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Displaying drugs 326 - 350 of 14566 in total

Melphalan

Melphalan is a nitrogen mustard or bischloroethylamine type alkylating agent. It was first synthesized in the early 1950s by substituting L-phenylalanine for the methyl group on nitrogen mustard.[A261150, A261155] Melphalan is used in the treatment of multiple myeloma and ovarian carcinoma. It is also used for high-conditioning before hematopoietic stem...
Approved
Matched Description: … [L40928] It was first synthesized in the early 1950s by substituting L-phenylalanine for the methyl group ... [A261150, A261155] Melphalan is used in the treatment of multiple myeloma and ovarian carcinoma. ... Melphalan is a nitrogen mustard or bischloroethylamine type alkylating agent. …
Matched Products: … İÇEREN FLAKON+1 ADET ÇÖZÜCÜ İÇEREN FLAKON ... ERİOLAN 50 MG ENJEKSİYONLUK/İNFÜZYONLUK ÇÖZELTİ İÇİN LİYOFİLİZE TOZ VE ÇÖZÜCÜ, 1 ADET LİYOFİLİZE TOZ …

Tazobactam

Tazobactam is an antibiotic of the beta-lactamase inhibitor class that prevents the breakdown of other antibiotics by beta-lactamase enzyme producing organisms. It is combined with Piperacillin and Ceftolozane for the treatment of a variety of bacterial infections. Piperacillin-tazobactam was initially approved by the FDA in 1994, and ceftolozane-tazobactam was approved...
Approved
Matched Iupac: … (2S,3S,5R)-3-methyl-4,4,7-trioxo-3-[(1H-1,2,3-triazol-1-yl)methyl]-4lambda6-thia-1-azabicyclo[3.2.0]heptane …
Matched Description: … It is combined with [Piperacillin] and [Ceftolozane] for the treatment of a variety of bacterial infections ... by the FDA in 2014[FDA label], providing wider antibacterial coverage for gram-negative infections. ... In June 2019, ceftolozane-tazobactam was approved by the FDA for treating hospital-acquired bacterial …
Matched Mixtures name: … Zosyn in Galaxy Containers ... Zosyn in Galaxy Containers ... Zosyn in Galaxy Containers …
Matched Categories: … Heterocyclic Compounds, 1-Ring …

Erlotinib

Erlotinib is an inhibitor of the epidermal growth factor receptor (EGFR) tyrosine kinase that is used in the treatment of non-small cell lung cancer, pancreatic cancer and several other types of cancer. It is typically marketed under the trade name Tarceva. Erlotinib binds to the epidermal growth factor receptor (EGFR)...
Approved
Investigational
Matched Description: … This finding introduces the potential use of erlotinib in the treatment of JAK2V617F-positive PV and ... Erlotinib binds to the epidermal growth factor receptor (EGFR) tyrosine kinase in a reversible fashion ... in the treatment of non-small cell lung cancer, pancreatic cancer and several other types of cancer. …
Matched Categories: … P-glycoprotein substrates with a Narrow Therapeutic Index ... Cytochrome P-450 CYP1A2 Substrates with a Narrow Therapeutic Index ... Cytochrome P-450 CYP2C8 Substrates with a Narrow Therapeutic Index ... Cytochrome P-450 CYP2D6 Substrates with a Narrow Therapeutic Index ... Cytochrome P-450 CYP3A4 Substrates with a Narrow Therapeutic Index …

Oxybutynin

Overactive bladder (OAB) is a common condition negatively impacting the lives of millions of patients worldwide. Due to its urinary symptoms that include nocturia, urgency, and frequency, this condition causes social embarrassment and a poor quality of life.[A185996,A185999] Oxybutynin, also marketed as Ditropan XL, is an anticholinergic medication used for...
Approved
Investigational
Matched Iupac: … 4-(diethylamino)but-2-yn-1-yl 2-cyclohexyl-2-hydroxy-2-phenylacetate …
Matched Description: … Overactive bladder (OAB) is a common condition negatively impacting the lives of millions of patients ... affected by OAB. ... since initial FDA approval in 1975. …
Matched Products: … Vesoxx 1 mg/ml Lösung zur intravesikalen Anwendung …

