Displaying drugs 401 - 425 of 2458 in total
Tolevamer
Sodium polystyrene sulfonate is a medication used to treat abnormally high potassium levels. It may be taken orally or by rectum, as an enema, and functions as a potassium-binding resin in the intestines. It is also an effective topical microbicide and spermicide, inhibiting the genital transfection of, among others, HIV.
Approved
Investigational
Matched Synonyms: … Polystyrene sulfonic acid ... poly(styrene-4-sulfonic acid) ... polystyrenesulfonic acid …
Matched Description: … It may be taken orally or by rectum, as an enema, and functions as a potassium-binding resin in the intestines ... It is also an effective topical microbicide and spermicide, inhibiting the genital transfection of, among …
Matched Salts name: … Tolevamer calcium …
Matched Categories: … Sulfur Acids ... Drugs for Treatment of Hyperkalemia and Hyperphosphatemia ... Sulfur Compounds ... Acids ... Acids, Noncarboxylic …
Matched Products: … Resonium Calcium ... CALCIUM POLYSTYRENE SULFONATE ... Jamp Calcium Polystyrene Sulfonate …
Matched Description: … It may be taken orally or by rectum, as an enema, and functions as a potassium-binding resin in the intestines ... It is also an effective topical microbicide and spermicide, inhibiting the genital transfection of, among …
Matched Salts name: … Tolevamer calcium …
Matched Categories: … Sulfur Acids ... Drugs for Treatment of Hyperkalemia and Hyperphosphatemia ... Sulfur Compounds ... Acids ... Acids, Noncarboxylic …
Matched Products: … Resonium Calcium ... CALCIUM POLYSTYRENE SULFONATE ... Jamp Calcium Polystyrene Sulfonate …
Calcium glycerophosphate
Calcium glycerophosphate is a DB01373 salt of glycerophosphoric acid that forms a white, fine, slightly hygroscopic powder. The commercial product is a mixture of calcium beta-, and D-, and L -alpha-glycerophosphate. By FDA, calcium glycerophosphate is considered a generally recognized as safe (GRAS) food ingredient as a nutrient supplement (source...
Approved
Matched Synonyms: … β-glycerophosphoric acid calcium salt ... calcium β-glycerophosphate ... Calcium beta-glycerophosphate …
Matched Name: … Calcium glycerophosphate …
Matched Iupac: … calcium 2-(phosphonooxy)propane-1,3-diol …
Matched Description: … The commercial product is a mixture of calcium beta-, and D-, and L -alpha-glycerophosphate. ... Calcium glycerophosphate is a [DB01373] salt of glycerophosphoric acid that forms a white, fine, slightly ... as a nutrient supplement (source of calcium or phosphorus), or in food products such as gelatins, puddings …
Matched Mixtures name: … Calcium Inj ... Somarexin and C 1000 ... NUTROPLEX LIQUID WITH IRON AND LYSINE …
Matched Name: … Calcium glycerophosphate …
Matched Iupac: … calcium 2-(phosphonooxy)propane-1,3-diol …
Matched Description: … The commercial product is a mixture of calcium beta-, and D-, and L -alpha-glycerophosphate. ... Calcium glycerophosphate is a [DB01373] salt of glycerophosphoric acid that forms a white, fine, slightly ... as a nutrient supplement (source of calcium or phosphorus), or in food products such as gelatins, puddings …
Matched Mixtures name: … Calcium Inj ... Somarexin and C 1000 ... NUTROPLEX LIQUID WITH IRON AND LYSINE …
Ketotifen
Ketotifen is a benzocycloheptathiophene derivative with potent antihistaminic and mast cell stabilizing properties. It has a similar structure to some other first-generation antihistamines such as cyproheptadine and azatadine. Ketotifen was first developed in Switzerland in 1970 by Sandoz Pharmaceuticals and was initially marketed for the treatment of anaphylaxis. In the...
