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Displaying drugs 2826 - 2850 of 9573 in total

Phendimetrazine

Phendimetrazine is a weight loss medication. Phendimetrazine is chemically related to amphetamines and is a Schedule III drug under the Convention on Psychotropic Substances and in the US since 1970.
Approved
Illicit

Promazine

A phenothiazine with actions similar to chlorpromazine but with less antipsychotic activity. It is primarily used in short-term treatment of disturbed behavior and as an antiemetic. It is currently not approved for use in the United States.
Approved
Vet approved
Matched Description: … It is primarily used in short-term treatment of disturbed behavior and as an antiemetic. …
Matched Categories: … Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome …

Modafinil

Modafinil is a stimulant drug marketed as a 'wakefulness promoting agent' and is one of the stimulants used in the treatment of narcolepsy. Narcolepsy is caused by dysfunction of a family of wakefulness-promoting and sleep-suppressing peptides, the orexins, whose neurons are activated by modafinil. The prexin neuron activation is associated...
Approved
Investigational
Matched Description: … Narcolepsy is caused by dysfunction of a family of wakefulness-promoting and sleep-suppressing peptides ... used in the treatment of narcolepsy. ... Modafinil is a stimulant drug marketed as a 'wakefulness promoting agent' and is one of the stimulants …
Matched Categories: … Metabolic Side Effects of Drugs and Substances …

Selegiline

A selective, irreversible inhibitor of Type B monoamine oxidase. It is used in newly diagnosed patients with Parkinson's disease. It may slow progression of the clinical disease and delay the requirement for levodopa therapy. It also may be given with levodopa upon onset of disability. (From AMA Drug Evaluations Annual,...
Approved
Investigational
Vet approved
Matched Description: … A selective, irreversible inhibitor of Type B monoamine oxidase. ... It also may be given with levodopa upon onset of disability. ... It may slow progression of the clinical disease and delay the requirement for levodopa therapy. …
Matched Categories: … Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome …

Sertraline

Sertraline is a popular antidepressant medication commonly known as a selective serotonin reuptake inhibitor (SSRI), and is similar to drugs such as Citalopram and Fluoxetine. Despite marked structural differences between compounds in this drug class, SSRIs exert similar pharmacological effects. Several weeks of therapy with sertraline may be required before...
Approved
Matched Description: … cause high levels of drowsiness, dizziness, blurred vision, and other undesirable effects. ... Several weeks of therapy with sertraline may be required before beneficial effects are noticed. ... Sertraline displays enhanced safety or tolerability than other classes of antidepressants, which frequently …
Matched Categories: … Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome …

Selumetinib

Activation of the Raf-MEK-ERK signalling pathway is known to be implemented in several types of malignancies; thus, mitogen-activated protein kinase kinase (MEK) inhibitors such as selumetinib are important tools that can target the problematic overactivity of this pathway. Results from clinical trials investigating earlier developed MEK inhibitors were underwhelming. However,...
Approved
Investigational
Matched Description: … Activation of the Raf-MEK-ERK signalling pathway is known to be implemented in several types of malignancies ... various types of tumours in Phase II trials. ... NF-1 is considered rare, with an estimated incidence of 1/3000 individuals. …

Anthralin

Anthralin (1,8‐dihydroxy‐9anthrone, dithranol) is an older anti-psoriatic agent that was first synthesized as a derivative of chrysarobin, obtained from the araroba tree in Brazil over 100 years ago. Adverse effects of anthralin include irritation and discoloration of the skin . This specific property of the molecule inspired workers to study...
Approved
Matched Description: … Adverse effects of anthralin include irritation and discoloration of the skin [A27277]. ... This specific property of the molecule inspired workers to study details of its pharmacology. ... It is a main active ingredient in topical skin formulations for the treatment of psoriasis. …

Prucalopride

Prucalopride is a dihydrobenzofurancarboxamide derivative from the benzofurane family that selectively stimulates 5-HT4 receptors and thus, it presents enterokinetic properties. The high selectivity of prucalopride allowed further development as it prevented the cardiac adverse reactions observed due to non-target effects of precedent therapies. Prucalopride was developed by Shire Development LLC...
Approved
Matched Description: … adverse reactions observed due to non-target effects of precedent therapies. ... [A37348] The high selectivity of prucalopride allowed further development as it prevented the cardiac …

