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Displaying drugs 351 - 375 of 9574 in total
Rilmenidine
Rilmenidine has been used in trials studying the treatment of Hypertension and Chronic Kidney Disease.
Approved
Investigational
Matched Description: … Rilmenidine has been used in trials studying the treatment of Hypertension and Chronic Kidney Disease …
Safinamide
Safinamide is for the treatment of parkinson's disease. It was approved in Europe in February 2015, and in the United States on March 21, 2017.
Approved
Investigational
Matched Description: … Safinamide is for the treatment of parkinson's disease. …
Matched Categories: … Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome …
Matched Categories: … Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome …
Cholecalciferol
Vitamin D, in general, is a secosteroid generated in the skin when 7-dehydrocholesterol located there interacts with ultraviolet irradiation - like that commonly found in sunlight . Both the endogenous form of vitamin D (that results from 7-dehydrocholesterol transformation), vitamin D3 (cholecalciferol), and the plant-derived form, vitamin D2 (ergocalciferol), are...
Approved
Nutraceutical
Matched Description: … vitamin d and are found in various types of food for daily intake [L5689]. ... Both the endogenous form of vitamin D (that results from 7-dehydrocholesterol transformation), vitamin ... Appropriate levels of vitamin D must be upheld in the body in order to maintain calcium and phosphorus …
Matched Categories: … Drugs for Treatment of Bone Diseases …
Matched Categories: … Drugs for Treatment of Bone Diseases …
Hydrochlorothiazide
Hydrochlorothiazide is the most commonly prescribed thiazide diuretic. It is indicated to treat edema and hypertension.[A185138,L8447,L8450] Hydrochlorothiazide use is common but declining in favour of angiotensin converting enzyme inhibitors. Many combination products are available containing hydrochlorothiazide and angiotensin converting enzyme inhibitors[L8390,L8423] or angiotensin II receptor blockers.[L7426,L7459]
Hydrochlorothiazide was granted FDA...
Approved
Vet approved
Matched Description: … [A185138,L8447,L8450] Hydrochlorothiazide use is common but declining in favour of angiotensin converting …
Matched Categories: … combinations of sulfonamides …
Matched Categories: … combinations of sulfonamides …
Nifedipine
Nifedipine, or BAY a 1040, is a first generation dihydropyridine L-type calcium channel blocker, similar to nicardipine.[A190210,A190273,A175390,L11383] Nifedipine was developed by Bayer and first described in the literature, along with other dihydropyridines, in 1972.[A175390,A190276] Since nifedipine's development, second and third generation dihydropyridines have been developed with slower onsets and longer...
Approved
Matched Description: … [A190273] The most popular of the third generation dihydropyridines is [amlodipine]. ... second and third generation dihydropyridines have been developed with slower onsets and longer durations of …
Matched Products: … NIFELAT R (20) …
Matched Products: … NIFELAT R (20) …
Ramelteon
Ramelteon is the first in a new class of sleep agents that selectively binds to the melatonin receptors in the suprachiasmatic nucleus (SCN). It is used for insomnia, particularly delayed sleep onset. Ramelteon has not been shown to produce dependence and has shown no potential for abuse.
Approved
Investigational
Matched Description: … Ramelteon is the first in a new class of sleep agents that selectively binds to the melatonin receptors …
Reviparin
Reviparin is a low molecular weight heparin which seems to have a better safety profile than unfractionated heparin. It is prepared from porcine intestinal mucosa by nitrous acid depolymerization. Reviparin has a molecular weight of 3.9 kDa. It was developed by Abbott laboratories and in 2009, reviparin presented an orphan...
Approved
Investigational
Matched Description: … Reviparin has a molecular weight of 3.9 kDa. …
Rifaximin
Rifaximin is a semisynthetic, rifamycin-based non-systemic antibiotic, meaning that the drug will not pass the gastrointestinal wall into the circulation as is common for other types of orally administered antibiotics. It has multiple indications and is used in treatment of traveller's diarrhea caused by E. coli; reduction in risk of...
