Floctafenine
Identification
- Name
- Floctafenine
- Accession Number
- DB08976
- Description
Floctafenine is an anti-inflammatory analgesic similar in action to aspirin. Floctafenine inhibits prostaglandin synthesis.
- Type
- Small Molecule
- Groups
- Approved, Withdrawn
- Structure
Structure for Floctafenine (DB08976)
- Weight
- Average: 406.3552
Monoisotopic: 406.114041657 - Chemical Formula
- C20H17F3N2O4
- Synonyms
- Floctafenina
- Floctafenine
- Floctafeninum
- External IDs
- R 4318
- R-4138
- R-4318
- RU 15750
Pharmacology
Accelerate your drug discovery research with the industry’s only fully connected ADMET dataset, ideal for:Accelerate your drug discovery research with our fully connected ADMET dataset- Indication
- Not Available
- Associated Conditions
- Contraindications & Blackbox Warnings
Contraindications & Blackbox WarningsWith our commercial data, access important information on dangerous risks, contraindications, and adverse effects.Our Blackbox Warnings cover Risks, Contraindications, and Adverse Effects- Pharmacodynamics
- Not Available
- Mechanism of action
- Not Available
- Absorption
- Not Available
- Volume of distribution
- Not Available
- Protein binding
- Not Available
- Metabolism
- Not Available
- Route of elimination
- Not Available
- Half-life
- Not Available
- Clearance
- Not Available
- Adverse Effects
Reduce medical errorsand improve treatment outcomes with our comprehensive & structured data on drug adverse effects.Reduce medical errors & improve treatment outcomes with our adverse effects data- Toxicity
- Not Available
- Affected organisms
- Not Available
- Pathways
- Not Available
- Pharmacogenomic Effects/ADRs
- Not Available
Interactions
- Drug Interactions
- This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Drug Interaction Integrate drug-drug
interactions in your softwareAbacavir Floctafenine may decrease the excretion rate of Abacavir which could result in a higher serum level. Abciximab The risk or severity of bleeding and hemorrhage can be increased when Floctafenine is combined with Abciximab. Acebutolol The risk or severity of adverse effects can be increased when Acebutolol is combined with Floctafenine. Aceclofenac The risk or severity of adverse effects can be increased when Aceclofenac is combined with Floctafenine. Acemetacin The risk or severity of adverse effects can be increased when Floctafenine is combined with Acemetacin. Acenocoumarol The risk or severity of bleeding and hemorrhage can be increased when Floctafenine is combined with Acenocoumarol. Acetaminophen The risk or severity of adverse effects can be increased when Acetaminophen is combined with Floctafenine. Acetohexamide The protein binding of Acetohexamide can be decreased when combined with Floctafenine. Acetylsalicylic acid The risk or severity of bleeding and hemorrhage can be increased when Floctafenine is combined with Acetylsalicylic acid. Aclidinium Floctafenine may decrease the excretion rate of Aclidinium which could result in a higher serum level. 
Improve patient outcomesBuild effective decision support tools with the industry’s most comprehensive drug-drug interaction checker.Learn more - Food Interactions
- Avoid alcohol. Consuming alcohol increases the risk of gastrointestinal irritation.
- Avoid herbs and supplements with anticoagulant/antiplatelet activity. Herbs with anticoagulant effects may increase the risk of gastrointestinal bleeding. Examples include garlic, ginger, bilberry, danshen, piracetam, and ginkgo biloba.
- Take after a meal. Food reduces gastric irritation.
- Take with a full glass of water.
