Displaying drugs 451 - 475 of 704 in total
Glisoxepide
Glisoxepide is one of the sulphonamide-derived oral antidiabetic drugs. It inhibits the uptake of bile acids into isolated rat hepatocytes. However it inhibits taurocholate uptake only in the absence of sodium ions. Glisoxepide uptake could be further inhibited by blockers of the hepatocellular monocarboxylate transporter, by the loop diuretic bumetanide,...
Investigational
Matched Description: … transporter, by the loop diuretic bumetanide, by 4,4'-diisothiocyano-2,2'-stilbenedisulfonate (DIDS) and ... are consistent with the transport of glisoxepide via the transport system for the unconjugated bile acid …
Matched Categories: … Sulfur Compounds ... Alimentary Tract and Metabolism …
Matched Categories: … Sulfur Compounds ... Alimentary Tract and Metabolism …
Elesclomol
Elesclomol is a novel, injectable, drug candidate that kills cancer cells by elevating oxidative stress levels beyond a breaking point, triggering programmed cell death. In preclinical models elesclomol showed potent killing of a broad range of cancer cell types at high doses, and an ability to strongly enhance the efficacy...
Investigational
Matched Description: … preclinical models elesclomol showed potent killing of a broad range of cancer cell types at high doses, and …
Matched Categories: … Sulfur Compounds …
Matched Categories: … Sulfur Compounds …
KD3010
KD3010 is a small molecule peroxisome proliferator-activator receptor delta (PPAR Delta) agonist for the treatment of metabolic disorders, including obesity.
Investigational
Matched Iupac: … ]sulfonyl}-2,3-dihydro-1H-indene-2-carboxylic acid ... 4-methylbenzene-1-sulfonic acid; 4-{[(2R,6S)-2,6-dimethyl-4-[4-(trifluoromethoxy)phenyl]piperazin-1-yl …
Matched Categories: … Sulfur Compounds …
Matched Categories: … Sulfur Compounds …
Vidupiprant
Vidupiprant has been used in trials studying the treatment and basic science of Asthma.
Investigational
Matched Iupac: … tert-butylcarbamoyl)-2-(2-chloro-4-cyclopropylbenzenesulfonamido)phenoxy]-5-chloro-2-fluorophenyl}acetic acid …
Matched Description: … Vidupiprant has been used in trials studying the treatment and basic science of Asthma. …
Matched Categories: … Sulfur Compounds …
Matched Description: … Vidupiprant has been used in trials studying the treatment and basic science of Asthma. …
Matched Categories: … Sulfur Compounds …
Sivelestat
Sivelestat has been used in trials studying the treatment of Acute Lung Injury and Respiratory Distress Syndrome, Adult.
Investigational
Matched Iupac: … 2-[(2-{4-[(2,2-dimethylpropanoyl)oxy]benzenesulfonamido}phenyl)formamido]acetic acid …
Matched Description: … Sivelestat has been used in trials studying the treatment of Acute Lung Injury and Respiratory Distress …
Matched Categories: … Sulfur Compounds ... Amino Acids, Peptides, and Proteins …
Matched Description: … Sivelestat has been used in trials studying the treatment of Acute Lung Injury and Respiratory Distress …
Matched Categories: … Sulfur Compounds ... Amino Acids, Peptides, and Proteins …
S-adenosyl-L-homocysteine
5'-S-(3-Amino-3-carboxypropyl)-5'-thioadenosine. Formed from S-adenosylmethionine after transmethylation reactions.
Experimental
Matched Iupac: … amino-4-({[(2S,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl}sulfanyl)butanoic acid …
Matched Categories: … Amino Acids, Sulfur ... Sulfur Compounds ... Amino Acids, Peptides, and Proteins ... Nucleic Acids, Nucleotides, and Nucleosides …
Matched Categories: … Amino Acids, Sulfur ... Sulfur Compounds ... Amino Acids, Peptides, and Proteins ... Nucleic Acids, Nucleotides, and Nucleosides …
LCL-161
LCL161 has been used in trials studying the treatment of Leukemia, Neoplasms, Solid Tumors, Breast Cancer, and Ovarian Cancer, among others.
Investigational
Matched Description: … has been used in trials studying the treatment of Leukemia, Neoplasms, Solid Tumors, Breast Cancer, and …
Matched Categories: … Sulfur Compounds …
Matched Categories: … Sulfur Compounds …
Letosteine
Letosteine is a mucolytic used in the treatment of chronic bronchopneumopathies and related conditions.
Experimental
Matched Iupac: … 2-{2-[(2-ethoxy-2-oxoethyl)sulfanyl]ethyl}-1,3-thiazolidine-4-carboxylic acid …
Matched Description: … Letosteine is a mucolytic used in the treatment of chronic bronchopneumopathies and related conditions …
Matched Categories: … Sulfur Compounds ... Cough and Cold Preparations …
Matched Description: … Letosteine is a mucolytic used in the treatment of chronic bronchopneumopathies and related conditions …
Matched Categories: … Sulfur Compounds ... Cough and Cold Preparations …
Alethine
Alethine is studied in the treatment of cancer. It belongs to a family of chemicals called disulfides. It is a low molecular weight disulfide that has been shown to exhibit in vivo antitumor activity in murine myeloma and melanoma models.