Approved
Matched Description: … allergic symptoms and disorders,[A231204] including urticaria, mastocytosis, and food allergy. ... Ketotifen is a benzocycloheptathiophene derivative[A231204] with potent antihistaminic and mast cell ... It has a similar structure to some other first-generation antihistamines such as [cyproheptadine] and …
Matched Categories: … Decongestants and Antiallergics ... Sulfur Compounds …
Matched Products: … Up and Up Eye Itch Relief …
Matched Categories: … Decongestants and Antiallergics ... Sulfur Compounds …
Matched Products: … Up and Up Eye Itch Relief …
Borage oil
Borage oil, or borage seed oil, is a rich source of gamma-linolenic acid (GLA) that is obtained from the seeds of the Borago officinalis (borage). Borage oil is used as an herbal treatment of skin disorders including eczema, seborrheic dermatitis, and neurodermatitis as well as other inflammatory, cardiovascular and endocrine...
Approved
Investigational
Matched Synonyms: … Borago officinalis …
Matched Description: … the seeds of the Borago officinalis (borage). ... Borage oil, or borage seed oil, is a rich source of gamma-linolenic acid (GLA) that is obtained from ... clinical efficacy and long-term effects are not fully elucidated yet. …
Matched Categories: … Fatty Acids ... Linolenic Acids ... Fatty Acids, Omega-6 ... Fatty Acids, Essential ... Fatty Acids, Unsaturated …
Matched Description: … the seeds of the Borago officinalis (borage). ... Borage oil, or borage seed oil, is a rich source of gamma-linolenic acid (GLA) that is obtained from ... clinical efficacy and long-term effects are not fully elucidated yet. …
Matched Categories: … Fatty Acids ... Linolenic Acids ... Fatty Acids, Omega-6 ... Fatty Acids, Essential ... Fatty Acids, Unsaturated …
Sulfate ion
Experimental
Investigational
Matched Synonyms: … Sulfuric acid ion(2-) …
Matched Categories: … Sulfur Acids ... Sulfuric Acids ... Sulfur Compounds …
Matched Categories: … Sulfur Acids ... Sulfuric Acids ... Sulfur Compounds …
Polistes metricus venom protein
Polistes metricus venom protein is an extract of Polistes metricus venom. Polistes metricus venom protein is used in allergenic testing.
Approved
Matched Synonyms: … Metricus paper wasp venom protein …
Matched Name: … Polistes metricus venom protein …
Matched Description: … Polistes metricus venom protein is an extract of Polistes metricus venom. ... Polistes metricus venom protein is used in allergenic testing. …
Matched Mixtures name: … Wasp Hymenoptera Venom Venomil Diagnostic ... Wasp Hymenoptera Venom Venomil Maintenance ... Wasp Hymenoptera Venom Venomil Diagnostic …
Matched Categories: … Bee and Wasp Venom …
Matched Name: … Polistes metricus venom protein …
Matched Description: … Polistes metricus venom protein is an extract of Polistes metricus venom. ... Polistes metricus venom protein is used in allergenic testing. …
Matched Mixtures name: … Wasp Hymenoptera Venom Venomil Diagnostic ... Wasp Hymenoptera Venom Venomil Maintenance ... Wasp Hymenoptera Venom Venomil Diagnostic …
Matched Categories: … Bee and Wasp Venom …
Bazlitoran
Bazlitoran is under investigation in clinical trial NCT02092909 (Phase 1/2 Dose Escalation Study in Patients With Relapsed or Refractory Waldenstrom's Macroglobulinemia).
Investigational
Matched Synonyms: … Antagonist of the endosomal Toll-like receptors (TLRs) 7, 8, and 9 …
Matched Categories: … Nucleic Acids, Nucleotides, and Nucleosides …
Matched Categories: … Nucleic Acids, Nucleotides, and Nucleosides …
5-aminonaphthalene-2-sulfonic acid
Experimental
Matched Synonyms: … 1-naphthylamine-6-sulfonic acid ... 5-naphthylamine-2-sulfonic acid ... α-naphthylamine-6-sulfonic acid …
Matched Name: … 5-aminonaphthalene-2-sulfonic acid …
Matched Iupac: … 5-aminonaphthalene-2-sulfonic acid …
Matched Name: … 5-aminonaphthalene-2-sulfonic acid …
Matched Iupac: … 5-aminonaphthalene-2-sulfonic acid …
Althea root
Experimental
Matched Synonyms: … Althaea officinalis root …
Matched Categories: … Cough and Cold Preparations …
Matched Categories: … Cough and Cold Preparations …
Calcium levulinate
The relatively new calcium levulinate is produced from a direct reaction between L- or levulinic acid levulose and calcium hydroxide . The resultant calcium levulinate formulation, when used as a calcium supplement, possesses a high calcium content that is observed to be 14.8% higher than the content typically found in...
