Identification
- Summary
Floctafenine is an anti-inflammatory analgesic used to manage mild to moderate acute pain.
- Generic Name
- Floctafenine
- DrugBank Accession Number
- DB08976
- Background
Floctafenine is an anti-inflammatory analgesic similar in action to aspirin. Floctafenine inhibits prostaglandin synthesis.
- Type
- Small Molecule
- Groups
- Approved, Withdrawn
- Structure
Structure for Floctafenine (DB08976)
- Weight
- Average: 406.3552
Monoisotopic: 406.114041657 - Chemical Formula
- C20H17F3N2O4
- Synonyms
- Floctafenina
- Floctafenine
- Floctafeninum
- External IDs
- R 4318
- R-4138
- R-4318
- RU 15750
Pharmacology
- Indication
Not Available
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- Contraindications & Blackbox Warnings
Avoid life-threatening adverse drug eventsImprove clinical decision support with information on contraindications & blackbox warnings, population restrictions, harmful risks, & more.Avoid life-threatening adverse drug events & improve clinical decision support.- Pharmacodynamics
Not Available
- Mechanism of action
- Not Available
- Absorption
Not Available
- Volume of distribution
Not Available
- Protein binding
Not Available
- Metabolism
- Not Available
- Route of elimination
Not Available
- Half-life
Not Available
- Clearance
Not Available
- Adverse Effects
Improve decision support & research outcomesWith structured adverse effects data, including: blackbox warnings, adverse reactions, warning & precautions, & incidence rates.Improve decision support & research outcomes with our structured adverse effects data.- Toxicity
Not Available
- Pathways
- Not Available
- Pharmacogenomic Effects/ADRs
- Not Available
Interactions
- Drug Interactions
- This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Drug Interaction Integrate drug-drug
interactions in your softwareAbacavir Floctafenine may decrease the excretion rate of Abacavir which could result in a higher serum level. Abciximab The risk or severity of bleeding and hemorrhage can be increased when Floctafenine is combined with Abciximab. Acebutolol The risk or severity of adverse effects can be increased when Acebutolol is combined with Floctafenine. Aceclofenac The risk or severity of adverse effects can be increased when Aceclofenac is combined with Floctafenine. Acemetacin The risk or severity of adverse effects can be increased when Floctafenine is combined with Acemetacin. Acenocoumarol The risk or severity of bleeding and hemorrhage can be increased when Floctafenine is combined with Acenocoumarol. Acetaminophen The risk or severity of adverse effects can be increased when Acetaminophen is combined with Floctafenine. Acetohexamide The protein binding of Acetohexamide can be decreased when combined with Floctafenine. Acetylsalicylic acid The risk or severity of adverse effects can be increased when Acetylsalicylic acid is combined with Floctafenine. Aclidinium Floctafenine may decrease the excretion rate of Aclidinium which could result in a higher serum level. 
Identify potential medication risksEasily compare up to 40 drugs with our drug interaction checker.Get severity rating, description, and management advice.Learn more - Food Interactions
- Avoid alcohol. Consuming alcohol increases the risk of gastrointestinal irritation.
- Avoid herbs and supplements with anticoagulant/antiplatelet activity. Herbs with anticoagulant effects may increase the risk of gastrointestinal bleeding. Examples include garlic, ginger, bilberry, danshen, piracetam, and ginkgo biloba.
- Take after a meal. Food reduces gastric irritation.
- Take with a full glass of water.