Investigational
Matched Description: … molecular weight disulfide that has been shown to exhibit in vivo antitumor activity in murine myeloma and …
Matched Categories: … Sulfur Compounds …
Matched Categories: … Sulfur Compounds …
LGD-6972
LGD-6972 is under investigation in clinical trial NCT01919684 (Study to Evaluate Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of LGD-6972 in Healthy Subjects and Subjects With Type 2 Diabetes Mellitus).
Investigational
Matched Iupac: … -yl}-2-({2',4',6'-trimethyl-[1,1'-biphenyl]-4-yl}carbamoyl)ethyl]phenyl}formamido)ethane-1-sulfonic acid …
Matched Description: … Pharmacodynamics of LGD-6972 in Healthy Subjects and Subjects With Type 2 Diabetes Mellitus). ... investigation in clinical trial NCT01919684 (Study to Evaluate Safety, Tolerability, Pharmacokinetics and …
Matched Categories: … Sulfur Acids ... Sulfur Compounds …
Matched Description: … Pharmacodynamics of LGD-6972 in Healthy Subjects and Subjects With Type 2 Diabetes Mellitus). ... investigation in clinical trial NCT01919684 (Study to Evaluate Safety, Tolerability, Pharmacokinetics and …
Matched Categories: … Sulfur Acids ... Sulfur Compounds …
LSZ-102
LSZ-102 is under investigation in clinical trial NCT02734615 (Phase I/Ib Trial of LSZ102 Single Agent or LSZ102 + LEE011 or LSZ102 + BYL719 in ER+ Breast Cancers).
Investigational
Matched Iupac: … 4-({2-[2-(1,1-difluoroethyl)-4-fluorophenyl]-6-hydroxy-1-benzothiophen-3-yl}oxy)phenyl]prop-2-enoic acid …
Matched Categories: … Sulfur Compounds …
Matched Categories: … Sulfur Compounds …
Racecadotril
Racecadotril has been investigated for the basic science and treatment of Diarrhea, Acute Diarrhea, and Acute Gastroenteritis.
Investigational
Matched Description: … Racecadotril has been investigated for the basic science and treatment of Diarrhea, Acute Diarrhea, and …
Matched Categories: … Amino Acids, Sulfur ... Sulfur Compounds ... Alimentary Tract and Metabolism ... Amino Acids, Peptides, and Proteins …
Matched Categories: … Amino Acids, Sulfur ... Sulfur Compounds ... Alimentary Tract and Metabolism ... Amino Acids, Peptides, and Proteins …
Glucoraphanin
Glucoraphanin is under investigation in clinical trial NCT01879878 (Pilot Study Evaluating Broccoli Sprouts in Advanced Pancreatic Cancer [POUDER Trial]).
Investigational
Matched Iupac: … 2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]sulfanyl}pentylidene)amino]oxy}sulfonic acid …
Matched Categories: … Sulfur Compounds …
Matched Categories: … Sulfur Compounds …
Aleglitazar
Aleglitazar is an investigational drug from the company Hoffmann–La Roche and is currently in a phase III clinical trial called ALECARDIO. It is being investigated for use in patients with type II diabetes to reduce their risks of cardiovascular mortality and morbidity. Aleglitazar is an agonist at the peroxisome proliferator-activated...
Investigational
Matched Iupac: … (2S)-2-methoxy-3-{4-[2-(5-methyl-2-phenyl-1,3-oxazol-4-yl)ethoxy]-1-benzothiophen-7-yl}propanoic acid …
Matched Description: … Aleglitazar is an investigational drug from the company Hoffmann–La Roche and is currently in a phase ... glucose levels in a synergistic manner while also having limited side effects and toxicity. ... trial called SYNCHRONY, with type II diabetic patients, aleglitazar was able to control both lipid and …
Matched Categories: … Sulfur Compounds …
Matched Description: … Aleglitazar is an investigational drug from the company Hoffmann–La Roche and is currently in a phase ... glucose levels in a synergistic manner while also having limited side effects and toxicity. ... trial called SYNCHRONY, with type II diabetic patients, aleglitazar was able to control both lipid and …
Matched Categories: … Sulfur Compounds …
Epalrestat
Epalrestat is under investigation in clinical trial NCT03244358 (Evaluation of Epalrestat in Metastatic Triple-negative Breast Cancer).
Investigational
Matched Iupac: … 5Z)-5-[(2E)-2-methyl-3-phenylprop-2-en-1-ylidene]-4-oxo-2-sulfanylidene-1,3-thiazolidin-3-yl]acetic acid …
Matched Categories: … Sulfur Compounds …
Matched Categories: … Sulfur Compounds …
Ertiprotafib
Ertiprotafib belongs to a novel class of insulin sensitizers developed for treatment of type 2 diabetes. In insulin-resistant rodent models, ertiprotafib and a close analog lowered both fasting blood glucose and insulin levels and improved glycemic excursion during an oral glucose tolerance test.