Sodium zirconium cyclosilicate

Sodium zirconium cyclosilicate is approved as the trade product Lokelma developed by AstraZeneca - an insoluble, non-absorbed sodium zirconium silicate, formulated as a powder for oral suspension that acts as a highly selective potassium removing agent. It is administered orally and is odorless, tasteless, and stable at room temperature. Approval...
Approved
Investigational
Matched Description: … time to achieving normal potassium levels in the blood was 2.2 hours, with 92% of patients achieving ... [L2933] Approval of the medication is supported by data from three double-blind, placebo-controlled trials ... Sodium zirconium cyclosilicate is approved as the trade product Lokelma developed by AstraZeneca - an …
Matched Categories: … Compounds used in a research, industrial, or household setting ... Drugs for Treatment of Hyperkalemia and Hyperphosphatemia …

Anthrax vaccine

Anthrax vaccine is a vaccine used for the pre- or post-exposure prophylaxis of disease in those at high risk of, suspected or confirmed exposure to Bacillus anthracis. It is subcutaneously or intramuscularly administered. It is derived from cell-free filtrates of microaerophilic cultures of an avirulent, nonencapsulated strain of Bacillus anthracis...
Approved
Matched Description: … [L47526] It is considered one of the most likely agents to be used in a biological attack. ... Anthrax vaccine is a vaccine used for the pre- or post-exposure prophylaxis of disease in those at high ... [L47561] There are currently 2 anthrax vaccines approved by the FDA: BioThrax in August 15, 2016 and …

Omaveloxolone

Omaveloxolone (RTA-408) is a semisynthetic oleanane triterpenoid with antioxidant and anti-inflammatory properties.[A257534,A257539] Omaveloxolone acts as an activator of nuclear factor (erythroid-derived 2)-like 2 (Nrf2), a transcription factor that mitigates oxidative stress. In patients with Friedreich's ataxia, a genetic disease involving mitochondrial dysfunction, the Nrf2 pathway is impaired, and Nrf2 activity...
Approved
Investigational
Matched Description: … [A257529] In February 2023, omaveloxolone was approved by the FDA for the treatment of Friedreich's ataxia ... Therefore, the use of Nrf2 activators such as omaveloxolone represents a therapeutic advantage in this ... In patients with Friedreich's ataxia, a genetic disease involving mitochondrial dysfunction, the Nrf2 …

Dabrafenib

Dabrafenib mesylate (Tafinlar) is a reversible ATP-competitive kinase inhibitor and targets the MAPK pathway. It was approved on May 29, 2013, for the treatment of melanoma with V600E or V6000K mutation. It was also used for metastatic non-small cell lung cancer with the same mutation. In May 2018, Tafinlar (dabrafenib),...
Approved
Investigational
Matched Iupac: … N-{3-[5-(2-aminopyrimidin-4-yl)-2-tert-butyl-1,3-thiazol-4-yl]-2-fluorophenyl}-2,6-difluorobenzene-1- …
Matched Description: … to treat anaplastic thyroid cancer caused by an abnormal BRAF V600E gene. ... It was approved on May 29, 2013, for the treatment of melanoma with V600E or V6000K mutation. ... Dabrafenib mesylate (Tafinlar) is a reversible ATP-competitive kinase inhibitor and targets the MAPK …
Matched Categories: … Heterocyclic Compounds, 1-Ring ... Organic Anion Transporter 1 Inhibitors ... P-glycoprotein substrates with a Narrow Therapeutic Index ... Cytochrome P-450 CYP2C19 Substrates with a Narrow Therapeutic Index ... Cytochrome P-450 CYP2C8 Substrates with a Narrow Therapeutic Index …

