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Displaying drugs 2751 - 2775 of 15886 in total

Butriptyline

Butriptyline is a tricyclic antidepressant which has been used in Europe since 1974. It is the isobutyl side chain homologue of amitriptyline.
Approved
Withdrawn
Matched Iupac: … dimethyl(2-methyl-3-{tricyclo[9.4.0.0^{3,8}]pentadeca-1(15),3,5,7,11,13-hexaen-2-yl}propyl)amine …

Alirocumab

Alirocumab is a biopharmaceutical that obtained FDA approval in July 2015 as a second line treatment for high cholesterol in adults whose LDL-cholesterol (LDL-C) is not controlled by the combination of diet and statin treatment. It is a human monoclonal antibody part of the family of the PCSK9 inhibitors which...
Approved
Matched Description: … high cholesterol in adults whose LDL-cholesterol (LDL-C) is not controlled by the combination of diet and ... FDA approval was contingent on the completion of further clinical trials to better determine efficacy and …
Matched Categories: … Amino Acids, Peptides, and Proteins …

Janssen COVID-19 Vaccine

The Janssen COVID-19 vaccine (Ad26.COV2.S) is a recombinant vaccine that contains an adenovirus serotype 26 (Ad26) vector expressing a stabilized SARS-CoV-2 spike protein. The vaccine was created in collaboration with Johnson and Johnson (J&J), Janssen Pharmaceutical, and the Beth Israel Deaconess Medical Center. A preclinical study in hamsters infected with...
Approved
Investigational
Matched Description: … The vaccine was created in collaboration with Johnson and Johnson (J&J), Janssen Pharmaceutical, and ... -2 infection[A220053] showed a single immunization with the vaccine-elicited neutralizing responses and ... protected against SARS-CoV-2 induced pneumonia and mortality, providing protection against the disease …

Gallamine triethiodide

A synthetic nondepolarizing blocking drug. The actions of gallamine triethiodide are similar to those of tubocurarine, but this agent blocks the cardiac vagus and may cause sinus tachycardia and, occasionally, hypertension and increased cardiac output. It should be used cautiously in patients at risk from increased heart rate but may...
Approved
Matched Description: … may cause sinus tachycardia and, occasionally, hypertension and increased cardiac output. ... gallamine triethiodide are similar to those of tubocurarine, but this agent blocks the cardiac vagus and …

Verteporfin

Verteporfin, marketed as Visudyne, is a benzoporphyrin derivative comprising a 50:50 mixture of two isomers: CL-315555 and CL-315585. It is used as a photosensitizer in photodynamic therapy to eliminate abnormal blood vessels in wet form macular degeneration. Verteporfin accumulates in these abnormal blood vessels and, when stimulated by nonthermal red...
Approved
Investigational
Matched Description: … as Visudyne, is a benzoporphyrin derivative comprising a 50:50 mixture of two isomers: [CL-315555] and ... Verteporfin accumulates in these abnormal blood vessels and, when stimulated by nonthermal red light ... wavelength of 693 nm in the presence of oxygen, produces highly reactive short-lived singlet oxygen and …

Tranylcypromine

A propylamine formed from the cyclization of the side chain of amphetamine. This monoamine oxidase inhibitor is effective in the treatment of major depression, dysthymic disorder, and atypical depression. It also is useful in panic and phobic disorders (From AMA Drug Evaluations Annual, 1994, p311). Tranylcypromine is a racemate comprising...
Approved
Investigational
Matched Description: … monoamine oxidase inhibitor is effective in the treatment of major depression, dysthymic disorder, and ... It also is useful in panic and phobic disorders (From AMA Drug Evaluations Annual, 1994, p311). ... Tranylcypromine is a racemate comprising equal amounts of (1R,2S)- and (1S,2R)-2-phenylcyclopropan-1- …

Carbinoxamine

Carbinoxamine is a first generation antihistamine that competes with free histamine for binding at HA-receptor sites. This antagonizes the effects of histamine on HA-receptors, leading to a reduction of the negative symptoms brought on by histamine HA-receptor binding. The product label for carbinoxamine as an over the counter cough and...
Approved
Matched Description: … The product label for carbinoxamine as an over the counter cough and cold medicine is being modified ... to state "do not use" in children under 4 years of age in order to prevent and reduce misuse, as many ... labeling, which promoted unapproved uses (including management of congestion, cough, the common cold, and …