Investigational
Matched Iupac: … (2R)-2-(4-{9-bromo-2,3-dimethylnaphtho[2,3-b]thiophen-4-yl}-2,6-dimethylphenoxy)-3-phenylpropanoic acid …
Matched Description: … and insulin levels and improved glycemic excursion during an oral glucose tolerance test. ... In insulin-resistant rodent models, ertiprotafib and a close analog lowered both fasting blood glucose …
Matched Categories: … Sulfur Compounds …
Matched Description: … and insulin levels and improved glycemic excursion during an oral glucose tolerance test. ... In insulin-resistant rodent models, ertiprotafib and a close analog lowered both fasting blood glucose …
Matched Categories: … Sulfur Compounds …
Rigosertib
Rigosertib has been used in trials studying the treatment and basic science of MDS, RAEB, Cancer, Hepatoma, and Neoplasms, among others.
Investigational
Matched Iupac: … 2-[(2-methoxy-5-{[(E)-2-(2,4,6-trimethoxyphenyl)ethenesulfonyl]methyl}phenyl)amino]acetic acid …
Matched Description: … , and Neoplasms, among others. ... Rigosertib has been used in trials studying the treatment and basic science of MDS, RAEB, Cancer, Hepatoma …
Matched Categories: … Sulfur Compounds ... Amino Acids, Peptides, and Proteins …
Matched Description: … , and Neoplasms, among others. ... Rigosertib has been used in trials studying the treatment and basic science of MDS, RAEB, Cancer, Hepatoma …
Matched Categories: … Sulfur Compounds ... Amino Acids, Peptides, and Proteins …
Lanifibranor
Lanifibranor is under investigation in clinical trial NCT03008070 (Phase 2b Study in NASH to Assess IVA337).
Investigational
Matched Iupac: … 4-[1-(1,3-benzothiazole-6-sulfonyl)-5-chloro-1H-indol-2-yl]butanoic acid …
Matched Categories: … Sulfur Compounds …
Matched Categories: … Sulfur Compounds …
Bucillamine
Bucillamine has been used in trials studying the treatment and prevention of Gout and Rheumatoid Arthritis.
Investigational
Matched Iupac: … (2R)-2-(2-methyl-2-sulfanylpropanamido)-3-sulfanylpropanoic acid …
Matched Description: … Bucillamine has been used in trials studying the treatment and prevention of Gout and Rheumatoid Arthritis …
Matched Categories: … Amino Acids, Sulfur ... Sulfur Compounds ... Amino Acids, Peptides, and Proteins ... Penicillamine and Similar Agents ... Antiinflammatory and Antirheumatic Products …
Matched Description: … Bucillamine has been used in trials studying the treatment and prevention of Gout and Rheumatoid Arthritis …
Matched Categories: … Amino Acids, Sulfur ... Sulfur Compounds ... Amino Acids, Peptides, and Proteins ... Penicillamine and Similar Agents ... Antiinflammatory and Antirheumatic Products …
Irosustat
Irosustat has been investigated for the treatment of Metastatic Breast Cancer and Locally Advanced Breast Cancer.
Investigational
Matched Description: … Irosustat has been investigated for the treatment of Metastatic Breast Cancer and Locally Advanced Breast …
Matched Categories: … Sulfur Acids ... Sulfur Compounds …
Matched Categories: … Sulfur Acids ... Sulfur Compounds …
Acetylcysteine zinc
Experimental
Matched Categories: … Amino Acids, Peptides, and Proteins ... Amino Acids, Sulfur ... Sulfur Compounds …
Deferitazole
Deferitazole is an iron chelator. It has been used in trials studying the treatment and basic science of Beta-thalassemia, Hepatic Impairment, Impaired Renal Function, Transfusional Iron Overload, and Iron Overload Due to Repeated Red Blood Cell Transfusions.
Investigational
Matched Iupac: … hydroxy-3-{2-[2-(2-methoxyethoxy)ethoxy]ethoxy}phenyl)-4-methyl-4,5-dihydro-1,3-thiazole-4-carboxylic acid …
Matched Description: … It has been used in trials studying the treatment and basic science of Beta-thalassemia, Hepatic Impairment ... , Impaired Renal Function, Transfusional Iron Overload, and Iron Overload Due to Repeated Red Blood Cell …
Matched Categories: … Sulfur Compounds …
Matched Description: … It has been used in trials studying the treatment and basic science of Beta-thalassemia, Hepatic Impairment ... , Impaired Renal Function, Transfusional Iron Overload, and Iron Overload Due to Repeated Red Blood Cell …
Matched Categories: … Sulfur Compounds …
Displaying drugs 451 - 475 of 704 in total