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Displaying drugs 776 - 800 of 14420 in total

Alemtuzumab

Alemtuzumab is a humanized monoclonal antibody specific to lymphocyte antigens. It is a recombinant DNA-derived humanized monoclonal antibody (Campath-1H) that is directed against the 21-28 kD cell surface glycoprotein, CD52. The Campath-1H antibody is an IgG1 kappa with the human variable framework and constant regions, and complementarity-determining regions from a...
Approved
Investigational
Matched Description: … The Campath-1H antibody is an IgG1 kappa with the human variable framework and constant regions, and ... [L43397] It is marketed as LEMTRADA for multiple sclerosis (MS) treatment and CAMPTAH for B-cell chronic ... The dose of alemtuzumab used for B-CLL is much higher than that for MS, and also at more frequent dosing …
Matched Categories: … Amino Acids, Peptides, and Proteins ... Antineoplastic and Immunomodulating Agents …

Sucralfate

Sucralfate is a medication that is widely used to prevent and treat a number of diseases in the gastrointestinal tract such as duodenal ulcers [FDA label], gastro-esophageal reflux disease (GERD), gastritis, peptic ulcer disease, stress ulcer, in addition to dyspepsia . It is considered a cytoprotective agent, protecting cells in...
Approved
Matched Description: … It is sold under many brands and is available in both tablet and suspension forms. ... Sucralfate has been shown to be a well-tolerated and safe drug. ... Sucralfate is a medication that is widely used to prevent and treat a number of diseases in the gastrointestinal …
Matched Categories: … Alimentary Tract and Metabolism ... Drugs for Peptic Ulcer and Gastro-Oesophageal Reflux Disease (Gord) …

Propylthiouracil

A thiourea antithyroid agent. Propythiouracil inhibits the synthesis of thyroxine and inhibits the peripheral conversion of throxine to tri-iodothyronine. It is used in the treatment of hyperthyroidism. (From Martindale, The Extra Pharmacopeoia, 30th ed, p534)
Approved
Investigational
Matched Description: … Propythiouracil inhibits the synthesis of thyroxine and inhibits the peripheral conversion of throxine …
Matched Categories: … Sex Hormones and Insulins ... Hormones, Hormone Substitutes, and Hormone Antagonists …

Glofitamab

Glofitamab is a full-length bispecific monoclonal antibody with affinity for both CD20 and CD3 surface antigens found on B- and T-cells, respectively. It has a 2:1 configuration, with bivalency towards CD20 and monovalency towards CD3, and works by recruiting T-cells directly to the surface of cancerous B-cells.[L45698,A258488] Glofitamab was approved...
Approved
Investigational
Matched Description: … It has a 2:1 configuration, with bivalency towards CD20 and monovalency towards CD3, and works by recruiting ... antigens found on B- and T-cells, respectively. ... Glofitamab is a full-length bispecific monoclonal antibody with affinity for both CD20 and CD3 surface …
Matched Categories: … Amino Acids, Peptides, and Proteins …

Echinacea purpurea

Approved
Experimental
Matched Categories: … Herbs and Natural Products …

Eleuthero

Eleuthero is a plant/plant extract used in some OTC (over-the-counter) products. It is not an approved drug.
Approved
Experimental
Matched Categories: … Herbs and Natural Products …

Trastuzumab deruxtecan

Trastuzumab deruxtecan is a HER2-directed antibody attached to a topoisomerase inhibitor that is approved for use in certain types of treatment-resistant HER2-positive cancers. It is classified as an antibody-drug conjugate. The cleavable peptide linker used to bind the antibody and drug in this product distinguishes it from other members of...
Approved
Investigational
Matched Description: … The cleavable peptide linker used to bind the antibody and drug in this product distinguishes it from ... A188988] Trastuzumab deruxtecan was developed by Daiichi Sankyo in collaboration with AstraZeneca and …
Matched Categories: … Amino Acids, Peptides, and Proteins ... Antineoplastic and Immunomodulating Agents ... MONOCLONAL ANTIBODIES AND ANTIBODY DRUG CONJUGATES …

Oxyphenbutazone

Oxyphenbutazone was withdrawn from the Canadian market in March 1985 due to concerns regarding bone marrow suppression.
Approved
Withdrawn
Matched Categories: … Antiinflammatory and Antirheumatic Products ... Topical Products for Joint and Muscular Pain ... Antiinflammatory and Antirheumatic Products, Non-Steroids …

Methyprylon

Methyprylon is a sedative of the piperidinedione derivative family that was previously used for the treatment of insomnia. However, with the introduction of newer drugs with fewer side effects, such as benzodiazepines, the clinical use of methyprylon is now limited. Methyprylon was withdrawn from the U.S. market in June 1965...
Approved
Illicit
Withdrawn
Matched Description: … Methyprylon was withdrawn from the U.S. market in June 1965 and the Canadian market in September 1990 …
Matched Categories: … Hypnotics and Sedatives …

