Displaying drugs 2526 - 2550 of 15064 in total
Mephenytoin
Mephenytoin is used for the treatment of refractory partial epilepsy. Mephenytoin is a solid. This compound belongs to the phenylhydantoins. These are heterocyclic aromatic compounds containing an imiazolidinedione moiety substituted by a phenyl group. Mephenytoin is known to target sodium channel protein type 5 subunit alpha. Cytochrome P450 2C19, Cytochrome...
Approved
Investigational
Withdrawn
Matched Description: … Mephenytoin and oxazolidinedione derivatives are associated with higher incidences of blood dyscrasias ... Cytochrome P450 2C19, Cytochrome P450 2C8, Cytochrome P450 2C9, Cytochrome P450 2B6, Cytochrome P450 1A2, and …
Methylene blue
Methylene blue is an oxidation-reduction agent. The intravenous form of methylene blue is approved by the FDA for the treatment of pediatric and adult patients with acquired methemoglobinemia. Historically, it has been widely used in Africa to treat malaria, but now it disappeared when chloroquine (CQ) and other drugs entered...
Approved
Investigational
Matched Description: … The intravenous form of methylene blue is approved by the FDA for the treatment of pediatric and adult ... proposed trade name Rember) is an investigational drug being developed by the University of Aberdeen and ... Historically, it has been widely used in Africa to treat malaria, but now it disappeared when chloroquine (CQ) and …
Benzoin
Benzoin is a white crystalline compound prepared by condensation of benzaldehyde in potassium cyanide, and is used in organic syntheses. This should not be confused with benzoin gum from STYRAX (see DB11222). Benzoin is an FDA-approved colour additive used for marking fruits and vegetables.
Approved
Experimental
Matched Description: … Benzoin is an FDA-approved colour additive used for marking fruits and vegetables. ... Benzoin is a white crystalline compound prepared by condensation of benzaldehyde in potassium cyanide, and …
p-tert-Butylphenol-formaldehyde resin (low molecular weight)
p-tert-Butylphenol-formaldehyde resin is a widely used adhesive chemical used in a wide variety of commercially available products and a known dermatological sensitizer and allergen [A34290,A34291].
Sensitivity to p-tert-Butylphenol-formaldehyde resin may be identified with a clinical patch test.
Approved
Experimental
Matched Description: … a known dermatological sensitizer and allergen [A34290,A34291]. ... resin is a widely used adhesive chemical used in a wide variety of commercially available products and …
Bromotheophylline
Bromotheophylline is the active moiety of pamabrom, a mixture of 2-amino-2-methyl-propanol and bromotheophylline. From this mixture, bromotheophylline acts as a weak diuretic that has been used along with some analgesics to relieve the symptoms of premenstrual syndrome. Bromotheophylline is categorized on the FDA as a drug substance with an inactive...
Approved
Matched Description: … Bromotheophylline is the active moiety of pamabrom, a mixture of 2-amino-2-methyl-propanol and bromotheophylline …
Venetoclax
Venetoclax is a BCL-2 inhibitor that was initially approved by the FDA in April 2016 [FDA label]. Proteins in the B cell CLL/lymphoma 2 (BCL-2) family are important regulators of the apoptotic (programmed cell death) process , . Venetoclax is used to treat chronic lymphocytic leukemia (CLL) and certain types...
Approved
Investigational
Matched Description: … Venetoclax is used to treat chronic lymphocytic leukemia (CLL) and certain types of small lymphocytic …
Matched Categories: … Antineoplastic and Immunomodulating Agents …
Matched Categories: … Antineoplastic and Immunomodulating Agents …
Alectinib
Alectinib is a second generation oral drug that selectively inhibits the activity of anaplastic lymphoma kinase (ALK) tyrosine kinase. It is specifically used in the treatment of non-small cell lung cancer (NSCLC) expressing the ALK-EML4 (echinoderm microtubule-associated protein-like 4) fusion protein that causes proliferation of NSCLC cells. Inhibition of ALK...
Approved
Investigational
Matched Description: … Inhibition of ALK prevents phosphorylation and subsequent downstream activation of STAT3 and AKT resulting …
Matched Categories: … Antineoplastic and Immunomodulating Agents …
Matched Categories: … Antineoplastic and Immunomodulating Agents …
Orciprenaline
A beta-adrenergic agonist used in the treatment of asthma and bronchospasms. [PubChem]
Approved
Matched Description: … A beta-adrenergic agonist used in the treatment of asthma and bronchospasms. [PubChem] …
Debrisoquine
An adrenergic neuron-blocking drug similar in effects to guanethidine. It is also noteworthy in being a substrate for a polymorphic cytochrome P-450 enzyme. Persons with certain isoforms of this enzyme are unable to properly metabolize this and many other clinically important drugs. They are commonly referred to as having a...
