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Displaying drugs 926 - 950 of 1334 in total
Savolitinib
Savolitinib has been used in trials studying the treatment and health services research of Tumor, Food Effect, Gastric Cancer, Health Subjects, and Colorectal Cancer, among others.
Investigational
Matched Categories: … Tyrosine Kinase Inhibitors …
Sinbaglustat
Investigational
Dilmapimod
Dilmapimod has been used in trials studying the treatment and diagnostic of Nerve Trauma, Inflammation, Pain, Neuropathic, Arthritis, Rheumatoid, and Coronary Heart Disease, among others. Dilmapimod (SB-681323) is a p38 MAP-kinase inhibitor that has potential uses in inflammatory conditions such as RA (Rheumatoid Arthritis). Previous p38 MAP-kinase inhibitors have been...
Investigational
Matched Description: … Previous p38 MAP-kinase inhibitors have been hindered in development by liver toxicity. ... Dilmapimod (SB-681323) is a p38 MAP-kinase inhibitor that has potential uses in inflammatory conditions …
Icotinib
Icotinib is a potent and specific epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI)
Icotinib was approved in China by the SFDA in June, 2011 and in January 2014, Beta Pharma, Inc. was given a “May Proceed” from the US FDA to conduct a Phase I study for the...
Experimental
Investigational
Matched Description: … Icotinib is a potent and specific epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor ( …
Matched Categories: … Protein Kinase Inhibitors ... Tyrosine Kinase Inhibitors ... Epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors …
Matched Categories: … Protein Kinase Inhibitors ... Tyrosine Kinase Inhibitors ... Epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors …
Sodium tripolyphosphate
Sodium tripolyphosphate is an inorganic compound with formula Na5P3O10 and the sodium salt of the polyphosphate penta-anion. It is used as a component of a wide range domestic and industrial products, particularly detergents.
Vet approved
Y-27632
Y-27632 is an inhibitor of Rho-associated protein kinase. It inhibits calcium sensitization to affect smooth muscle relaxation.
Experimental
Matched Description: … Y-27632 is an inhibitor of Rho-associated protein kinase. …
AZD-8330
AZD-8330 is a potent, selective, orally active MEK inhibitor that blocks signal transduction pathways implicated in cancer cell proliferation and survival. AZD-8330 has shown tumor suppressive activity in multiple preclinical models of human cancer including melanoma, pancreatic, colon, lung, and breast cancers.
Investigational
Matched Categories: … Protein Kinase Inhibitors …
KAI-1678
KAI-1678 is under investigation in clinical trial NCT01106716 (Safety and Efficacy Study of KAI-1678 to Treat Pain in Subjects With Postherpetic Neuralgia).
Investigational
Matched Categories: … Protein Kinase C-epsilon, antagonists & inhibitors …
Ivarmacitinib
Ivarmacitinib (SHR0302) is a selective inhibitor of Janus kinase 1 (JAK1) under investigation for the treatment of various immuno-inflammatory conditions. While ivarmactinib has yet to receive marketing authorization, as of February 2022 clinical trials are ongoing or completed evaluating its use in atopic dermatitis,[L40604,L40619,L40629] ankylosing spondylitis, rheumatoid arthritis, psoriatic arthritis,...
Experimental
Investigational
Matched Description: … Ivarmacitinib (SHR0302) is a selective inhibitor of Janus kinase 1 (JAK1) under investigation for the …
Matched Categories: … Janus Kinase 1, antagonists & inhibitors …
Matched Categories: … Janus Kinase 1, antagonists & inhibitors …
Amyl acetate
Experimental
NVL-655
NVL-655 is an orally bioavailable, brain-penetrant anaplastic lymphoma kinase (ALK) inhibitor inhibitor being investigated for the treatment of non-small cell lung cancer.
Investigational
Matched Description: … NVL-655 is an orally bioavailable, brain-penetrant anaplastic lymphoma kinase (ALK) inhibitor inhibitor …
Bafetinib
Bafetinib has been used in trials studying the treatment of Adult Gliosarcoma, Adult Mixed Glioma, Adult Glioblastoma, Chronic Myeloid Leukemia, and Acute Lymphocytic Leukemia, among others.
Investigational
Matched Categories: … Protein Kinase Inhibitors …
CYC116
CYC116 is a novel anticancer compound with a unique target profile involving both cell cycle and angiogenesis inhibition mechanisms. In preclinical studies, CYC116 has demonstrated antitumor activity in both solid tumors and hematological cancers.
Cyclacel's small molecule investigational drug, CYC116, is the third orally-available Cyclacel drug to enter development, which...
Investigational
Matched Description: … development, which demonstrated anticancer activity with a mechanism consistent with inhibition of Aurora kinase …
Matched Categories: … Protein Kinase Inhibitors …
Matched Categories: … Protein Kinase Inhibitors …
Gedatolisib
Gedatolisib has been used in trials studying the basic science and treatment of Neoplasm, Ovary Cancer, Breast Cancer, Advanced Cancer, and Endometrial Cancer, among others.
Investigational
Matched Categories: … Protein Kinase Inhibitors …
Safingol
Safingol has been used in trials studying the treatment of Unspecified Adult Solid Tumor, Protocol Specific.
Investigational
Matched Categories: … Protein Kinase C, antagonists & inhibitors …
5-(4-((2S,5S)-5-(4-chlorobenzyl)-2-methylmorpholino)piperidin-1-yl)-1H-1,2,4-triazol-3-amine
Investigational
Matched Categories: … Protein Kinase Inhibitors …
Radotinib
Radotinib is under investigation for the treatment of Leukemia, Myelogenous, Chronic, BCR-ABL Positive.
Investigational
Matched Categories: … Tyrosine Kinase Inhibitors …
Wortmannin
Wortmannin is a steroid metabolite of Penicillium funiculosum and Talaromyces wortmannii fungi. This drug acts as a nonspecific, covalent inhibitor of phosphoinositide 3-kinase enzymes (PI3Ks).
Experimental
Matched Description: … This drug acts as a nonspecific, covalent inhibitor of phosphoinositide 3-kinase enzymes (PI3Ks). …
Matched Categories: … Protein Kinase Inhibitors …
Matched Categories: … Protein Kinase Inhibitors …
N-chlorotaurine
N-chlorotaurine is an inhibitor of inducible nitric oxide synthase and IkappaB kinase.
Investigational
Matched Description: … N-chlorotaurine is an inhibitor of inducible nitric oxide synthase and IkappaB kinase. …
Abivertinib
Abivertinib is a tyrosine kinase inhibitor targeted against mutant forms of both human epidermal growth factor receptor (EGFR) and Bruton's tyrosine kinase (BTK). It has been investigated for use in the treatment of non-small cell lung cancer (NSCLC) and B-cell malignancies. In binding to and inhibiting EGFR and BTK receptors,...
Investigational
Matched Description: … factor receptor (EGFR) and Bruton's tyrosine kinase (BTK). ... Abivertinib is a tyrosine kinase inhibitor targeted against mutant forms of both human epidermal growth …
Matched Categories: … Protein Kinase Inhibitors ... Tyrosine Kinase Inhibitors …
Matched Categories: … Protein Kinase Inhibitors ... Tyrosine Kinase Inhibitors …
Staurosporine
An indolocarbazole that is a potent protein kinase C inhibitor which enhances cAMP-mediated responses in human neuroblastoma cells. (Biochem Biophys Res Commun 1995;214(3):1114-20)
Experimental
Matched Description: … An indolocarbazole that is a potent protein kinase C inhibitor which enhances cAMP-mediated responses …
Displaying drugs 926 - 950 of 1334 in total