Thrombomodulin Alfa

Thrombomodulin Alfa is a novel, recombinant and soluble thrombomodulin (ART-123). It is a human protein with both thrombin inhibiting and protein C stimulating activities, for the potential treatment of thromboembolism and blood clotting disorders, such as disseminated intravascular thromboembolism.
Approved
Investigational
Matched Description: … Thrombomodulin Alfa is a novel, recombinant and soluble thrombomodulin (ART-123). ... It is a human protein with both thrombin inhibiting and protein C stimulating activities, for the potential ... treatment of thromboembolism and blood clotting disorders, such as disseminated intravascular thromboembolism …
Matched Categories: … Amino Acids, Peptides, and Proteins …

Isoxaflutole

Balance has been investigated for the treatment of Chronic Renal Failure and Peritoneal Membrane Disorder.
Approved
Experimental
Investigational
Matched Description: … Balance has been investigated for the treatment of Chronic Renal Failure and Peritoneal Membrane Disorder …
Matched Categories: … Amino Acids, Peptides, and Proteins …

Dotatate gallium Ga-68

Dotatate gallium (Ga-68) is a somatostatin-2 receptor analog which is radiolabeled with gallium 68 as a positron-emitting radioisotope. Ga-68 dotatate has a high affinity for somatostatin-2 receptor and it is rapidly excreted from the nontarget sites which gives it an ideal candidate for imaging neuroendocrine tumors. Dotatate gallium (Ga-68) explotes...
Approved
Investigational
Matched Description: … Ga-68 dotatate has a high affinity for somatostatin-2 receptor and it is rapidly excreted from the nontarget ... [A31358] Dotatate gallium 68 was developed by Advanced Accelerator Applications USA, Inc. and FDA approved ... Dotatate gallium (Ga-68) explotes its ability to detect somatostatin receptor scintigraphy and this characteristic …
Matched Categories: … Amino Acids, Peptides, and Proteins …

Ferrous succinate

Approved
Matched Categories: … Blood and Blood Forming Organs …

Mafenide

Mafenide is a sulfonamide-type antimicrobial agent used to treat severe burns. It acts by reducing the bacterial population present in the burn tissue and promotes healing of deep burns. In 1998, mafenide acetate was approved under the FDA’s accelerated approval regulations. In November 2022, the use of mafenide acetate (powder...
Approved
Vet approved
Withdrawn
Matched Description: … It acts by reducing the bacterial population present in the burn tissue and promotes healing of deep …
Matched Categories: … Genito Urinary System and Sex Hormones ... Gynecological Antiinfectives and Antiseptics …

Mazindol

Mazindol is a tricyclic anorexigenic agent that is unrelated to and less toxic than amphetamine, but with some similar side effects. It inhibits uptake of catecholamines and blocks the binding of cocaine to the dopamine uptake transporter. Mazindol is only approved in the United States for the treatment of Duchenne...
Approved
Investigational
Matched Description: … Mazindol is a tricyclic anorexigenic agent that is unrelated to and less toxic than [amphetamine], but ... Mazindol is only approved in the United States for the treatment of Duchenne muscular dystrophy, and ... It inhibits uptake of catecholamines and blocks the binding of cocaine to the dopamine uptake transporter …
Matched Categories: … Alimentary Tract and Metabolism ... Anorexigenic Agents & Respiratory and CNS Stimulants ... Anorexigenic Agents & Respiratory and Cerebral Stimulants, Miscellaneous …

Linzagolix

Linzagolix is a non-peptide, selective antagonist of the gonadotropin-releasing hormone (GnRH) receptor. It has been studied for the treatment of estrogen-dependent conditions such as uterine fibroids and endometriosis.[A253642,A253647] It is similar to other GnRH receptor antagonists like cetrorelix, relugolix, and elagolix. Uterine fibroids occur in >70% of women of reproductive...
Approved
Matched Description: … , and reproductive dysfunction. ... [A253642,A253647] It is similar to other GnRH receptor antagonists like [cetrorelix], [relugolix], and ... Uterine fibroids occur in >70% of women of reproductive age, and when symptomatic are associated with …
Matched Categories: … Pituitary and Hypothalamic Hormones and Analogues ... Sex Hormones and Insulins …

Bromazepam

One of the benzodiazepines that is used in the treatment of anxiety disorders. It is a Schedule IV drug in the U.S. and Canada and under the Convention on Psychotropic Substances. It is a intermediate-acting benzodiazepine.
Approved
Illicit
Investigational
Matched Description: … It is a Schedule IV drug in the U.S. and Canada and under the Convention on Psychotropic Substances. …
Matched Categories: … Hypnotics and Sedatives ... Benzodiazepine hypnotics and sedatives ... Benzodiazepines and benzodiazepine derivatives …