Approved
Investigational
Matched Description: … Persons with certain isoforms of this enzyme are unable to properly metabolize this and many other clinically …
Tucatinib
Tucatinib is a kinase inhibitor drug used with trastuzumab and capecitabine in the treatment of unresectable or metastatic HER-2 positive breast cancer. It was developed by Seattle Genetics and approved by the FDA on April 17, 2020. Tucatinib is a promising new treatment for patients with metastatic breast cancer who...
Approved
Investigational
Matched Description: … It was developed by Seattle Genetics and approved by the FDA on April 17, 2020. ... Tucatinib is a kinase inhibitor drug used with [trastuzumab] and [capecitabine] in the treatment of unresectable …
Matched Categories: … Antineoplastic and Immunomodulating Agents …
Matched Categories: … Antineoplastic and Immunomodulating Agents …
Ranibizumab
Ranibizumab is a recombinant humanized IgG1 kappa isotype monoclonal antibody fragment directed against human vascular endothelial growth factor A (VEGF-A), which is a glycoprotein implicated in the pathophysiology of age-related macular degeneration.[A2301, L38978] Ranibizumab is used to treat various ocular disorders with abnormal growth of blood vessels, such as neovascular...
Approved
Matched Description: … , and Health Canada respectively. ... [L41429] It is marketed under the brand names LUCENTIS and SUSVIMO. ... after [bevacizumab], another anti-VEGF anticancer drug, was discovered to inhibit neovascularization and …
Matched Categories: … Amino Acids, Peptides, and Proteins …
Matched Categories: … Amino Acids, Peptides, and Proteins …
Pemigatinib
Pemigatinib is a small molecule kinase inhibitor with antitumour activity. It works by inhibiting fibroblast growth factor receptors (FGFRs), which are receptor tyrosine kinases that activate signalling pathways in tumour cells. FGFRs gained attention as potential therapeutic targets in selected cancers, as FGFR gene alterations were observed in a wide...
Approved
Investigational
Matched Description: … physiological processes, such as cancer cell proliferation, enhanced angiogenesis, and evasion of cell ... [L13068] Cholangiocarcinoma is the most common primary malignancy affecting the biliary tract and the ... Pemigatinib is marketed under the brand name Pemazyre, and it is available as oral tablets.[L13050] …
Matched Categories: … Antineoplastic and Immunomodulating Agents …
Matched Categories: … Antineoplastic and Immunomodulating Agents …
Omidubicel
Omidubicel is a nicotinamide-modified allogeneic hematopoietic progenitor cell therapy derived from cord blood used as an allogeneic stem cell donor source. Umbilical blood cord cells are expanded ex-vivo and nicotinamide (a form of vitamin B3) is used as an active agent in the culture system to inhibit the differentiation and...
Approved
Investigational
Matched Description: … of hematopoietic stem and progenitor cells. ... Umbilical blood cord cells are expanded _ex-vivo_ and [nicotinamide] (a form of vitamin B3) is used as ... an active agent in the culture system to inhibit the differentiation and increase the functionality …
Recombinant stabilized RSV A prefusion F antigen
Recombinant stabilized RSV B prefusion F antigen is one component of a bivalent respiratory syncytial virus (RSV) vaccine called Abrysvo. The vaccine comprises two antigens - the other being recombinant stabilized RSV A prefusion F antigen - which have been expressed in Chinese hamster ovary cell lines and then purified...
Approved
Matched Description: … then purified and lyophilized. ... stabilized RSV A prefusion F antigen] - which have been expressed in Chinese hamster ovary cell lines and ... virus vaccine, adjuvanted] (Arexvy), Abrysvo is reconstituted with sterile water prior to injection and …
Coral snake (micrurus fulvius) immune globulin antivenin (equine)
North American Coral Snake Antivenin (Equine) is a horse-derived antivenin indicated for the treatment of envenomation caused by North American coral snake bites. It is intravenously administered so that the antivenin binds to and neutralizes coral snake venom.
The antivenin is a refined, concentrated, and lyophilized preparation of serum globulins...
Approved
Experimental
Matched Description: … It is intravenously administered so that the antivenin binds to and neutralizes coral snake venom. ... The antivenin is a refined, concentrated, and lyophilized preparation of serum globulins obtained by ... Prior to lyophilization, the product contains 0.25% phenol and 0.005% thiomerosal (mercury derivative …
Floctafenine
Floctafenine is an anti-inflammatory analgesic similar in action to aspirin. Floctafenine inhibits prostaglandin synthesis.
