Displaying drugs 4301 - 4325 of 8178 in total
Caricotamide
Caricotamide is under investigation in clinical trial NCT00746590 (Study of Anti-tumour Effects and Safety of Prolarix™ in Hepatocellular Carcinoma).
Investigational
Matched Description: … of Prolarix™ in Hepatocellular Carcinoma). ... Caricotamide is under investigation in clinical trial NCT00746590 (Study of Anti-tumour Effects and Safety …
Tosedostat
Tosedostat has been used in trials studying the treatment and supportive care of AML, Leukemia, Pancreas Cancer, Multiple Myeloma, and Pancreatic Cancer, among others.
Tosedostat is an inhibitor of the M1 family of aminopeptidases, in particular PuSA, and LTA4 hydrolase. It has demonstrated anti-tumour activity in a number of models...
Investigational
Matched Description: … Tosedostat is an inhibitor of the M1 family of aminopeptidases, in particular PuSA, and LTA4 hydrolase ... It has demonstrated anti-tumour activity in a number of models of cancer, both as a single agent and ... Tosedostat has been used in trials studying the treatment and supportive care of AML, Leukemia, Pancreas …
Tanaproget
Tanaproget (NSP-989) is an investigational non-steroidal progestin. It is a high affinity, high efficacy agonist of the progesterone receptor (PR) with a much more selective binding profile relative to most conventional progestins. Because of this tanaproget may prove to produce fewer side effects in comparison. It is currently in the...
Investigational
Matched Description: … of the PR in positron emission tomography. ... Because of this tanaproget may prove to produce fewer side effects in comparison. ... It is a high affinity, high efficacy agonist of the progesterone receptor (PR) with a much more selective …
Tarenflurbil
Tarenflurbil is an investigational drug that was studied in patients with mild Alzheimer's disease. It is a selective amyloid lowering agent (SALA) that reduces levels of the toxic peptide amyloid beta 42 (Aβ42) in cultured human cells and in animal models. Aβ42 is the primary initiator of neurotoxicity and amyloid...
Investigational
Matched Description: … Aβ42 is the primary initiator of neurotoxicity and amyloid plaque development in the brains of Alzheimer's ... In June 2008 development of the drug for Alzheimer's disease was discontinued. ... Tarenflurbil has also been used in trials studying the treatment of Prostate Cancer. …
Covid-19 Coronavirus Artificial Antigen Presenting Cell Vaccine
Through analysis of potential immunogenic targets of the SARS-Cov2 genome, a synthetic ‘minigene’ was developed using domains of viral structural proteins and a polyprotein protease. Specifically, the COVID-19 infection relies on the binding of the Spike protein to an ACEII receptor, and with the described approach, the vaccine uses these...
Investigational
Matched Description: … Through analysis of potential immunogenic targets of the SARS-Cov2 genome, a synthetic ‘minigene’ was ... developed using domains of viral structural proteins and a polyprotein protease. ... Specifically, the COVID-19 infection relies on the binding of the Spike protein to an ACEII receptor, …
Indium In-111 satumomab pendetide
Tumor associated glycoprotein (TAG) 72 (B72.3) monoclonal antibody conjugated with Indium 111 for radioimaging colon tumors. Satumomab Pendetide (trade name: OncoScint®) is no longer commercially available.
Experimental
Withdrawn
Josamycin
A macrolide antibiotic from Streptomyces narbonensis. The drug has antimicrobial activity against a wide spectrum of pathogens.
Investigational
Matched Description: … The drug has antimicrobial activity against a wide spectrum of pathogens. …
Camptothecin
Camptothecin is an alkaloid isolated from the stem wood of the Chinese tree, Camptotheca acuminata. This compound selectively inhibits the nuclear enzyme DNA topoisomerase, type I. Several semisynthetic analogs of camptothecin have demonstrated antitumor activity.
Experimental
Matched Description: … Several semisynthetic analogs of camptothecin have demonstrated antitumor activity. ... Camptothecin is an alkaloid isolated from the stem wood of the Chinese tree, Camptotheca acuminata …
Isatoribine
Isatoribine is a selective agonist of TLR7.
