Displaying drugs 226 - 250 of 615 in total
Zelavespib
Zelavespib (PU-H71) has been used in trials studying the treatment of LYMPHOMA, Solid Tumors, Metastatic Solid Tumor, and Myeloproliferative Neoplasms (MPN).
Investigational
Matched Synonyms: … 9H-purine-9-propanamine, 6-amino-8-((6-iodo-1,3-benzodioxol-5-yl)thio)-N-(1-methylethyl)- …
Inosinic Acid
Inosine 5'-Monophosphate. A purine nucleotide which has hypoxanthine as the base and one phosphate group esterified to the sugar moiety.
Experimental
Matched Description: … A purine nucleotide which has hypoxanthine as the base and one phosphate group esterified to the sugar …
Matched Categories: … Purine Nucleotides …
Matched Categories: … Purine Nucleotides …
Sambucus nigra flowering top
Experimental
3'-deoxyguanosine
3'-deoxyguanosine is a solid. This compound belongs to the purine nucleosides and analogues. These are compounds comprising a purine base attached to a sugar. This medication targets the protein purine nucleoside phosphorylase.
Experimental
Matched Description: … This compound belongs to the purine nucleosides and analogues. ... These are compounds comprising a purine base attached to a sugar. ... This medication targets the protein purine nucleoside phosphorylase. …
Tezacitabine
A synthetic purine nucleoside analogue with potential antineoplastic activity.
Investigational
Matched Description: … A synthetic purine nucleoside analogue with potential antineoplastic activity. …
Sinefungin
Sinefungin is a solid. This compound belongs to the purine nucleosides and analogues. These are compounds comprising a purine base attached to a sugar. The proteins that adenosyl-ornithine target include RdmB, modification methylase TaqI, rRNA (adenine-N6-)-methyltransferase, and modification methylase RsrI.
Experimental
Matched Description: … This compound belongs to the purine nucleosides and analogues. ... These are compounds comprising a purine base attached to a sugar. …
Matched Categories: … Purine Nucleosides …
Matched Categories: … Purine Nucleosides …
Inosine
A purine nucleoside that has hypoxanthine linked by the N9 nitrogen to the C1 carbon of ribose. It is an intermediate in the degradation of purines and purine nucleosides to uric acid and in pathways of purine salvage. It also occurs in the anticodon of certain transfer RNA molecules. (Dorland,...
Experimental
Investigational
Matched Description: … of purine salvage. ... A purine nucleoside that has hypoxanthine linked by the N9 nitrogen to the C1 carbon of ribose. ... It is an intermediate in the degradation of purines and purine nucleosides to uric acid and in pathways …
Matched Categories: … Purine Nucleosides …
Matched Categories: … Purine Nucleosides …
N(4)-Adenosyl-N(4)-methyl-2,4-diaminobutanoic acid
N(4)-adenosyl-n(4)-methyl-2,4-diaminobutanoic acid is a solid. This compound belongs to the purine nucleosides and analogues. These are compounds comprising a purine base attached to a sugar.
Experimental
Matched Description: … This compound belongs to the purine nucleosides and analogues. ... These are compounds comprising a purine base attached to a sugar. …
Alanosine
An amino acid analogue and antibiotic derived from the bacterium Streptomyces alanosinicus with antimetabolite and potential antineoplastic activities.
Investigational
Hypoxanthine
Hypoxanthine is a purine and a reaction intermediate in the metabolism of adenosine and in the formation of nucleic acids by the salvage pathway.
Experimental
Matched Description: … Hypoxanthine is a purine and a reaction intermediate in the metabolism of adenosine and in the formation …
Tubercidin
An antibiotic purine ribonucleoside that readily substitutes for adenosine in the biological system, but its incorporation into DNA and RNA has an inhibitory effect on the metabolism of these nucleic acids.
