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Displaying drugs 3426 - 3450 of 4017 in total
Experimental
Matched Name: … 5-(5-CHLORO-2-THIENYL)-N-{(3S)-1-[(1S)-1-METHYL-2-MORPHOLIN-4-YL-2-OXOETHYL]-2-OXOPYRROLIDIN-3-YL}-1H
Matched Iupac: … 5-(5-chlorothiophen-2-yl)-N-[(3S)-1-[(2S)-1-(morpholin-4-yl)-1-oxopropan-2-yl]-2-oxopyrrolidin-3-yl]- ... 1H-1,2,4-triazole-3-sulfonamide …
Experimental
Matched Name: … 5-Chloro-thiophene-2-carboxylic acid ((3S,4S)-1-{[2-fluoro-4-(2-oxo-2H-pyridin-1-yl)-phenylcarbamoyl] …
Matched Iupac: … 5-chloro-N-[(3S,4S)-1-({[2-fluoro-4-(2-oxo-1,2-dihydropyridin-1-yl)phenyl]carbamoyl}methyl)-4-hydroxypyrrolidin …
Protriptyline hydrochloride is a dibenzocycloheptene-derivative tricyclic antidepressant (TCA). TCAs are structurally similar to phenothiazines. They contain a tricyclic ring system with an alkyl amine substituent on the central ring. In non-depressed individuals, protriptyline does not affect mood or arousal, but may cause sedation. In depressed individuals, protriptyline exerts a positive...
Approved
Matched Synonyms: … 3-(5H-dibenzo[a,d][7]annulen-5-yl)-N-methylpropan-1-amine ... 3-(5H-dibenzo[a,d]cyclohepten-5-yl)-N-methyl-1-propanamine ... 7-(3-methylaminopropyl)-1,2:5,6-dibenzocycloheptatriene …
Matched Iupac: … methyl(3-{tricyclo[9.4.0.0^{3,8}]pentadeca-1(15),3,5,7,9,11,13-heptaen-2-yl}propyl)amine …
Matched Description: … TCAs also block histamine H1 receptors, alpha1-adrenergic receptors and muscarinic ... TCAs are potent inhibitors of serotonin and norepinephrine reuptake. ... In addition, TCAs down-regulate cerebral cortical β-adrenergic receptors and sensitize post-synaptic …
Investigational
Matched Synonyms: … -d-gluco-heptopyranosyl-(1->4))-2-deoxy-, sulfate ... -d-allofuranosyl-(1->5)-o-(2-amino-2,7-dideoxy-d-glycero-.alpha. …
Matched Name: … NB-124 sulfate …
Matched Iupac: … (2R,3S,4R,5R,6S)-5-amino-6-{[(1R,2R,3S,4R,6S)-4,6-diamino-2-{[(2S,3R,4S,5R)-5-[(1S)-1-aminoethyl]-3,4 ... -dihydroxyoxolan-2-yl]oxy}-3-hydroxycyclohexyl]oxy}-2-[(1R)-1-hydroxyethyl]oxane-3,4-diol; sulfuric acid …
Matched Categories: … Heterocyclic Compounds, 1-Ring …
Irpagratinib (ABSK011) is a highly selective inhibitor of fibroblast growth factor receptor (FGFR) 4.
