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Displaying drugs 2951 - 2975 of 9608 in total

Avibactam

Avibactam is a non-β-lactam β-lactamase inhibitor that is available in combination with ceftazidime (Avycaz). This combination was approved by the FDA on February 25, 2015 for the treatment of complicated intra-abdominal infections in combination with metronidazole, and the treatment of complicated urinary tract infections, including pyelonephritis caused by antibiotic resistant-pathogens,...
Approved
Matched Description: … infections in combination with metronidazole, and the treatment of complicated urinary tract infections ... This combination was approved by the FDA on February 25, 2015 for the treatment of complicated intra-abdominal …

Zavegepant

Zavegepant (BHV-3500) is a calcitonin gene-related peptide (CGRP) receptor antagonist. CGRP is released from sensory nerves and acts as a strong vasodilator, and thanks to these properties, it is involved in pain pathways. CGRP receptors are expressed in the central and peripheral nervous system; however, CGRP does not cross the...
Approved
Investigational
Matched Description: … is beneficial in the treatment of migraine. ... of migraine with or without aura in adults. ... [L45505,L45510] A clinical trial (NCT04804033) is currently investigating the efficacy and safety of …

Carisoprodol

Originally approved by the FDA in 1959 [FDA label], carisoprodol is a centrally acting muscle relaxant used in painful musculoskeletal conditions in conjunction with physical therapy and other medications . This drug is available by itself in an oral tablet or combined with aspirin, or in a fixed-dose combination with...
Approved
Matched Description: … Schedule IV substance under the controlled substances act in several US states due to alarming rates of ... abuse [A176062, A176077] despite having a low potential for abuse in addition to a low risk of dependence …

Recombinant stabilized RSV A prefusion F antigen

Recombinant stabilized RSV B prefusion F antigen is one component of a bivalent respiratory syncytial virus (RSV) vaccine called Abrysvo. The vaccine comprises two antigens - the other being recombinant stabilized RSV A prefusion F antigen - which have been expressed in Chinese hamster ovary cell lines and then purified...
Approved
Matched Description: … through six months of age. ... Recombinant stabilized RSV B prefusion F antigen is one component of a bivalent respiratory syncytial ... [L48066] Abrysvo was first approved by the FDA in May 2023 for use in patients ≥60 years of age, and …

Selexipag

Selexipag was approved by the United States FDA on December 22, 2015 for the treatment of pulmonary arterial hypertension (PAH) to delay disease progression and reduce risk of hospitalization. PAH is a relatively rare disease with usually a poor prognosis requiring more treatment options to prolong long-term outcomes. Marketed by...
Approved
Matched Description: … hypertension (PAH) to delay disease progression and reduce risk of hospitalization. ... Selexipag was approved by the United States FDA on December 22, 2015 for the treatment of pulmonary arterial ... under brand name Uptravi, selexipag and its active metabolite, ACT-333679 (MRE-269), act as agonists of …

Nifurtimox

Chagas disease, caused by a parasite known as Trypanosoma cruzi (T.cruzi), is a vector-transmitted disease affecting animals and humans in the Americas. It is commonly known as American Trypanosomiasis. The CDC estimates that approximately 8 million people in Central America, South America, and Mexico are infected with T. cruzi, without...
Approved
Investigational
Matched Description: … L15366] Nifurtimox, developed by Bayer, is a nitrofuran antiprotozoal drug used in the treatment of ... [L15361] A convenient feature of Bayer's formulation is the ability to divide the scored tablets manually …

Entrectinib

Entrectinib is a tropomyosin receptor tyrosine kinase (TRK) TRKA, TRKB, TRKC, proto-oncogene tyrosine-protein kinase ROS1, and anaplastic lymphoma kinase (ALK) inhibitor. It was approved by the FDA in August 2019 for use in the treatment of ROS1-positive metastatic non-small cell lung cancer and NTRK gene fusion positive solid tumors. Entrectinib's...
Approved
Investigational
Matched Description: … [L8081] It was approved by the FDA in August 2019 for use in the treatment of ROS1-positive metastatic ... [L8207] Entrectinib's approved use is meant as a last line of therapy due to its accelerated approval ... over similar ALK inhibitors such as [alectinib], [ceritinib], and [lorlatinib] due to a wider range of …

Bronopol

Bronopol, or 2-Bromo-2-nitro-1,3-propanediol, is an organic compound with wide-spectrum antimicrobial properties. First synthesized in 1897, bronopol was primarily used as a preservative for pharmaceuticals and was registered in the United States in 1984 for use in industrial bactericides, slimicides and preservatives . Bronopol is used as a microbicide or microbiostat...
Approved
Matched Description: … The agent is largely available commercially as an antibacterial for a variety of industrial purposes ... Nevertheless, ongoing contemporary re-evaluations of bronopol use in large markets such as Canada now ... ] and in other products where it may not primarily be used in the role of a non-medicinal preservative …