Vadadustat

One of the most common symptoms of advanced renal disease is anemia, caused primarily by the inability of the kidney to respond to anemic conditions with a corresponding increase in erythropoietin (EPO) production. The treatment of anemia associated with chronic kidney disease (CKD) has traditionally involved the administration of exogenous...
Approved
Investigational
Matched Description: … One of the most common symptoms of advanced renal disease is anemia, caused primarily by the inability ... These transcription factors serve a multitude of roles, including the stimulation of erythropoiesis. ... of CKD, and increases in overall mortality. …

Fexofenadine

Fexofenadine is an over-the-counter second-generation antihistamine used in the treatment of various allergic symptoms. It is selective for the H1 receptor, carries little-to-no activity at off-targets, and does not cross the blood-brain barrier - this is in contrast to previous first-generation antihistamines, such as diphenhydramine, which readily bind to off-targets...
Approved
Investigational
Matched Description: … Fexofenadine is an over-the-counter second-generation antihistamine used in the treatment of various ... [A1452] Fexofenadine is the major active metabolite of [terfenadine][A1495] and is administered as a …
Matched Products: … FEXOFF-R …

Red bell pepper

Red bell pepper allergenic extract is used in allergenic testing.
Approved

Antihemophilic factor, human recombinant

Human recombinant antihemophilic factor (AHF) or Factor VIII, 2332 residues, glycosylated, produced by CHO cells
Approved
Investigational

Isavuconazole

Isavuconazole is an triazole antifungal with broad spectrum of activity and good safety profile . It is approved by the FDA and EMA for the treatment of invasive aspergillosis and mucormycosis. It works by inhibiting fungal cell membrane synthesis. Invasive fungal infections pose significant clinical challenges for patients, especially those...
Approved
Investigational
Matched Description: … It is approved by the FDA and EMA for the treatment of invasive aspergillosis and mucormycosis. ... Isavuconazole is an triazole antifungal with broad spectrum of activity and good safety profile [A32026 ... In vitro, most of the _Candida_ species, most _Aspergillus_ species, Mucorales, _Cryptococcus_ spp., …

Flecainide

Flecainide is a Class I anti-arrhythmic agent like encainide and propafenone. Flecainide’s development began in 1966 and was first synthesized in 1972 as an attempt to generate new anesthetics. It is used to prevent supraventricular and ventricular arrhythmias, as well as paroxysmal atrial fibrillation and flutter.[L8878,L5056] Flecainide was granted FDA...
Approved
Withdrawn

Epirubicin

An anthracycline which is the 4'-epi-isomer of doxorubicin. The compound exerts its antitumor effects by interference with the synthesis and function of DNA.
Approved
Matched Description: … An anthracycline which is the 4'-epi-isomer of doxorubicin. ... The compound exerts its antitumor effects by interference with the synthesis and function of DNA. …

Potassium nitrate

Potassium nitrate is an inorganic salt with a chemical formula of KNO3. It is a natural source of nitrate and has been used as a constituent for several different purposes, including food preservatives, fertilizers, tree stump removal, rocket propellants, and fireworks. Potassium nitrate is a common active ingredient in toothpaste,...
Approved
Matched Description: … Potassium nitrate is an inorganic salt with a chemical formula of KNO3. ... It is a natural source of nitrate and has been used as a constituent for several different purposes, ... It provides increasing protection against painful sensitivity of the teeth to cold, heat, acids, sweets …

Mecasermin rinfabate

Mecasermin rinfabate is approved for severe primary insulin-like growth factor (IGF) deficiency or in patients with GH gene deletion who have developed antibodies to growth hormone (GH) . Mecasermin rinfabate is similar to DB01277 in that both drugs contain recombinant DNA origin insulin-like growth factor 1 (IGF-1). Mecasermin rinfabate however,...
Approved
Matched Description: … The binding of IGF-1 to IGFBP-3 is said to extend the half life and reduce the clearance of IGF-1 in ... patients with growth hormone resistant syndromes and low levels of IGFBP-3 though this may represent …

