Displaying drugs 426 - 450 of 1018 in total
Calendula officinalis whole
Calendula officinalis whole is a plant/plant extract used in some OTC (over-the-counter) products. It is not an approved drug.
Experimental
Matched Synonyms: … Calendula Officinalis Whole Extract …
Matched Name: … Calendula officinalis whole …
Matched Description: … Calendula officinalis whole is a plant/plant extract used in some OTC (over-the-counter) products. …
Matched Name: … Calendula officinalis whole …
Matched Description: … Calendula officinalis whole is a plant/plant extract used in some OTC (over-the-counter) products. …
Salix alba bark volatile oil
Salix alba bark volatile oil is a plant/plant extract used in some OTC (over-the-counter) products. It is not an approved drug.
Experimental
Matched Synonyms: … Golden Willow Bark Volatile Oil ... White Willow Bark Volatile Oil ... Salix Vitellina Bark Volatile Oil …
Matched Name: … Salix alba bark volatile oil …
Matched Description: … Salix alba bark volatile oil is a plant/plant extract used in some OTC (over-the-counter) products. …
Matched Name: … Salix alba bark volatile oil …
Matched Description: … Salix alba bark volatile oil is a plant/plant extract used in some OTC (over-the-counter) products. …
Docetaxel
Docetaxel is a clinically well established anti-mitotic chemotherapy medication used for the treatment of different types of cancer, including breast, ovarian, and non-small cell lung cancer. Docetaxel is a complex diterpenoid molecule and a semisynthetic analogue of paclitaxel.[A259676,L46466] Docetaxel reversibly binds to microtubulin with high affinity in a 1:1 stoichiometric...
Approved
Investigational
Matched Description: … chemotherapy medication used for the treatment of different types of cancer, including breast, ovarian, and ... Docetaxel is a complex diterpenoid molecule and a semisynthetic analogue of [paclitaxel]. ... microtubulin with high affinity in a 1:1 stoichiometric ratio, allowing it to prevent cell division and …
Matched Salts name: … Docetaxel trihydrate …
Matched Categories: … Antineoplastic and Immunomodulating Agents …
Matched Products: … Oncotaxel Concentrate and solvent for solution for infusion 40 mg/ ml ... DOCETAXEL TRIHYDRATE …
Matched Salts name: … Docetaxel trihydrate …
Matched Categories: … Antineoplastic and Immunomodulating Agents …
Matched Products: … Oncotaxel Concentrate and solvent for solution for infusion 40 mg/ ml ... DOCETAXEL TRIHYDRATE …
Macadamia oil
Macadamia oil is a plant/plant extract used in some OTC (over-the-counter) products. It is not an approved drug.
Experimental
Matched Synonyms: … Macadamia Ternifolia Seed Oil ... Macadamia Integrifolia Seed Oil ... Macadamia Nut Oil …
Matched Name: … Macadamia oil …
Matched Description: … Macadamia oil is a plant/plant extract used in some OTC (over-the-counter) products. …
Matched Name: … Macadamia oil …
Matched Description: … Macadamia oil is a plant/plant extract used in some OTC (over-the-counter) products. …
Olodaterol
Olodaterol is a novel, long-acting beta2-adrenergic agonist (LABA) that exerts its pharmacological effect by binding and activating beta2-adrenergic receptors located primarily in the lungs. Beta2-adrenergic receptors are membrane-bound receptors that are normally activated by endogenous epinephrine whose signalling, via a downstream L-type calcium channel interaction, mediates smooth muscle relaxation and...
Approved
Matched Description: … novel, long-acting beta2-adrenergic agonist (LABA) that exerts its pharmacological effect by binding and ... LABAs including improved convenience and compliance and improved airflow over a 24-hour period. ... signalling, via a downstream L-type calcium channel interaction, mediates smooth muscle relaxation and …
Matched Categories: … olodaterol and tiotropium bromide …
Matched Products: … STRIVERDI RESP 2.5UG WV ... STRIVERDI RESPI 2.5UG WV ... STRIVERDI RESPIM 2.5UG/HUB …
Matched Categories: … olodaterol and tiotropium bromide …
Matched Products: … STRIVERDI RESP 2.5UG WV ... STRIVERDI RESPI 2.5UG WV ... STRIVERDI RESPIM 2.5UG/HUB …
Grape seed oil
Grape seed oil is a plant/plant extract used in some OTC (over-the-counter) products. It is not an approved drug.
