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Displaying drugs 301 - 325 of 655 in total

Nitrazepam

A benzodiazepine derivative used as an anticonvulsant and hypnotic.
Approved
Matched Description: … A benzodiazepine derivative used as an anticonvulsant and hypnotic. …
Matched Categories: … Hypnotics and Sedatives ... Benzodiazepine hypnotics and sedatives ... Benzodiazepines and benzodiazepine derivatives …

Tipranavir

Tipranavir is a sulfonamide-containing dyhydropyrone and a nonpeptidic protease inhibitor that targets the HIV protease. Tipranavir and ritonavir are coadministered to treat HIV.
Approved
Investigational
Matched Description: … Tipranavir and ritonavir are coadministered to treat HIV. ... Tipranavir is a sulfonamide-containing dyhydropyrone and a nonpeptidic protease inhibitor that targets …

Conivaptan

Conivaptan is a non-peptide inhibitor of antidiuretic hormone (vasopressin). It was approved in 2004 for hyponatremia (low blood sodium levels) caused by syndrome of inappropriate antidiuretic hormone (SIADH). Conivaptan inhibits both isotypes of the vasopressin receptor (V1a and V2).
Approved
Investigational
Matched Description: … Conivaptan inhibits both isotypes of the vasopressin receptor (V1a and V2). ... It was approved in 2004 for hyponatremia (low blood sodium levels) caused by syndrome of inappropriate …

Iopodic acid

Iopodic acid, also known by the name of ipodate, is classified as a cholecystographic agent formed by a weak organic acid that contains a tri-iodinated benzene ring with iodine at positions 2, 4 and 6. Due to its particular structure, it presents a high degree of lipid solubility and a...
Approved
Investigational
Withdrawn
Matched Name: … Iopodic acid …
Matched Iupac: … 3-(3-{[(dimethylamino)methylidene]amino}-2,4,6-triiodophenyl)propanoic acid …
Matched Description: … a weak organic acid that contains a tri-iodinated benzene ring with iodine at positions 2, 4 and 6. ... Iopodic acid, also known by the name of ipodate, is classified as a cholecystographic agent formed by ... It was developed and filed to the FDA by the company BRACCO. …
Matched Salts name: … Ipodate sodium …
Matched Categories: … sodium iopodate …
Matched Products: … Oragrafin Sodium 0.5gm …

Dolutegravir

Dolutegravir is an HIV-1 integrase inhibitor that blocks the strand transfer step of the integration of the viral genome into the host cell (INSTI). The effect of this drug has no homology in human host cells, which gives it excellent tolerability and minimal toxicity. Dolutegravir was developed by ViiV Healthcare...
Approved
Matched Description: … [A31342] Dolutegravir was developed by ViiV Healthcare and FDA-approved on August 12, 2013. ... The effect of this drug has no homology in human host cells, which gives it excellent tolerability and …
Matched Salts name: … Dolutegravir sodium …
Matched Categories: … lamivudine and dolutegravir ... dolutegravir and rilpivirine ... lamivudine, abacavir and dolutegravir ... lamivudine, tenofovir disoproxil and dolutegravir …

Pemetrexed

Pemetrexed is a chemotherapy drug that is manufactured and marketed by Eli Lilly and Company under the brand name Alimta. It is indicated for use in combination with cisplatin for the treatment of patients with malignant pleural mesothelioma whose disease is either unresectable or who are otherwise not candidates for...
Approved
Investigational
Matched Iupac: … )-2-{[4-(2-{2-amino-4-oxo-1H,4H,7H-pyrrolo[2,3-d]pyrimidin-5-yl}ethyl)phenyl]formamido}pentanedioic acid …
Matched Description: … Pemetrexed is a chemotherapy drug that is manufactured and marketed by Eli Lilly and Company under the …
Matched Categories: … Amino Acids, Peptides, and Proteins ... Antineoplastic and Immunomodulating Agents ... Folic Acid Analogues ... Folic Acid Antagonists ... Nucleic Acid Synthesis Inhibitors …