Crotalus atrox antivenin

Each year it is estimated there are 45,000 snakebites in the US and 300,000 to 400,000 bites worldwide. About 8000 of these snakebites involve venomous snake species. The majority of people bitten are males and about 50% occur in the age group of 18 to 28 . Crotalus atrox antivenin...
Approved
Experimental
Matched Description: … Each year it is estimated there are 45,000 snakebites in the US and 300,000 to 400,000 bites worldwide ... isolating the antivenin of interest through fractionation and chromatography techniques. ... The majority of people bitten are males and about 50% occur in the age group of 18 to 28 [F113]. …

Modified vaccinia ankara

Modified Vaccinia Ankara (MVA) refers to an attenuated strain of the Vaccinia virus. Vaccines using MVA are live and non-replicating, and are produced using Modified Vaccinia Ankara-Bavarian Nordic (MVA-BN).[L42660,L42670]
Approved
Matched Description: … Vaccines using MVA are live and non-replicating, and are produced using Modified Vaccinia Ankara-Bavarian …

Fluindione

Fluindione is under investigation for the treatment of Venous Thrombosis, Pulmonary Embolism, Permanent Atrial Fibrillation, and Anticoagulating Treatment on a Duration at Least 12-month-old Superior. Fluindione has been investigated for the treatment of Blood Coagulation Disorders.
Approved
Investigational
Matched Description: … investigation for the treatment of Venous Thrombosis, Pulmonary Embolism, Permanent Atrial Fibrillation, and …
Matched Categories: … Blood and Blood Forming Organs …

Tenapanor

Tenapanor is a novel, small molecule medication approved in September 2019 for the treatment of constipation-predominant irritable bowel-syndrome (IBS-C). It was first designed and synthesized in 2012. As an inhibitor of the sodium/hydrogen exchanger isoform 3 (NHE3) transporter, it is the first and currently only medication within its class[A185489,A185492,A185495] and...
Approved
Investigational
Matched Iupac: … 3-{2-[2-(2-{3-[(4S)-6,8-dichloro-2-methyl-1,2,3,4-tetrahydroisoquinolin-4-yl]benzenesulfonamido}ethoxy ... )ethoxy]ethyl}-1-{4-[({2-[2-(2-{3-[(4S)-6,8-dichloro-2-methyl-1,2,3,4-tetrahydroisoquinolin-4-yl]benzenesulfonamido …
Matched Description: … [L8558] It was first designed and synthesized in 2012. ... currently only medication within its class[A185489,A185492,A185495] and therefore exists as a novel ... A185492] As an inhibitor of the sodium/hydrogen exchanger isoform 3 (NHE3) transporter, it is the first and …
Matched Categories: … Alimentary Tract and Metabolism …

Rasagiline

Rasagiline is an irreversible inhibitor of monoamine oxidase and is used as a monotherapy in early Parkinson's disease or as an adjunct therapy in more advanced cases.
Approved
Matched Description: … Rasagiline is an irreversible inhibitor of monoamine oxidase and is used as a monotherapy in early Parkinson's …

Calfactant

Calfactant is a sterile, non-pyrogenic lung surfactant intended for intratracheal instillation. It is an off-white suspension of an extract of natural surfactant from calf lungs suspended in 0.9% saline. Each milliliter of calfactant contains 35mg of phospholipids (including 26 mg phosphatidylcholine of which 16 mg is disaturated phosphatidylcholine) and 0.65mg...
Approved
Matched Description: … 0.65mg of proteins including surfactant-associated proteins B and C. ... phospholipids (including 26 mg phosphatidylcholine of which 16 mg is disaturated phosphatidylcholine) and ... decrease the incidence of respiratory distress syndrome, mortality due to respiratory distress syndrome, and …

Aluminum oxide

Aluminum oxide has a chemical formula Al2O3. It is amphoteric in nature, and is used in various chemical, industrial and commercial applications. It is considered an indirect additive used in food contact substances by the FDA.
Approved
Matched Description: … It is amphoteric in nature, and is used in various chemical, industrial and commercial applications. …

Tripelennamine

A histamine H1 antagonist with low sedative action but frequent gastrointestinal irritation. It is used to treat asthma; HAY fever; urticaria; and rhinitis; and also in veterinary applications. Tripelennamine is administered by various routes, including topically.
Approved
Vet approved
Matched Description: … It is used to treat asthma; HAY fever; urticaria; and rhinitis; and also in veterinary applications. …

