Displaying drugs 426 - 450 of 8033 in total
Epinephrine
Epinephrine, also known as adrenaline, is a hormone and neurotransmitter and produced by the adrenal glands that can also be used as a drug due to its various important functions. Though it has long been used in the treatment of hypersensitivity reactions, epinephrine in the auto-injector form (EpiPen) has been...
Approved
Vet approved
Matched Description: … It can be used in severe cases of croup [L4824]. ... In general, the most common uses of parenteral epinephrine are to relieve respiratory distress due to ... bronchospasm, to provide rapid relief of hypersensitivity (anaphylactic or anaphylactoid) reactions …
Fluvastatin
Fluvastatin is an antilipemic agent that competitively inhibits hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonic acid, the rate-limiting step in cholesterol biosynthesis. Fluvastatin belongs to a class of medications called statins and is used to reduce plasma cholesterol levels and prevent cardiovascular disease. It...
Approved
Matched Description: … Fluvastatin is a racemate comprising equimolar amounts of (3R,5S)- and (3S,5R)-fluvastatin. ... Fluvastatin belongs to a class of medications called statins and is used to reduce plasma cholesterol ... HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonic acid, the rate-limiting step in cholesterol …
Dimethyl fumarate
Dimethyl fumarate is an agent indicated for the treatment of relapsing forms of multiple sclerosis.[A253942,L43752] The mechanism of action of dimethyl fumarate in multiple sclerosis is not well understood. It is thought to involve dimethyl fumarate degradation to its active metabolite monomethyl fumarate (MMF) then MMF up-regulates the Nuclear factor...
Approved
Investigational
Matched Description: … Dimethyl fumarate is an agent indicated for the treatment of relapsing forms of multiple sclerosis. ... [A253942,L43752] The mechanism of action of dimethyl fumarate in multiple sclerosis is not well understood ... [A253917] Prior to its FDA approval, dimethyl fumarate had been used in Germany for treatment of psoriasis …
Potassium hydroxide
Potassium hydroxide, also known as lye is an inorganic compound with the chemical formula KOH. Also commonly referred to as caustic potash, it is a potent base that is marketed in several forms including pellets, flakes, and powders. It is used in various chemical, industrial and manufacturing applications. Potassium hydroxide...
Approved
Matched Description: … several good manufacturing practice conditions of use. ... Liquid drain cleaners contain 25 to 36% of potassium hydroxide [L1946]. ... Recently, it has been studied for efficacy and tolerability in the treatment of warts. …
Lumasiran
Lumasiran is a small interfering RNA used in the treatment of primary hyperoxaluria type 1 (PH1). This condition, caused by a deficiency in the enzyme alanine-glyoxylate aminotransferase, leads to an accumulation of oxalate, causing calcium crystal formation. These patients experience frequent kidney stones, nephrocalcinosis, and renal failure. Oxlumo, producted by...
Approved
Investigational
Matched Description: … of crystallization, [pyridoxine], and renal transplant. ... Lumasiran is a small interfering RNA used in the treatment of primary hyperoxaluria type 1 (PH1). ... caused by a deficiency in the enzyme alanine-glyoxylate aminotransferase, leads to an accumulation of …
Vutrisiran
Vutrisiran is a double-stranded small interfering ribonucleic acid (siRNA) that targets wild-type and mutant transthyretin (TTR) messenger RNA (mRNA). This siRNA therapeutic is indicated for the treatment of neuropathies associated with hereditary transthyretin-mediated amyloidosis (ATTR), a condition caused by mutations in the TTR gene. More than 130 TTR mutations have...
Approved
Investigational
Matched Description: … that deposit in different types of tissues. ... , a residue that enables the delivery of siRNA to hepatocytes. ... By targeting TTR mRNA, vutrisiran reduces the serum levels of TTR. …
Bortezomib
Bortezomib is a dipeptide boronic acid derivative and proteasome inhibitor used to treat multiple myeloma and mantle cell lymphoma. The 26S proteasome is a protein complex that degrades ubiquitinated proteins in the ubiquitin-proteasome pathway: reversible inhibition of the 26S proteasome, leading to cell cycle arrest and apoptosis of cancer cells,...
Approved
Investigational
Matched Description: … main mechanism of action of bortezomib. ... [L14180] However, multiple mechanisms may be involved in the anticancer activity of bortezomib. ... the 26S proteasome, leading to cell cycle arrest and apoptosis of cancer cells, is thought to be the …
Fenofibrate
Fenofibrate is a fibric acid derivative like clofibrate and gemfibrozil. Fenofibrate is used to treat primary hypercholesterolemia, mixed dyslipidemia, severe hypertriglyceridemia.[L8588,L8591]
Fenofibrate was granted FDA approval on 31 December 1993.
Approved
Metyrapone
An inhibitor of the enzyme steroid 11-beta-monooxygenase. It is used as a test of the feedback hypothalamic-pituitary mechanism in the diagnosis of cushing syndrome.
