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Displaying drugs 4051 - 4075 of 4207 in total
Clomipramine, the 3-chloro analog of imipramine, is a dibenzazepine-derivative tricyclic antidepressant (TCA). TCAs are structurally similar to phenothiazines. They contain a tricyclic ring system with an alkyl amine substituent on the central ring. In non-depressed individuals, clomipramine does not affect mood or arousal, but may cause sedation. In depressed individuals,...
Approved
Investigational
Vet approved
Matched Description: … TCAs also block histamine-H1 receptors, α1-adrenergic receptors and muscarinic ... TCAs also down-regulate cerebral cortical β-adrenergic receptors and sensitize post-synaptic serotonergic ... See toxicity section below for a complete listing of side effects. …
Matched Categories: … Tricyclics and Other Norepinephrine-reuptake Inhibitors …
Matched Products: … CLOMIPRAMIN-NEURAX 75 RET ... ANAFRANIL SR 75 MG UZATILMIŞ SALIMLI BÖLÜNEBİLİR TABLET, 20 ADET …
Betaine is a methyl group donor that functions in the normal metabolic cycle of methionine. It is a naturally occurring choline derivative commonly ingested through diet, with a role in regulating cellular hydration and maintaining cell function.[A252235,A252240] Homocystinuria is an inherited disorder that leads to the accumulation of homocysteine in...
Approved
Investigational
Nutraceutical
Matched Synonyms: … Acidol
Matched Description: … occurring choline derivative commonly ingested through diet, with a role in regulating cellular hydration and ... A252240] Homocystinuria is an inherited disorder that leads to the accumulation of homocysteine in plasma and ... levels, patients can be treated with vitamin B6 ([pyridoxine]), vitamin B12 ([cobalamin]), [folate] and
Matched Mixtures name: … Glutamic Acid Pepsin and Betaine Tablets ... Neo Life Beta Gest Tab ... Glutamic Acid HCl Betaine HCl W Pepsin …
Matched Categories: … Amino Acids and Derivatives ... Alimentary Tract and Metabolism ... Acid Preparations …
Matched Products: … HOMOSİSTİNEX 1 G ORAL TOZ, 180 GRAM
Experimental
Matched Name: … 1-(2-DEOXY-5-O-PHOSPHONO-BETA-D-ERYTHRO-PENTOFURANOSYL)-4-METHYL-1H-INDOLE …
Matched Iupac: … {[(2R,3S,5R)-3-hydroxy-5-(4-methyl-1H-indol-1-yl)oxolan-2-yl]methoxy}phosphonic acid
Experimental
Matched Name: … 1-(2-DEOXY-5-O-PHOSPHONO-BETA-D-ERYTHRO-PENTOFURANOSYL)-5-NITRO-1H-INDOLE …
Matched Iupac: … {[(2R,3S,5R)-3-hydroxy-5-(5-nitro-1H-indol-1-yl)oxolan-2-yl]methoxy}phosphonic acid
Sirpiglenastat, also known as DRP-104, is a prodrug of 6-diazo-5-oxo-L-norleucine (DON), which is a broad-acting glutamine antagonist. It is under investigation in clinical trial NCT04471415 (Study to Investigate DRP-104 in Adults With Advanced Solid Tumors).
Investigational
Matched Synonyms: … L-norleucine, n-acetyl-l-tryptophyl-6-diazo-5-oxo-, 1-methylethyl ester
Experimental
Matched Name: … 6-AMINO-4-[2-(4-METHYLPHENYL)ETHYL]-1,7-DIHYDRO-8H-IMIDAZO[4,5-G]QUINAZOLIN-8-ONE …
Matched Iupac: … 6-amino-4-[2-(4-methylphenyl)ethyl]-1H,7H,8H-imidazo[4,5-g]quinazolin-8-one …
Warfarin is an anticoagulant drug normally used to prevent blood clot formation as well as migration. Although originally marketed as a pesticide (d-Con, Rodex, among others), Warfarin has since become the most frequently prescribed oral anticoagulant in North America. Warfarin has several properties that should be noted when used medicinally,...