Poractant alfa

Poractant alfa is a pulmonary surfactant marketed as Curosurf in the United States and Canada. It is used to treat Respiratory Distress Syndrome (RDS) in premature infants with an endogenous pulmonary surfactant deficiency. Poractant alfa is an extract of natural porcine lung surfactant consisting of 99% polar lipids (mainly phospholipids)...
Approved
Matched Description: … Poractant alfa is a pulmonary surfactant marketed as Curosurf in the United States and Canada. ... 1% hydrophobic low molecular weight proteins (surfactant associated proteins SP-B and SP-C). ... an extract of natural porcine lung surfactant consisting of 99% polar lipids (mainly phospholipids) and …

Cat dander extract

Cat dander extract is either subcutaneously or intracutaneously administered and contains dry cat dander or dry defatted cat pelt. It is used in the diagnosis and treatment (immunotherapy) of patients with a history of allergy to cats. An allergic reaction to cats is induced by the presence of antigen-specific IgE...
Approved
Matched Description: … Cat dander extract is either subcutaneously or intracutaneously administered and contains dry cat dander ... It is used in the diagnosis and treatment (immunotherapy) of patients with a history of allergy to cats ... The allergy diagnostic process involves assessing allergy history, clinical evaluation, and skin test …

Dexmedetomidine

An agonist of receptors, adrenergic alpha-2 that is used in veterinary medicine for its analgesic and sedative properties. It is the racemate of dexmedetomidine.
Approved
Vet approved
Matched Description: … An agonist of receptors, adrenergic alpha-2 that is used in veterinary medicine for its analgesic and …
Matched Categories: … Hypnotics and Sedatives ... Miscellaneous Anxiolytics Sedatives and Hypnotics …

Trihexyphenidyl

Trihexyphenidyl is a centrally acting muscarinic antagonist used for treatment of parkinsonism and drug-induced extrapyramidal disorders.[L31773,L31778] Its discovery was published in 1949 in a study looking for drugs with antispasmodic activity. Trihexyphenidyl is rarely used in the treatment of parkinsonism, and is not a first line treatment due to significant...
Approved
Matched Description: … Trihexyphenidyl is a centrally acting muscarinic antagonist used for treatment of parkinsonism and drug-induced ... [A229103] Trihexyphenidyl is rarely used in the treatment of parkinsonism, and is not a first line treatment …

Pipotiazine

Pipotiazine has actions similar to those of other phenothiazines. Among the different phenothiazine derivatives, it appears to be less sedating and to have a weak propensity for causing hypotension or potentiating the effects of CNS depressants and anesthetics. However, it produces a high incidence of extra pyramidal reactions. It is...
Approved
Investigational
Matched Description: … for causing hypotension or potentiating the effects of CNS depressants and anesthetics. ... Among the different phenothiazine derivatives, it appears to be less sedating and to have a weak propensity ... Symptoms of overdose include severe extrapyramidal manifestations, hypotension, lethargy and sedation …

Tacrine

A centerally active cholinesterase inhibitor that has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders. Tacrine has been discontinued for the United States market.
Approved
Investigational
Withdrawn
Matched Description: … in the treatment of Alzheimer's disease and other central nervous system disorders. ... inhibitor that has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and …

Isoxsuprine

A beta-adrenergic agonist that causes direct relaxation of uterine and vascular smooth muscle. Its vasodilating actions are greater on the arteries supplying skeletal muscle than on those supplying skin. It is used in the treatment of peripheral vascular disease and in premature labor.
Approved
Withdrawn
Matched Description: … It is used in the treatment of peripheral vascular disease and in premature labor. ... A beta-adrenergic agonist that causes direct relaxation of uterine and vascular smooth muscle. …

Benziodarone

Benziodarone is a uricostatic and a uricosuric agent which is sold also under the name Amplivex-Labaz. It is used in the treatment of gout . It was withdrawn from France markets and British markets due to its effects causing Jaundice in patients [T487, A175636].
Approved
Withdrawn
Matched Description: … Benziodarone is a uricostatic and a uricosuric agent which is sold also under the name Amplivex-Labaz ... It was withdrawn from France markets and British markets due to its effects causing Jaundice in patients …

Tizanidine

Tizanidine is a fast-acting drug used for the management of muscle spasm, which may result from the effects of multiple sclerosis, stroke, an acquired brain injury, or a spinal cord injury . It may also be caused by musculoskeletal injury . Regardless of the cause, muscle spasticity can be an...
Approved
Investigational
Matched Description: … Regardless of the cause, muscle spasticity can be an extremely painful and debilitating condition. …

Methoxamine

An alpha-adrenergic agonist that causes prolonged peripheral vasoconstriction. It has little if any direct effect on the central nervous system.
Approved
Investigational
Matched Categories: … Adrenergic and Dopaminergic Agents …
Displaying drugs 2751 - 2775 of 15886 in total