Displaying drugs 4301 - 4325 of 11652 in total
Savolitinib
Savolitinib has been used in trials studying the treatment and health services research of Tumor, Food Effect, Gastric Cancer, Health Subjects, and Colorectal Cancer, among others.
Investigational
Matched Iupac: … 4-{1-[(1S)-1-{imidazo[1,2-a]pyridin-6-yl}ethyl]-1H-[1,2,3]triazolo[4,5-b]pyrazin-6-yl}-1-methyl-1H-pyrazole …
Elesclomol
Elesclomol is a novel, injectable, drug candidate that kills cancer cells by elevating oxidative stress levels beyond a breaking point, triggering programmed cell death. In preclinical models elesclomol showed potent killing of a broad range of cancer cell types at high doses, and an ability to strongly enhance the efficacy...
Investigational
Matched Description: … levels beyond a breaking point, triggering programmed cell death. ... Elesclomol is a novel, injectable, drug candidate that kills cancer cells by elevating oxidative stress ... In preclinical models elesclomol showed potent killing of a broad range of cancer cell types at high …
Sennosides
Sennosides (also known as senna glycoside or senna) is a medication used to treat constipation[FDA Label] and empty the large intestine before surgery. The medication is taken by mouth or via the rectum[FDA Label]. It typically begins working in minutes when given by rectum and within twelve hours when given...
Experimental
Matched Description: … It is a weaker laxative than bisacodyl or castor oil[A177092]. ... Sennosides (also known as senna glycoside or senna) is a medication used to treat constipation[FDA Label ... Sennoside A, one of the sennosides present in the laxative medication, has recently proven effective …
Matched Salts name: … Sennosides A and B …
Matched Salts name: … Sennosides A and B …
Pexacerfont
Pexacerfont has been investigated for the treatment of Alcoholism, Anxiety Disorder, Alcohol Dependence, and Alcohol-Related Disorders.
Investigational
Matched Iupac: … N-[(2R)-butan-2-yl]-8-(6-methoxy-2-methylpyridin-3-yl)-2,7-dimethylpyrazolo[1,5-a][1,3,5]triazin-4-amine …
Niflumic acid
Niflumic acid is an analgesic and anti-inflammatory agent used in the treatment of rheumatoid arthritis.
Experimental
Dipraglurant
Dipraglurant has been used in trials studying the treatment of Parkinson's Disease. It is a metabotropic glutamate receptor 5 (mGluR5) negative allosteric modulator (NAM).
Investigational
Matched Iupac: … 2-(4-{6-fluoroimidazo[1,2-a]pyridin-2-yl}but-1-yn-1-yl)pyridine …
Matched Description: … It is a metabotropic glutamate receptor 5 (mGluR5) negative allosteric modulator (NAM). …
Matched Description: … It is a metabotropic glutamate receptor 5 (mGluR5) negative allosteric modulator (NAM). …
Decoglurant
Decoglurant has been used in trials studying the treatment of Major Depressive Disorder.
Investigational
Matched Iupac: … 5-{2-[7-(trifluoromethyl)-5-[4-(trifluoromethyl)phenyl]pyrazolo[1,5-a]pyrimidin-3-yl]ethynyl}pyridin- …
Denecimig
Delpacibart is a humanized, bispecific, bivalent monoclonal antibody against coagulation factor 9.
Investigational
Matched Description: … Delpacibart is a humanized, bispecific, bivalent monoclonal antibody against coagulation factor 9. …
Alvespimycin
Alvespimycin is a derivative of geldanamycin and heat shock protein (HSP) 90 inhibitor. It has been used in trials studying the treatment of solid tumor in various cancer as an antitumor agent. In comparison to the first HSP90 inhibitor tanespimycin, it exhibits some pharmacologically desirable properties such as reduced metabolic...
Investigational
Matched Description: … Alvespimycin is a derivative of geldanamycin and heat shock protein (HSP) 90 inhibitor. …
Matched Categories: … HSP90 Heat-Shock Proteins …
Matched Categories: … HSP90 Heat-Shock Proteins …
Coagulin-B
Coagulin-B is an adeno-associated viral vector expressing human blood-coagulation Factor IX.[A259038, A259043] It was previously investigated for the treatment of hemophilia; however, the manufacturing company discontinued the Phase I trial in 2004, halting its further development and investigation.