Desirudin

Desirudin is a direct inhibitor of human thrombin. It has a protein structure that is similar to that of hirudin, the naturally occurring anticoagulant present in the peripharyngeal glands in the medicinal leech, Hirudo medicinalis. Hirudin is a single polypeptide chain of 65 amino acids residues and contains three disulfide...
Approved
Matched Description: … Desirudin has a chemical formula of C287H440N80O110S6 with a molecular weight of 6963.52. ... Desirudin is a direct inhibitor of human thrombin. ... It has a protein structure that is similar to that of hirudin, the naturally occurring anticoagulant …

Angiotensin II

Angiotensin II is under investigation for the treatment of Sepsis, Septic Shock, Diabetes Mellitus, and Acute Renal Failure. Angiotensin II has been investigated for the treatment, basic science, and diagnostic of Hypertension, Renin Angiotensin System, and Idiopathic Membranous Nephropathy. As of December 21, 2017 the FDA approved La Jolla Pharmaceutical's...
Approved
Investigational
Matched Description: … The novelty of the medication lies in the fact that it is the first and only use of synthetic human angiotensin ... Angiotensin II is under investigation for the treatment of Sepsis, Septic Shock, Diabetes Mellitus, and ... Angiotensin II has been investigated for the treatment, basic science, and diagnostic of Hypertension …

Donepezil

In 2016, the global burden of dementia was estimated to be 43.8 million, demonstrating a significant increase from a global prevalence of 20.2 million in 1990. Donepezil, also known as Aricept, is a piperidine derivative acetylcholinesterase inhibitor used in the management of the dementia of Alzheimer's Disease, and in some...
Approved
Matched Description: … the dementia of Alzheimer's Disease, and in some cases, is used to manage other types of dementia. ... the symptoms of its associated dementia. ... increase from a global prevalence of 20.2 million in 1990. …

Acetylsalicylic acid

Also known as Aspirin, acetylsalicylic acid (ASA) is a commonly used drug for the treatment of pain and fever due to various causes. Acetylsalicylic acid has both anti-inflammatory and antipyretic effects. This drug also inhibits platelet aggregation and is used in the prevention of blood clots stroke, and myocardial infarction...
Approved
Vet approved
Matched Description: … Interestingly, the results of various studies have demonstrated that long-term use of acetylsalicylic ... It should be kept out of reach from young children, toddlers, and infants [FDA label]. ... Also known as _Aspirin_, acetylsalicylic acid (ASA) is a commonly used drug for the treatment of pain …
Matched Mixtures name: … CAFIASPIRINA(R) COMPRIMIDOS ... Bubbles R Better Effervescent Cold Relief …

Formestane

Formestane was the first selective, type I, steroidal aromatase inhibitor used in the treatment of estrogen-receptor positive breast cancer in post-menopausal women. Formestane suppresses estrogen production from anabolic steroids or prohormones. Formestane is also a prohormone of 4-hydroxytestosterone, an active steroid with weak androgenic activity and mild aromatase inhibitor activity....
Approved
Investigational
Withdrawn
Matched Description: … Some clinical data has suggested that the clinically recommended dose of 250mg was too low. ... Formestane is also a prohormone of 4-hydroxytestosterone, an active steroid with weak androgenic activity ... Formestane was the first selective, type I, steroidal aromatase inhibitor used in the treatment of estrogen-receptor …

Sitagliptin

Sitagliptin is an oral dipeptidyl peptidase-4 (DPP-4) inhibitor used in conjunction with diet and exercise to improve glycemic control in patients with type 2 diabetes mellitus[FDA label,A2260,A2255,A2256]. The effect of this medication leads to glucose dependent increases in insulin and decreases in glucagon to improve control of blood sugar[FDA label,A2255]....
Approved
Investigational
Matched Description: … to improve control of blood sugar[FDA label,A2255]. ... The effect of this medication leads to glucose dependent increases in insulin and decreases in glucagon …
Matched Mixtures name: … SIPTATINMET R …

Ferumoxytol

Ferumoxytol is an intravenously administered iron preparation indicated in the EU and the US for the treatment of iron deficiency anemia in adult patients with chronic kidney disease (CKD) . It is comprised of superparamagnetic iron oxide nanoparticles which are coated by a semi-synthetic carbohydrate shell in an isotonic, neutral...
Approved
Investigational
Matched Description: … is an intravenously administered iron preparation indicated in the EU and the US for the treatment of ... It is comprised of superparamagnetic iron oxide nanoparticles which are coated by a semi-synthetic carbohydrate …