Investigational
Matched Description: … Isatoribine is a selective agonist of TLR7. …
Olcegepant
Boehringer Ingelheim Pharmaceuticals’ olcegepant (BIBN 4096) is a selective Calcitonin Gene-Related Peptide (CGRP) antagonist, a new class of drugs in development for the treatment of acute migraine attacks. Olcegepant is undergoing phase II trials in Europe and the US, with preliminary results suggesting that CGRP antagonists may represent a potential...
Investigational
Matched Description: … drugs in development for the treatment of acute migraine attacks. ... olcegepant (BIBN 4096) is a selective Calcitonin Gene-Related Peptide (CGRP) antagonist, a new class of ... preliminary results suggesting that CGRP antagonists may represent a potential new approach to the treatment of …
Metralindole
Metralindole, also known as Inkazan, is similar in structure and pharmacology to pirlindole. It functions as a reversible inhibitor of monoamine oxidase A. In Russia, this drug was investigated for potential antidepressant activity.
Experimental
Matched Description: … It functions as a reversible inhibitor of monoamine oxidase A. …
Fucoxanthin
Fucoxanthin is under investigation in clinical trial NCT03613740 (Effect of Fucoxanthin on the Components of the Metabolic Syndrome, Insulin Sensitivity and Insulin Secretion). Fucoxanthin isis a marine carotenoid mainly found in brown algae, giving them a brown or olive-green color. Fucoxanthin is investigated for its anti-inflammatory, antinociceptive and anti-cancer effects....
Investigational
Matched Description: … action of fucoxanthin is not fully elucidated. ... an animal model of duodenal, skin, colon and liver cancer. ... of the Metabolic Syndrome, Insulin Sensitivity and Insulin Secretion). …
Colforsin
Potent activator of the adenylate cyclase system and the biosynthesis of cyclic AMP. From the plant Coleus forskohlii. Has antihypertensive, positive inotropic, platelet aggregation inhibitory, and smooth muscle relaxant activities; also lowers intraocular pressure and promotes release of hormones from the pituitary gland.
Experimental
Investigational
Matched Description: … Potent activator of the adenylate cyclase system and the biosynthesis of cyclic AMP. ... inhibitory, and smooth muscle relaxant activities; also lowers intraocular pressure and promotes release of …
PTI-801
PTI-801 represents a new class of drugs to treat pain. PTI-801 can minimize the opioid tolerance, dependence or addiction that is often associated with repeat use of oxycodone. It is a combination of oxycodone with ultralow-dose naltrexone, an opioid antagonist.
Investigational
Matched Description: … PTI-801 represents a new class of drugs to treat pain. ... It is a combination of oxycodone with ultralow-dose naltrexone, an opioid antagonist. ... can minimize the opioid tolerance, dependence or addiction that is often associated with repeat use of …
Sulisobenzone
Sulisobenzone is approved by the FDA in concentrations of up to 10% and in Canada, is approved by Health Canada at the same concentrations . It works to filter out both UVA and UVB rays, protecting the skin from sun UV damage .
The UV-filter substance, sulisobenzone (BP-4) is widely...
Experimental
Matched Description: … It falls under the drug category of _benzophenones_. ... Sulisobenzone is approved by the FDA in concentrations of up to 10% and in Canada, is approved by Health ... The benzophenones are a group of aromatic ketones that have both pharmaceutical and industrial applications …
Resiquimod
A substance being studied in the treatment of some types of skin cancer. When put on the skin, resiquimod causes some immune cells to make certain chemicals that may help them kill tumor cells. It is also being studied to find out if adding it to a tumor vaccine improves...
Investigational
Matched Description: … A substance being studied in the treatment of some types of skin cancer. ... It is a type of imidazoquinoline and a type of immunomodulator. …
BacTRL-spike
BacTRL-Spike is composed of a bacterial medium with colony-forming-units of live Bifidobacterium longum engineered to deliver synthetic DNA encoding spike protein from SARS-CoV-2 contained by plasmids. The vaccine was developed by Symvivo Corporation. As of June, 2020, the company is pursuing a Phase 1, Randomized, Observer-Blind, Placebo-Controlled Trial (NCT04334980) to...