Approved
Experimental
Matched Synonyms: … Calcium laevulate ... Calcium levulinate anhydrous …
Matched Name: … Calcium levulinate …
Matched Iupac: … calcium bis(4-oxopentanoate) …
Matched Description: … levulose and calcium hydroxide [L2765]. ... Calcium levulinate can be used alone, or with calcium lactate, calcium chloride, and other compounds, ... , condiments, beer, beverages, soft drinks, milk and milk products, soy milk and soy products with calcium …
Matched Mixtures name: … Calcium Inj ... CALCIO AL 10% AMPOLLAS ... CALCIUM PICKEN %10 ENJEKSİYONLUK ÇÖZELTİ 100 AMPUL …
Matched Salts name: … Calcium levulinate dihydrate …
Matched Categories: … Alimentary Tract and Metabolism ... Keto Acids ... Calcium Salts ... Carboxylic Acids ... calcium laevulate …
Matched Name: … Calcium levulinate …
Matched Iupac: … calcium bis(4-oxopentanoate) …
Matched Description: … levulose and calcium hydroxide [L2765]. ... Calcium levulinate can be used alone, or with calcium lactate, calcium chloride, and other compounds, ... , condiments, beer, beverages, soft drinks, milk and milk products, soy milk and soy products with calcium …
Matched Mixtures name: … Calcium Inj ... CALCIO AL 10% AMPOLLAS ... CALCIUM PICKEN %10 ENJEKSİYONLUK ÇÖZELTİ 100 AMPUL …
Matched Salts name: … Calcium levulinate dihydrate …
Matched Categories: … Alimentary Tract and Metabolism ... Keto Acids ... Calcium Salts ... Carboxylic Acids ... calcium laevulate …
Decylsulfonic acid
Experimental
Matched Synonyms: … Decane-1-sulfonic acid …
Matched Name: … Decylsulfonic acid …
Matched Iupac: … decane-1-sulfonic acid …
Matched Name: … Decylsulfonic acid …
Matched Iupac: … decane-1-sulfonic acid …
Phosphoric acid
Phosphoric Acid is a colorless, odorless phosphorus-containing inorganic acid. Phosphoric acid is a sequestering agent which binds many divalent cations, including Fe++, Cu++, Ca++, and Mg++.
Approved
Matched Name: … Phosphoric acid …
Matched Iupac: … phosphoric acid …
Matched Description: … , and Mg++. ... Phosphoric Acid is a colorless, odorless phosphorus-containing inorganic acid. ... Phosphoric acid is a sequestering agent which binds many divalent cations, including Fe++, Cu++, Ca++ …
Matched Categories: … Phosphorus Acids ... Phosphorus Compounds ... Acids ... Acid Etching, Dental ... Acids, Noncarboxylic …
Matched Iupac: … phosphoric acid …
Matched Description: … , and Mg++. ... Phosphoric Acid is a colorless, odorless phosphorus-containing inorganic acid. ... Phosphoric acid is a sequestering agent which binds many divalent cations, including Fe++, Cu++, Ca++ …
Matched Categories: … Phosphorus Acids ... Phosphorus Compounds ... Acids ... Acid Etching, Dental ... Acids, Noncarboxylic …
Mucuna pruriens seed
Mucuna pruriens seed is a plant/plant extract used in some OTC (over-the-counter) products. It is not an approved drug.