Infliximab

Infliximab is a tumor necrosis factor (TNF-alpha or TNF-α) blocker and a chimeric monoclonal IgG1 antibody composed of human constant (75%) and murine variable (25%) regions . Infliximab is produced by a recombinant cell line cultured by continuous perfusion. Tumor necrosis factor-alpha (TNF-α) is a key proinflammatory cytokine involved in...
Approved
Matched Description: … composed of human constant (75%) and murine variable (25%) regions [A31469]. ... Infliximab is a tumor necrosis factor (TNF-alpha or TNF-α) blocker and a chimeric monoclonal IgG1 antibody ... Its hyperactivity and enhanced signalling pathways can be observed in inflammatory diseases where it …
Matched Categories: … Amino Acids, Peptides, and Proteins ... Antineoplastic and Immunomodulating Agents …

Revefenacin

Revefenacin is a novel biphenyl carbamate tertiary amine agent that belongs to the family of the long-acting muscarinic antagonists (LAMA). The labile primary amide in the structure produces a "soft-drug" site that allows rapid systemic clearance and minimizing of the systemically mediated adverse reactions. The LAMA group falls into a...
Approved
Investigational
Matched Description: … [A40026] It was developed by Theravance Biopharma and FDA approved on November 9, 2018.[L4818] ... The LAMA group falls into a parent category known as long-acting inhaled bronchodilators and this type ... labile primary amide in the structure produces a "soft-drug" site that allows rapid systemic clearance and …

Cisplatin

Cisplatin, cisplatinum or cis-diamminedichloroplatinum(II) (CDDP) is a platinum-based chemotherapy drug used to treat various types of cancers, including sarcomas, some carcinomas (e.g. small cell lung cancer, and ovarian cancer), lymphomas and germ cell tumors. It was the first member of its class, which now also includes carboplatin and oxaliplatin.
Approved
Matched Description: … ovarian cancer), lymphomas and germ cell tumors. ... It was the first member of its class, which now also includes carboplatin and oxaliplatin. ... to treat various types of cancers, including sarcomas, some carcinomas (e.g. small cell lung cancer, and …
Matched Categories: … Indicators and Reagents ... Antineoplastic and Immunomodulating Agents …

Ardeparin

Ardeparin, marketed under the US trade name Normiflo, is a low molecular weight heparin (LMWH) anticoagulant used for the prevention of postoperative venous thrombosis. Ardeparin is derived via peroxide degradation of heparin extracted from porcine intestinal mucosa. Its molecular weight ranges from 2000 to 15,000 with an average molecular weight...
Approved
Investigational
Withdrawn
Matched Categories: … Heparin and similars …

Pipradrol

Pipradrol (Meratran) was initially developed in the 1950s as an antidepressant, however, the adverse effects associated with its use and its abuse potential led to its withdrawal and international regulation . Pipradrol was made illegal in many countries in 1970s because of its potential for abuse. It is currently classified...
Approved
Matched Description: … acute toxicity and has been linked to three fatalities. ... its abuse potential led to its withdrawal and international regulation [L2524]. ... Experimentation with the drug and its derivatives for recreational purposes has led to many cases of …
Matched Categories: … Psychostimulants, Agents Used for ADHD and Nootropics …

Copper oxodotreotide Cu-64

Copper Cu 64 dotatate is a newly approved Cu labeled somatostatin analog and has several advantages over 68Ga-labeled somatostatin analogs for positron emission tomography (PET). Copper Cu 64 dotatate has a longer half-life and can be produced once a day as opposed to several times a day, and lower positron...
Approved
Matched Description: … times a day, and lower positron energy lending to improved spatial resolution. ... Copper Cu 64 dotatate is a newly approved Cu labeled somatostatin analog and has several advantages over ... [A220348] Copper Cu 64 dotatate has a longer half-life and can be produced once a day as opposed to several …
Matched Categories: … Amino Acids, Peptides, and Proteins …

Efanesoctocog alfa

Efanesoctocog alfa (BIVV001) is a recombinant factor VIII (FVIII) analogue fusion protein used for the routine prophylaxis, perioperative management of bleeding and on-demand treatment and control of bleeding episodes in patients with hemophilia A. The use of FVIII replacement products is beneficial in patients with hemophilia A; however, their quality...
Approved
Investigational
Matched Description: … on-demand treatment and control of bleeding episodes in patients with hemophilia A. ... FVIII) analogue fusion protein used for the routine prophylaxis, perioperative management of bleeding and ... [A257464] Efanesoctocog alfa was designed to have an extended half-life, and to surpass the half-life …
Matched Categories: … Amino Acids, Peptides, and Proteins …

Betibeglogene autotemcel

Betibeglogene autotemcel is an autologous gene therapy that adds functional copies of the β-globin gene (βA-T87Q-globin) to hematopoietic stem cells in order to treat β-thalassemia. β-thalassemia is a condition caused by mutations in the β-globin gene (HBB) that leads to a significant decrease in the production of β-globin. This affects...
Approved
Investigational
Matched Description: … transfusions are required for survival and the prevention of serious complications. ... This affects hemoglobin levels, and in patients with severe forms of this disease, long-term red cell ... with an HLA-identical sibling donor due to the risks of graft rejection, graft-versus-host disease, and …
Matched Categories: … Blood and Blood Forming Organs …
Displaying drugs 776 - 800 of 14420 in total