Products
Comprehensive & structured drug product infoFrom application numbers to product codes, connect different identifiers through our commercial datasets.Easily connect various identifiers back to our datasets- International/Other Brands
- Diralgan / Idalon / Novodolan
- Brand Name Prescription Products
Name Dosage Strength Route Labeller Marketing Start Marketing End Region Image Floctafenine Tablet Oral Aa Pharma Inc 2001-11-14 Not applicable Canada 
Floctafenine Tablet Oral Aa Pharma Inc 2001-11-14 Not applicable Canada Idarac Tablet Oral Sanofi Synthelabo 1985-12-31 2004-08-05 Canada Idarac Tablet Oral Sanofi Synthelabo 1988-12-31 2004-08-05 Canada
Categories
- ATC Codes
- N02BG04 — Floctafenine
- Drug Categories
- Acids, Carbocyclic
- Agents causing hyperkalemia
- Agents that produce hypertension
- Aminobenzoates
- Analgesics
- Analgesics, Non-Narcotic
- Anti-Inflammatory Agents
- Anti-Inflammatory Agents, Non-Steroidal
- Antirheumatic Agents
- Benzene Derivatives
- Benzoates
- Central Nervous System Agents
- Miscellaneous Analgesics and Antipyretics
- Nephrotoxic agents
- Nervous System
- Non COX-2 selective NSAIDS
- Peripheral Nervous System Agents
- Sensory System Agents
- Classification
- Not classified
Chemical Identifiers
- UNII
- O04HVX6A9Q
- CAS number
- 23779-99-9
- InChI Key
- APQPGQGAWABJLN-UHFFFAOYSA-N
- InChI
- InChI=1S/C20H17F3N2O4/c21-20(22,23)15-6-3-5-13-17(8-9-24-18(13)15)25-16-7-2-1-4-14(16)19(28)29-11-12(27)10-26/h1-9,12,26-27H,10-11H2,(H,24,25)
- IUPAC Name
- 2,3-dihydroxypropyl 2-{[8-(trifluoromethyl)quinolin-4-yl]amino}benzoate
- SMILES
- OCC(O)COC(=O)C1=CC=CC=C1NC1=CC=NC2=C(C=CC=C12)C(F)(F)F
References
- Synthesis Reference
U.S. Patent 3,644,368.
- General References
- Not Available
- External Links
- PubChem Compound
- 76958517
- PubChem Substance
- 310264938
- ChemSpider
- 3243
- 4444
- ChEBI
- 31612
- ChEMBL
- CHEMBL2105075
- Wikipedia
- Floctafenine
- AHFS Codes
- 28:08.92 — Miscellaneous Analgesics and Antipyretics
Clinical Trials
Pharmacoeconomics
- Manufacturers
- Not Available
- Packagers
- Not Available
- Dosage Forms
Form Route Strength Tablet Oral Tablet Oral 200 MG - Prices
- Not Available
- Patents
- Not Available
Properties
- State
- Solid
- Experimental Properties
Property Value Source melting point (°C) 179-180 U.S. Patent 3,644,368. - Predicted Properties
Property Value Source Water Solubility 0.0346 mg/mL ALOGPS logP 3.05 ALOGPS logP 4.43 ChemAxon logS -4.1 ALOGPS pKa (Strongest Acidic) 13.62 ChemAxon pKa (Strongest Basic) 5.84 ChemAxon Physiological Charge 0 ChemAxon Hydrogen Acceptor Count 5 ChemAxon Hydrogen Donor Count 3 ChemAxon Polar Surface Area 91.68 Å2 ChemAxon Rotatable Bond Count 8 ChemAxon Refractivity 98.72 m3·mol-1 ChemAxon Polarizability 37.76 Å3 ChemAxon Number of Rings 3 ChemAxon Bioavailability 1 ChemAxon Rule of Five Yes ChemAxon Ghose Filter Yes ChemAxon Veber's Rule No ChemAxon MDDR-like Rule Yes ChemAxon - Predicted ADMET Features
- Not Available
Spectra
- Mass Spec (NIST)
- Not Available
- Spectra
Spectrum Spectrum Type Splash Key Predicted MS/MS Spectrum - 10V, Positive (Annotated) Predicted LC-MS/MS Not Available Predicted MS/MS Spectrum - 20V, Positive (Annotated) Predicted LC-MS/MS Not Available Predicted MS/MS Spectrum - 40V, Positive (Annotated) Predicted LC-MS/MS Not Available Predicted MS/MS Spectrum - 10V, Negative (Annotated) Predicted LC-MS/MS Not Available Predicted MS/MS Spectrum - 20V, Negative (Annotated) Predicted LC-MS/MS Not Available Predicted MS/MS Spectrum - 40V, Negative (Annotated) Predicted LC-MS/MS Not Available
Drug created on June 09, 2014 20:37 / Updated on February 24, 2021 19:34