Experimental
Matched Synonyms: … Cowage Seed ... Atmagupta Seed ... Cowitch Seed …
Matched Name: … Mucuna pruriens seed …
Matched Description: … Mucuna pruriens seed is a plant/plant extract used in some OTC (over-the-counter) products. …
Matched Name: … Mucuna pruriens seed …
Matched Description: … Mucuna pruriens seed is a plant/plant extract used in some OTC (over-the-counter) products. …
Polygala senega root
Approved
Experimental
Matched Synonyms: … Senega officinalis ... Senega officinalis root …
Matched Categories: … Cough and Cold Preparations …
Matched Categories: … Cough and Cold Preparations …
Etevritamab
Investigational
Matched Synonyms: … RECEPTOR, RECEPTOR TYROSINE-PROTEIN KINASE ERBB-1, ERBB1, HER1, HER-1, ERBB) VARIANT III (EGFRVIII)) AND …
Magnesium silicate
Magnesium silicate is a compound of magnesium oxide and silicon. It is the magnesium salt of silicic acid containing an unspecified amount of water. The molecular formula can be expressed more clearly as MgSiO3.xH2O. It is known as talc and it presents many uses in the cosmetic industry, food industry...
Approved
Matched Name: … Magnesium silicate …
Matched Description: … Magnesium silicate is a compound of magnesium oxide and silicon. ... [T186] It is known as talc and it presents many uses in the cosmetic industry, food industry and pharmaceutical ... It is the magnesium salt of silicic acid containing an unspecified amount of water. …
Matched Categories: … Alimentary Tract and Metabolism ... Aluminum and magnesium containing antacids ... Silicates ... magnesium silicate ... Gastric Acid Lowering Agents …
Matched Description: … Magnesium silicate is a compound of magnesium oxide and silicon. ... [T186] It is known as talc and it presents many uses in the cosmetic industry, food industry and pharmaceutical ... It is the magnesium salt of silicic acid containing an unspecified amount of water. …
Matched Categories: … Alimentary Tract and Metabolism ... Aluminum and magnesium containing antacids ... Silicates ... magnesium silicate ... Gastric Acid Lowering Agents …
Arabica coffee bean
Arabica coffee bean allergenic extract is used in allergenic testing.
Approved
Matched Synonyms: … Coffea moka seed ... Coffea arabica seed ... Coffea sundana seed …
Vespula germanica venom protein
Vespula germanica venom protein is an extract of Vespula germanica venom. Vespula germanica venom protein is used in allergenic testing.
Approved
Matched Synonyms: … German wasp venom protein …
Matched Name: … Vespula germanica venom protein …
Matched Description: … Vespula germanica venom protein is an extract of Vespula germanica venom. ... Vespula germanica venom protein is used in allergenic testing. …
Matched Mixtures name: … Yellow Jacket Hymenoptera Venom Venomil Diagnostic ... Yellow Jacket Hymenoptera Venom Venomil Maintenance ... Mixed Vespid Hymenoptera Venom Venomil Maintenance …
Matched Categories: … Bee and Wasp Venom ... Standardized Insect Venom Allergenic Extract …
Matched Name: … Vespula germanica venom protein …
Matched Description: … Vespula germanica venom protein is an extract of Vespula germanica venom. ... Vespula germanica venom protein is used in allergenic testing. …
Matched Mixtures name: … Yellow Jacket Hymenoptera Venom Venomil Diagnostic ... Yellow Jacket Hymenoptera Venom Venomil Maintenance ... Mixed Vespid Hymenoptera Venom Venomil Maintenance …
Matched Categories: … Bee and Wasp Venom ... Standardized Insect Venom Allergenic Extract …
Alendronic acid
Alendronic acid is a second generation bisphosphonate that is used for the treatment of some forms of osteoperosis and Paget's disease[FDA Label][A959,A203111]. It functions by preventing resorption of bone[FDA Label] .
