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Displaying drugs 2926 - 2950 of 9630 in total
Conivaptan
Conivaptan is a non-peptide inhibitor of antidiuretic hormone (vasopressin). It was approved in 2004 for hyponatremia (low blood sodium levels) caused by syndrome of inappropriate antidiuretic hormone (SIADH). Conivaptan inhibits both isotypes of the vasopressin receptor (V1a and V2).
Approved
Investigational
Matched Description: … Conivaptan is a non-peptide inhibitor of antidiuretic hormone (vasopressin). ... Conivaptan inhibits both isotypes of the vasopressin receptor (V1a and V2). ... It was approved in 2004 for hyponatremia (low blood sodium levels) caused by syndrome of inappropriate …
Edoxudine
Edoxudine is a deoxythymidine analog with activity against herpes simplex virus. It is a potent and selective inhibitor of herpes simplex virus type 1 and 2. The obtained product is an antiviral ointment. The activity of edoxudine against herpes simplex virus was first recognized in 1967. It was later recognized...
Approved
Investigational
Withdrawn
Matched Description: … It is a potent and selective inhibitor of herpes simplex virus type 1 and 2. ... [L2407] The activity of edoxudine against herpes simplex virus was first recognized in 1967. ... It was later recognized to be effective in vivo in a preclinical model of keratitis caused by herpes …
Thimerosal
Thiomersal (INN), commonly known in the U.S. as thimerosal, is an organomercury compound. This compound is a well-established and widely used antiseptic and antifungal agent.
Developed in 1927, thimerosal has been and is still being used as a preservative in some cosmetics, topical pharmaceuticals, and biological drug products, which includes...
Approved
Insulin lispro
Insulin lispro is a rapid-acting form of insulin used for the treatment of hyperglycemia caused by Type 1 and Type 2 Diabetes. Insulin is prescribed for the management of diabetes mellitus to mimic the activity of endogenously produced human insulin, a peptide hormone produced by beta cells of the pancreas...
Approved
Matched Description: … high levels of insulin in a short period of time to mimic the release of endogenous insulin from the ... , with a goal of avoiding any periods of hypoglycemia. ... Insulin lispro is a rapid-acting form of insulin used for the treatment of hyperglycemia caused by Type …
Sorafenib
Sorafenib is a bi-aryl urea and an oral multikinase inhibitor. It targets cell surface tyrosine kinase receptors and downstream intracellular kinases that are implicated in tumour cell proliferation and tumour angiogenesis. First approved by the FDA and European Commission in 2007 for the treatment of hepatocellular carcinoma, sorafenib is also...
Approved
Investigational
Matched Description: … [A255852] First approved by the FDA and European Commission in 2007 for the treatment of hepatocellular …
Olodaterol
Olodaterol is a novel, long-acting beta2-adrenergic agonist (LABA) that exerts its pharmacological effect by binding and activating beta2-adrenergic receptors located primarily in the lungs. Beta2-adrenergic receptors are membrane-bound receptors that are normally activated by endogenous epinephrine whose signalling, via a downstream L-type calcium channel interaction, mediates smooth muscle relaxation and...
Approved
Matched Description: … of COPD or for the treatment of asthma. ... Elevation of these two molecules induces bronchodilation by relaxation of airway smooth muscles. ... (COPD) and the progressive airflow obstruction that is characteristic of it. …
Lorlatinib
Lorlatinib is a third-generation ALK tyrosine kinase inhibitor (TKI) for patients with ALK-positive metastatic non-small cell lung cancer which was first approved by the US FDA in November of 2018. It was subsequently approved by the EMA in 2019 for the treatment of select patients with previously treated advanced ALK-positive...
Approved
Investigational
Matched Description: … It was subsequently approved by the EMA in 2019 for the treatment of select patients with previously ... ALK-positive metastatic non-small cell lung cancer[L39905] which was first approved by the US FDA in November of …
Apixaban
Apixaban is an oral, direct, and highly selective factor Xa (FXa) inhibitor of both free and bound FXa, as well as prothrombinase, independent of antithrombin III for the prevention and treatment of thromboembolic diseases[Label,A6897]. It is marketed under the name Eliquis[Label,L6043]. Apixaban was approved by the FDA on December 28,...