Approved
Matched Description: … , and drug interactions have also been documented with warfarin use. ... during pregnancy which can result in fetal bleeding, spontaneous abortion, preterm birth, stillbirth, and ... Additional adverse effects such as necrosis, purple toe syndrome, osteoporosis, valve and artery calcification …
Matched Salts cas: … 2610-86-8
Matched Categories: … Blood and Blood Forming Organs ... Warfarin and isomers …
Matched Products: … VARFARİN 5 MG TABLET, 20 ADET …
Sapropterin (tetrahydrobiopterin or BH4) is a cofactor in the synthesis of nitric oxide. It is also essential in the conversion of phenylalanine to tyrosine by the enzyme phenylalanine-4-hydroxylase; the conversion of tyrosine to L-dopa by the enzyme tyrosine hydroxylase; and conversion of tryptophan to 5-hydroxytryptophan via tryptophan hydroxylase.
Approved
Investigational
Matched Synonyms: … R-THBP …
Matched Description: … phenylalanine-4-hydroxylase; the conversion of tyrosine to L-dopa by the enzyme tyrosine hydroxylase; and
Matched Salts cas: … 69056-38-8
Matched Categories: … Alimentary Tract and Metabolism ... Enzymes and Coenzymes ... Various Alimentary Tract and Metabolism Products …
Experimental
Matched Name: … 7-(5-DEOXY-BETA-D-RIBOFURANOSYL)-5-IODO-7H-PYRROLO[2,3-D]PYRIMIDIN-4-AMINE …
Experimental
Matched Name: … (4R)-7-chloro-9-methyl-1-oxo-1,2,4,9-tetrahydrospiro[beta-carboline-3,4'-piperidine]-4-carbonitrile …
Matched Iupac: … (4'R)-7'-chloro-9'-methyl-1'-oxo-1',2',4',9'-tetrahydrospiro[piperidine-4,3'-pyrido[3,4-b]indole]-4'- …
Experimental
Matched Name: … N-{3-[4-(3-amino-propyl)-piperazin-1-yl]-propyl}-3-nitro-5-(galactopyranosyl)-beta-benzamide …
Filgrastim is a short-acting recombinant, non-pegylated human granulocyte colony-stimulating factor (G-CSF) analog produced by recombinant DNA technology. It has an amino acid sequence identical to endogenous G-CSF, but it is non-glycosylated unlike the endogenous G-CSF and has an N-terminal methionine added in the sequence for expression in E. Coli. Human...
Approved
Matched International brands: … Gran
Matched Description: … [L36325] Filgrastim-sndz was approved on March 6, 2015 [L40768] and filgrastim-ayow was approved on March ... It has an amino acid sequence identical to endogenous G-CSF, but it is non-glycosylated unlike the endogenous ... 2, 2022. …
Matched Categories: … Amino Acids, Peptides, and Proteins ... Antineoplastic and Immunomodulating Agents …
Matched Products: … GRAN ... LEUCOSTIM(R) 300 MCG/PREFILLED SYRINGE ... LEUCOSTIM(R) 480 MCG/PREFILLED SYRINGE …
Experimental
Matched Name: … N-{3-[4-(3-aminopropyl)piperazin-1-yl]propyl}-3-(alpha-D-galactopyranosyloxy)-5-nitrobenzamide …
Ceftaroline fosamil is a cephalosporin antibacterial indicated for the treatment of the following infections caused by designated susceptible bacteria: Acute bacterial skin and skin structure infections. Community-acquired bacterial pneumonia.
Approved
Investigational
Matched Synonyms: … phosphonoamino)-1,2,4-thiadiazol-3-yl]acetyl]amino]-3-[4-(1-methylpyridin-1-ium-4-yl)-1,3-thiazol-2-yl]sulfanyl]-8- …
Matched Iupac: … 6R,7R)-2-carboxylato-7-[(2Z)-2-(ethoxyimino)-2-[5-(phosphonoamino)-1,2,4-thiadiazol-3-yl]acetamido]-8- …
Matched Description: … treatment of the following infections caused by designated susceptible bacteria: Acute bacterial skin and
Matched Categories: … beta-Lactams ... beta Lactam Antibiotics …
Heart failure is a multifactorial condition that affects roughly 1-2% of the adult population. Often the result of long-term myocardial ischemia, cardiomyopathy, or other cardiac insults, heart failure results from an inability of the heart to perfuse peripheral tissues with sufficient oxygen and metabolites, resulting in complex systemic pathologies. Heart...
