHANCER/PROMOTER PLUS HUMAN MINI-DYSTROPHIN GENE PLUS ADENO-ASSOCIATED VIRUS 9 INVERTED TERMINAL REPEAT …
Lesinurad
Lesinurad is an oral uric acid transporter 1 (URAT1) inhibitor indicated for the treatment of hyperuricemia associated with gout. It reduces serum uric acid concentration through the inhibition of URAT1, an enzyme responsible for reuptake of uric acid from the renal tubule, and OAT4, another uric acid transporter associated with...
Approved
Investigational
Matched Synonyms: … {[5-bromo-4-(4-cyclopropylnaphthalen-1-yl)-4H-1,2,4-triazol-3-yl]sulfanyl}acetic acid …
Matched Iupac: … 2-{[5-bromo-4-(4-cyclopropylnaphthalen-1-yl)-4H-1,2,4-triazol-3-yl]sulfanyl}acetic acid …
Matched Description: … through the inhibition of URAT1, an enzyme responsible for reuptake of uric acid from the renal tubule, and ... In August 2017, a combination oral therapy consisting of lesinurad and [DB00437] was FDA-approved under …
Matched Iupac: … 2-{[5-bromo-4-(4-cyclopropylnaphthalen-1-yl)-4H-1,2,4-triazol-3-yl]sulfanyl}acetic acid …
Matched Description: … through the inhibition of URAT1, an enzyme responsible for reuptake of uric acid from the renal tubule, and ... In August 2017, a combination oral therapy consisting of lesinurad and [DB00437] was FDA-approved under …
Soybean oil
Derived from soybeans, soybean oil is a common vegetable oil and a source of polyunsaturated and saturated fatty acids. It is a complex mixture of triglycerides where per 100 g, soybean oil has 16 g of saturated fat, 23 g of monounsaturated fat, and 58 g of polyunsaturated fat. The...
Approved
Matched Synonyms: … Glycine gracilis seed oil …
Matched Description: … Derived from soybeans, soybean oil is a common vegetable oil and a source of polyunsaturated and saturated ... triglycerides where per 100 g, soybean oil has 16 g of saturated fat, 23 g of monounsaturated fat, and ... fatty acids are linoleic (48% - 58%), oleic (17% - 30%), palmitic (9% -13%), linolenic (4% - 11%), and …
Matched Mixtures name: … SOLNARA Everything Blood circulation Nattokinase(Control blood pressure and Improve blood circulation ... SOLNARA Everything Blood circulation Nattokinase(Control blood pressure and Improve blood circulation …
Matched Categories: … Diet, Food, and Nutrition …
Matched Description: … Derived from soybeans, soybean oil is a common vegetable oil and a source of polyunsaturated and saturated ... triglycerides where per 100 g, soybean oil has 16 g of saturated fat, 23 g of monounsaturated fat, and ... fatty acids are linoleic (48% - 58%), oleic (17% - 30%), palmitic (9% -13%), linolenic (4% - 11%), and …
Matched Mixtures name: … SOLNARA Everything Blood circulation Nattokinase(Control blood pressure and Improve blood circulation ... SOLNARA Everything Blood circulation Nattokinase(Control blood pressure and Improve blood circulation …
Matched Categories: … Diet, Food, and Nutrition …
Diethyltoluamide
Diethyltoluamide (DEET) is the common active ingredient in many insect repellent products. It is widely used to repel biting pests such as mosquitoes and ticks. Every year, DEET formulations are used to protect populations from mosquito-borne illnesses like West Nile Virus, the Zika virus, malaria, and/or tick-borne illnesses like Lyme...