Brigatinib

Brigatinib, originally named AP26113, is a reversible dual inhibitor of anaplastic lymphoma kinase (ALK) and epidermal growth factor receptor (EGFR). It presents selectivity against the mutant forms of EGFR compared to the wild-type. It also exhibits selectivity against 9 different Crizotinib-resistant mutants of the EML4-ALK fusion gene, which is a...
Approved
Investigational
Matched Iupac: … 5-chloro-N4-[2-(dimethylphosphoryl)phenyl]-N2-{2-methoxy-4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl] …
Matched Description: … fusion gene, which is a pivotal player in the transformation of susceptible lung parenchyma. ... [A31313] Brigatinib was developed by Ariad Pharmaceuticals, a subsidiary of Takeda Pharmaceutical Company ... It presents selectivity against the mutant forms of EGFR compared to the wild-type. …
Matched Categories: … MATE 1 Inhibitors ... Heterocyclic Compounds, 1-Ring ... Cytochrome P-450 CYP2C8 Substrates with a Narrow Therapeutic Index ... Cytochrome P-450 CYP3A4 Substrates with a Narrow Therapeutic Index …

Valproic acid

Valproic acid, or valproate, is an fatty acid derivative and anticonvulsant originally synthesized in 1881 by Beverly S. Burton. It enjoyed use as a popular organic solvent in industry and pharmaceutical manufacturing for nearly a century. In 1963, a serendipitous discovery was made by George Carraz during his investigations into...
Approved
Investigational
Matched Description: … is the subject of many clinical trials in a variety of cancer types. ... In 1963, a serendipitous discovery was made by George Carraz during his investigations into the anticonvulsant ... It is currently a compound of interest in the field of oncology for its anti-proliferative effects and …
Matched Mixtures name: … Depakine Chronosphere 50 mg Retardgranulat in Beuteln ... Depakine Chronosphere 50 mg Retardgranulat in Beuteln ... Depakine Chronosphere 250 mg Retardgranulat in Beuteln …
Matched Categories: … Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome ... UGT1A1 Substrates with a Narrow Therapeutic Index ... UGT1A3 Substrates with a Narrow Therapeutic Index ... UGT1A6 Substrates with a Narrow Therapeutic Index ... UGT1A9 Substrates with a Narrow Therapeutic Index …

Niraparib

Niraparib is an orally active poly (ADP-ribose) polymerase (PARP) inhibitor. By blocking the enzymes responsible for DNA repair, niraparib induces cytotoxicity in cancer cells. Niraparib is selective towards PARP-1 and PARP-2. First approved by the FDA on March 27, 2017, niraparib is used to treat epithelial ovarian, fallopian tube, or...
Approved
Investigational
Matched Description: … By blocking the enzymes responsible for DNA repair, niraparib induces cytotoxicity in cancer cells. ... [L43277] Niraparib was approved by the European Commission on November 16, 2017 [L43742] and by Health ... [L43277] Niraparib is selective towards PARP-1 and PARP-2. …
Matched Categories: … MATE 1 Substrates with a Narrow Therapeutic Index ... MATE 1 Inhibitors ... MATE 1 Substrates ... MATE 2 Substrates with a Narrow Therapeutic Index ... Heterocyclic Compounds, 1-Ring …

Levocarnitine

Constituent of striated muscle and liver. It is used therapeutically to stimulate gastric and pancreatic secretions and in the treatment of hyperlipoproteinemias.
Approved
Investigational
Matched Synonyms: … 3-Carboxy-2-hydroxy-N,N,N-trimethyl-1-propanaminium hydroxide, inner salt …
Matched Description: … It is used therapeutically to stimulate gastric and pancreatic secretions and in the treatment of hyperlipoproteinemias ... Constituent of striated muscle and liver. …
Matched Salts cas: … 6645-46-1 …
Matched Products: … CARNISIN 1 G / 10ML SOLUCION ... CARNITENE 1 ÇİĞNEME TABLETİ, 10 ADET ... L-Carnitin "Fresenius" 1 g - Ampullen …

Sage

Sage allergenic extract is used in allergenic testing.
Approved
Matched Description: … Sage allergenic extract is used in allergenic testing. …