Sugammadex

Sugammadex is a selective relaxant binding agent indicated for reversal of neuromuscular blockade induced by rocuronium bromide and vecuronium bromide during surgery. Rocuronium bromide and vecuronium bromide are neuromuscular blocking medications that cause temporary paralysis and are especially useful for general anesthesia, ventilation, or tracheal intubation that patients may require...
Approved
Matched Description: … Sugammadex is a selective relaxant binding agent indicated for reversal of neuromuscular blockade induced ... Sugammadex provides a new treatment option to reverse the effects of those medications and possibly help …

Dinoprostone

Dinoprostone is a naturally occurring prostaglandin E2 (PGE2). It has important effects in labour. It also stimulates osteoblasts to release factors which stimualtes bone resorption by osteoclasts. As a prescription drug it is used as a vaginal suppository, to prepare the cervix for labour and to induce labour.
Approved

Juglans regia pollen

Juglans regia pollen is the pollen of the Juglans regia plant. Juglans regia pollen is mainly used in allergenic testing.
Approved
Matched Description: … Juglans regia pollen is the pollen of the Juglans regia plant. …

Rhizopus stolonifer

Rhizopus stolonifer is a fungus which can provoke allergic reactions. Rhizopus stolonifer extract is used in allergenic testing.
Approved

Calcium carbonate

Calcium carbonate is an inorganic salt used as an antacid. It is a basic compound that acts by neutralizing hydrochloric acid in gastric secretions. Subsequent increases in pH may inhibit the action of pepsin. An increase in bicarbonate ions and prostaglandins may also confer cytoprotective effects. Calcium carbonate may also...
Approved
Investigational
Matched Description: … Subsequent increases in pH may inhibit the action of pepsin. …
Matched Products: … Co De R T …

Clotiazepam

Clotiazepam is a thienodiazepine, not approved for sale in the U.S. or Canada, but has been approved in the U.K. It is a schedule IV drug in Canada.
Approved
Illicit

Flotufolastat F-18

Flotufolastat F-18 (18F-rhPSMA-7.3) is an 18F-labeled ligand that targets the prostate-specific membrane antigen (PSMA).[A259846,L46731] In patients with recurrent prostate cancer that require localized treatment, the use of 18F-labeled ligands for positron emission tomography (PET) offers accurate diagnostic imaging. Unlike 68Ga-labeled PSMA-targeting ligands, 18F-labeled compounds targeting this protein have a longer...
Approved
Investigational
Matched Description: … [A259846] In May 2023, the FDA approved the use of flotufolastat F-18 for PET of PSMA-positive lesions ... a high level of accumulation in tumors. ... A259846,L46731] In patients with recurrent prostate cancer that require localized treatment, the use of …

Arsenic trioxide

Arsenic trioxide is a chemotherapeutic agent of idiopathic function used to treat leukemia that is unresponsive to first line agents. It is suspected that arsenic trisulfide induces cancer cells to undergo apoptosis. In general, arsenic is known to be a naturally toxic substance capable of eliciting a variety of dangerous...
Approved
Investigational
Matched Description: … In general, arsenic is known to be a naturally toxic substance capable of eliciting a variety of dangerous ... Arsenic trioxide is a chemotherapeutic agent of idiopathic function used to treat leukemia that is unresponsive …

Protirelin

Protirelin is the pharmaceutically available synthetic analogue of the endogenous peptide thyrotropin-releasing hormone (TRH). It is a tri-peptide tropic hormone, released by the hypothalamus, that stimulates the release of Thyroid Stimulating Hormone (TSH) and prolactin from the anterior pituitary. Although not currently available in any FDA-approved product, protirelin is a...
Approved
Investigational
Matched Description: … Protirelin is the pharmaceutically available synthetic analogue of the endogenous peptide thyrotropin-releasing ... It is a tri-peptide tropic hormone, released by the hypothalamus, that stimulates the release of Thyroid ... Although not currently available in any FDA-approved product, protirelin is a component of the TRH Test …

Abrocitinib

Abrocitinib is an oral small-molecule inhibitor of Janus kinase 1 (JAK1). Janus kinases are intracellular enzymes involved in transduction pathways that regulate hematopoiesis and immune cell function. The Janus kinase (JAK)–signal transducer and activator of transcription (STAT) signalling pathway plays a central role in the pathogenesis of a variety of...
Approved
Investigational
Matched Description: … plays a central role in the pathogenesis of a variety of autoimmune and inflammatory diseases, including ... Abrocitinib is an oral small-molecule inhibitor of Janus kinase 1 (JAK1). ... [L39774] The Janus kinase (JAK)–signal transducer and activator of transcription (STAT) signalling pathway …
Displaying drugs 2951 - 2975 of 9608 in total