Displaying drugs 226 - 241 of 241 in total
XR5944
XR5944 is a DNA bis-intercalating anticancer drug. It has both intercalating and antineoplastic activities.
Investigational
Matched Iupac: … 9-methyl-N-(2-{[2-({2-[(9-methylphenazin-1-yl)formamido]ethyl}amino)ethyl]amino}ethyl)phenazine-1-carboxamide …
Matched Description: … XR5944 is a DNA bis-intercalating anticancer drug. ... It has both intercalating and antineoplastic activities. …
Matched Description: … XR5944 is a DNA bis-intercalating anticancer drug. ... It has both intercalating and antineoplastic activities. …
FLT190
FLT190 is a recombinant adeno-associated viral vector serotype S3 containing DNA encoding for human alpha-galactosidase A.
Investigational
Matched Description: … FLT190 is a recombinant adeno-associated viral vector serotype S3 containing DNA encoding for human alpha-galactosidase …
GS-100
GS-100 is an adeno-associated virus serotype 9 virus particle containing viral DNA that includes an expression cassette containing the human NGLY1 gene coding sequence
Investigational
Matched Description: … cassette containing the human NGLY1 gene coding sequence ... GS-100 is an adeno-associated virus serotype 9 virus particle containing viral DNA that includes an expression …
Troxacitabine
Troxacitabine is a nucleoside analog with antineoplastic activity. There has been growing interest in its development for the treatment of patients with refractory lymphoproliferative conditions.
Investigational
Matched Iupac: … 4-amino-1-[(2S,4S)-2-(hydroxymethyl)-1,3-dioxolan-4-yl]-1,2-dihydropyrimidin-2-one …
Matched Categories: … Heterocyclic Compounds, 1-Ring …
Matched Categories: … Heterocyclic Compounds, 1-Ring …
PR-104
Investigational
Matched Iupac: … [2-({2-[(2-bromoethyl)[2-(methanesulfonyloxy)ethyl]amino]-3,5-dinitrophenyl}formamido)ethoxy]phosphonic …
VB10.16
VB10.16 is a novel therapeutic antigen-presenting cell-targeting DNA vaccine developed to treat HPV16-positive cancers. It is composed of three parts, one encodes the E6/E7 fusion protein of human papillomavirus (HPV) type 16 (HPV16), a dimerization entity, and the part encoding a protein that specifically binds to antigen-presenting cells (APCs).
Investigational
Matched Description: … VB10.16 is a novel therapeutic antigen-presenting cell-targeting DNA vaccine developed to treat HPV16 ... It is composed of three parts, one encodes the E6/E7 fusion protein of human papillomavirus (HPV) type ... 16 (HPV16), a dimerization entity, and the part encoding a protein that specifically binds to antigen-presenting …
SCIB1
SCIB1 is an investigational cancer vaccine being developed by Scancell Ltd. It is being investigated for the treatment of melanoma. It consists of plasmid DNA molecules that express a modified antibody in human cells, working to stimulate the patient's T cells to have a stronger reaction against melanoma cells.
Investigational
Matched Description: … It consists of plasmid DNA molecules that express a modified antibody in human cells, working to stimulate …
Umifenovir
Umifenovir is an indole-based, hydrophobic, dual-acting direct antiviral/host-targeting agent used for the treatment and prophylaxis of influenza and other respiratory infections. It has been in use in Russia for approximately 25 years and in China since 2006. Its invention is credited to a collaboration between Russian scientists from several research...
Investigational
Matched Iupac: … ethyl 6-bromo-4-[(dimethylamino)methyl]-5-hydroxy-1-methyl-2-[(phenylsulfanyl)methyl]-1H-indole-3-carboxylate …
Matched Description: … non-enveloped RNA and DNA viruses, including _Flavivirus_,[A191388] Zika virus,[A191391] foot-and-mouth ... prophylaxis of influenza and other respiratory infections. ... C viruses, chikungunya virus, reovirus, Hantaan virus, and coxsackie virus B5. …
Matched Categories: … Heterocyclic Compounds, 2-Ring …
Matched Description: … non-enveloped RNA and DNA viruses, including _Flavivirus_,[A191388] Zika virus,[A191391] foot-and-mouth ... prophylaxis of influenza and other respiratory infections. ... C viruses, chikungunya virus, reovirus, Hantaan virus, and coxsackie virus B5. …
Matched Categories: … Heterocyclic Compounds, 2-Ring …
KP-1461
KP-1461 is a potent, non-chain-terminating, mutagenic deoxyribonucleoside analogue. Designated a DNA covert nucleoside, the drug consists of a modified base that incorporates randomly into HIV and pairs with multiple bases.