Clascoterone

Clascoterone (cortexolone 17α-propionate, CB-03-01) is a novel antagonist of androgen receptors. It binds to androgen receptors with high affinity. By competing with androgens for binding to androgen receptors, clascoterone works by blocking the androgen receptor signalling cascades that promote acne pathogenesis, such as sebaceous gland proliferation, excess sebum production, and...
Approved
Investigational
Matched Description: … Clascoterone (cortexolone 17α-propionate, CB-03-01) is a novel antagonist of androgen receptors. ... [A218846] In August 2020, FDA approved clascoterone for the first-in-class topical treatment of acne …

Rabies immune globulin, human

IMOGAM Rabies Pasteurized is indicated for post-exposure prophylaxis in persons suspected of exposure to rabies, who have not previously received a complete immunization regimen with a cell culture produced rabies vaccine. Persons previously vaccinated with other types of rabies vaccines in whom adequate antibody levels have not been demonstrated should...
Approved
Matched Description: … IMOGAM Rabies Pasteurized is indicated for post-exposure prophylaxis in persons suspected of exposure ... Persons previously vaccinated with other types of rabies vaccines in whom adequate antibody levels have ... If IMOGAM Rabies Pasteurized is not administered as recommended at the initiation of the post-exposure …
Matched Products: … BERIRAB(R) P …

Mometasone furoate

Mometasone furoate is a corticosteroid drug that can be used for the treatment of asthma, rhinitis, and certain skin conditions[FDA Label][F4292,F4295]. It has a glucocorticoid receptor binding affinity 22 times stronger than dexamethasone and higher than many other corticosteroids as well . Mometasone furoate is formulated as a dry powder...
Approved
Investigational
Vet approved
Matched Description: … Mometasone furoate is a corticosteroid drug that can be used for the treatment of asthma, rhinitis, and …

Mucor racemosus

Mucor racemosus is a fungus which can provoke allergic reactions. Mucor racemosus extract is used in allergenic testing.
Approved

Riltozinameran

The Omicron variant of SARS-CoV-2 is a variant of concern that was first reported in November 2021. It tends to cause less severe disease but is significantly more virulent than both the original virus and earlier variants (e.g. Delta). As of November 2022, it is the primary circulating variant of...
Approved
Investigational
Matched Description: … The Omicron variant of SARS-CoV-2 is a variant of concern that was first reported in November 2021. ... [L43917] As of November 2022, it is the primary circulating variant of concern according to the World ... [L43917] Riltozinameran is an mRNA vaccine encoding the S glycoprotein of SARS-CoV-2 Omicron variant …

Bromazepam

One of the benzodiazepines that is used in the treatment of anxiety disorders. It is a Schedule IV drug in the U.S. and Canada and under the Convention on Psychotropic Substances. It is a intermediate-acting benzodiazepine.
Approved
Illicit
Investigational
Matched Description: … One of the benzodiazepines that is used in the treatment of anxiety disorders. …

Piracetam

Piracetam is a nootropic drug in the racetams group, with chemical name 2-oxo-1-pyrrolidine acetamide. It shares the same 2-oxo-pyrrolidone base structure with pyroglutamic acid and is a cyclic derivative of the neurotransmitter γ-aminobutyric acid (GABA). However its mechanism of action differ from that of endogenous GABA. Piracetam has neuroprotective and...
Approved
Investigational
Matched Description: … However its mechanism of action differ from that of endogenous GABA. ... shares the same 2-oxo-pyrrolidone base structure with pyroglutamic acid and is a cyclic derivative of …

Phenytoin

Phenytoin is classified as a hydantoin derivative and despite its narrow therapeutic index, it is one of the most commonly used anticonvulsants.[A33595,A188832,A189219] Since it's introduction about 80 years ago, phenytoin has not only been established as an effective anti-epileptic, but has also been investigated for several other indications such as...
Approved
Vet approved
Matched Description: … Phenytoin is classified as a hydantoin derivative and despite its narrow therapeutic index, it is one of ... [A189219,A35884] Both parenteral and oral formulations of phenytoin are available on the market. …
Matched Categories: … Inducers of Drug Clearance ... Metabolic Side Effects of Drugs and Substances …
Matched Products: … EPAMIN(R) SUSPENSION …
Displaying drugs 2826 - 2850 of 9573 in total