Approved
Matched Description: … , as well as prothrombinase, independent of antithrombin III for the prevention and treatment of thromboembolic ... Apixaban is an oral, direct, and highly selective factor Xa (FXa) inhibitor of both free and bound FXa …
Ancestim
Ancestim is a non-glycosylated recombinant methionyl human stem cell factor. It is a 166 amino acid protein produced by E. coli with an amino acid sequence that is identical to the natural sequence predicted from human DNA sequence analysis, except for the addition of an N-terminal methionine . Ancestim was...
Approved
Investigational
Withdrawn
Matched Description: … It was submitted to the FDA under the status of recommendation for approval with a 10 to 1 votes. ... identical to the natural sequence predicted from human DNA sequence analysis, except for the addition of ... [T68] It was also approved by Health Canada in 1999 but it is currently under the status of canceled …
Olaparib
Olaparib is a selective and potent inhibitor of poly (ADP-ribose) polymerase (PARP) enzymes, PARP1 and PARP2.[L41100, L40908, L43792] PARP inhibitors represent a novel class of anti-cancer therapy and they work by taking advantage of a defect in DNA repair in cancer cells with BRCA mutations and inducing cell death. Olaparib...
Approved
Matched Description: … Olaparib is a selective and potent inhibitor of poly (ADP-ribose) polymerase (PARP) enzymes, PARP1 and ... [L41100, L40908, L43792] PARP inhibitors represent a novel class of anti-cancer therapy and they work ... by taking advantage of a defect in DNA repair in cancer cells with BRCA mutations and inducing cell …
Alnus rubra pollen
Alnus rubra pollen is the pollen of the Alnus rubra plant. Alnus rubra pollen is mainly used in allergenic testing.
Approved
Matched Description: … Alnus rubra pollen is the pollen of the Alnus rubra plant. …
Rhus Glabra Pollen
Rhus Glabra Pollen pollen is the pollen of the Rhus Glabra Pollen plant. The pollen is mainly used in allergenic testing.
Approved
Experimental
Matched Description: … Rhus Glabra Pollen pollen is the pollen of the Rhus Glabra Pollen plant. …
Coagulation Factor IX (Recombinant)
Recombinant Coagulation Factor IX is a purified Factor IX glycoprotein produced by recombinant DNA technology. It has a primary amino acid sequence that is identical to the Ala148 allelic form of human factor IX, and has structural and functional characteristics similar to those of endogenous factor IX. It is not...
Approved
Investigational
Matched Description: … and has structural and functional characteristics similar to those of endogenous factor IX. ... It has a primary amino acid sequence that is identical to the Ala148 allelic form of human factor IX, ... Recombinant Factor IX is indicated for the control and prevention of bleeding episodes in adult and pediatric …
Technetium Tc-99m red blood cells
Technetium Tc-99m red blood cells is a radiopharmaceutical diagnostic agent that is intravenously administered to be used in blood pool imaging, including cardiac first pass and gated equilibrium imaging and for detection of sites of gastrointestinal bleeding. It is clinically useful in early detection and localization of bleeding sites, and...
Approved
Matched Description: … of hemangioma [A32178, A32179]. ... sites of gastrointestinal bleeding. ... in blood pool imaging, including cardiac first pass and gated equilibrium imaging and for detection of …
Artemether
Artemether is an antimalarial agent used to treat acute uncomplicated malaria. It is administered in combination with lumefantrine for improved efficacy. This combination therapy exerts its effects against the erythrocytic stages of Plasmodium spp. and may be used to treat infections caused by P. falciparum and unidentified Plasmodium species, including...
Approved
Matched Description: … This combination therapy exerts its effects against the erythrocytic stages of Plasmodium spp. …
Givinostat
Givinostat is a small molecule histone deacetylase (HDAC) inhibitor. It has been investigated as a treatment for a variety of inflammatory diseases, like Crohn's disease and juvenile idiopathic arthritis, cancers like leukemia and lymphoma, as well as several muscular dystrophies. In the context of muscular dystrophy, inhibitors of HDAC appear...
Approved
Investigational
Matched Description: … In the context of muscular dystrophy, inhibitors of HDAC appear to exert their therapeutic effects by ... 6 years of age with Duchenne muscular dystrophy (DMD). ... It has been investigated as a treatment for a variety of inflammatory diseases, like Crohn's disease …
Ferric pyrophosphate citrate
Ferric pyrophosphate citrate is a soluble iron replacement product. Free iron presents several side effects as it can catalyze free radical formation and lipid peroxidation as well as the presence of interactions of iron in plasma. The ferric ion is strongly complexed by pyrophosphate and citrate. FPC is categorized in...
