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Displaying drugs 376 - 400 of 11619 in total
Binimetinib
Binimetinib, also known as Mektovi, is a potent and selective oral mitogen-activated protein kinase 1/2 (MEK 1/2) inhibitor which is combined with Encorafenib.[A34275,L3335]
On June 27, 2018, the Food and Drug Administration approved the combination of Encorafenib and binimetinib (BRAFTOVI and MEKTOVI, from Array BioPharma Inc.) in combination for patients...
Approved
Investigational
Matched Iupac: … 5-[(4-bromo-2-fluorophenyl)amino]-4-fluoro-N-(2-hydroxyethoxy)-1-methyl-1H-1,3-benzodiazole-6-carboxamide …
Matched Description: … (MEK 1/2) inhibitor which is combined with [Encorafenib]. ... Binimetinib, also known as _Mektovi_, is a potent and selective oral mitogen-activated protein kinase 1/2 …
Matched Categories: … Heterocyclic Compounds, 2-Ring ... MAP Kinase Kinase 2, antagonists & inhibitors …
Matched Description: … (MEK 1/2) inhibitor which is combined with [Encorafenib]. ... Binimetinib, also known as _Mektovi_, is a potent and selective oral mitogen-activated protein kinase 1/2 …
Matched Categories: … Heterocyclic Compounds, 2-Ring ... MAP Kinase Kinase 2, antagonists & inhibitors …
Nedosiran
Nedosiran is an RNA interference targeting hepatic lactate dehydrogenase, the enzyme responsible for the conversion of glyoxylate to oxalate. Oxalate, particularly calcium oxalate, precipitation is the main cause of kidney stones formation; therefore, blocking the production of oxalate can help alleviate renal symptoms. Nedosiran was approved by the FDA on...
Approved
Investigational
Matched Description: … This approval is based on the favorable results from the pivotal phase 2 PHYOXTM2 and interim ... [A261685]
Nedosiran was approved by the FDA on October 2nd, 2023, under the brand name …
Clopidogrel
Clopidogrel is a prodrug of a platelet inhibitor used to reduce the risk of myocardial infarction and stroke.[A180508,L7213] Clopidogrel is indicated to reduce the risk of myocardial infarction for patients with non-ST elevated acute coronary syndrome (ACS), patients with ST-elevated myocardial infarction, and in recent MI, stroke, or established peripheral...
Approved
Matched Iupac: … methyl (2S)-2-(2-chlorophenyl)-2-{4H,5H,6H,7H-thieno[3,2-c]pyridin-5-yl}acetate …
Matched Categories: … Heterocyclic Compounds, 2-Ring …
Matched Categories: … Heterocyclic Compounds, 2-Ring …
Interferon alfacon-1
Interferon alfacon-1 is a recombinant non-naturally occurring type-I interferon. The 166-amino acid sequence of Interferon alfacon-1 was derived by scanning the sequences of several natural interferon alpha subtypes and assigning the most frequently observed amino acid in each corresponding position. Four additional amino acid changes were made to facilitate the...
Approved
Investigational
Zinc chloride
Zinc chloride is a solution of ions indicated for use in total parenteral nutrition to maintain zinc levels and prevent deficiency syndromes. Zinc chloride was granted FDA approval before 26 June 1986.
Approved
Investigational
Matched Iupac: … zinc(2+) dichloride …
Matched Mixtures name: … AMINOMIX 2 SOLÜSYON, 1000 ML ... AMINOMIX 2 SOLÜSYON, 2000 ML ... AMINOMIX 2 NOVUM 1000 ML …
Matched Mixtures name: … AMINOMIX 2 SOLÜSYON, 1000 ML ... AMINOMIX 2 SOLÜSYON, 2000 ML ... AMINOMIX 2 NOVUM 1000 ML …
Curvularia inaequalis
Curvularia inaequalis is a fungus which can provoke allergic reactions. Curvularia inaequalis extract is used in allergenic testing.
Approved
Matched Mixtures name: … Mold Mix 2 ... Mold Mix 2 ... Mold Mix 2 …
Sodium fluorophosphate
Sodium monofluorophosphate is used in OTC dental preparations to help protect against cavities.
Approved
Matched Mixtures name: … Ron 2 …
Matched Products: … White Glo 2 in 1 with Mouthwash ... Brush Buddies Value 2 pack Whitening …
Matched Products: … White Glo 2 in 1 with Mouthwash ... Brush Buddies Value 2 pack Whitening …
Fusarium graminearum
Fusarium graminearum allergenic extract is used in allergenic testing.
Approved
Experimental
Matched Mixtures name: … Mold Mix 2 ... Mold Mix 2 ... Mold Mix 2 …
Rhizopus arrhizus var. arrhizus
Rhizopus arrhizus var. arrhizus is a fungus which can provoke allergic reactions. Rhizopus arrhizus var. arrhizus extract is used in allergenic testing.
