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Displaying drugs 176 - 200 of 14516 in total

Corticorelin ovine triflutate

Corticorelin, available commercially as corticorelin ovine triflutate (tradename Acthrel), is a synthetic form of the peptide human corticotropin-releasing hormone (hCRH), a potent stimulator of adrenocorticotropic hormone (ACTH) release from the anterior pituitary. Endogenous forms hCRH are involved in the stress response and its main function is stimulation of the pituitary...
Approved
Matched Description: … (hCRH), a potent stimulator of adrenocorticotropic hormone (ACTH) release from the anterior pituitary ... ovine triflutate (tradename Acthrel), is a synthetic form of the peptide human corticotropin-releasing hormone ... Endogenous forms hCRH are involved in the stress response and its main function is stimulation of the …
Matched Categories: … Hormones, Hormone Substitutes, and Hormone Antagonists ... Amino Acids, Peptides, and Proteins ... Pituitary Hormone-Releasing Hormones …

Betamethasone phosphate

Betamethasone phosphate is a prodrug that is rapidly hydrolyzed, providing rapidly accessible betamethasone to agonize glucocorticoid receptors. Betamethasone provides greater anti-inflammatory activity than prednisolone with less sodium and water retention. Betamethasone sodium phosphate was granted FDA approval on 3 March 1965.
Approved
Vet approved
Matched Description: … and water retention. ... [L11994] Betamethasone sodium phosphate was granted FDA approval on 3 March 1965.[L11994] ... [L11994] Betamethasone provides greater anti-inflammatory activity than [prednisolone] with less sodium …
Matched Categories: … Hormones, Hormone Substitutes, and Hormone Antagonists …

Dutasteride

Dutasteride is an oral synthetic 4-azasteroid commonly marketed under the trade name Avodart. It is a novel dual 5α-reductase inhibitor that works by blocking both isoforms of 5α-reductase enzymes in a potent, selective, and irreversible manner. Type I and II 5α-reductase enzymes convert testosterone into dihydrotestosterone (DHT), a primary hormonal...
Approved
Investigational
Matched Description: … hormonal mediator that plays a role in the development and enlargement of the prostate gland. ... [A1909] Type I and II 5α-reductase enzymes convert testosterone into dihydrotestosterone (DHT), a primary ... 5α-reductase inhibitor that works by blocking both isoforms of 5α-reductase enzymes in a potent, selective, and …
Matched Mixtures name: … Dutasteride and tamsulosin hydrochloride ... Dutasteride and Tamsulosin Hydrochloride ... Dutasteride and tamsulosin hydrochloride …
Matched Categories: … Hormones, Hormone Substitutes, and Hormone Antagonists ... Hormone Antagonists ... tamsulosin and dutasteride ... Genito Urinary System and Sex Hormones …

Pidolic acid

Pidolic acid is a naturally occurring but little-studied amino acid derivative that can be formed enzymatically or non-enzymatically and participates as a biological intermediate with unique pharmacodynamics in various chemical pathways [A32991, L2729]. Elevations of the acid in blood levels may be associated with problems of glutamine or glutathione metabolism...
Approved
Investigational
Matched Description: … occurring but little-studied amino acid derivative that can be formed enzymatically or non-enzymatically and ... Pidolic acid, in general, is found in large quantities in brain tissue and other tissues in bound form …
Matched Salts name: … Sodium pidolate …
Matched Categories: … Alimentary Tract and Metabolism ... Amino Acids, Peptides, and Proteins …

Abaloparatide

Abaloparatide is an N-terminal analog of parathyroid hormone-related protein (PTHrP) and an agonist at the parathyroid hormone type 1 (PTH1) receptor. It is a synthetic 34 amino acid peptide with 41% homology to human parathyroid hormone 1-34 and human PTHrP 1-34. Abaloparatide and PTHrP share the first 21 amino acids...
Approved
Investigational
Matched Description: … Abaloparatide is an N-terminal analog of parathyroid hormone-related protein (PTHrP) [A256778] and an ... [L740] It is a synthetic 34 amino acid peptide with 41% homology to human parathyroid hormone 1-34 and ... agonist at the parathyroid hormone type 1 (PTH1) receptor. …
Matched Categories: … Hormones, Hormone Substitutes, and Hormone Antagonists ... Parathyroid Hormone-Related Protein ... Sex Hormones and Insulins ... Amino Acids, Peptides, and Proteins ... Parathyroid Hormones and Analogues …