Tobramycin

Aminoglycosides, many of which are derived directly from Streptomyces spp., are concentration-dependent bactericidal antibiotics with a broad spectrum of activity against Gram-positive and Gram-negative organisms. Inhaled tobramycin is notable for its use in treating chronic Pseudomonas aeruginosa infections in cystic fibrosis patients, as P. aeruginosa is notoriously inherently resistant to...
Approved
Investigational
Matched Description: … concentration-dependent bactericidal antibiotics with a broad spectrum of activity against Gram-positive and ... [A232294, A232299, L32739] However, tobramycin can also be administered intravenously and topically to ... L32744, L32749] Its use is limited in some cases by characteristic toxicities such as nephrotoxicity and …
Matched Mixtures name: … Tobramycin and Dexamethasone ... Tobramycin and Dexamethasone ... Tobramycin and Dexamethasone …
Matched Products: … Tobramycin in Sodium Chloride …

Eslicarbazepine acetate

Eslicarbazepine acetate (ESL) is an anticonvulsant medication approved for use in Europe, the United States and Canada as an adjunctive therapy for partial-onset seizures that are not adequately controlled with conventional therapy. Eslicarbazepine acetate is a prodrug that is rapidly converted to eslicarbazepine, the primary active metabolite in the body....
Approved
Matched Description: … stabilizing the inactivated state of voltage-gated sodium channels, thus preventing their return to ... Eslicarbazepine acetate (ESL) is an anticonvulsant medication approved for use in Europe, the United States and ... Eslicarbazepine acetate is marketed as Aptiom in North America and Zebinix or Exalief in Europe. …
Matched Categories: … Eslicarbazepine and prodrugs ... Sodium Channel Blockers ... Voltage-Gated Sodium Channel Blockers …

Sulfamerazine

A sulfanilamide that is used as an antibacterial agent.
Approved
Vet approved
Matched Salts name: … Sulfamerazine sodium …
Matched Categories: … Sulfonamides and trimethoprim ... sulfamerazine and trimethoprim ... Genito Urinary System and Sex Hormones ... Gynecological Antiinfectives and Antiseptics …

Lamotrigine

Lamotrigine is an antiepileptic drug belonging in the phenyltriazine class. It is used in the treatment of both epilepsy and as a mood stabilizer in bipolar disorder. Lamotrigine is the first medication since lithium granted Food and Drug Administration (FDA) approval for the maintenance treatment of bipolar type I. It...
Approved
Investigational
Matched Description: … It is used in the treatment of both epilepsy and as a mood stabilizer in bipolar disorder. ... Lamotrigine is the first medication since lithium granted Food and Drug Administration (FDA) approval ... [A191350] Lamotrigine has relatively few side-effects and does not require laboratory monitoring. …
Matched Categories: … Sodium Channel Blockers ... Calcium-Regulating Hormones and Agents …

Spironolactone

Spironolactone is a potassium-sparing diuretic. It binds to mineralocorticoid receptors and functions as aldosterone antagonists. It promotes sodium and water excretion and potassium retention. Spironolactone was originally developed purely for this ability before other pharmacodynamic properties of the drug were discovered.[A11837, A178246] It is indicated to treat several conditions, including...
Approved
Matched Description: … [A178192] It promotes sodium and water excretion and potassium retention. ... It binds to mineralocorticoid receptors and functions as aldosterone antagonists. ... [L44602] Off-label uses of spironolactone include hirsutism, female pattern hair loss, and adult acne …
Matched Mixtures name: … Spironolactone and Hydrochlorothiazide ... Spironolactone and Hydrochlorothiazide ... Spironolactone and Hydrochlorothiazide …
Matched Categories: … Hormones, Hormone Substitutes, and Hormone Antagonists …

Theophylline

A methylxanthine derivative from tea with diuretic, smooth muscle relaxant, bronchial dilation, cardiac and central nervous system stimulant activities. Mechanistically, theophylline acts as a phosphodiesterase inhibitor, adenosine receptor blocker, and histone deacetylase activator. Theophylline is marketed under several brand names such as Uniphyl and Theochron, and it is indicated mainly...
Approved
Matched Description: … Theophylline is marketed under several brand names such as Uniphyl and Theochron, and it is indicated ... mainly for asthma, bronchospasm, and COPD. ... methylxanthine derivative from tea with diuretic, smooth muscle relaxant, bronchial dilation, cardiac and …
Matched Mixtures name: … Theophylline 4mg and 5% Dextrose Inj ... Theophylline 1.6mg and 5% Dextrose Inj ... Theophylline 0.8mg and 5% Dextrose Inj …
Matched Salts name: … Theophylline sodium glycinate …
Matched Categories: … Xanthines and Adrenergics ... theophylline and adrenergics …