Approved
Matched Mixtures name: … Mold Mix 2 ... Mold Mix 2 ... Mold Mix 2 …
Isoetharine
Isoetharine is a relatively selective beta-2 adrenergic agonist. It is a catechol-like agent. Isoetharine is a fast-acting bronchodilator used for emphysema, bronchitis and asthma.
Approved
Matched Iupac: … 4-{1-hydroxy-2-[(propan-2-yl)amino]butyl}benzene-1,2-diol …
Matched Description: … Isoetharine is a relatively selective beta-2 adrenergic agonist. It is a catechol-like agent. …
Matched Categories: … Adrenergic beta-2 Receptor Agonists ... Selective Beta 2-adrenergic Agonists …
Matched Description: … Isoetharine is a relatively selective beta-2 adrenergic agonist. It is a catechol-like agent. …
Matched Categories: … Adrenergic beta-2 Receptor Agonists ... Selective Beta 2-adrenergic Agonists …
Benzethonium
Benzethonium is a synthetic quaternary ammonium salt with surfactant, antiseptic, and broad spectrum antimicrobial properties. Its salt form, benzethonium chloride, is primarily used as a skin disinfectant at concentrations of 0.1-0.2 %, which are safe and effective concentrations for the compound specified by the U.S. Food and Drug Administration (FDA)....
Approved
Matched Iupac: … benzyldimethyl(2-{2-[4-(2,4,4-trimethylpentan-2-yl)phenoxy]ethoxy}ethyl)azanium …
Matched Products: … Hand-Giene E-2 ... Alpha Foaming E-2 …
Matched Products: … Hand-Giene E-2 ... Alpha Foaming E-2 …
Vamorolone
Vamorolone is a novel and fully synthetic glucocorticoid developed by Santhera Pharmaceuticals. It is used to manage inflammation and immune dysregulation in patients with Duchenne muscular dystrophy (DMD), a neuromuscular disorder characterized by the insidious regression of neuromuscular function and the most common form of muscular dystrophy in the United...
Approved
Investigational
Matched Iupac: … (1R,2R,3aS,3bS,9aS,11aS)-1-hydroxy-1-(2-hydroxyacetyl)-2,9a,11a-trimethyl-1H,2H,3H,3aH,3bH,4H,5H,7H,9aH …
Matched Description: … L48676] Vamorolone was approved by the FDA in October 2023 for the management of DMD in patients ≥2 …
Matched Description: … L48676] Vamorolone was approved by the FDA in October 2023 for the management of DMD in patients ≥2 …
Capivasertib
Hormone receptor (HR) positive, especially estrogen receptor-positive, HER2-negative breast cancer is the most common subtype of metastatic breast cancer, resulting in more than 400,000 deaths annually. Although endocrine-based therapy is the first line of treatment, resistance eventually emerges, leaving chemotherapy the only but often ineffective treatment left. Therefore, significant research...
Approved
Investigational
Matched Categories: … MATE 2 Inhibitors …
Darbepoetin alfa
Human erythropoietin with 2 aa substitutions to enhance glycosylation (5 N-linked chains), 165 residues (MW=37 kD). Produced in Chinese hamster ovary (CHO) cells by recombinant DNA technology.
Approved
Investigational
Matched Description: … Human erythropoietin with 2 aa substitutions to enhance glycosylation (5 N-linked chains), 165 residues …
Vibrio cholerae CVD 103-HgR strain live antigen
Vibrio cholerae CVD 103-HgR strain live antigen is a component of Vaxchora, an oral vaccine for immunization against Vibrio cholerae serogroup O1. Cholera is an acute bacterial disease of the small intestine caused by Vibrio cholerae, which is gram-negative bacteria. Two serogroups of V. cholerae, O1 and O139, are causative...
Approved
Investigational
Yohimbine
A plant alkaloid with alpha-2-adrenergic blocking activity. Yohimbine has been used as a mydriatic and in the treatment of impotence. It is also alleged to be an aphrodisiac.
Approved
Investigational
Vet approved
Matched Iupac: … methyl (1S,15R,18S,19R,20S)-18-hydroxy-3,13-diazapentacyclo[11.8.0.0^{2,10}.0^{4,9}.0^{15,20}]henicosa-2( …
Matched Description: … A plant alkaloid with alpha-2-adrenergic blocking activity. …
Matched Categories: … Heterocyclic Compounds, 2-Ring ... Adrenergic alpha-2 Receptor Antagonists …
Matched Description: … A plant alkaloid with alpha-2-adrenergic blocking activity. …
Matched Categories: … Heterocyclic Compounds, 2-Ring ... Adrenergic alpha-2 Receptor Antagonists …
Segesterone acetate
Segesterone acetate is a steroidal progestin or synthetic progesterone and a 19-norprogesterone derivative with no CH3 group radical in position 6 . In animal studies, segesterone acetate was shown to be one of the most potent progestins . It mediates progestational activity 100 times higher than that of progesterone ....