Experimental
Matched Description: … An antibiotic purine ribonucleoside that readily substitutes for adenosine in the biological system, …
Matched Categories: … Purine Nucleosides …
Matched Categories: … Purine Nucleosides …
Tetrahydrofolic acid
Tetrahydrofolic acid is a folic acid derivative that is produced from dihydrofolic acid after conversion by dihydrofolate reductase. It is converted into 5,10-methylenetetrahydrofolate by serine hydroxymethyltransferase. It is a soluble coenzyme in many reactions, especially in the metabolism of amino acids and nucleic acids.
Nutraceutical
Paramethasone
A glucocorticoid with the general properties of corticosteroids. It has been used by mouth in the treatment of all conditions in which corticosteroid therapy is indicated except adrenal-deficiency states for which its lack of sodium-retaining properties makes it less suitable than hydrocortisone with supplementary fludrocortisone. (From Martindale, The Extra Pharmacopoeia,...
Experimental
Matched Description: … therapy is indicated except adrenal-deficiency states for which its lack of sodium-retaining properties makes …
Xanthine
A purine base found in most body tissues and fluids, certain plants, and some urinary calculi. It is an intermediate in the degradation of adenosine monophosphate to uric acid, being formed by oxidation of hypoxanthine. The methylated xanthine compounds caffeine, theobromine, and theophylline and their derivatives are used in medicine...
Experimental
Matched Iupac: … 2,3,6,7-tetrahydro-1H-purine-2,6-dione …
Matched Description: … A purine base found in most body tissues and fluids, certain plants, and some urinary calculi. …
Matched Description: … A purine base found in most body tissues and fluids, certain plants, and some urinary calculi. …
Topiroxostat
Topiroxostat is a selective xanthine oxidase inhibitor developed for treatment and management of hyperuricemia and gout. Xanthine oxidase, or xanthine oxidoreductase (XOR), regulates purine metabolism, and inhibition of the enzyme results in efficacious reduction of serum urate levels. Xanthine oxidase inhibitors are classified into two groups; purine analogs such as...
Experimental
Matched Description: … ], and non-purine agents which includes topiroxostat. ... Xanthine oxidase, or xanthine oxidoreductase (XOR), regulates purine metabolism, and inhibition of the ... Xanthine oxidase inhibitors are classified into two groups; purine analogs such as [DB00437] and [DB05262 …
8-azaguanine
8-azaguanine is one of the early purine analogs showing antineoplastic activity. It functions as an antimetabolite and is easily incorporated into ribonucleic acids.
Experimental
Matched Description: … 8-azaguanine is one of the early purine analogs showing antineoplastic activity. …
9-(4-hydroxybutyl)-N2-phenylguanine
9-(4-hydroxybutyl)-N2-phenylguanine is a solid. This compound belongs to the hypoxanthines. These are compounds containing the purine derivative 1H-purin-6(9H)-one. 9-(4-hydroxybutyl)-n2-phenylguanine is known to target thymidine kinase.
Experimental
Matched Description: … These are compounds containing the purine derivative 1H-purin-6(9H)-one. 9-(4-hydroxybutyl)-n2-phenylguanine …
Thiocolchicoside
Thiocolchicoside is a semi-synthetic derivative of the colchicine, a natural anti-inflammatory glycoside which originates from the flower seeds of Superba gloriosa. It is a muscle relaxant with anti-inflammatory and analgesic effects. It has potent convulsant activity and should not be administered to individuals prone to seizures.
Experimental
Matched Description: … semi-synthetic derivative of the colchicine, a natural anti-inflammatory glycoside which originates from the flower …
8-Aminotheophylline
Experimental
Matched Iupac: … 8-imino-1,3-dimethyl-2,3,6,7,8,9-hexahydro-1H-purine-2,6-dione …
Methylliberine
Investigational
Matched Iupac: … 2-methoxy-1,7,9-trimethyl-6,7,8,9-tetrahydro-1H-purine-6,8-dione …
9-Methyl Uric Acid
Experimental
Matched Iupac: … 9-methyl-2,3,6,7,8,9-hexahydro-1H-purine-2,6,8-trione …
Displaying drugs 226 - 250 of 615 in total