Mephenytoin

Mephenytoin is used for the treatment of refractory partial epilepsy. Mephenytoin is a solid. This compound belongs to the phenylhydantoins. These are heterocyclic aromatic compounds containing an imiazolidinedione moiety substituted by a phenyl group. Mephenytoin is known to target sodium channel protein type 5 subunit alpha. Cytochrome P450 2C19, Cytochrome...
Approved
Investigational
Withdrawn
Matched Description: … Mephenytoin is known to target sodium channel protein type 5 subunit alpha. ... Mephenytoin and oxazolidinedione derivatives are associated with higher incidences of blood dyscrasias ... Cytochrome P450 2C19, Cytochrome P450 2C8, Cytochrome P450 2C9, Cytochrome P450 2B6, Cytochrome P450 1A2, and …

Lodoxamide

Lodoxamide is a mast-cell stabilizer for topical administration into the eye. Mast-cell stabilizers, first one approved being cromolyn sodium, are used in treatment of ocular hypersensitivity reactions such as vernal conjunctivitis. These conditions often require treatment with anti-inflammatory medications such as ophthalmic NSAIDs or topical steroids which may cause systemic...
Approved
Matched Iupac: … {[3-(carboxyformamido)-2-chloro-5-cyanophenyl]carbamoyl}formic acid …
Matched Description: … Mast-cell stabilizers, first one approved being cromolyn sodium, are used in treatment of ocular hypersensitivity ... than topical steroids at decreasing inflammation, mast-cell stabilizers offer another treatment option and …
Matched Categories: … Decongestants and Antiallergics ... Amino Acids, Peptides, and Proteins …

Eslicarbazepine

Eslicarbazepine is an anti-epileptic medication available commercially as eslicarbazepine acetate.
Approved
Matched Categories: … Eslicarbazepine and prodrugs ... Sodium Channel Blockers ... Voltage-Gated Sodium Channel Blockers …

Potassium hydroxide

Potassium hydroxide, also known as lye is an inorganic compound with the chemical formula KOH. Also commonly referred to as caustic potash, it is a potent base that is marketed in several forms including pellets, flakes, and powders. It is used in various chemical, industrial and manufacturing applications. Potassium hydroxide...
Approved
Matched Description: … in electroplating, lithography, and paint and varnish removers. ... It is used in various chemical, industrial and manufacturing applications. ... Recently, it has been studied for efficacy and tolerability in the treatment of warts. …
Matched Categories: … Indicators and Reagents …

Magnesium gluconate

Magnesium gluconate is a magnesium salt of gluconate. It demonstrates the highest oral bioavailability of magnesium salts and is used as a mineral supplement. Magnesium is ubiquitous in the human body, and is naturally present in many foods, added to other food products, available as a dietary supplement and used...
Approved
Investigational
Matched Description: … and laxatives) [L2601]. ... It demonstrates the highest oral bioavailability of magnesium salts [L2608] and is used as a mineral ... Magnesium is ubiquitous in the human body, and is naturally present in many foods, added to other food …
Matched Mixtures name: … NUTROPLEX LIQUID WITH IRON AND LYSINE …
Matched Categories: … Alimentary Tract and Metabolism …

Silver sulfadiazine

Silver sulfadiazine is a sulfa derivative topical antibacterial used primarily on second- and third-degree burns.
Approved
Vet approved
Matched Description: … Silver sulfadiazine is a sulfa derivative topical antibacterial used primarily on second- and third-degree …
Matched Categories: … Genito Urinary System and Sex Hormones ... Gynecological Antiinfectives and Antiseptics …

Meradimate

Meradimate, before known as menthyl anthranilate, is used in a maximal concentration of 5% in different products as a UV filter. It is currently required to be named as meradimate in all FDA approved OTC products. Meradimate is approved by the FDA and Health Canada to be used as an...
Approved
Matched Description: … Meradimate is approved by the FDA and Health Canada to be used as an ingredient in sunblocking products …
Matched Mixtures name: … Sodium Sulfacetamide Sulfur ... Principal Secret Reclaim Sunscreen For Face and Body SPF 30 …

