Floctafenine

DB08976ApprovedWithdrawnSmall moleculeAnalgesics

Floctafenine is an anti-inflammatory analgesic used to manage mild to moderate acute pain. Floctafenine inhibits prostaglandin synthesis.

Chemical structure of Floctafenine
Mechanism
Curator reviewed
Formula / weight
C20H17F3N2O4 · 406.3552 g/mol (avg)
First approval
Canada, 2001
Code names
R-4138 · R-4318 · RU 15750

Resolves to

Compound
UNIIO04HVX6A9QCAS23779-99-9ChEMBLCHEMBL2105075ChEBI31612PubChem76958517
Clinical / RWD
RxNorm4444ATCN02BG04
Structure
InChIKeyAPQPGQGAWABJLN-UHFFFAOYSA-NSMILESOCC(O)COC(=O)C1=CC=CC=C1NC1=CC=NC2=C(C=CC=C12)C(F)(F)F
Targets
P23219PTGS1P35354PTGS2

What you can answer from here — as of July 03, 2026

2Protein targetsEach mapped to UniProt, with action and pharmacological action
Listed above
1,392Drug interactionsStructured to mechanism, not free text
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2Structured indicationsCondition, population, route and combination as fields, not prose
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15ContraindicationsEach with its own population and attribute set
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5Marketed productsAcross 2 countries and 3 labellers
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1ATC codeIncluding every combination product, plus 17 drug categories
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2+ReferencesStructured and connected to the statements they support
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Which drugs share a target with Floctafenine, and which of those have an active Phase 3 trial?

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