Approved
Matched International brands: … Repel …
Matched Description: … It is widely used to repel biting pests such as mosquitoes and ticks. ... /or tick-borne illnesses like Lyme disease and Rocky Mountain spotted fever. ... to protect populations from mosquito-borne illnesses like West Nile Virus, the Zika virus, malaria, and …
Matched Categories: … Antiparasitic Products, Insecticides and Repellents ... Benzamides and benzamide derivatives ... Insecticides and Repellents ... Scabicides, Insecticides and Repellents …
Matched Description: … It is widely used to repel biting pests such as mosquitoes and ticks. ... /or tick-borne illnesses like Lyme disease and Rocky Mountain spotted fever. ... to protect populations from mosquito-borne illnesses like West Nile Virus, the Zika virus, malaria, and …
Matched Categories: … Antiparasitic Products, Insecticides and Repellents ... Benzamides and benzamide derivatives ... Insecticides and Repellents ... Scabicides, Insecticides and Repellents …
CRA_16847
Experimental
Matched Synonyms: … 2-(3-{5-[AMINO(IMINIO)METHYL]-1H-BENZIMIDAZOL-2-YL}-5-BROMO-4-OXIDOPHENYL)SUCCINATE …
Matched Iupac: … (3R)-3-[3-bromo-5-(6-carbamimidoyl-1H-1,3-benzodiazol-2-yl)-4-oxidophenyl]-3-carboxypropanoate …
Matched Iupac: … (3R)-3-[3-bromo-5-(6-carbamimidoyl-1H-1,3-benzodiazol-2-yl)-4-oxidophenyl]-3-carboxypropanoate …
Denfivontinib
Investigational
Matched Synonyms: … 8-Bromo-2-((1-methylpiperidin-4-yl)amino)-4-((4-phenoxyphenyl)amino)pyrido[4,3-D]pyrimidin-5(6H)-one ... 8-bromo-2-[(1-methylpiperidin-4-yl)amino]-4-(4-phenoxyanilino)-6H-pyrido[4,3-d]pyrimidin-5-one …
Matched Iupac: … 8-bromo-2-[(1-methylpiperidin-4-yl)amino]-4-[(4-phenoxyphenyl)amino]-5H,6H-pyrido[4,3-d]pyrimidin-5-one …
Matched Iupac: … 8-bromo-2-[(1-methylpiperidin-4-yl)amino]-4-[(4-phenoxyphenyl)amino]-5H,6H-pyrido[4,3-d]pyrimidin-5-one …
Bupivacaine
Bupivacaine is a widely used local anesthetic agent.
Approved
Investigational
Matched Mixtures name: … Bupivacaine Hydrochloride and Epinephrine ... Bupivacaine Hci and Epinephrine ... Bupivacaine Hydrochloride and Epinephrine …
Matched Categories: … bupivacaine and meloxicam …
Matched Products: … SPICA SPINAL 0,5% HEAVY …
Matched Categories: … bupivacaine and meloxicam …
Matched Products: … SPICA SPINAL 0,5% HEAVY …
AVE-1625
AVE-1625 is an oral selective and potent antagonist of cannabinoid 1 (CB1) receptors having the same mechanism of action as rimonabant. It is currently developed in obesity and its associated comorbidities. AVE-1625 is also being developed for the treatment of Alzheimer disease.
Investigational
Matched Name: … AVE-1625 …
Matched Description: … AVE-1625 is an oral selective and potent antagonist of cannabinoid 1 (CB1) receptors having the same ... It is currently developed in obesity and its associated comorbidities. ... AVE-1625 is also being developed for the treatment of Alzheimer disease. …
Matched Description: … AVE-1625 is an oral selective and potent antagonist of cannabinoid 1 (CB1) receptors having the same ... It is currently developed in obesity and its associated comorbidities. ... AVE-1625 is also being developed for the treatment of Alzheimer disease. …
Progesterone
Progesterone is a hormone that occurs naturally in females, and is essential for endometrial receptivity, embryo implantation, and the successful establishment of pregnancy. A low progesterone concentration or an insufficient response to progesterone can cause infertility and pregnancy loss . Progesterone is used in various contraceptive preparations to prevent ovulation...
Approved
Vet approved
Matched Description: … Progesterone is a hormone that occurs naturally in females, and is essential for endometrial receptivity ... , embryo implantation, and the successful establishment of pregnancy. ... A low progesterone concentration or an insufficient response to progesterone can cause infertility and …
Matched Mixtures name: … Estradiol and Progesterone …
Matched Categories: … progesterone and estrogen ... Progesterone and Derivatives ... Genito Urinary System and Sex Hormones ... Hormones, Hormone Substitutes, and Hormone Antagonists ... Sex Hormones and Modulators of the Genital System …
Matched Products: … ANNEM´S …
Matched Mixtures name: … Estradiol and Progesterone …
Matched Categories: … progesterone and estrogen ... Progesterone and Derivatives ... Genito Urinary System and Sex Hormones ... Hormones, Hormone Substitutes, and Hormone Antagonists ... Sex Hormones and Modulators of the Genital System …
Matched Products: … ANNEM´S …
4-Bromo-2,5-dimethoxyamphetamine
Experimental
Illicit
Matched Name: … 4-Bromo-2,5-dimethoxyamphetamine …
Matched Iupac: … 1-(4-bromo-2,5-dimethoxyphenyl)propan-2-amine …
Matched Iupac: … 1-(4-bromo-2,5-dimethoxyphenyl)propan-2-amine …
NS-3728
NS3728 is an orally active chloride channel blocker for the treatment of cancer.