Approved
Matched Synonyms: … Alendronic acid ... Acido Alendronico ... Acide Alendronique …
Matched Name: … Alendronic acid …
Matched Iupac: … (4-amino-1-hydroxy-1-phosphonobutyl)phosphonic acid …
Matched Description: … osteoperosis and Paget's disease[FDA Label][A959,A203111]. ... Alendronic acid is a second generation bisphosphonate that is used for the treatment of some forms of …
Matched Mixtures name: … ACIDO ALENDRONICO E COLECALCIFEROLO EG ... ACIDO ALENDRONICO E COLECALCIFEROLO EG ... ACIDO ALENDRONICO E COLECALCIFEROLO EG …
Matched Salts name: … Alendronate calcium …
Matched Categories: … alendronic acid, calcium and colecalciferol, sequential ... alendronic acid and colecalciferol ... alendronic acid and alfacalcidol, sequential ... Drugs Affecting Bone Structure and Mineralization ... alendronic acid …
Matched Products: … ACIDO ALENDRONICO FIDIA ... ALENDRONAT ACIS 70MG ... ACIDO ALENDRONICO FG …
Matched Name: … Alendronic acid …
Matched Iupac: … (4-amino-1-hydroxy-1-phosphonobutyl)phosphonic acid …
Matched Description: … osteoperosis and Paget's disease[FDA Label][A959,A203111]. ... Alendronic acid is a second generation bisphosphonate that is used for the treatment of some forms of …
Matched Mixtures name: … ACIDO ALENDRONICO E COLECALCIFEROLO EG ... ACIDO ALENDRONICO E COLECALCIFEROLO EG ... ACIDO ALENDRONICO E COLECALCIFEROLO EG …
Matched Salts name: … Alendronate calcium …
Matched Categories: … alendronic acid, calcium and colecalciferol, sequential ... alendronic acid and colecalciferol ... alendronic acid and alfacalcidol, sequential ... Drugs Affecting Bone Structure and Mineralization ... alendronic acid …
Matched Products: … ACIDO ALENDRONICO FIDIA ... ALENDRONAT ACIS 70MG ... ACIDO ALENDRONICO FG …
Cefotaxime
Cefotaxime is a third-generation cephalosporin antibiotic. Like other third-generation cephalosporins, it has broad spectrum activity against Gram positive and Gram negative bacteria. In most cases, it is considered to be equivalent to ceftriaxone in terms of safety and efficacy. Cefotaxime sodium is marketed under various trade names including Claforan (Sanofi-Aventis).
Approved
Matched Synonyms: … aminothiazol-4-yl)-2-(methoxyimino)acetamido)-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid ... -thiazol-4-yl)-2-(methoxyimino)acetyl]amino}-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid ... amino-thiazol-4-yl)-2-[(Z)-methoxyimino]-acetylamino}-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid …
Matched Iupac: … 1,3-thiazol-4-yl)-2-(methoxyimino)acetamido]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid …
Matched Description: … Like other third-generation cephalosporins, it has broad spectrum activity against Gram positive and ... In most cases, it is considered to be equivalent to ceftriaxone in terms of safety and efficacy. …
Matched Categories: … Sulfur Compounds …
Matched Products: … Cefotaxime and Dextrose …
Matched Iupac: … 1,3-thiazol-4-yl)-2-(methoxyimino)acetamido]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid …
Matched Description: … Like other third-generation cephalosporins, it has broad spectrum activity against Gram positive and ... In most cases, it is considered to be equivalent to ceftriaxone in terms of safety and efficacy. …
Matched Categories: … Sulfur Compounds …
Matched Products: … Cefotaxime and Dextrose …
Sodium bicarbonate
Sodium bicarbonate is a white, crystalline powder that is commonly used as a pH buffering agent, an electrolyte replenisher, systemic alkalizer and in topical cleansing solutions.
Approved
Matched Synonyms: … Sodium acid carbonate ... Carbonic acid monosodium salt …
Matched Description: … powder that is commonly used as a pH buffering agent, an electrolyte replenisher, systemic alkalizer and …
Matched Mixtures name: … Juans Santo Remedio PARA LA ACIDEZ ... bicaVera 1,5 % Glucose, 1,25 mmol/l Calcium, Peritonealdialyselösung ... bicaVera 2,3 % Glucose, 1,25 mmol/l Calcium, Peritonealdialyselösung …
Matched Categories: … Antacids and Adsorbents ... Blood and Blood Forming Organs ... Blood Substitutes and Perfusion Solutions ... Carbonic Acid ... Gastric Acid Lowering Agents …
Matched Products: … Arm and Hammer Baking Soda …
Matched Description: … powder that is commonly used as a pH buffering agent, an electrolyte replenisher, systemic alkalizer and …
Matched Mixtures name: … Juans Santo Remedio PARA LA ACIDEZ ... bicaVera 1,5 % Glucose, 1,25 mmol/l Calcium, Peritonealdialyselösung ... bicaVera 2,3 % Glucose, 1,25 mmol/l Calcium, Peritonealdialyselösung …
Matched Categories: … Antacids and Adsorbents ... Blood and Blood Forming Organs ... Blood Substitutes and Perfusion Solutions ... Carbonic Acid ... Gastric Acid Lowering Agents …
Matched Products: … Arm and Hammer Baking Soda …
Coffea arabica seed, roasted
Coffea arabica seed, roasted allergenic extract is used in allergenic testing.