Investigational
Matched Synonyms: … 2-Propenamide, N-[(3S,4S)-3-[[6-(2,6-difluoro-3,5-dimethoxyphenyl)-8-(3-methoxy-3-methyl-1-azetidinyl ... N-[(3S,4S)-3-[[6-(2,6-Difluoro-3,5-dimethoxyphenyl)-8-(3-methoxy-3-methyl-1-azetidinyl)pyrido[3,4-d]pyrimidin …
Matched Iupac: … N-[(3S,4S)-3-{[6-(2,6-difluoro-3,5-dimethoxyphenyl)-8-(3-methoxy-3-methylazetidin-1-yl)pyrido[3,4-d]pyrimidin …
Experimental
Matched Name: … (2R)-2-[(1R)-1-{[(2S)-2-Carboxy-2-(4-hydroxyphenyl)acetyl]amino}-1-methoxy-2-oxoethyl]-5-methylene-5,6 ... -dihydro-2H-1,3-oxazine-4-carboxylic acid …
Matched Iupac: … (2R)-2-{1-[(2S)-2-carboxy-2-(4-hydroxyphenyl)acetamido]-1-methoxy-2-oxoethyl}-5-methylidene-5,6-dihydro ... -2H-1,3-oxazine-4-carboxylic acid …
Experimental
Matched Name: … 2-[4-[(Z)-2-Acetamido-3-oxo-3-[[(3S)-2-oxo-1-[(4-phenylphenyl)methyl]azepan-3-yl]amino]prop-1-enyl]-2 …
Matched Iupac: … 2-{4-[(1Z)-2-{[(3S)-1-({[1,1'-biphenyl]-4-yl}methyl)-2-oxoazepan-3-yl]carbamoyl}-2-acetamidoeth-1-en- ... 1-yl]-2-formylphenyl}acetic acid …
Experimental
Matched Name: … 5-CHLORO-THIOPHENE-2-CARBOXYLIC ACID ((3S,4S)-4-FLUORO- 1-{[2-FLUORO-4-(2-OXO-2H-PYRIDIN-1-YL)-PHENYLCARBAMOYL …
Matched Iupac: … 5-chloro-N-[(3S,4S)-4-fluoro-1-({[2-fluoro-4-(2-oxo-1,2-dihydropyridin-1-yl)phenyl]carbamoyl}methyl)pyrrolidin …
Experimental
Matched Name: … )-1H-[1,2,4]TRIAZOLO[1,5-A]PYRIDIN-4-IUM ... 6-(4-{(1S,2S)-2-AMINO-1-[(DIMETHYLAMINO)CARBONYL]-3-[(3S)-3-FLUOROPYRROLIDIN-1-YL]-3-OXOPROPYL}PHENYL …
Matched Iupac: … (2S,3S)-3-amino-4-[(3S)-3-fluoropyrrolidin-1-yl]-N,N-dimethyl-4-oxo-2-(4-{[1,2,4]triazolo[1,5-a]pyridin …
Levetiracetam is a drug within the pyrrolidine class that is used to treat various types of seizures stemming from epileptic disorders. It was first approved for use in the United States in 1999 and is structurally and mechanistically unrelated to other anti-epileptic drugs (AEDs).[L8606,L8600,L8615] Levetiracetam possesses a wide therapeutic index[L8615,A185918]...
Approved
Matched Iupac: … (2S)-2-(2-oxopyrrolidin-1-yl)butanamide …
Matched Description: … It was first approved for use in the United States in 1999 and is structurally and mechanistically unrelated ... [L8606,L8600,L8615] Levetiracetam possesses a wide therapeutic index[L8615,A185918] and little-to-no ... choice over other AEDs, a class of drugs notorious for having generally narrow therapeutic indexes and
Matched Categories: … Heterocyclic Compounds, 1-Ring …
Matched Products: … KEPPRA 100 MG/ML ORAL COZELTI, 150 ML + 1 ENJEKTOR ... EPIXX 100 MG/ML ORAL COZELTI, 150 ML + 1ML ENJEKTOR ... NETROLEX 100 MG/ML ORAL COZELTI, 150 ML …
Tiotropium is a long-acting, antimuscarinic bronchodilator used in the management of chronic obstructive pulmonary disease (COPD) and asthma.[A180163,L7084,L7087,L7090,L7093] Tiotropium acts mainly on M3 muscarinic receptors located in the airways to produce smooth muscle relaxation and bronchodilation.[A180163,L7084,L7087,L7090,L7093] Tiotropium is more specific for the subset of muscarinic receptors commonly found in the...