Human vaccinia virus immune globulin

Human vaccinia immune globulin (VIG) is a sterile solution containing the purified gamma globulin (IgG) fraction of plasma taken from healthy donors previously vaccinated with live vaccinia virus vaccine who possess high titers of anti-vaccinia virus antibody [FDA Label, A33814]. The IgG fraction is purified by the anion-exchange column chromatography...
Approved
Matched Description: … The IgG fraction is purified by the anion-exchange column chromatography method and the solution is solvent ... is only available in very limited quantities - all factors that may intervene with its availability and ... Nevertheless, VIG by virtue of the way it is produced is a poorly characterized and highly variable human …
Matched Categories: … Amino Acids, Peptides, and Proteins …

Corifollitropin alfa

Corifollitropin alfa, also known as Elonva is used in women undergoing fertility treatment to stimulate the development of more than one mature egg (oocyte) at a time in the ovaries. This drug used together with a gonadotropin-releasing hormone (GnRH) antagonist, a type of medicine also used in fertility treatments. Elonva...
Approved
Investigational
Matched Description: … This drug used together with _a gonadotropin-releasing hormone (GnRH) antagonist_, a type of medicine ... Multiple studies and a meta-analysis suggest that corifollitropin alfa is as efficacious as recombinant …
Matched Categories: … Hormones, Hormone Substitutes, and Hormone Antagonists ... Follicle Stimulating Hormone ... Genito Urinary System and Sex Hormones ... Sex Hormones and Modulators of the Genital System …

Carbimazole

An imidazole antithyroid agent. Carbimazole is metabolized to methimazole, which is responsible for the antithyroid activity.
Approved
Investigational
Matched Categories: … Hormones, Hormone Substitutes, and Hormone Antagonists ... Sex Hormones and Insulins ... Hormone Antagonists …

Tezacaftor

Tezacaftor is a drug of the cystic fibrosis transmembrane conductance regulator (CFTR) potentiator class. It was developed by Vertex Pharmaceuticals and FDA approved in combination with ivacaftor to manage cystic fibrosis. This drug was approved by the FDA on February 12, 2018. Cystic Fibrosis is an autosomal recessive disorder caused...
Approved
Investigational
Matched Description: … and sodium ions across cell membranes. ... Fibrosis Transmembrane Conductance Regulator (CFTR) protein, an ion channel involved in the transport of chloride ... consequently abnormal fluid and ion transport across cell membranes. …
Matched Categories: … ivacaftor and tezacaftor ... ivacaftor, tezacaftor and elexacaftor …

Macimorelin

Macimorelin, a novel and orally active ghrelin mimetic that stimulates GH secretion, is used in the diagnosis of adult GH deficiency (AGHD). More specifically, macimorelin is a peptidomimetic growth hormone secretagogue (GHS) that acts as an agonist of GH secretagogue receptor, or ghrelin receptor (GHS-R1a) to dose-dependently increase GH levels...
Approved
Investigational
Matched Description: … such as AIDS and cancer. ... Growth hormone (GH) is classically linked with linear growth during childhood. ... More specifically, macimorelin is a peptidomimetic growth hormone secretagogue (GHS) that acts as an …
Matched Categories: … Amino Acids, Peptides, and Proteins ... Growth Hormone Secretagogue Receptor Agonist ... Growth Hormone Secretagogue Receptor Agonists …

Metreleptin

Metreleptin, a recombinant analog of the human hormone leptin, is an orphan drug used to treat complications of leptin deficiency in people with lipodystrophy. Lipodystrophies include a range of disorders characterized by the reduction, absence, or altered distribution of adipose tissue. Complications of lipodystrophy include metabolic abnormalities such as hypertriglyceridemia,...
Approved
Matched Description: … Metreleptin, a recombinant analog of the human hormone leptin, is an orphan drug used to treat complications ... fasting glucose, reduced triglycerides, and reductions in food intake. ... include metabolic abnormalities such as hypertriglyceridemia, insulin resistance, diabetes mellitus, and …
Matched Categories: … Hormones, Hormone Substitutes, and Hormone Antagonists ... Amino Acids and Derivatives ... Alimentary Tract and Metabolism ... Amino Acids, Peptides, and Proteins ... Intercellular Signaling Peptides and Proteins …