Experimental
Matched Synonyms: … Wine Grape Seed Oil ... European Grape Seed Oil ... Grape Seed Volatile Oil …
Matched Name: … Grape seed oil …
Matched Description: … Grape seed oil is a plant/plant extract used in some OTC (over-the-counter) products. …
Matched Name: … Grape seed oil …
Matched Description: … Grape seed oil is a plant/plant extract used in some OTC (over-the-counter) products. …
Cocoa butter
Cocoa butter is an edible natural fat obtained from the Theobroma cocoa seeds that is predominantly found in dark chocolate . It is a rich source of monounsaturated and saturated fatty acids that mainly contains approximately 33% DB04224, 25% DB03796, and 33% DB03193 but does not contain caffeine or theobromine....
Approved
Matched Synonyms: … Cacao seed oil, fermented ... Theobroma cacao (cocoa) seed butter ... Theobroma oil …
Matched Description: … skin products such as lotions, creams, and bars intended to maintain skin softness. ... Cocoa butter is an edible natural fat obtained from the _Theobroma cocoa_ seeds that is predominantly ... Cocoa butter is included in chocolate and other food products, and can also be found in over-the-counter …
Matched Mixtures name: … Up and Up Hemorrhoidal ... Cocoa Butter, Phenylephrine Hydrochloride, Shark Liver Oil …
Matched Categories: … Antipruritics and Local Anesthetics ... Diet, Food, and Nutrition …
Matched Description: … skin products such as lotions, creams, and bars intended to maintain skin softness. ... Cocoa butter is an edible natural fat obtained from the _Theobroma cocoa_ seeds that is predominantly ... Cocoa butter is included in chocolate and other food products, and can also be found in over-the-counter …
Matched Mixtures name: … Up and Up Hemorrhoidal ... Cocoa Butter, Phenylephrine Hydrochloride, Shark Liver Oil …
Matched Categories: … Antipruritics and Local Anesthetics ... Diet, Food, and Nutrition …
Safflower oil
Safflower (Carthamus tinctorius L) is a herbaceous plant in the Asteraceae family. Extracted from the seeds of safflowers, safflower oil is a rich source of various saturated fatty acids, monounsaturated fatty acid (oleic acid) or essential n-6 polyunsaturated fatty acid (PUFA) linoleic acid [A32677, A32679], depending on the flower type....
Approved
Investigational
Matched Synonyms: … Carthamus tinctorius seed oil ... Safflower oil …
Matched Name: … Safflower oil …
Matched Description: … The constituents of safflower oil also include alpha-tocopherol, gamma-tocopherol, and mixed [DB11251 ... Safflower oil is approved for use as an indirect additive in food contact substances and is readily available ... Extracted from the seeds of safflowers, safflower oil is a rich source of various saturated fatty acids …
Matched Categories: … Diet, Food, and Nutrition ... Oils ... Plant Oils …
Matched Name: … Safflower oil …
Matched Description: … The constituents of safflower oil also include alpha-tocopherol, gamma-tocopherol, and mixed [DB11251 ... Safflower oil is approved for use as an indirect additive in food contact substances and is readily available ... Extracted from the seeds of safflowers, safflower oil is a rich source of various saturated fatty acids …
Matched Categories: … Diet, Food, and Nutrition ... Oils ... Plant Oils …
Evening primrose oil
Evening primrose oil comes from the extraction from Oenothera biennis seeds and it is commonly used as an alternative source for omega-6 essential fatty acids. In its composition it presents some fatty acids such as DB00132 and DB13854. Evening primrose oil has been filled for the FDA by Humanetics Corporation...