Approved
Withdrawn
Matched Categories: … Miscellaneous Analgesics and Antipyretics …
Iodine povacrylex
Iodine povacrylex (DuraPrep) is a surgical solution, film-forming iodophor complex that provides fast acting, persistent, broad-spectrum antimicrobial activity. DuraPrep solution is indicated for use as a patient preoperative skin preparation, for the preparation of the skin prior to surgery and to help reduce bacteria
that can potentially cause skin infection....
Approved
Matched Description: … It is a broad spectrum antiseptic and can provide almost 99.9% antiseptic conditions. ... for use as a patient preoperative skin preparation, for the preparation of the skin prior to surgery and ... cause skin defatting manifested by the following signs/symptoms; localized redness, itching, drying and …
Itraconazole
First synthesized in the early 1980s, itraconazole is a broad-spectrum triazole antifungal agent used to treat a variety of infections. It is a 1:1:1:1 racemic mixture of four diastereomers, made up of two enantiomeric pairs, each possessing three chiral centers. Itraconazole was first approved in the US in 1992 and...
Approved
Investigational
Matched Description: … [L50051] Itraconazole was first approved in the US in 1992 [L50056] and is available orally. …
Matched Categories: … Triazole and tetrazole derivatives ... Metabolic Side Effects of Drugs and Substances …
Matched Categories: … Triazole and tetrazole derivatives ... Metabolic Side Effects of Drugs and Substances …
Romidepsin
Romidepsin is a selective inhibitor of histone deacetylase, approved in the US in 2009 for the treatment of cutaneous T-cell lymphoma (CTCL) in patients who have received at least one prior systemic therapy.
Approved
Investigational
Matched Categories: … Amino Acids, Peptides, and Proteins ... Antineoplastic and Immunomodulating Agents …
Influenza B virus B/Darwin/7/2019 antigen (MDCK cell derived, propiolactone inactivated)
A seasonally-specific component of the influenza vaccine. The influenza vaccine, also known as the "flu shot", is a vaccine that protects against infection from the influenza viruses. Vaccines provide protection from influenza by exposing the immune system to the virus (or parts of the virus) which stimulates an immunological defence...
Approved
Matched Description: … Upon re-exposure to infectious influenza virus, the immune system is prepared to identify and destroy ... Inactivated vaccines contain a virus particle that has been grown in media and then subsequently killed ... There are two basic types of vaccines available: inactivated influenza vaccine (IIV) and live attenuated …
Influenza A virus A/Washington/19/2020 (H1N1) antigen (MDCK cell derived, propiolactone inactivated)
A seasonally-specific component of the influenza vaccine. The influenza vaccine, also known as the "flu shot", is a vaccine that protects against infection from the influenza viruses. Vaccines provide protection from influenza by exposing the immune system to the virus (or parts of the virus) which stimulates an immunological defence...
Approved
Matched Description: … Upon re-exposure to infectious influenza virus, the immune system is prepared to identify and destroy ... Inactivated vaccines contain a virus particle that has been grown in media and then subsequently killed ... There are two basic types of vaccines available: inactivated influenza vaccine (IIV) and live attenuated …
Sultopride
Sultopride is used in Japan, Hong Kong, and Europe to treat schizophrenia. It is of the drug class atypical antipsychotics .
Approved
Matched Description: … Sultopride is used in Japan, Hong Kong, and Europe to treat schizophrenia. …
Matched Categories: … Benzamides and benzamide derivatives …
Matched Categories: … Benzamides and benzamide derivatives …
Monobenzone
Monobenzone is the monobenzyl ether of hydroquinone used medically for depigmentation. Monobenzone occurs as a white, almost tasteless crystalline powder, soluble in alcohol and practically insoluble in water. It exerts a depigmenting effect on skin of mammals by increasing the excretion of melanin from the melanocytes. It may also cause...
Approved
Matched Description: … It may also cause destruction of melanocytes and permanent depigmentation. ... Monobenzone occurs as a white, almost tasteless crystalline powder, soluble in alcohol and practically …
Silanol
Silanol is an FDA-approved food contact substance that is commonly used in organosilicon chemistry and silicate mineralogy.
Approved
Matched Description: … Silanol is an FDA-approved food contact substance that is commonly used in organosilicon chemistry and …
Pentafluoropropane
Pentafluoropropane is under investigation in clinical trial NCT01673061 (Vapocoolant Spray for Numbing Small Boils Before Incision and Drainage).
Approved
Investigational
Matched Description: … investigation in clinical trial NCT01673061 (Vapocoolant Spray for Numbing Small Boils Before Incision and …
Displaying drugs 2526 - 2550 of 15064 in total