Isoprenaline

Isoprenaline is a non-selective beta adrenergic receptor agonist indicated to treat heart block, Adams-Stokes attacks, bronchospasm in anesthesia, cadiac arrest, hypovolemic shocks, septic shock, hypoperfusion, congestive hear failure, and cardiogenic shock.[A15638,L33160] Isoprenaline research in the 1940s found that this isopropyl analog of epinephrine dilated the bronchi, as well as raising...
Approved
Investigational
Matched Description: … anesthesia, cadiac arrest, hypovolemic shocks, septic shock, hypoperfusion, congestive hear failure, and ... [A233724,A233729] The US patent from 1943 states that this compound had a wider therapeutic index and ... found that this isopropyl analog of epinephrine dilated the bronchi, as well as raising the heart rate and …
Matched Categories: … Adrenergic and Dopaminergic Agents ... isoprenaline and other drugs for obstructive airway diseases …

Cholesterol

The principal sterol of all higher animals, distributed in body tissues, especially the brain and spinal cord, and in animal fats and oils.
Approved
Investigational
Matched Description: … cord, and in animal fats and oils. ... The principal sterol of all higher animals, distributed in body tissues, especially the brain and spinal …

Ergosterol

A steroid of interest both because its biosynthesis in FUNGI is a target of ANTIFUNGAL AGENTS, notably AZOLES, and because when it is present in SKIN of animals, ULTRAVIOLET RAYS break a bond to result in ERGOCALCIFEROL.
Approved
Experimental
Matched Description: … of interest both because its biosynthesis in FUNGI is a target of ANTIFUNGAL AGENTS, notably AZOLES, and …
Matched Categories: … Diet, Food, and Nutrition …

Sincalide

Sincalide is a medication given by injection to assist in the diagnosis of gallbladder and pancreas disorders. It is identified as the 8-amino acid C-terminal segment of cholecystokinin and is also known as CCK-8. Naturally occurring cholecystokinin is a gastrointestinal peptide hormone normally essential for stimulating protein and fat digestion...
Approved
Matched Description: … Naturally occurring cholecystokinin is a gastrointestinal peptide hormone normally essential for stimulating ... protein and fat digestion in the body. ... Furthermore, sincalide stimulates the pancreatic secretion of bicarbonate and enzymes. …
Matched Categories: … Hormones, Hormone Substitutes, and Hormone Antagonists ... Amino Acids, Peptides, and Proteins …

Eplerenone

Eplerenone, an aldosterone receptor antagonist similar to spironolactone, has been shown to produce sustained increases in plasma renin and serum aldosterone, consistent with inhibition of the negative regulatory feedback of aldosterone on renin secretion. The resulting increased plasma renin activity and aldosterone circulating levels do not overcome the effects of...
Approved
Matched Description: … antagonist similar to spironolactone, has been shown to produce sustained increases in plasma renin and ... The resulting increased plasma renin activity and aldosterone circulating levels do not overcome the ... mineralocorticoid receptors relative to its binding to recombinant human glucocorticoid, progesterone and …
Matched Categories: … Hormones, Hormone Substitutes, and Hormone Antagonists ... Hormone Antagonists …

Gluconic Acid

Commonly found in salts with sodium and calcium. Gluconic acid or gluconate is used to maintain the cation-anion balance on electrolyte solutions.
Approved
Investigational
Matched Description: … Commonly found in salts with sodium and calcium. …
Matched Mixtures name: … Normosol-R and Dextrose ... Plasma-Lyte 148 and dextrose ... Normosol-R and Dextrose …
Matched Salts name: … Sodium gluconate …

Octreotide

Acromegaly is a disorder caused by excess growth hormone (GH), increasing the growth of body tissues and causing metabolic dysfunction. In most cases, it results from an anterior pituitary growth hormone-releasing tumor. Typically, the feet, hands, and face grow abnormally large; organomegaly and insulin resistance may also occur. Acromegaly is...
Approved
Investigational
Matched Description: … and causing metabolic dysfunction. ... Typically, the feet, hands, and face grow abnormally large; organomegaly and insulin resistance may also ... , somatostatin, which inhibits the secretion of growth hormone. …
Matched Categories: … Pituitary and Hypothalamic Hormones and Analogues ... Sex Hormones and Insulins ... Amino Acids, Peptides, and Proteins ... Somatostatin and Analogues …

Beractant

Beractant is a pulmonary surfactant used for the treatment of Respiratory Distress Syndrome (RDS) in premature infants. Considered a natural source of surfactant as it is made from bovine lung extract, beractant contains a mixture of phospholipids, neutral lipids, fatty acids, and surfactant-associated proteins such as SP-B and SP-C. The...
Approved
Matched Description: … It is suspended in 0.9% sodium chloride solution, and heat-sterilized. ... surfactant-associated proteins such as SP-B and SP-C. ... from bovine lung extract, beractant contains a mixture of phospholipids, neutral lipids, fatty acids, and …