Approved
Matched Iupac: … (1R,2R,4S,5S,7R)-7-{[2-hydroxy-2,2-bis(thiophen-2-yl)acetyl]oxy}-9,9-dimethyl-3-oxa-9-azatricyclo[3.3.1.0 …
Matched Description: … antimuscarinic bronchodilator used in the management of chronic obstructive pulmonary disease (COPD) and ... Tiotropium acts mainly on M3 muscarinic receptors located in the airways to produce smooth muscle relaxation and
Matched Mixtures name: … FEROMIS 18/12 MCG İNHALASYON İÇİN TOZ İÇEREN KAPSÜL, 120 ADET ... FEROMIS 9/12 MCG INHALASYON TOZ ICEREN KAPSUL, 120 ADET ... AERODAY 18/12 MCG INHALASYON IÇIN TOZ IÇEREN BLISTER, 60 DOZ …
Matched Categories: … olodaterol and tiotropium bromide ... formoterol and tiotropium bromide …
Matched Products: … TIODAY CAPSAIR 18 MCG İNHALASYON İÇİN TOZ İÇEREN KAPSÜL, 120 ADET ... SPIRIVA 18 MCG CAPSULES ... BROMURO DE TIOTROPIO 18 µG CÁPSULA …
Investigational
Matched Synonyms: … 1h-1,5-benzodiazepine-2,4(3h,5h)-dione, 8-chloro-1-phenyl-7-chloro-5-phenyl-1,2,4,5-tetrahydro-3h-1,5
Matched Iupac: … 8-chloro-1-phenyl-2,3,4,5-tetrahydro-1H-1,5-benzodiazepine-2,4-dione …
Investigational
Matched Synonyms: … 7h-furo(3,2-g)(1)benzopyran-7-one, 3-((2-aminoethoxy)methyl)-2,5,9-trimethyl- …
Matched Categories: … Heterocyclic Compounds, 1-Ring …
A phenothiazine with pharmacological activity similar to that of both chlorpromazine and promethazine. It has the histamine-antagonist properties of the antihistamines together with central nervous system effects resembling those of chlorpromazine. (From Martindale, The Extra Pharmacopoeia, 30th ed, p604)
Approved
Investigational
Matched Synonyms: … (-)-(2R)-3-(2-methoxy-10H-phenothiazin-10-yl)-N,N,2-trimethylpropan-1-amine ... (-)-10-(3-(Dimethylamino)-2-methylpropyl)-2-methoxyphenothiazine …
Matched Iupac: … [(2R)-3-(2-methoxy-10H-phenothiazin-10-yl)-2-methylpropyl]dimethylamine …
Matched Description: … A phenothiazine with pharmacological activity similar to that of both chlorpromazine and promethazine …
Matched Categories: … Adrenergic alpha-1 Receptor Antagonists …
Matched Products: … LEVOMEPROMAZIN-NEURAX 100 ... SINOGAN® 100 MG TABLETAS. ... Nozinan 100 mg - Filmtabletten …
Forodesine is a highly potent, orally active, rationally designed PNP inhibitor that has shown activity in preclinical studies with malignant cells and clinical utility against T-cell acute lymphoblastic leukemia and cutaneous T-cell lymphoma. Additional preliminary findings support its use for the management of some B-cell malignancies.
Investigational
Matched Synonyms: … (1S)-1,4-dideoxy-4-imino-(9-deazahypoxanthin-9-yl)-D-ribitol ... 1,4-Dideoxy-4-aza-1-(S)-(9-deazahypoxanthin-9-yl)-D-ribitol …
Matched Description: … rationally designed PNP inhibitor that has shown activity in preclinical studies with malignant cells and ... clinical utility against T-cell acute lymphoblastic leukemia and cutaneous T-cell lymphoma. …
Matched Salts cas: … 284490-13-7 …
Matched Categories: … Nucleic Acids, Nucleotides, and Nucleosides ... Heterocyclic Compounds, 1-Ring …
Osimertinib is an oral, third-generation epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) drug developed by AstraZeneca Pharmaceuticals.[A7926,L43453] Its use is indicated for the treatment of metastatic non-small cell lung cancer (NSCLC) in cases where tumour EGFR expression is positive for the T790M mutation as detected by FDA-approved testing...
Approved
Matched Synonyms: … N-(2-{[2-(dimethylamino)ethyl](methyl)amino}-4-methoxy-5-{[4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl]amino …
Matched Iupac: … N-(2-{[2-(dimethylamino)ethyl](methyl)amino}-4-methoxy-5-{[4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl]amino …
Matched Description: … Approximately 10% of patients with NSCLC have a rapid and clinically effective response to EGFR-TKIs ... [A7927] More specifically, deletions around the LREA motif in exon 19 and exon 21 L858R point mutations ... where tumour EGFR expression is positive for the T790M mutation as detected by FDA-approved testing and
Matched Salts cas: … 1421373-66-1
Matched Categories: … Antineoplastic and Immunomodulating Agents ... Heterocyclic Compounds, 1-Ring …
Investigational
Matched Synonyms: … ,3aR,6aS)-octahydrocyclopenta[c]pyrrol-1-yl)methanone ... -(4-cyclopropylpyrimidin-5-yl)-4-fluorophenoxy)-1,2,4-triazin-5-yl)-2,7-diazaspiro[3.5]nonan-7-yl)((1S
BMS-986251 is under investigation in clinical trial NCT03329885 (A Study of Experimental Medication BMS-986251, Taken by Mouth, in Healthy Participants and Patients With Average to Very Serious Psoriasis).
