Josamycin is a macrolide antibiotic used for the treatment of various susceptible bacterial infections. A macrolide antibiotic from Streptomyces narbonensis.
- Mechanism
- Curator reviewed
The mechanism of action of macrolides such as Josamycin is via inhibition of bacterial protein biosynthesis by binding reversibly to the subunit 50S of the bacterial ribosome, thereby inhibiting translocation of peptidyl tRNA. This action is mainly bacteriostatic, but can also be bactericidal in high concentrations. Macrolides tend to accumulate within leukocytes, and are therefore actually transported into the site of infection.
- Primary indication
- For the treatment of bacterial infections.Curator reviewed · 8 structured indications
- Formula / weight
- C42H69NO15 · 827.995 g/mol (avg)
- Also known as
- Kitasamycin A3 · Leucomycin A3
- Code names
- Antibiotic yl-704 A3 · EN-141 · Yl-704 A3
Resolves to
XJSFLOJWULLJQS-NGVXBBESSA-NSMILESCO[C@H]1[C@@H](CC(=O)O[C@H](C)C\C=C\C=C\[C@H](O)[C@H](C)C[C@H](CC=O)[C@@H]1O[C@@H]1O[C@H](C)[C@@H](O[C@H]2C[C@@](C)(O)[C@@H](OC(=O)CC(C)C)[C@H](C)O2)[C@@H]([C@H]1O)N(C)C)OC(C)=OWhat you can answer from here — as of September 12, 2026
Which drugs share a target with Josamycin, and which of those have an active Phase 3 trial?
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