Investigational
Matched Synonyms: … N-[4-bromo-2-(1H-1,2,3,4-tetrazol-5-yl)phenyl]-N'-[3,5-bis(trifluoromethyl)phenyl]urea …
Matched Iupac: … 1-[3,5-bis(trifluoromethyl)phenyl]-3-[5-bromo-2-(2H-1,2,3,4-tetrazol-5-yl)phenyl]urea …
Matched Iupac: … 1-[3,5-bis(trifluoromethyl)phenyl]-3-[5-bromo-2-(2H-1,2,3,4-tetrazol-5-yl)phenyl]urea …
Botaretigene sparoparvovec
Investigational
Matched Synonyms: … PIGMENTOSA GTPASE REGULATOR RPGR-ORF15 ISOFORM GENE VARIANT PLUS ADENO-ASSOCIATED VIRUS 2 INVERTED TERMINAL REPEAT …
Bedaquiline
Bedaquiline is a bactericidal antimycobacterial drug belonging to the class of diarylquinoline. The quinolinic central heterocyclic nucleus with alcohol and amine side chains is responsible for bedaquiline-mediated antimycobacterial activity. Although it is closely related to fluoroquinolones, bedaquiline does not affect DNA gyrase; instead, bedaquiline inhibits the c subunit of ATP...
Approved
Matched Synonyms: … 1-(6-Bromo-2-methoxy-quinolin-3-yl)-4-dimethylamino-2-naphthalen-1-yl-1-phenyl-butan-2-ol …
Matched Iupac: … (1R,2S)-1-(6-bromo-2-methoxyquinolin-3-yl)-4-(dimethylamino)-2-(naphthalen-1-yl)-1-phenylbutan-2-ol …
Matched Description: … The quinolinic central heterocyclic nucleus with alcohol and amine side chains is responsible for bedaquiline-mediated ... the current standard of TB treatment of anti-TB drugs for 2 months, including 2 key drugs [isoniazid] and ... [rifampin], is highly effective, the emergence of multidrug-resistant TB (MDR-TB) to [isoniazid] and …
Matched Iupac: … (1R,2S)-1-(6-bromo-2-methoxyquinolin-3-yl)-4-(dimethylamino)-2-(naphthalen-1-yl)-1-phenylbutan-2-ol …
Matched Description: … The quinolinic central heterocyclic nucleus with alcohol and amine side chains is responsible for bedaquiline-mediated ... the current standard of TB treatment of anti-TB drugs for 2 months, including 2 key drugs [isoniazid] and ... [rifampin], is highly effective, the emergence of multidrug-resistant TB (MDR-TB) to [isoniazid] and …
Bretylium
Bretylium blocks the release of noradrenaline from the peripheral sympathetic nervous system, and is used in emergency medicine, cardiology, and other specialties for the acute management of ventricular tachycardia and ventricular fibrillation. The primary mode of action for bretylium is thought to be inhibition of voltage-gated K(+) channels. Recent evidence...
Approved
Matched Synonyms: … 2-bromo-N-ethyl-N,N-dimethylbenzenemethanaminium …
Matched Description: … Bretylium blocks the release of noradrenaline from the peripheral sympathetic nervous system, and is ... tachycardia and ventricular fibrillation. ... used in emergency medicine, cardiology, and other specialties for the acute management of ventricular …
Matched Mixtures name: … Bretylium Tosylate 0.4% and Dextrose 5% Inj ... Bretylium Tosylate 0.2% and Dextrose 5% Inj …
Matched Description: … Bretylium blocks the release of noradrenaline from the peripheral sympathetic nervous system, and is ... tachycardia and ventricular fibrillation. ... used in emergency medicine, cardiology, and other specialties for the acute management of ventricular …
Matched Mixtures name: … Bretylium Tosylate 0.4% and Dextrose 5% Inj ... Bretylium Tosylate 0.2% and Dextrose 5% Inj …
Displaying drugs 676 - 700 of 784 in total