Investigational
Matched Synonyms: … -1H-BENZO(E)INDOLE-3-CARBONYL)-3-METHYLCYCLOHEXANE-1-CARBOXYLIC ACID ... (1R,3S,4R)-4-((3AR,9BR)-9B-((4-FLUOROPHENYL)SULFONYL)-7-(PERFLUOROPROPAN-2-YL)-2,3,3A,4,5,9B-HEXAHYDRO …
Matched Description: … NCT03329885 (A Study of Experimental Medication BMS-986251, Taken by Mouth, in Healthy Participants and
Acyclovir is a deoxynucleoside analog antiviral used to treat herpes simplex, Varicella zoster, herpes zoster, herpes labialis, and acute herpetic keratitis.[L7303,L7315,L7318,L7321,L7324,L7327] Acyclovir is generally used first line in the treatment of these viruses and some products are indicated for patients as young as 6 years old. Acyclovir was granted FDA...
Approved
Matched Description: … analog antiviral used to treat herpes simplex, _Varicella zoster_, herpes zoster, herpes labialis, and ... L7315,L7318,L7321,L7324,L7327] Acyclovir is generally used first line in the treatment of these viruses and
Matched Mixtures name: … HERPAZON % 5 + % 1 KREM, 5 GRAM ... Activir Duo 50 mg/g + 10 mg/g Creme …
Matched Categories: … Acyclovir and prodrug ... MATE 1 Substrates ... Nucleosides and Nucleotides ... Nucleosides and Nucleotides Excl. Reverse Transcriptase Inhibitors ... Herpesvirus Nucleoside Analog DNA Polymerase Inhibitor …
Matched Products: … ACICLOSTAD 50MG/1G ... HERPEDERM KREM, 10 G ... ULKAVIR % 5 KREM, 10 G …
Experimental
Matched Name: … 1-Ter-Butyl-3-P-Tolyl-1h-Pyrazolo[3,4-D]Pyrimidin-4-Ylamine …
Matched Iupac: … 1-tert-butyl-3-(4-methylphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine …
Experimental
Matched Name: … 4-(1-Benzyl-3-Carbamoylmethyl-2-Methyl-1h-Indol-5-Yloxy)-Butyric Acid …
Matched Iupac: … 4-{[1-benzyl-3-(carbamoylmethyl)-2-methyl-1H-indol-5-yl]oxy}butanoic acid …
Experimental
Matched Name: … 2,5-dibenzyloxy-3-hydroxy-hexanedioic acid bis-[(2-hydroxy-indan-1-yl)-amide] …
Matched Iupac: … (2R,3R,5R)-2,5-bis(benzyloxy)-3-hydroxy-N,N'-bis[(1S,2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl]hexanediamide …
Experimental
Matched Name: … N-(4-MORPHOLINE)CARBONYL-B-(1-NAPHTHYL)-L-ALANINE-L-LEUCINE BORONIC ACID …
Matched Iupac: … [(1R)-3-methyl-1-[(2R)-2-[(morpholine-4-carbonyl)amino]-3-(naphthalen-1-yl)propanamido]butyl]boronic …
Experimental
Matched Name: … 1-((2-HYDROXYETHOXY)METHYL)-5-(3-(BENZYLOXY)BENZYL)PYRIMIDINE-2,4(1H,3H)-DIONE …
Matched Iupac: … 5-{[3-(benzyloxy)phenyl]methyl}-1-[(2-hydroxyethoxy)methyl]-1,2,3,4-tetrahydropyrimidine-2,4-dione …
Experimental
Matched Name: … 1-({2-[2-(4-CHLOROPHENYL)ETHYL]-1,3-DIOXOLAN-2-YL}METHYL)-1H-IMIDAZOLE …
Matched Iupac: … 1-({2-[2-(4-chlorophenyl)ethyl]-1,3-dioxolan-2-yl}methyl)-1H-imidazole …
Displaying drugs 3426 - 3450 of 4017 in total