Approved
Matched Description: … failure results from an inability of the heart to perfuse peripheral tissues with sufficient oxygen and ... and peripheral vasodilation in acute decongested heart failure. ... failure is underpinned by numerous physiological changes, including alteration in β-adrenergic signalling and
Matched Products: … MULTİFLEKS KARDİYOMİL 20 MG/100 ML IV İNFÜZYONLUK ÇÖZELTİ …
Experimental
Matched Name: … 1-(6-CYANO-3-PYRIDYLCARBONYL)-5',8'-DIFLUOROSPIRO[PIPERIDINE-4,2'(1'H)-QUINAZOLINE]-4'-AMINE …
Matched Iupac: … 5-({4'-amino-5',8'-difluoro-1'H-spiro[piperidine-4,2'-quinazolin]-1-yl}carbonyl)pyridine-2-carbonitrile …
Experimental
Matched Name: … (3AS,4R,9BR)-2,2-DIFLUORO-4-(4-HYDROXYPHENYL)-1,2,3,3A,4,9B-HEXAHYDROCYCLOPENTA[C]CHROMEN-8-OL …
Matched Iupac: … (2R,6S,7R)-4,4-difluoro-7-(4-hydroxyphenyl)-8-oxatricyclo[7.4.0.0^{2,6}]trideca-1(9),10,12-trien-12-ol …
Experimental
Matched Name: … N-(3-(8-CYANO-4-(PHENYLAMINO)PYRAZOLO[1,5-A][1,3,5]TRIAZIN-2-YLAMINO)PHENYL)ACETAMIDE …
Matched Iupac: … N-(3-{[8-cyano-4-(phenylamino)pyrazolo[1,5-a][1,3,5]triazin-2-yl]amino}phenyl)acetamide …
Amphotericin B shows a high order of in vitro activity against many species of fungi. Histoplasma capsulatum, Coccidioides immitis, Candida species, Blastomyces dermatitidis, Rhodotorula, Cryptococcus neoformans, Sporothrix schenckii, Mucor mucedo, and Aspergillus fumigatus are all inhibited by concentrations of amphotericin B ranging from 0.03 to 1.0 mcg/mL in vitro. While...
Approved
Investigational
Matched Iupac: … trimethyl-13-oxo-14,39-dioxabicyclo[33.3.1]nonatriaconta-19,21,23,25,27,29,31-heptaene-36-carboxylic acid
Matched Description: … Blastomyces dermatitidis, Rhodotorula, Cryptococcus neoformans, Sporothrix schenckii, Mucor mucedo, and ... The antibiotic is without effect on bacteria, rickettsiae, and viruses. ... Pseudallescheria boydii and Fusarium sp. are often resistant to amphotericin B. …
Matched Categories: … Alimentary Tract and Metabolism ... Antiinfectives and Antiseptics for Local Oral Treatment ... Genito Urinary System and Sex Hormones ... Gynecological Antiinfectives and Antiseptics …
Matched Products: … AMPHOLIP ® 100MG/20ML ... ABELCET 100 MG/20 ML IV INF. ICIN. SUS. ICEREN FLAKON, 1 ADET …
Tacrolimus (also FK-506 or Fujimycin) is an immunosuppressive drug whose main use is after organ transplant to reduce the activity of the patient's immune system and so the risk of organ rejection. It is also used in a topical preparation in the treatment of severe atopic dermatitis, severe refractory uveitis...