Approved
Investigational
Matched Description: … It is used as a test of the feedback hypothalamic-pituitary mechanism in the diagnosis of cushing syndrome ... An inhibitor of the enzyme steroid 11-beta-monooxygenase. …
Amyl Nitrite
Amyl Nitrite is an antihypertensive medicine. Amyl nitrite is employed medically to treat heart diseases such as angina and to treat cyanide poisoning. Its use as a prescription medicine comes from its ability to lower blood pressure. As an inhalant, it also has psychoactive effect which has led to illegal...
Approved
Icatibant
Icatibant is a synthetic decapeptide with 5 nonproteinogenic amino acid antagonist targeting the B2 receptors with a similar affinity to bradykinin. It is resistant to bradykinin-cleaving enzyme degradation and has a potency of 2-3 times higher than earlier B2 receptors antagonists, thus representing a new class of medication.[A4017,A263041] It was...
Approved
Investigational
Matched Description: … earlier B2 receptors antagonists, thus representing a new class of medication. ... It is resistant to bradykinin-cleaving enzyme degradation and has a potency of 2-3 times higher than ... [A4017,A263041] It was investigated as a potential treatment of hereditary angioedema (HAE) as bradykinin …
Tagraxofusp
Tagraxofusp is a CD123-directed cytotoxin. It is a fusion protein composed of a human interleukin-3 (IL-3) that is genetically fused to the catalytic and translocation domains of truncated diphtheria toxin (DT) produced in Escherichia coli.[A253762, A253887, L43702] Tagraxofusp received its first global approval by the FDA on December 21, 2018...
Approved
Investigational
Matched Description: … and translocation domains of truncated diphtheria toxin (DT) produced in _Escherichia coli_. ... It is a fusion protein composed of a human interleukin-3 (IL-3) that is genetically fused to the catalytic …
Carvedilol
Carvedilol is a racemic mixture where the S(-) enantiomer is both a beta and alpha-1 adrenoceptor blocker, and the R(+) enantiomer is an alpha-1 adrenoceptor blocker.[L7889,L7892] It is currently used to treat heart failure, left ventricular dysfunction, and hypertension.[L7889,L7892] The dual action of carvedilol is advantageous in combination therapies as...
Approved
Investigational
Matched Description: … of moderate hypertension. ... of 2 drugs have a decreased incidence of adverse effects compared to high dose monotherapy in the treatment ... [L7889,L7892] The dual action of carvedilol is advantageous in combination therapies as moderate doses …
Scopolamine
Scopolamine is a tropane alkaloid isolated from members of the Solanaceae family of plants, similar to atropine and hyoscyamine, all of which structurally mimic the natural neurotransmitter acetylcholine.[A228423, A228763] Scopolamine was first synthesized in 1959, but to date, synthesis remains less efficient than extracting scopolamine from plants. As an acetylcholine...
Approved
Investigational
Matched Description: … Scopolamine is a tropane alkaloid isolated from members of the _Solanaceae_ family of plants, similar ... to [atropine] and [hyoscyamine], all of which structurally mimic the natural neurotransmitter [acetylcholine ... [A228423, A228758] As a result of its anticholinergic effects, scopolamine is being investigated for …
Entecavir
Entecavir is an oral antiviral drug used in the treatment of hepatitis B infection. It is marketed under the trade name Baraclude (BMS).
Entecavir is a guanine analogue that inhibits all three steps in the viral replication process, and the manufacturer claims that it is more efficacious than previous agents...
Approved
Investigational
Matched Description: … Entecavir is an oral antiviral drug used in the treatment of hepatitis B infection. …
Tamoxifen
Tamoxifen is a non-steroidal antiestrogen used to treat estrogen receptor positive breast cancers as well as prevent the incidence of breast cancer in high risk populations.[A1025,L7799,L7802] Tamoxifen is used alone or as an adjuvant in these treatments.[L7799,L7802] Tamoxifen may no longer be the preferred treatment for these types of cancers...
Approved
Matched Description: … antiestrogen used to treat estrogen receptor positive breast cancers as well as prevent the incidence of ... [L7799,L7802] Tamoxifen may no longer be the preferred treatment for these types of cancers as patients …
Carbidopa
Carbidopa presents a chemical denomination of N-amino-alpha-methyl-3-hydroxy-L-tyrosine monohydrate. It potently inhibits aromatic amino acid decarboxylase (DDC) and due to its chemical properties, it does not cross the blood-brain barrier. Due to its activity, carbidopa is always administered concomitantly with levodopa. An individual formulation containing solely carbidopa was generated to treat...