Lumasiran

Lumasiran is a small interfering RNA used in the treatment of primary hyperoxaluria type 1 (PH1). This condition, caused by a deficiency in the enzyme alanine-glyoxylate aminotransferase, leads to an accumulation of oxalate, causing calcium crystal formation. These patients experience frequent kidney stones, nephrocalcinosis, and renal failure. Oxlumo, producted by...
Approved
Investigational
Matched Description: … [L23554] These patients experience frequent kidney stones, nephrocalcinosis, and renal failure. ... consisted of symptomatic treatment such as hyperhydration, inhibitors of crystallization, [pyridoxine], and …
Matched Salts name: … Lumasiran sodium …
Matched Categories: … HAO1-directed Small Interfering Ribonucleic Acid (siRNA) ... Alimentary Tract and Metabolism ... Nucleic Acids, Nucleotides, and Nucleosides ... Various Alimentary Tract and Metabolism Products …

Prednisolone acetate

Prednisolone acetate is a prednisolone molecule bound to an acetate functional group by an ester bond. Prednisolone acetate was granted FDA approval in 1955.
Approved
Vet approved

Digoxin

Digoxin is one of the oldest cardiovascular medications used today. It is a common agent used to manage atrial fibrillation and the symptoms of heart failure. Digoxin is classified as a cardiac glycoside and was initially approved by the FDA in 1954. This drug originates from the foxglove plant, also...
Approved
Matched Description: … [A178225] It is a common agent used to manage atrial fibrillation and the symptoms of heart failure. ... [A178234] Digoxin is classified as a cardiac glycoside and was initially approved by the FDA in 1954. ... plant, also known as the _Digitalis_ plant[T610], studied by William Withering, an English physician and …
Matched Categories: … Digoxin and derivatives …

Vutrisiran

Vutrisiran is a double-stranded small interfering ribonucleic acid (siRNA) that targets wild-type and mutant transthyretin (TTR) messenger RNA (mRNA). This siRNA therapeutic is indicated for the treatment of neuropathies associated with hereditary transthyretin-mediated amyloidosis (ATTR), a condition caused by mutations in the TTR gene. More than 130 TTR mutations have...
Approved
Investigational
Matched Description: … Vutrisiran is a double-stranded small interfering ribonucleic acid (siRNA) that targets wild-type and ... [A249025,L42065] This delivery platform gives vutrisiran high potency and metabolic stability, and allows ... prevalent among hereditary ATTR patients with polyneuropathy, especially in Portugal, France, Sweden, and …
Matched Salts name: … Vutrisiran sodium …
Matched Categories: … Nucleic Acids, Nucleotides, and Nucleosides …

Avibactam

Avibactam is a non-β-lactam β-lactamase inhibitor that is available in combination with ceftazidime (Avycaz). This combination was approved by the FDA on February 25, 2015 for the treatment of complicated intra-abdominal infections in combination with metronidazole, and the treatment of complicated urinary tract infections, including pyelonephritis caused by antibiotic resistant-pathogens,...
Approved
Matched Iupac: … [(2S,5R)-2-carbamoyl-7-oxo-1,6-diazabicyclo[3.2.1]octan-6-yl]oxidanesulfonic acid …
Matched Description: … 2015 for the treatment of complicated intra-abdominal infections in combination with metronidazole, and ... As there is limited clinical safety and efficacy data, Avycaz should be reserved for patients over 18 …
Matched Salts name: … Avibactam sodium …

Hydrocortisone phosphate

Approved
Vet approved
Matched Iupac: … 3H,3aH,3bH,4H,5H,7H,8H,9H,9aH,9bH,10H,11H,11aH-cyclopenta[a]phenanthren-1-yl]-2-oxoethoxy}phosphonic acid …
Matched Salts name: … Hydrocortisone sodium phosphate …
Matched Categories: … Hydrocortisone and derivatives ... Hormones, Hormone Substitutes, and Hormone Antagonists …
Displaying drugs 301 - 325 of 655 in total