Investigational
Nutraceutical
Matched Synonyms: … Oenothera biennis seed oil ... Oenothera muricata seed oil ... Oenothera pycnocarpa seed oil …
Matched Name: … Evening primrose oil …
Matched Description: … Evening primrose oil comes from the extraction from _Oenothera biennis_ seeds and it is commonly used ... In its composition it presents some fatty acids such as [DB00132] and [DB13854]. ... [L1113] By the EMA, evening primrose oil is approved in herbal preparations.[L2851] …
Matched Mixtures name: … BLACKMORES EVENING PRIMROSE OIL + FISH OIL CAPSULE ... Gamma Oil ... BiO-LiFE Evening Primrose Oil & Fish Oil 500mg Capsules …
Matched Categories: … Oils ... Plant Oils …
Matched Products: … Halagel Evening Primrose Oil ... Evening Primrose Oil 450 mg L-Vcaps ... SURBEX BIO-ENHANCED EVENING PRIMROSE OIL …
Matched Name: … Evening primrose oil …
Matched Description: … Evening primrose oil comes from the extraction from _Oenothera biennis_ seeds and it is commonly used ... In its composition it presents some fatty acids such as [DB00132] and [DB13854]. ... [L1113] By the EMA, evening primrose oil is approved in herbal preparations.[L2851] …
Matched Mixtures name: … BLACKMORES EVENING PRIMROSE OIL + FISH OIL CAPSULE ... Gamma Oil ... BiO-LiFE Evening Primrose Oil & Fish Oil 500mg Capsules …
Matched Categories: … Oils ... Plant Oils …
Matched Products: … Halagel Evening Primrose Oil ... Evening Primrose Oil 450 mg L-Vcaps ... SURBEX BIO-ENHANCED EVENING PRIMROSE OIL …
Magnesium citrate
Magnesium citrate is a low volume and osmotic cathartic agent. The cathartic action works primarily through the high osmolarity of the solution which draws large amounts of fluid into space where is used. Magnesium citrate is considered by the FDA as an approved inactive ingredient for approved drug products under...
Approved
Matched Synonyms: … Magnesium citrate ... Magnesium dicitrate …
Matched Name: … Magnesium citrate …
Matched Description: … Magnesium citrate is a low volume and osmotic cathartic agent. ... [T215] Magnesium citrate is considered by the FDA as an approved inactive ingredient for approved drug …
Matched Mixtures name: … Calcium and Magnesium Citrate With Vitamin D ... Calcium and Magnesium Citrate and Vitamin D 250mg/125mg/200iu ... LiquiCal with Magnesium …
Matched Categories: … Alimentary Tract and Metabolism ... Blood and Blood Forming Organs ... Blood Substitutes and Perfusion Solutions ... magnesium citrate ... magnesium citrate …
Matched Products: … Magnesium Citrate ... Magesium Citrate ... Citrate of Magnesium …
Matched Name: … Magnesium citrate …
Matched Description: … Magnesium citrate is a low volume and osmotic cathartic agent. ... [T215] Magnesium citrate is considered by the FDA as an approved inactive ingredient for approved drug …
Matched Mixtures name: … Calcium and Magnesium Citrate With Vitamin D ... Calcium and Magnesium Citrate and Vitamin D 250mg/125mg/200iu ... LiquiCal with Magnesium …
Matched Categories: … Alimentary Tract and Metabolism ... Blood and Blood Forming Organs ... Blood Substitutes and Perfusion Solutions ... magnesium citrate ... magnesium citrate …
Matched Products: … Magnesium Citrate ... Magesium Citrate ... Citrate of Magnesium …
Mentha arvensis top
Mentha arvensis top is a plant/plant extract used in some OTC (over-the-counter) products. It is not an approved drug.
Experimental
Matched Synonyms: … Mentha Herb ... Menthae Herba ... Mentha Gentilis Top …
Matched Name: … Mentha arvensis top …
Matched Description: … Mentha arvensis top is a plant/plant extract used in some OTC (over-the-counter) products. …
Matched Name: … Mentha arvensis top …
Matched Description: … Mentha arvensis top is a plant/plant extract used in some OTC (over-the-counter) products. …
Clindamycin
Clindamycin is a semi-synthetic lincosamide antibiotic used in the treatment of a variety of serious infections due to susceptible microorganisms[L11599,L11596] as well as topically for acne vulgaris. It has a relatively narrow spectrum of activity that includes anaerobic bacteria as well as gram-positive cocci and bacilli and gram-negative bacilli. Interestingly,...