Investigational
Matched Iupac: … -2-yl}carbamate ... heptyl N-{5-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-4-oxo-1,4,5,6-tetrahydro-1,3,5-triazin …
Matched Description: … HIV and pairs with multiple bases. ... Designated a DNA covert nucleoside, the drug consists of a modified base that incorporates randomly into …
Matched Categories: … Nucleic Acids, Nucleotides, and Nucleosides …
Matched Description: … HIV and pairs with multiple bases. ... Designated a DNA covert nucleoside, the drug consists of a modified base that incorporates randomly into …
Matched Categories: … Nucleic Acids, Nucleotides, and Nucleosides …
XMT-1001
XMT-1001 is a polymer-based prodrug of camptothecin (CPT), a well-characterized topoisomerase I inhibitor with potent anti-tumor activity. It is a water-soluble macromolecular conjugate of camptothecin (CPT). In this novel CPT pro-drug, CPT is conjugated with a 70 kDa biodegradable hydrophilic polyacetal, poly (1-hydroxymethylene hydroxylmethylformal). XMT-1001 has demonstrated an improved therapeutic...
Investigational
Matched Description: … XMT-1001 has demonstrated an improved therapeutic window as compared with CPT and irinotecan in human ... this novel CPT pro-drug, CPT is conjugated with a 70 kDa biodegradable hydrophilic polyacetal, poly (1- …
Hydrocortisone aceponate
Experimental
Vet approved
Matched Iupac: … (1R,3aS,3bS,9aR,9bS,10S,11aS)-1-[2-(acetyloxy)acetyl]-10-hydroxy-9a,11a-dimethyl-7-oxo-1H,2H,3H,3aH,3bH ... ,4H,5H,7H,8H,9H,9aH,9bH,10H,11H,11aH-cyclopenta[a]phenanthren-1-yl propanoate …
Matched Categories: … Hydrocortisone and derivatives ... Hormones, Hormone Substitutes, and Hormone Antagonists …
Matched Categories: … Hydrocortisone and derivatives ... Hormones, Hormone Substitutes, and Hormone Antagonists …
NUC B1000
NUC B1000 is an expressed interfering RNA (eiRNA)- based product consisting of a plasmid DNA construct designed to produce four short interfering RNA (siRNA) molecules, formulated with a proprietary cationic-lipid delivery system. eiRNA is an approach to RNAi therapeutics, whereby a plasmid DNA coding for desired dsRNA is delivered to...
Investigational
Matched Description: … On January 11, 2008, it was announced that NUC B1000 was entering a phase 1 human safety study of its ... NUC B1000 is an expressed interfering RNA (eiRNA)- based product consisting of a plasmid DNA construct ... [F3910] eiRNA is an approach to RNAi therapeutics, whereby a plasmid DNA coding for desired dsRNA is …
Tirapazamine
Tirapazamine, also known as SR-4233, is an experimental anticancer drug that is activated in hypoxic conditions. This activation is very useful as this hypoxic state is found in human solid tumors in a common phenomenon known as tumor hypoxia. Hence, tirapazamine is solely activated in those hypoxic areas of solid...
Investigational
Matched Description: … This activation is very useful as this hypoxic state is found in human solid tumors in a common phenomenon ... Tirapazamine entered phase III testing in 2006 for patients with head and neck cancer and gynecological ... into consideration that normally, the cells in these hypoxic regions are resistant to radiotherapy and …
Matched Categories: … Heterocyclic Compounds, 1-Ring …
Matched Categories: … Heterocyclic Compounds, 1-Ring …
Curcuma xanthorrhiza oil
Curcuma xanthorrhiza oil is extracted from Curcuma xanthorrhiza Roxb., a member of the ginger family (Zingiberaceae) that is widely distributed in the region of Southeastern Asia . Curcuma xanthorrhiza is also known as Javanese Turmeric or Temoe Lawak . For centuries, Curcuma xanthorrhiza oil has been used as a traditional...
Nutraceutical
Matched Description: … _Curcuma xanthorrhiza_ oil is comprised of 1-2% of curcumin and 3-12% volatile oil, which mainly contains ... Curcumin is a mixture of dicinnamoylmethane derivatives and other phenolic and non-phenolic diarylheptanoids ... _Curcuma xanthorrhiza_ oil is found as an active ingredient in cosmetic and hygienic products, and marketing …
VPM1002
The bacille Calmette-Guérin (BCG) vaccine protects against severe extrapulmonary forms of tuberculosis (TB) but does not adequately protect against pulmonary TB -- the most prevalent form of TB. This recombinant BCG, VPM1002, has been created in response and investigated for preventing pulmonary TB in newborns and TB recurrence in adults...
Investigational
Matched Description: … apoptosis, because of antigens and bacterial DNA being released into the cytosol of the host cell due ... As of August 2020, this vaccine is being tested for prophylaxis against COVID-19 in human clinical trials ... TB in newborns and TB recurrence in adults through post-exposure immunization. …
Displaying drugs 226 - 241 of 241 in total