Investigational
Matched Description: … BacTRL-Spike is composed of a bacterial medium with colony-forming-units of live Bifidobacterium longum ... Trial (NCT04334980) to test the safety and immunogenicity of the vaccine. ... As of June, 2020, the company is pursuing a Phase 1, Randomized, Observer-Blind, Placebo-Controlled …
β-Methylfentanyl
β-Methylfentanyl is an analgesic of the opioid class. It is an analog of the potent opioid, fentanyl.
Illicit
Matched Description: … It is an analog of the potent opioid, fentanyl. ... β-Methylfentanyl is an analgesic of the _opioid_ class. …
Flufenoxuron
Flufenoxuron is under investigation in clinical trial NCT00922870 (Evaluation of Hemodynamic Effects of Cascade Hemofiltration in Septic Shock).
Investigational
Matched Description: … of Cascade Hemofiltration in Septic Shock). ... Flufenoxuron is under investigation in clinical trial NCT00922870 (Evaluation of Hemodynamic Effects …
Phenserine
Phenserine is under development by Axonyx, a US biopharmaceutical company that focuses on treatments for dementia. Phenserine is a next generation acetylcholinesterase (AChE) inhibitor indicated for the treatment of AD. Unlike currently marketed AChE inhibitors, it has a dual mechanism of action that also includes anti-amyloid activity, which may confer...
Investigational
Matched Description: … Phenserine is a next generation acetylcholinesterase (AChE) inhibitor indicated for the treatment of ... substantiated in an ongoing clinical trial then phenserine may open the door to an entirely new type of ... Unlike currently marketed AChE inhibitors, it has a dual mechanism of action that also includes anti-amyloid …
Dirucotide
Dirucotide is a synthetically prepared peptide. In particular, the sequence prepared is a 17 amino acid chain that is identical to a section of myelin basic protein (MBP) that is found in humans. Dirucotide has been developed for the treatment of multiple sclerosis (MS). Developed at the University of Alberta,...
Investigational
Matched Description: … Dirucotide has been developed for the treatment of multiple sclerosis (MS). ... Developed at the University of Alberta, dirucotide is being investigated by BioMS Medical Corp. ... In particular, the sequence prepared is a 17 amino acid chain that is identical to a section of myelin …
Bradanicline
Bradanicline, a novel small molecule that modulates the activity of the neuronal nicotinic receptor (NNR) subtype known as alpha7(α7). Bradanicline belongs to a new class of drugs for the treatment of central nervous system diseases and disorders.
Investigational
Matched Description: … Bradanicline belongs to a new class of drugs for the treatment of central nervous system diseases and ... Bradanicline, a novel small molecule that modulates the activity of the neuronal nicotinic receptor ( …
PF-05241328
PF-05241328 is under investigation in clinical trial NCT01165736 (To Calculate the Pharmacokinetics (Concentration of Compound in and Rate of Excretion From the Blood) Following a Very Low Dose of Compound Which Will Not Have Any Pharmacological Activity).
Investigational
Matched Description: … Compound in and Rate of Excretion From the Blood) Following a Very Low Dose of Compound Which Will Not ... under investigation in clinical trial NCT01165736 (To Calculate the Pharmacokinetics (Concentration of …
LY-2452473
Ly2452473 is under investigation for the supportive care of Prostate Cancer. Ly2452473 has been investigated for the treatment of Erectile Dysfunction.
Investigational
Matched Description: … Ly2452473 is under investigation for the supportive care of Prostate Cancer. ... Ly2452473 has been investigated for the treatment of Erectile Dysfunction. …
AZD-6482
AZD-6482 is under investigation in clinical trial NCT00688714 (Study to Investigate Safety and Tolerability of a Single Dose of AZD6482).
Investigational
Matched Description: … a Single Dose of AZD6482). ... is under investigation in clinical trial NCT00688714 (Study to Investigate Safety and Tolerability of …
Displaying drugs 4301 - 4325 of 8178 in total