Approved
Vet approved
Matched Description: … bacilli and gram-negative bacilli. ... used off-label in the treatment of toxoplasmosis, malaria, and babesiosis. ... relatively narrow spectrum of activity that includes anaerobic bacteria as well as gram-positive cocci and …
Matched Mixtures name: … Clindamycin Phosphate and Tretinion ... Clindamycin Phosphate and Benzoyl Peroxide ... Clindamycin Phosphate and Benzoyl Peroxide Clindamycin Phosphate and Benzoyl Peroxide …
Matched Salts name: … Clindamycin phosphate …
Matched Categories: … Genito Urinary System and Sex Hormones ... Gynecological Antiinfectives and Antiseptics ... Macrolides, Lincosamides and Streptogramins …
Matched Products: … Clindamycin Phosphate ... Cleocin Phosphate ... Clindamycin phosphate …
Matched Mixtures name: … Clindamycin Phosphate and Tretinion ... Clindamycin Phosphate and Benzoyl Peroxide ... Clindamycin Phosphate and Benzoyl Peroxide Clindamycin Phosphate and Benzoyl Peroxide …
Matched Salts name: … Clindamycin phosphate …
Matched Categories: … Genito Urinary System and Sex Hormones ... Gynecological Antiinfectives and Antiseptics ... Macrolides, Lincosamides and Streptogramins …
Matched Products: … Clindamycin Phosphate ... Cleocin Phosphate ... Clindamycin phosphate …
Acazicolcept
Investigational
Matched Synonyms: … cell costimulator ligand variant immunoglobulin domain designed to inhibit simultaneously the CD28 and …
Matched Categories: … Amino Acids, Peptides, and Proteins …
Matched Categories: … Amino Acids, Peptides, and Proteins …
Anise oil
Experimental
Matched Synonyms: … Anise seed oil ... Anise seed oil colombia ... Pimpinella anisum seed oil …
Matched Name: … Anise oil …
Matched Categories: … Oils …
Matched Name: … Anise oil …
Matched Categories: … Oils …
Magnesium oxide
Magnesium oxide is an inorganic compound that occurs in nature as the mineral periclase. In aqueous media combines quickly with water to form magnesium hydroxide. It is used as an antacid and mild laxative and has many nonmedicinal uses.
Approved
Matched Synonyms: … Magnesia ... Magnesium oxide …
Matched Name: … Magnesium oxide …
Matched Iupac: … magnesium(2+) oxidandiide …
Matched Description: … It is used as an antacid and mild laxative and has many nonmedicinal uses. ... In aqueous media combines quickly with water to form magnesium hydroxide. ... Magnesium oxide is an inorganic compound that occurs in nature as the mineral periclase. …
Matched Mixtures name: … Magnesium and Zinc ... Calcium and Magnesium Tablets ... Calcium, Magnesium, Zinc and D …
Matched Categories: … Aluminum and magnesium containing antacids ... Alimentary Tract and Metabolism ... Magnesium Salts ... magnesium oxide ... magnesium oxide …
Matched Products: … Magnesium Oxide ... Magnesium-tab ... Magnesium Oxide HA …
Matched Name: … Magnesium oxide …
Matched Iupac: … magnesium(2+) oxidandiide …
Matched Description: … It is used as an antacid and mild laxative and has many nonmedicinal uses. ... In aqueous media combines quickly with water to form magnesium hydroxide. ... Magnesium oxide is an inorganic compound that occurs in nature as the mineral periclase. …
Matched Mixtures name: … Magnesium and Zinc ... Calcium and Magnesium Tablets ... Calcium, Magnesium, Zinc and D …
Matched Categories: … Aluminum and magnesium containing antacids ... Alimentary Tract and Metabolism ... Magnesium Salts ... magnesium oxide ... magnesium oxide …
Matched Products: … Magnesium Oxide ... Magnesium-tab ... Magnesium Oxide HA …
Flurbiprofen
Flurbiprofen, a propionic acid derivative, is a nonsteroidal anti-inflammatory agent (NSAIA) with antipyretic and analgesic activity. Oral formulations of flurbiprofen may be used for the symptomatic treatment of rheumatoid arthritis, osteoarthritis and anklylosing spondylitis. Flurbiprofen may also be used topically prior to ocular surgery to prevent or reduce intraoperative miosis....