Approved
Matched Description: … Carbidopa presents a chemical denomination of N-amino-alpha-methyl-3-hydroxy-L-tyrosine monohydrate. ... [L5110] On the other hand, the combination treatment of carbidopa/levodopa was originally developed by ... Watson Labs but the historical information by the FDA brings back to the approval of this combination …
Ivabradine
Ivabradine is a novel heart rate lowering medicine for the symptomatic management of stable angina pectoralis and symptomatic chronic heart failure. Ivabradine, brand name Corlanor, was approved by the FDA in April 2015 for the treatment of chronic heart failure in patients with an ejection fraction of ≤35%, in sinus...
Approved
Matched Description: … Ivabradine is a novel heart rate lowering medicine for the symptomatic management of stable angina pectoralis ... Ivabradine, brand name Corlanor, was approved by the FDA in April 2015 for the treatment of chronic heart ... failure in patients with an ejection fraction of ≤35%, in sinus rhythm with resting heart rate ≥70 beats …
Cefiderocol
Cefiderocol is a cephalosporin antibacterial drug and exerts a mechanism of action similar to other β-lactam antibiotics.[FDA Label] Unlike other agents in this category, cefiderocol is a siderophore able to undergo active transport into the bacterial cell through iron channels. It represents a significant addition to antibacterial treatment option as...
Approved
Investigational
Matched Description: … [A189150] A concern noted in the trial was a 0.3% higher rate of all cause mortality, the cause of which ... Cefiderocol is a cephalosporin antibacterial drug and exerts a mechanism of action similar to other β-lactam ... [FDA Label] This indication was supported by a positive clinical trial composed of 448 patients with …
Bisoprolol
Bisoprolol is a cardioselective β1-adrenergic blocking agent used to treat high blood pressure.[A180472,L7219] It is considered a potent drug with a long-half life that can be used once daily to reduce the need for multiple doses of antihypertensive drugs. Bisoprolol is generally well tolerated, likely due to its β1-adrenergic receptor...
Approved
Matched Description: … potent drug with a long-half life that can be used once daily to reduce the need for multiple doses of ... receptor selectivity and is a useful alternative to non-selective β-blocker drugs in the treatment of …
Proguanil
Proguanil is a prophylactic antimalarial drug, which works by stopping the malaria parasite, Plasmodium falciparum and Plasmodium vivax, from reproducing once it is in the red blood cells. It does this by inhibiting the enzyme, dihydrofolate reductase, which is involved in the reproduction of the parasite.
Approved
Matched Description: … does this by inhibiting the enzyme, dihydrofolate reductase, which is involved in the reproduction of …
Teriparatide
Teriparatide is a recombinant parathyroid hormone (PTH) analog and a potent osteoanabolic agent. It is made up of the first amino(N)-terminal 34 amino acids of the human PTH. First approved in the United States in November 2002 and in Europe in April 2003, teriparatide makes the first approved drug in...
Approved
Investigational
Matched Description: … [A251395] It is made up of the first amino(N)-terminal 34 amino acids of the human PTH. ... [A251395] Teriparatide is used in the treatment of osteoporosis in men and women.[L42590, L42595] ... and in Europe in April 2003,[A251400] teriparatide makes the first approved drug in a new category of …
Teprotumumab
Teprotumumab is a fully human IgG1 monoclonal antibody directed against the human insulin-like growth factor-1 receptor. Following a clinical trial in which its efficacy in the treatment of thyroid eye disease (TED) was assessed, it received "breakthrough therapy" designation from the FDA in 2016 and was approved by the FDA...
Approved
Investigational
Matched Description: … [L11359] Following a clinical trial in which its efficacy in the treatment of thyroid eye disease (TED ... [L11350] Thyroid eye disease is a potentially debilitating complication of Graves' Disease involving ... designation from the FDA in 2016[A190129] and was approved by the FDA in January 2020 for the treatment of …
Ublituximab
CD20, an antigen expressed by various B and T cells, is an attractive therapeutic target in various cancers and autoimmune conditions.[A244195, A244200, A244205] Monoclonal antibodies for B cell depletion rely on their binding affinity and ability to clear bound cells through mechanisms such as antibody-dependent cellular cytotoxicity (ADCC), mediated by...
Approved
Investigational
Matched Description: … forms of multiple sclerosis in adult patients. ... [A241045] In December 2022, ublituximab was approved by the US FDA for the treatment of relapsing forms ... of multiple sclerosis, becoming the first and only anti-CD20 monoclonal antibody for multiple sclerosis …
Elagolix
Elagolix has been used in trials studying the basic science and treatment of Endometriosis, Folliculogenesis, Uterine Fibroids, Heavy Uterine Bleeding, and Heavy Menstrual Bleeding. As of 24 July 2018, however, the U.S. Food and Drug Administration (FDA) approved AbbVie's elagolix under the brand name Orilissa as the first and only...
Approved
Investigational
Matched Description: … As of 24 July 2018, however, the U.S. ... Elagolix has been used in trials studying the basic science and treatment of Endometriosis, Folliculogenesis ... It has been determined that endometriosis is one of the most common gynecologic disorders in the United …
Displaying drugs 426 - 450 of 8033 in total