Fluconazole

Fluconazole, commonly known as Diflucan, is an antifungal drug used for the treatment of both systemic and superficial fungal infections in a variety of tissues. It was initially approved by the FDA in 1990. This drug is an azole antifungal, in the same drug family as ketoconazole and itraconazole. Fluconazole...
Approved
Investigational
Matched Iupac: … 2-(2,4-difluorophenyl)-1,3-bis(1H-1,2,4-triazol-1-yl)propan-2-ol …
Matched Description: … It was initially approved by the FDA in 1990. ... and superficial fungal infections in a variety of tissues. ... The side effect profile of this drug is minimal. …
Matched Mixtures name: … Ciclopirox 8% / Fluconazole 1% / Terbinafine HCl 1% ... Canesoral Combi 1 Day ... Fluconazole 4% / Ibuprofen 2% / Itraconazole 1% / Terbinafine HCl 4% …
Matched Products: … Fluconazole in Dextrose ... Fluconazole in Sodium Chloride ... Fluconazole In Sodium Chloride Injection USP …

Lactitol

Lactitol, also known as 4-β-D-galactopyranosyl-D-glucitol, is a sugar alcohol synthesized from lactose. It is used in food manufacturing as a nutritive sweetener and is approximately 35% as sweet as table sugar (i.e. sucrose). Clinically, lactitol has been investigated for use as an osmotic laxative and, along with other non-absorbable disaccharides...
Approved
Investigational
Matched Description: … the treatment of hepatic encephalopathy in patients with cirrhosis. ... [A190915,A190918] Pizensy, an oral lactitol powder for solution, was approved by the FDA for use in ... [A190918] It is used in food manufacturing as a nutritive sweetener and is approximately 35% as sweet …
Matched Categories: … Compounds used in a research, industrial, or household setting …

Ferric subsulfate

Ferric subsulfate is a stypic or hemostatic agent that causes agglutination of surface proteins resulting in local hemostasis. It has the chemical formula Fe4(OH)2(SO4)5. It is used after superficial skin biopsies.
Approved
Experimental
Matched Description: … Ferric subsulfate is a stypic or hemostatic agent that causes agglutination of surface proteins resulting ... in local hemostasis. ... It has the chemical formula Fe4(OH)2(SO4)5. It is used after superficial skin biopsies. …

Lithium citrate

Approved
Matched Iupac: … trilithium(1+) 2-hydroxypropane-1,2,3-tricarboxylate …
Matched Categories: … Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome …

Histamine

A depressor amine derived by enzymatic decarboxylation of histidine. It is a powerful stimulant of gastric secretion, a constrictor of bronchial smooth muscle, a vasodilator, and also a centrally acting neurotransmitter.
Approved
Investigational
Matched Iupac: … 2-(1H-imidazol-4-yl)ethan-1-amine …
Matched Description: … A depressor amine derived by enzymatic decarboxylation of histidine. ... It is a powerful stimulant of gastric secretion, a constrictor of bronchial smooth muscle, a vasodilator ... , and also a centrally acting neurotransmitter. …
Matched Salts cas: … 51-74-1 …
Matched Categories: … Heterocyclic Compounds, 1-Ring …

Tyrothricin

Tyrothricin is an antibiotic peptide complex produced and extracted from the aerobic Gram-positive bacillus Brevibacillus parabrevis [L4019, L4021, A32851] which was previously categorized as Bacillus brevis and Bacillus aneurinolyticus . This complex is a mixture comprised of 60% tyrocidine cationic cyclic decapeptides (consisting largely of the six predominant tyrocidines, TrcA/A1,...
Approved
Matched Description: … This complex is a mixture comprised of 60% tyrocidine cationic cyclic decapeptides (consisting largely ... microbial resistance during the over 60 years of therapeutic use the complex has provided [A36360]. ... 40% neutral linear gramicidins (where valine-gramicidin A is often the major gramicidin present, although …

Technetium Tc-99m exametazime

Technetium Tc-99m exametazime is a radiopharmaceutical sold under the trade name Ceretec used in the detection of altered regional cerebral perfusion in stroke and other cerebrovascular diseases. It can also be used for the labelling of leukocytes to localise intra-abdominal infections and inflammatory bowel disease. Exametazime, also known as hexamethylpropyleneamine...
Approved
Matched Description: … Technetium Tc-99m exametazime is a radiopharmaceutical sold under the trade name Ceretec used in the ... detection of altered regional cerebral perfusion in stroke and other cerebrovascular diseases. ... Exametazime, also known as hexamethylpropyleneamine oxime or HMPAO, acts as a chelating agent for the …
Matched Categories: … Compounds used in a research, industrial, or household setting ... Diagnostic Uses of Chemicals …