Approved
Investigational
Matched Description: … Flurbiprofen is structurally and pharmacologically related to fenoprofen, ibuprofen, and ketoprofen. ... Flurbiprofen, a propionic acid derivative, is a nonsteroidal anti-inflammatory agent (NSAIA) with antipyretic and ... formulations of flurbiprofen may be used for the symptomatic treatment of rheumatoid arthritis, osteoarthritis and …
Matched Categories: … Antiinflammatory and Antirheumatic Products ... Antiinflammatory and Antirheumatic Products, Non-Steroids ... Topical Products for Joint and Muscular Pain …
Matched Products: … Strepsils MaxPro Honey and Lemon lozenges 8.75mg …
Matched Categories: … Antiinflammatory and Antirheumatic Products ... Antiinflammatory and Antirheumatic Products, Non-Steroids ... Topical Products for Joint and Muscular Pain …
Matched Products: … Strepsils MaxPro Honey and Lemon lozenges 8.75mg …
Magnesium Aluminum Silicate
Magnesium aluminum silicate is a naturally occurring mineral obtained from silicate ores of the montmorillonite group . It is refined to a powder for use in cosmetic and pharmaceutical applications as an absorbent, anticaking agent, opacifying agent, viscosity-increasing agent, suspending agent, tablet and capsule disintegrant, and
tablet binder. It also...
Approved
Matched Synonyms: … Aluminii magnesii silicas ... Aluminium magnesium silicate ... Aluminum magnesium silicate …
Matched Name: … Magnesium Aluminum Silicate …
Matched Description: … , and tablet binder. ... It is refined to a powder for use in cosmetic and pharmaceutical applications as an absorbent, anticaking ... agent, opacifying agent, viscosity-increasing agent, suspending agent, tablet and capsule disintegrant …
Matched Name: … Magnesium Aluminum Silicate …
Matched Description: … , and tablet binder. ... It is refined to a powder for use in cosmetic and pharmaceutical applications as an absorbent, anticaking ... agent, opacifying agent, viscosity-increasing agent, suspending agent, tablet and capsule disintegrant …
Fennel
Approved
Experimental
Matched Synonyms: … Fennel ... Fennel, sweet ... Sweet fennel …
Matched Name: … Fennel …
Matched Name: … Fennel …
Somatrogon
Somatrogon is a long-acting recombinant human growth hormone. Growth hormone is a peptide hormone secreted by the pituitary gland that plays a crucial role in promoting longitudinal growth during childhood and adolescence and regulating metabolic function in adulthood. Recombinant growth hormone therapy for growth hormone deficiency and other conditions has...
Approved
Matched Synonyms: … .)-(118-145)-PEPTIDE (1-28) WITH HUMAN SOMATOTROPIN (GROWTH HORMONE, GH) (29-219) AND TWO TANDEM COPIES …
Matched Description: … adolescence and regulating metabolic function in adulthood. ... of somatrogon and allows its once-weekly dosing. ... by the pituitary gland that plays a crucial role in promoting longitudinal growth during childhood and …
Matched Categories: … Amino Acids, Peptides, and Proteins ... Pituitary and Hypothalamic Hormones and Analogues ... Anterior Pituitary Lobe Hormones and Analogues ... Sex Hormones and Insulins ... Hormones, Hormone Substitutes, and Hormone Antagonists …
Matched Description: … adolescence and regulating metabolic function in adulthood. ... of somatrogon and allows its once-weekly dosing. ... by the pituitary gland that plays a crucial role in promoting longitudinal growth during childhood and …
Matched Categories: … Amino Acids, Peptides, and Proteins ... Pituitary and Hypothalamic Hormones and Analogues ... Anterior Pituitary Lobe Hormones and Analogues ... Sex Hormones and Insulins ... Hormones, Hormone Substitutes, and Hormone Antagonists …
Magnesium acetate
Approved
Matched Synonyms: … acetato de magnesio ... magnesium diacetate ... Magnesium di(acetate) …
Matched Name: … Magnesium acetate …
Matched Iupac: … magnesium(2+) diacetate …
Matched Mixtures name: … Normosol-M and Dextrose ... Normosol-M and Dextrose …
Matched Name: … Magnesium acetate …
Matched Iupac: … magnesium(2+) diacetate …
Matched Mixtures name: … Normosol-M and Dextrose ... Normosol-M and Dextrose …
Taraxacum officinale leaf
Taraxacum officinale leaf is a plant/plant extract used in some OTC (over-the-counter) products. It is not an approved drug.