Approved
Investigational
Matched Description: … the drug will not pass the gastrointestinal wall into the circulation as is common for other types of ... in risk of overt hepatic encephalopathy recurrence; as well as diarrhea-predominant irritable bowel ... It has multiple indications and is used in treatment of traveller's diarrhea caused by E. coli; reduction …
Phenylpropanolamine
Phenylpropanolamine is a sympathomimetic agent that acts as a nonselective adrenergic receptor agonist and norepinephrine reuptake inhibitor. It has been used as a decongestant and appetite suppressant. Currently, it is withdrawn from the market in Canada and the United States due to the risk for hemorrahgic strokes.
Approved
Vet approved
Withdrawn
Matched Mixtures name: … EXOVIT (R) CAPSULAS …
Phentolamine
Phentolamine is a reversible, non-selective alpha-adrenergic blocker that induces vasodilation. While initially introduced to the market for the treatment of hypertension, this clinical use was halted due to cardiovascular and gastrointestinal adverse effects with the prolonged use of large oral doses of phentolamine.[A261781, A261786] It has several therapeutic uses, including...
Approved
Matched Description: … of phentolamine. ... prevention of norepinephrine-induced extravasation, diagnosis of pheochromocytoma, reversal of soft-tissue ... anesthesia, and treatment of pharmacologically-induced mydriasis. …
Capsaicin
Capsaicin is most often used as a topical analgesic and exists in many formulations of cream, liquid, and patch preparations of various strengths; however, it may also be found in some dietary supplements. Capsaicin is a naturally-occurring botanical irritant in chili peppers, synthetically derived for pharmaceutical formulations. The most recent...
Approved
Matched Description: … Capsaicin is most often used as a topical analgesic and exists in many formulations of cream, liquid, ... and patch preparations of various strengths; however, it may also be found in some dietary supplements …
Matched Products: … Penetrex(r) Arthritis Pain Relief …
Matched Products: … Penetrex(r) Arthritis Pain Relief …
Regorafenib
Regorafenib is an orally-administered inhibitor of multiple kinases. It is used for the treatment of metastatic colorectal cancer, advanced gastrointestinal stromal tumours, and hepatocellular carcinoma. FDA approved on September 27, 2012. Approved use of Regorafenib was expanded to treat Hepatocellular Carcinoma in April 2017.
Approved
Matched Description: … Regorafenib is an orally-administered inhibitor of multiple kinases. ... Approved use of Regorafenib was expanded to treat Hepatocellular Carcinoma in April 2017. ... It is used for the treatment of metastatic colorectal cancer, advanced gastrointestinal stromal tumours …
rhThrombin
rhThrombin (recombinant human thrombin) is being developed by ZymoGenetics, Inc. as a general aid to achieving hemostasis during surgery. ZymoGenetics is developing rhThrombin, a recombinant form of human thrombin that is not derived from animal or human blood, as an aid to controlling bleeding during surgery. Thrombin is used in...
Approved
Investigational
Matched Description: … The production of recombinant proteins is not dependent on the availability of blood from animals or ... ZymoGenetics is developing rhThrombin, a recombinant form of human thrombin that is not derived from ... Bovine-derived thrombin has been associated with the development of antibodies that may cross-react with …
Rilonacept
Rilonacept is a dimeric fusion protein consisting of portions of IL-1R and the IL-1R accessory protein linked to the Fc portion of immunoglobulin G1. Rilonacept functions as an interleukin 1 inhibitor and is used in the treatment of CAPS, also known as cryopyrin-associated periodic syndromes, including familial cold auto-inflammatory syndrome...
Approved
Investigational
Matched Description: … Rilonacept is a dimeric fusion protein consisting of portions of IL-1R and the IL-1R accessory protein ... linked to the Fc portion of immunoglobulin G1. ... Rilonacept functions as an interleukin 1 inhibitor and is used in the treatment of CAPS, also known as …
Reslizumab
Reslizumab is a humanized interleukin-5 (IL-5) antagonist monoclonal antibody (IgG4 kappa) that is produced by recombinant DNA technology in murine myeloma non-secreting 0 (NS0) cells. IL-5 is a pro-inflammatory cytokine that is responsible for the growth and differentiation, recruitment, activation, and survival of eosinophils [FDA Label]. Elevated levels of eosinophils...