Approved
Experimental
Investigational
Matched Iupac: … (1R,3aS,3bR,9aR,9bS,11aS)-1-acetyl-11a-methyl-2-methylidene-7-oxo-1H,2H,3H,3aH,3bH,4H,5H,7H,8H,9H,9aH …
Picosulfuric acid
Picosulfuric acid is found in laxative products. Sodium picosulfate is a used to treat constipation or induce colon cleansing to prepare the large bowels before colonoscopy or surgery. The combination product containing sodium picosulfate and magnesium citrate was introduced to the Canadian market in 2005 and has been used in...
Approved
Matched Iupac: … {4-[(pyridin-2-yl)[4-(sulfooxy)phenyl]methyl]phenyl}oxidanesulfonic acid …
Matched Mixtures name: … PICOPREP 10 MG / 3,5 G /12 G ORAL ÇÖZELTI IÇIN TOZ, 2 SAŞE ... CITRAFLEET 0.01 G/ 3.50 G/ 10.97 G ORAL ÇÖZELTI HAZIRLAMAK IÇIN TOZ IÇEREN SAŞE , 2 ADET …
Matched Mixtures name: … PICOPREP 10 MG / 3,5 G /12 G ORAL ÇÖZELTI IÇIN TOZ, 2 SAŞE ... CITRAFLEET 0.01 G/ 3.50 G/ 10.97 G ORAL ÇÖZELTI HAZIRLAMAK IÇIN TOZ IÇEREN SAŞE , 2 ADET …
Fenoldopam
A dopamine D1 receptor agonist that is used as an antihypertensive agent. It lowers blood pressure through arteriolar vasodilation.
Approved
Matched Categories: … Heterocyclic Compounds, 2-Ring …
Oxyphenisatin acetate
Oxyphenisatin acetate is the pro-drug of oxyphenisatin (3,3-bis(4-hydroxyphenyl)-1H-indol-2-one). The FDA withdrew its approval for the use of oxyphenisatin acetate due to safety reasons.
Approved
Investigational
Withdrawn
Matched Iupac: … 4-{3-[4-(acetyloxy)phenyl]-2-oxo-2,3-dihydro-1H-indol-3-yl}phenyl acetate …
Matched Description: … Oxyphenisatin acetate is the pro-drug of [oxyphenisatin] (3,3-bis(4-hydroxyphenyl)-1H-indol-2-one). …
Matched Categories: … Heterocyclic Compounds, 2-Ring …
Matched Description: … Oxyphenisatin acetate is the pro-drug of [oxyphenisatin] (3,3-bis(4-hydroxyphenyl)-1H-indol-2-one). …
Matched Categories: … Heterocyclic Compounds, 2-Ring …
Dacarbazine
An antineoplastic agent. It has significant activity against melanomas. (from Martindale, The Extra Pharmacopoeia, 31st ed, p564). Dacarbazine with Oblimersen is in clinical trials for the treatment of malignant melanoma.
Approved
Investigational
Voriconazole
Voriconazole (Vfend, Pfizer) is a triazole antifungal medication used to treat serious fungal infections. It is used to treat invasive fungal infections that are generally seen in patients who are immunocompromised. These include invasive candidiasis, invasive aspergillosis, and emerging fungal infections. The increased affinity of voriconazole for 14-alpha sterol demethylase...
Approved
Matched Iupac: … (3S)-2-(2,4-difluorophenyl)-3-(5-fluoropyrimidin-4-yl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol …
Cabozantinib
Cabozantinib was first approved in 2012 and is a non-specific tyrosine kinase inhibitor. It was initially approved in the US under the brand name Cometriq, which is indicated for the treatment of metastatic medullary thyroid cancer. In 2016, a capsule formulation (Cabometyx) was approved for the treatment of advanced renal...
Approved
Investigational
Magnesium chloride
Magnesium chloride salts are highly soluble in water and the hydrated form of magnesium chloride can be extracted from brine or sea water.
Approved
Matched Iupac: … magnesium(2+) dichloride …
Matched Mixtures name: … Prismasol 2 ... CAPD/DPCA 2 ... DIANEAL PD-2 with Dextrose …
Matched Mixtures name: … Prismasol 2 ... CAPD/DPCA 2 ... DIANEAL PD-2 with Dextrose …
Periplaneta americana
American cockroach allergenic extract is used in allergenic testing.
Approved
Matched Mixtures name: … 2 Cockroach Mix ... 2 Cockroach Mix ... 2 Cockroach Mix …
Displaying drugs 376 - 400 of 11619 in total