Experimental
Matched Synonyms: … Taraxacum Officinale Dry Leaf ... Taraxacum Officinale (Dandelion) Leaf Extract ... Dandelion Leaf (Taraxacum Officinale Weber Ex Wigg.) …
Matched Name: … Taraxacum officinale leaf …
Matched Description: … Taraxacum officinale leaf is a plant/plant extract used in some OTC (over-the-counter) products. …
Matched Name: … Taraxacum officinale leaf …
Matched Description: … Taraxacum officinale leaf is a plant/plant extract used in some OTC (over-the-counter) products. …
Aripiprazole
Aripiprazole is an atypical antipsychotic orally indicated for the treatment of schizophrenia, bipolar I, major depressive disorder, irritability associated with autism, and Tourette's. It is also indicated as an injection for agitation associated with schizophrenia or bipolar mania. Aripiprazole exerts its effects through agonism of dopaminergic and 5-HT1A receptors and...
Approved
Investigational
Matched Description: … [L45859] Aripiprazole exerts its effects through agonism of dopaminergic and 5-HT1A receptors and antagonism ... of alpha-adrenergic and 5-HT2A receptors. ... treatment of schizophrenia, bipolar I, major depressive disorder, irritability associated with autism, and …
Matched Categories: … Aripiprazole and prodrugs …
Matched Products: … Abilify Maintena 400 mg powder and solvent for prolonged-release suspension for injection ... ABILIFY MAINTENA POWDER AND SOLVENT FOR PROLONGED RELEASE SUSPENSION FOR INJECTION 400 MG …
Matched Categories: … Aripiprazole and prodrugs …
Matched Products: … Abilify Maintena 400 mg powder and solvent for prolonged-release suspension for injection ... ABILIFY MAINTENA POWDER AND SOLVENT FOR PROLONGED RELEASE SUSPENSION FOR INJECTION 400 MG …
Rosa centifolia flower oil
Rosa centifolia flower oil is a plant/plant extract used in some OTC (over-the-counter) products. It is not an approved drug.
Experimental
Matched Synonyms: … Rosa Centifolia Flower Volatile Oil ... Cabbage Rose Oil ... Rosa Centifolia Flower Water …
Matched Name: … Rosa centifolia flower oil …
Matched Description: … Rosa centifolia flower oil is a plant/plant extract used in some OTC (over-the-counter) products. …
Matched Name: … Rosa centifolia flower oil …
Matched Description: … Rosa centifolia flower oil is a plant/plant extract used in some OTC (over-the-counter) products. …
Magaldrate
Magaldrate is an antacid drug used for the treatment of esophagitis, duodenal and gastric ulcers, and gastroesophageal reflux. Magaldrate has been discontinued in the US market.
Approved
Withdrawn
Matched Synonyms: … Hydrate magnesium aluminate activated sulfate ... Magnesium aluminate hydrate ... Aluminium magnesium hydroxide sulfate hydrate …
Matched Description: … Magaldrate is an antacid drug used for the treatment of esophagitis, duodenal and gastric ulcers, and …
Matched Categories: … Aluminum and magnesium containing antacids ... Alimentary Tract and Metabolism ... magaldrate and antiflatulents ... Magnesium Compounds …
Matched Description: … Magaldrate is an antacid drug used for the treatment of esophagitis, duodenal and gastric ulcers, and …
Matched Categories: … Aluminum and magnesium containing antacids ... Alimentary Tract and Metabolism ... magaldrate and antiflatulents ... Magnesium Compounds …
Coconut oil
Coconut oil is a plant/plant extract used in some OTC (over-the-counter) products. It is not an approved drug.
Experimental
Matched Synonyms: … Cocos Nucifera Seed Oil ... Coconut oil ... Oil,cocnt …
Matched Name: … Coconut oil …
Matched Description: … Coconut oil is a plant/plant extract used in some OTC (over-the-counter) products. …
Matched Mixtures name: … Hair Loss and Scalp Moisturizing ... Oil ... Oil …
Matched Categories: … Oils ... Plant Oils …
Matched Products: … Oil …
Matched Name: … Coconut oil …
Matched Description: … Coconut oil is a plant/plant extract used in some OTC (over-the-counter) products. …
Matched Mixtures name: … Hair Loss and Scalp Moisturizing ... Oil ... Oil …
Matched Categories: … Oils ... Plant Oils …
Matched Products: … Oil …
Displaying drugs 426 - 450 of 1018 in total