Indium In-111 pentetreotide

Indium In 111 pentetreotide (Octreoscan) has been used in trials studying the diagnostic of SARCOIDOSIS, Solid Tumors, and cushing syndrome.
Approved
Investigational
Matched Description: … pentetreotide (Octreoscan) has been used in trials studying the diagnostic of SARCOIDOSIS, Solid Tumors, and …
Matched Categories: … Hormones, Hormone Substitutes, and Hormone Antagonists ... Amino Acids, Peptides, and Proteins ... Pituitary Hormone Release Inhibiting Hormones …

Hydroxyprogesterone caproate

Hydroxyprogesterone caproate is a synthetic steroid hormone that is similar to medroxyprogesterone acetate and megestrol acetate. It is an ester derivative of 17α-hydroxyprogesterone formed from caproic acid (hexanoic acid). Hydroxyprogesterone caproate was previously marketed under the trade name Delalutin by Squibb, which was approved by the U.S. Food and Drug...
Approved
Investigational
Matched Description: … Hydroxyprogesterone caproate is a synthetic steroid hormone that is similar to medroxyprogesterone acetate ... and megestrol acetate. ... Food and Drug Administration (FDA) in 1956 and withdrawn from marketing in 1999.[L46118] The U.S. …
Matched Categories: … Hormones, Hormone Substitutes, and Hormone Antagonists ... Hormone Antagonists ... Progesterone and Derivatives ... Combination Contraceptives (with Estrogen and derivatives) …

Flutamide

An antiandrogen with about the same potency as cyproterone in rodent and canine species.
Approved
Investigational
Matched Description: … An antiandrogen with about the same potency as cyproterone in rodent and canine species. …
Matched Categories: … Hormones, Hormone Substitutes, and Hormone Antagonists ... Hormone Antagonists and Related Agents ... Antineoplastic and Immunomodulating Agents ... Hormone Antagonists …

Testosterone undecanoate

Testosterone undecanoate is the ester prodrug of testosterone and has a mid-chain fatty acid at the carbon 17β position. It was developed via fatty acid esterification of testosterone in order to achieve orally administer testosterone. There are oral and intramuscular formulations available for testosterone undecanoate: both formulations are indicated for...
Approved
Investigational
Matched Description: … [L35970,L8932,L41355] Testosterone is a critical male hormone that is responsible for the normal ... growth and development of the male sex organs and for the maintenance of secondary sex characteristics ... of testosterone deficiency, such as decreased libido, erectile dysfunction, and loss of muscle and bone …
Matched Categories: … Hormones, Hormone Substitutes, and Hormone Antagonists ... Testosterone and derivatives …

Drospirenone

Drospirenone is a synthetic progestin commonly found in the popular oral contraceptive, Yaz in combination with Ethinyl estradiol. Most recently, it was approved by both Health Canada and the FDA in combination with Estetrol as an oral contraceptive therapy.[L33199,L33174] Aside from its contraceptive effects, drospirenone is used with estrogens to...
Approved
Matched Description: … [L7973] Most recently, it was approved by both Health Canada and the FDA in combination with [Estetrol ... ,L33174] Aside from its contraceptive effects, drospirenone is used with estrogens to control acne and ... during the postpartum period, and this should be considered when assessing potential risks of hormonal …
Matched Mixtures name: … Drospirenone and Ethinyl Estradiol ... Drospirenone and Ethinyl Estradiol ... Drospirenone and Ethinyl Estradiol …
Matched Categories: … Hormones, Hormone Substitutes, and Hormone Antagonists ... Hormone Antagonists ... drospirenone and estetrol ... drospirenone and estrogen ... drospirenone and ethinylestradiol …

Tirzepatide

Tirzepatide is a novel dual glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptor agonist. Dual GIP/GLP-1 agonists gained increasing attention as new therapeutic agents for glycemic and weight control as they demonstrated better glucose control and weight loss compared to selective GLP-1 receptor agonists in preclinical and clinical trials....
Approved
Investigational
Matched Description: … agonists in preclinical and clinical trials. ... only GIP and GLP-1 receptor agonist for this indication. ... Tirzepatide is a novel dual glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide …
Matched Categories: … Hormones, Hormone Substitutes, and Hormone Antagonists ... Alimentary Tract and Metabolism ... Amino Acids, Peptides, and Proteins ... Receptors, Gastrointestinal Hormone …
Displaying drugs 176 - 200 of 14516 in total