Approved
Investigational
Matched Description: … and nonallergic forms of asthma where eosinophilia is prominent. ... cytokine that is responsible for the growth and differentiation, recruitment, activation, and survival of ... Elevated levels of eosinophils increase the risk for asthma exacerbations, including both allergic forms …
Resmetirom
Resmetirom is a thyroid hormone receptor-beta (THR-beta) agonist. On March 14, 2024, it was approved by the FDA as the first treatment of liver fibrosis due to noncirrhotic non-alcoholic steatohepatitis (NASH), which is a form of non-alcoholic fatty liver disease (NAFLD). Thyroid hormones directly regulate lipid metabolism in the liver;...
Approved
Investigational
Matched Description: … non-alcoholic steatohepatitis (NASH), which is a form of non-alcoholic fatty liver disease (NAFLD). ... On March 14, 2024, it was approved by the FDA as the first treatment of liver fibrosis due to noncirrhotic …
Ritiometan
Ritiometan is a nasal spray which is marketed by the name Nécyrane in France. It is indicated for use in viral rhinitis/ the common cold.
Approved
Remdesivir
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of coronavirus disease 2019 (COVID-19), which is a respiratory disease that is capable of progressing to viral pneumonia and acute respiratory distress syndrome (ARDS); COVID-19 can be fatal. Like other RNA viruses, SARS-CoV-2 depends on an RNA-dependent RNA polymerase...
Approved
Investigational
Matched Description: … [A191379, A222393] Broad antiviral activity of remdesivir is suggested by its mechanism of action,[A222398 ... Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of coronavirus disease ... 2019 (COVID-19), which is a respiratory disease that is capable of progressing to viral pneumonia and …
Ripretinib
Ripretinib is a kinase inhibitor used for the treatment of advanced gastrointestinal stromal tumor (GIST) that has not adequately responded to other kinase inhibitors such as sunitinib and imatinib. Ripretinib, also known as Qinlock, is manufactured by Deciphera Pharmaceuticals and was initially approved by the FDA on May 15, 2020....
Approved
Matched Description: … treatment with a minimum of 3 other kinase inhibitors. ... Ripretinib is a kinase inhibitor used for the treatment of advanced gastrointestinal stromal tumor (GIST ... [L13769]
It is the first drug approved as a fourth-line therapy in the specific setting of prior …
Rufinamide
Rufinamide is a triazole derivative and an anticonvulsant medication to treat seizure disorders like Lennox-Gastuat syndrome, a form of childhood epilepsy. Clinical trials suggest its efficacy in the treatment of partial seizures.
Approved
Matched Description: … Clinical trials suggest its efficacy in the treatment of partial seizures. ... derivative and an anticonvulsant medication to treat seizure disorders like Lennox-Gastuat syndrome, a form of …
Felodipine
Felodipine is a long-acting 1,4-dihydropyridine calcium channel blocker (CCB)b. It acts primarily on vascular smooth muscle cells by stabilizing voltage-gated L-type calcium channels in their inactive conformation. By inhibiting the influx of calcium in smooth muscle cells, felodipine prevents calcium-dependent myocyte contraction and vasoconstriction. Felodipine is the most potent CCB...
Approved
Investigational
Matched Description: … , exhibits competitive antagonism of the mineralcorticoid receptor, inhibits the activity of calmodulin-dependent ... By inhibiting the influx of calcium in smooth muscle cells, felodipine prevents calcium-dependent myocyte ... In addition to binding to L-type calcium channels, felodipine binds to a number of calcium-binding proteins …
Olanzapine
Olanzapine is a thienobenzodiazepine classified as an atypical or second-generation antipsychotic agent. The second-generation antipsychotics were introduced in the 90s and quickly gained traction due to their impressive efficacy, reduced risk for extrapyramidal side effects and reduced susceptibility to drug-drug interactions. Olanzapine very closely resembles clozapine and only differs by...
Approved
Investigational
Matched Description: … very closely resembles [clozapine] and only differs by two additional methyl groups and the absence of …
Matched Categories: … Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome …
Matched Products: … ZAPIN(R) 10 MG TABLETA RECUBIERTA …
Matched Categories: … Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome …
Matched Products: … ZAPIN(R) 10 MG TABLETA RECUBIERTA …
Displaying drugs 351 - 375 of 9574 in total