Approved
Matched Synonyms: … Coffea moka roasted seed ... Coffea arabica roasted seed ... Coffea arabica seed, roasted …
Matched Name: … Coffea arabica seed, roasted …
Matched Description: … Coffea arabica seed, roasted allergenic extract is used in allergenic testing. …
Matched Name: … Coffea arabica seed, roasted …
Matched Description: … Coffea arabica seed, roasted allergenic extract is used in allergenic testing. …
3-(N-morpholino)propanesulfonic acid
Experimental
Matched Synonyms: … Morpholinopropane sulfonic acid ... 3-morpholinopropanesulfonic acid …
Matched Name: … 3-(N-morpholino)propanesulfonic acid …
Matched Iupac: … 3-(morpholin-4-yl)propane-1-sulfonic acid …
Matched Name: … 3-(N-morpholino)propanesulfonic acid …
Matched Iupac: … 3-(morpholin-4-yl)propane-1-sulfonic acid …
Hyaluronic acid
Hyaluronic acid (HA) is an anionic, nonsulfated glycosaminoglycan found in connective, epithelial, and neural tissues; it was first isolated in 1934. Karl Meyer and John Palmer obtained glycosaminoglycan (GAG) from the bovine eye, giving it the name “hyaluronic acid”. HA is involved in many important physiological processes, including but not...
Approved
Vet approved
Matched Name: … Hyaluronic acid …
Matched Iupac: … 3R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy}-4,5-dihydroxyoxane-2-carboxylic acid …
Matched Description: … Hyaluronic acid (HA) is an anionic, nonsulfated glycosaminoglycan found in connective, epithelial, and ... [A230133] Several preparations of hyaluronic acid have been approved by the FDA and are available in ... hyaluronic acid”. …
Matched Mixtures name: … Hyaluronic Acid 60mg and Lidocaine 2% PF ... ELDEEN AGE TWENTY ONE MifitPatch and Serum ... ELDEEN AGE TWENTY ONE MifitPatch and Serum …
Matched Categories: … Preparations for Treatment of Wounds and Ulcers ... hyaluronic acid ... hyaluronic acid ... hyaluronic acid ... hyaluronic acid …
Matched Products: … Hyaluronic Acid Micro ... Hyaluronic Acid ... Hyaluronic Acid Gel …
Matched Iupac: … 3R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy}-4,5-dihydroxyoxane-2-carboxylic acid …
Matched Description: … Hyaluronic acid (HA) is an anionic, nonsulfated glycosaminoglycan found in connective, epithelial, and ... [A230133] Several preparations of hyaluronic acid have been approved by the FDA and are available in ... hyaluronic acid”. …
Matched Mixtures name: … Hyaluronic Acid 60mg and Lidocaine 2% PF ... ELDEEN AGE TWENTY ONE MifitPatch and Serum ... ELDEEN AGE TWENTY ONE MifitPatch and Serum …
Matched Categories: … Preparations for Treatment of Wounds and Ulcers ... hyaluronic acid ... hyaluronic acid ... hyaluronic acid ... hyaluronic acid …
Matched Products: … Hyaluronic Acid Micro ... Hyaluronic Acid ... Hyaluronic Acid Gel …
Calcium undecylenate
Approved
Experimental
Matched Synonyms: … Calcium 10-undecenoate ... Calcium undecylenate ... Calcium diundec-10-enoate …
Matched Name: … Calcium undecylenate …
Matched Iupac: … calcium bis(undec-10-enoate) …
Matched Name: … Calcium undecylenate …
Matched Iupac: … calcium bis(undec-10-enoate) …
Displaying drugs 401 - 425 of 2458 in total