Technetium Tc-99m succimer

Technetium Tc-99m (99mTc) succimer, also known as technetium Tc-99m dimercaptosuccinic acid (DMSA), is a radioactive diagnostic agent used to evaluate functional renal tissue and tubular function in patients with renal parenchymal disorders. It works by binding to the cortical region of the kidneys. Technetium Tc-99m succimer is used with gamma...
Approved
Matched Description: … It works by binding to the cortical region of the kidneys. ... approved by the FDA on February 23, 2022, under the market name NephroScan. ... [L40558] The use of technetium Tc-99m succimer for the detection of kidney cortical defects was first …
Matched Categories: … Compounds used in a research, industrial, or household setting ... Diagnostic Uses of Chemicals …

Human thrombin

Human thrombin is a sterile solution, pH 6.8-7.2, containing highly purified human thrombin for the activation of clotting. Thrombin is a highly specific serine protease encoded by the F2 gene that transforms soluble fibrinogen into insoluble fibrin. This transformation mimics the final coagulation cascade step which involves the clotting mass...
Approved
Matched Description: … Thrombin is a highly specific serine protease encoded by the F2 gene that transforms soluble fibrinogen ... to the wound surface and achieves hemostasis and sealing of open tissues. ... Furthermore, human thrombin is manufactured by chromatographic purification of prothrombin from cryo-poor …

Pralsetinib

Pralsetinib, similar to the previously approved selpercatinib, is a kinase inhibitor with enhanced specificity for RET tyrosine kinase receptors (RTKs) over other RTK classes.[A202055, A219751, L15986] Enhanced RET (Rearranged during transfection) oncogene expression is a hallmark of many cancers, including non-small cell lung cancer. Although multikinase inhibitors, including cabozantinib, ponatinib,...
Approved
Investigational
Matched Iupac: … (1s,4s)-N-[(1S)-1-[6-(4-fluoro-1H-pyrazol-1-yl)pyridin-3-yl]ethyl]-1-methoxy-4-{4-methyl-6-[(5-methyl ... -1H-pyrazol-3-yl)amino]pyrimidin-2-yl}cyclohexane-1-carboxamide …
Matched Description: … [A202049, A202055, L15986] Although a phase 1/2 trial of pralsetinib termed ARROW (NCT03037385) is ... It is currently marketed under the brand name GAVRETO™ by Blueprint Medicines.[L15986] ... Pralsetinib, similar to the previously approved [selpercatinib], is a kinase inhibitor with enhanced …
Matched Categories: … MATE 1 Inhibitors ... Heterocyclic Compounds, 1-Ring …

Tetradecyl hydrogen sulfate (ester)

Sodium tetradecyl sulfate is an anionic surface-active agent which is used for its wetting properties in the industry and is also used in medicine as a blood vessel irritant and sclerosing agent for hemorrhoids and varicose veins . Sodium tetradecyl sulfate has been widely used since the 1950s, and in...
Approved
Matched Description: … of injecting a 1% solution into spider angiomas in 144 patients was made. ... the industry and is also used in medicine as a blood vessel irritant and sclerosing agent for hemorrhoids ... Sodium tetradecyl sulfate has been widely used since the 1950s, and in 1978 the first successful report …
Matched Products: … Veinfibro 1 % Injektionslösung …

Poa compressa pollen

Poa compressa pollen is the pollen of the Poa compressa plant. Poa compressa pollen is mainly used in allergenic testing.
Approved
Matched Description: … Poa compressa pollen is the pollen of the Poa compressa plant. ... Poa compressa pollen is mainly used in allergenic testing. …
Matched Mixtures name: … Mixture of Standardized and Non-Standardized Inland Grasses ... Mixture of Twenty-Two Standardized and Non-Standardized Grasses ... Mixture of Standardized and Non-Standardized Coastal Grasses …
Displaying drugs 326 - 350 of 14566 in total