Investigational
Tenofovir
Tenofovir is an acyclic nucleotide diester analog of adenosine monophosphate. In the most strict sense and due to the fact that it presents a phosphate group bound to the nitrogenous base, it is determined as an actual nucleotide analog. The antiviral activities of tenofovir were first reported in 1993 and...
Experimental
Investigational
Matched Description: … [A37693] In the most strict sense and due to the fact that it presents a phosphate group bound to the …
SNX-2112
SNX-2112 is a heat shock protein 90 (Hsp90) inhibitor.
Investigational
Matched Description: … SNX-2112 is a heat shock protein 90 (Hsp90) inhibitor.[A253137] …
Matched Categories: … HSP90 Heat-Shock Proteins, antagonists & inhibitors …
Matched Categories: … HSP90 Heat-Shock Proteins, antagonists & inhibitors …
Ganetespib
Ganetespib is under investigation for the treatment of BREAST CANCER, Small Cell Lung Cancer, Acute Myeloid Leukaemia, and Myelodysplastic Syndrome.
Investigational
Matched Categories: … HSP90 Heat-Shock Proteins, antagonists & inhibitors …
(S)-camphor
(S)-camphor, or L(-)-Camphor, is a stereoisomer of DB01744, a bicyclic monoterpene known to potentiate both heat and cold sensations . (S)-camphor is not the naturally-occurring stereoisomer but displays similar TRPV channel affinity and current inhibition . DB01744 is isolated from the wood of the camphor laurel tree, Cinnamomum camphora, and...
Experimental
Matched Description: … both heat and cold sensations [A33087]. ... by causing sensitization to heat and coolness to relieve minor muscle and joint pain [A33086]. ... (S)-camphor, or L(-)-Camphor, is a stereoisomer of [DB01744], a bicyclic monoterpene known to potentiate …
Hypericin
Hypericin is under investigation for the treatment of Cutaneous T-cell Lymphoma.
Investigational
Matched Categories: … Benz(a)Anthracenes …
Fazadinium bromide
Experimental
Matched Iupac: … -1H-4lambda5-imidazo[1,2-a]pyridin-4-ylium dibromide ... 3-methyl-1-[(E)-2-{3-methyl-2-phenyl-1H-4lambda5-imidazo[1,2-a]pyridin-4-ylium-1-yl}diazen-1-yl]-2-phenyl …
Hexobarbital
A barbiturate that is effective as a hypnotic and sedative.
Experimental
Matched Description: … A barbiturate that is effective as a hypnotic and sedative. …
Minodronic acid
Investigational
Matched Iupac: … (1-hydroxy-2-{imidazo[1,2-a]pyridin-3-yl}-1-phosphonoethyl)phosphonic acid …
BIIB021
BIIB021 has been investigated for the treatment of Tumors and Lymphoma.
Investigational
Matched Categories: … HSP90 Heat-Shock Proteins, antagonists & inhibitors …
Verucerfont
Verucerfont has been used in trials studying the treatment of Congenital Adrenal Hyperplasia.
Investigational
Matched Iupac: … 4-methoxy-2-methylphenyl)-2,5-dimethyl-N-[(1S)-1-(3-methyl-1,2,4-oxadiazol-5-yl)propyl]pyrazolo[1,5-a] …
Methylmalonic Acid
A malonic acid derivative which is a vital intermediate in the metabolism of fat and protein. Abnormalities in methylmalonic acid metabolism lead to methylmalonic aciduria. This metabolic disease is attributed to a block in the enzymatic conversion of methylmalonyl CoA to succinyl CoA. [PubChem]
Experimental
Matched Description: … This metabolic disease is attributed to a block in the enzymatic conversion of methylmalonyl CoA to succinyl ... CoA. ... A malonic acid derivative which is a vital intermediate in the metabolism of fat and protein. …
2-(Pyrido[1,2-E]Purin-4-Yl)Amino-Ethanol
Experimental
IPI-493
IPI-493 has been used in trials studying the treatment of Advanced Malignancies.
Investigational
Matched Categories: … HSP90 Heat-Shock Proteins, antagonists & inhibitors …
Displaying drugs 4301 - 4325 of 11652 in total