Approved
Investigational
Matched Description: … interactions of iron in plasma. ... side effects as it can catalyze free radical formation and lipid peroxidation as well as the presence of …
Nizatidine
A histamine H2 receptor antagonist with low toxicity that inhibits gastric acid secretion. The drug is used for the treatment of duodenal ulcers.
Approved
Matched Description: … The drug is used for the treatment of duodenal ulcers. …
Chromium
Chromium is a transition element with the chemical symbol Cr and atomic number 24 that belongs to Group 6 of the periodic table. It is used in various chemical, industrial and manufacturing applications such as wood preservation and metallurgy. The uses of chromium compounds depend on the valency of chromium,...
Approved
Matched Description: … blood glucose, regulation of insulin resistance and metabolism of lipids. ... The uses of chromium compounds depend on the valency of chromium, where trivalent Cr (III) compounds ... According to the National Institute of Health, the daily dietary reference intake (DRI) of chromium for …
Podophyllin
Podophyllin is a resin extracted from the roots of Podophyllum peltatum (American mandrake) and Podophyllum emodi, which contains numerous compounds, amongst which is podophyllin (as well as the drug podophyllotoxin). Podophyllin is the principal active component. Podophyllin arrests mitosis in metaphase.
Approved
Matched Description: … Podophyllin is a resin extracted from the roots of _Podophyllum peltatum_ (American mandrake) and _Podophyllum …
Ingenol mebutate
Ingenol mebutate was approved by the FDA in January 2012, and it is marketed under the name Picato®. Picato gel is indicated for the topical treatment of actinic keratosis. Before approval, ingenol mebutate was called PEP005 as an investigational drug. PEP005 is a selective small molecule activator of protein kinase...
Approved
Matched Description: … Picato gel is indicated for the topical treatment of actinic keratosis. ... peplus, whose sap has been used as a traditional medicine for the treatment of skin conditions including ... PEP005 is a selective small molecule activator of protein kinase C (PKC) extracted from the plant Euphorbia …
Calcium gluconate
Calcium gluconate is used as mineral supplement and medication when there is insufficient calcium in the diet. Supplementation may be done to treat or prevent osteoporosis or rickets, consequences of hypocalcemia. It can also be taken by mouth but is not recommended by injection into a muscle.
Calcium Gluconate Injection,...
Approved
Vet approved
Matched Description: … Calcium saccharate provides 6% of the total calcium and stabilizes the supersaturated solution of calcium ... Each 10 mL of the injection provides 93 mg elemental calcium (Ca++) equivalent to 1 g of calcium gluconate ... Supplementation may be done to treat or prevent osteoporosis or rickets, consequences of hypocalcemia …
Calcium carbonate
Calcium carbonate is an inorganic salt used as an antacid. It is a basic compound that acts by neutralizing hydrochloric acid in gastric secretions. Subsequent increases in pH may inhibit the action of pepsin. An increase in bicarbonate ions and prostaglandins may also confer cytoprotective effects. Calcium carbonate may also...
Approved
Investigational
Matched Description: … Subsequent increases in pH may inhibit the action of pepsin. …
Matched Products: … Co De R T …
Matched Products: … Co De R T …
Etravirine
Etravirine is an antiretroviral agent more specifically classified as a Non-Nucleoside Reverse Transcriptase Inhibitor (NNRTI). Etraverine is used clinically for the treatment of human immunodeficiency virus type 1 (HIV-1) infection. On January 18, 2007, the FDA granted accelerated approved for the use of etravirine 100mg tablets in the treatment of...
Approved
Matched Description: … of rashes in patients taking etravirine, lead to a modification of etravirine's monograph. ... Common side effects of use include mild to moderate rash within the first 6 weeks of therapy, nausea, ... Etravirine exerts its effects via direct inhibition of the reverse transcriptase enzyme of human immunodeficiency …
Sitagliptin
Sitagliptin is an oral dipeptidyl peptidase-4 (DPP-4) inhibitor used in conjunction with diet and exercise to improve glycemic control in patients with type 2 diabetes mellitus[FDA label,A2260,A2255,A2256]. The effect of this medication leads to glucose dependent increases in insulin and decreases in glucagon to improve control of blood sugar[FDA label,A2255]....
Approved
Investigational
Matched Description: … to improve control of blood sugar[FDA label,A2255]. ... The effect of this medication leads to glucose dependent increases in insulin and decreases in glucagon …
Matched Mixtures name: … SIPTATINMET R …
Matched Mixtures name: … SIPTATINMET R …
Displaying drugs 2926 - 2950 of 9630 in total