Approved
Investigational
Matched Description: … drug whose main use is after organ transplant to reduce the activity of the patient's immune system and ... the treatment of severe atopic dermatitis, severe refractory uveitis after bone marrow transplants, and ... This FKBP12-FK506 complex inhibits calcineurin which inhibits T-lymphocyte signal transduction and IL …
Matched Mixtures name: … Hyaluronic Acid Sodium Salt 1% / Tacrolimus 0.1% / Urea 20% ... Hyaluronic Acid Sodium Salt 1% / Niacinamide 4% / Tacrolimus 0.1% …
Matched Categories: … Antineoplastic and Immunomodulating Agents ... Skin and Mucous Membrane Agents …
Matched Products: … ADVAGRAF(R) 1 MG ... ADVAGRAF(R) 0.5 MG ... TOPİCLİN %0.1 MERHEM, 30 GRAM
Experimental
Matched Name: … Chloro-2-Fluoro-Phenyl)-4-Cyano-5-(2,2-Dimethyl-Propyl)-Pyrrolidine-2-Carbonyl]-Amino}-3-Methoxy-Benzoic Acid
Adalimumab is a subcutaneously administered biological disease modifier for the treatment of rheumatoid arthritis and other chronic debilitating diseases mediated by tumor necrosis factor.[A39984,A39999] It was originally launched by Abbvie in the U.S. and approved in 2002 by the FDA. This drug is frequently known as Humira. It is produced...
Approved
Experimental
Matched Description: … - which was approved in August 2022 -,[L42935] and adalimumab-aacf - which was approved in October 2023 ... [A39984,A39999] It was originally launched by Abbvie in the U.S. and approved in 2002 by the FDA. ... a subcutaneously administered biological disease modifier for the treatment of rheumatoid arthritis and
Matched Categories: … Amino Acids, Peptides, and Proteins ... Antineoplastic and Immunomodulating Agents ... Tumor necrosis factor alpha (TNF-alpha) inhibitors …
Matched Products: … HUMIRA 80 MG/0.8 ML PEN ... HUMIRA 80 MG/0.8 ML SPR ... AMGEVITA 20 mg/0.4 ml solution for injection in pre-filled syringe …
Rocuronium (rapid onset-curonium) is a desacetoxy analogue of vecuronium with a more rapid onset of action. It is an aminosteroid non-depolarizing neuromuscular blocker or muscle relaxant used in modern anaesthesia, to facilitate endotracheal intubation and to provide skeletal muscle relaxation during surgery or mechanical ventilation. Introduced in 1994, rocuronium has...
Approved
Matched Iupac: … 1-[(1R,2S,3aS,3bR,5aS,7S,8S,9aS,9bS,11aS)-1-(acetyloxy)-7-hydroxy-9a,11a-dimethyl-8-(morpholin-4-yl)- …
Matched Description: … It is commonly marketed under the trade names Zemuron and Esmeron. ... neuromuscular blocker or muscle relaxant used in modern anaesthesia, to facilitate endotracheal intubation and ... Introduced in 1994, rocuronium has rapid onset, and intermediate duration of action. …
Matched Products: … ROCUREX(R)100MG …
Initially approved by the FDA in 1997, quetiapine is a second-generation atypical antipsychotic used in schizophrenia, major depression, and bipolar disorder. Quetiapine demonstrates a high level of therapeutic efficacy and low risk of adverse effects during long-term treatment. It is well-tolerated and a suitable option for some patients with high...
Approved
Matched Description: … , quetiapine is a second-generation atypical antipsychotic used in schizophrenia, major depression, and ... as [clozapine] and [olanzapine]. ... [L8546] Quetiapine demonstrates a high level of therapeutic efficacy and low risk of adverse effects …
Matched Categories: … Diazepines, Oxazepines, Thiazepines and Oxepines ... Adrenergic alpha-Antagonists ... Adrenergic alpha-1 Receptor Antagonists …
Matched Products: … QUETIAPIN BETA 25MG ... QUETIAPIN BETA 100MG ... QUETIAPIN BETA 200MG …
A specific blocker of dopamine receptors. It speeds gastrointestinal peristalsis, causes prolactin release, and is used as antiemetic and tool in the study of dopaminergic mechanisms.
Approved
Investigational
Vet approved
Matched Description: … It speeds gastrointestinal peristalsis, causes prolactin release, and is used as antiemetic and tool …
Matched Mixtures name: … RABELIS PLUS 20/10 MG KAPSUL, 30 ADET ... RABELIS PLUS 20/30 MG MR KAPSUL, 30 ADET …
Matched Categories: … Alimentary Tract and Metabolism …
Matched Products: … DOMPERIDON BETA 10MG TABL ... MOTILIUM 1 MG/ML ORAL SUSPANSIYON, 200 ML ... DOPROKİN 1 MG/ML ORAL SÜSPANSİYON, 200 ML …
Displaying drugs 4051 - 4075 of 4207 in total