Products
Drug product information from 10+ global regionsOur datasets provide approved product information including:dosage, form, labeller, route of administration, and marketing period.Access drug product information from over 10 global regions.- International/Other Brands
- Diralgan / Idalon / Novodolan
- Brand Name Prescription Products
Name Dosage Strength Route Labeller Marketing Start Marketing End Region Image Floctafenine Tablet 400 mg Oral Aa Pharma Inc 2001-11-14 Not applicable Canada 
Floctafenine Tablet 200 mg Oral Aa Pharma Inc 2001-11-14 Not applicable Canada Idarac Tablet 400 mg Oral Sanofi Synthelabo 1988-12-31 2004-08-05 Canada Idarac Tablet 200 mg Oral Sanofi Synthelabo 1985-12-31 2004-08-05 Canada
Categories
- ATC Codes
- N02BG04 — Floctafenine
- Drug Categories
- Acids, Carbocyclic
- Agents causing hyperkalemia
- Agents that produce hypertension
- Aminobenzoates
- Analgesics
- Analgesics, Non-Narcotic
- Anti-Inflammatory Agents
- Anti-Inflammatory Agents, Non-Steroidal
- Antirheumatic Agents
- Benzene Derivatives
- Benzoates
- Miscellaneous Analgesics and Antipyretics
- Nephrotoxic agents
- Nervous System
- Non COX-2 selective NSAIDS
- Peripheral Nervous System Agents
- Sensory System Agents
- Classification
- Not classified
- Affected organisms
- Not Available
Chemical Identifiers
- UNII
- O04HVX6A9Q
- CAS number
- 23779-99-9
- InChI Key
- APQPGQGAWABJLN-UHFFFAOYSA-N
- InChI
- InChI=1S/C20H17F3N2O4/c21-20(22,23)15-6-3-5-13-17(8-9-24-18(13)15)25-16-7-2-1-4-14(16)19(28)29-11-12(27)10-26/h1-9,12,26-27H,10-11H2,(H,24,25)
- IUPAC Name
- 2,3-dihydroxypropyl 2-{[8-(trifluoromethyl)quinolin-4-yl]amino}benzoate
- SMILES
- OCC(O)COC(=O)C1=CC=CC=C1NC1=CC=NC2=C(C=CC=C12)C(F)(F)F
References
- Synthesis Reference
U.S. Patent 3,644,368.
- General References
- Not Available
- External Links
- PubChem Compound
- 76958517
- PubChem Substance
- 310264938
- ChemSpider
- 3243
- 4444
- ChEBI
- 31612
- ChEMBL
- CHEMBL2105075
- Wikipedia
- Floctafenine
Clinical Trials
Pharmacoeconomics
- Manufacturers
- Not Available
- Packagers
- Not Available
- Dosage Forms
Form Route Strength Tablet Oral 200 mg Tablet Oral 400 mg Tablet Oral - Prices
- Not Available
- Patents
- Not Available
Properties
- State
- Solid
- Experimental Properties
Property Value Source melting point (°C) 179-180 U.S. Patent 3,644,368. - Predicted Properties
Property Value Source Water Solubility 0.0346 mg/mL ALOGPS logP 3.05 ALOGPS logP 4.43 ChemAxon logS -4.1 ALOGPS pKa (Strongest Acidic) 13.62 ChemAxon pKa (Strongest Basic) 5.84 ChemAxon Physiological Charge 0 ChemAxon Hydrogen Acceptor Count 5 ChemAxon Hydrogen Donor Count 3 ChemAxon Polar Surface Area 91.68 Å2 ChemAxon Rotatable Bond Count 8 ChemAxon Refractivity 98.72 m3·mol-1 ChemAxon Polarizability 37.76 Å3 ChemAxon Number of Rings 3 ChemAxon Bioavailability 1 ChemAxon Rule of Five Yes ChemAxon Ghose Filter Yes ChemAxon Veber's Rule No ChemAxon MDDR-like Rule Yes ChemAxon - Predicted ADMET Features
- Not Available
Spectra
- Mass Spec (NIST)
- Not Available
- Spectra
Spectrum Spectrum Type Splash Key Predicted MS/MS Spectrum - 10V, Positive (Annotated) Predicted LC-MS/MS Not Available Predicted MS/MS Spectrum - 20V, Positive (Annotated) Predicted LC-MS/MS Not Available Predicted MS/MS Spectrum - 40V, Positive (Annotated) Predicted LC-MS/MS Not Available Predicted MS/MS Spectrum - 10V, Negative (Annotated) Predicted LC-MS/MS Not Available Predicted MS/MS Spectrum - 20V, Negative (Annotated) Predicted LC-MS/MS Not Available Predicted MS/MS Spectrum - 40V, Negative (Annotated) Predicted LC-MS/MS Not Available
Drug created at June 09, 2014 20:37 / Updated at August 07, 2022 05:31