Displaying drugs 26 - 50 of 258 in total
Oxytocin
Sir Henry H. Dale first identified oxytocin and its uterine contractile properties in 1906.[A229008,A228593,A229108] Like all other neurohypophysial hormones, oxytocin is composed of nine amino acids with a disulfide bridge between the Cys 1 and 6 residues.[A229008,A228593] In the mid-1950s, synthetic oxytocin was successfully synthesized by a biochemist named Vincent...
Approved
Vet approved
Matched Description: … ,A229108] Like all other neurohypophysial hormones, oxytocin is composed of nine amino acids with a disulfide …
Ensulizole
Ensulizole, also known as 2-phenylbenzimidazole-5-sulfonic acid, is a water-soluble sunscreen agent that absorbs strongly at UV-B wavelengths. It is commonly found in cosmetic products and sunscreen formulas in combination with other UV filter compounds due to its minimal protection against UV-A wavelengths. Due to its water solubility, ensulizole is commonly...
Approved
Matched Mixtures name: … Octinoxate,octisalate,avobenzone,octocrylene,ensulizole,titanium Dioxide ... Octisalate,octocrylene,octinoxate,zinc Oxide,titanium Dioxide,ensulizole …
Octocrylene
Octocrylene is a compound often used as an additive in sun screen, and is thought to have skin moisturizing effects because of its emollient properties. What makes this chemical such a popular additive to sun block, is its ability to neutralize UV radiation dissipated by sunlight, and to minimize skin...
Approved
Investigational
Matched Mixtures name: … Octinoxate,octisalate,avobenzone,octocrylene,ensulizole,titanium Dioxide ... Octisalate,octocrylene,octinoxate,zinc Oxide,titanium Dioxide,ensulizole …
Titanium dioxide
Titanium dioxide, also known as titanium(IV) oxide or titania, is the naturally occurring oxide of titanium. It is used as a pigment under the names titanium white, Pigment White 6 (PW6), or CI 77891. It is typically extracted from ilmenite, rutile and anatase.
Approved
Matched Synonyms: … Titanium dioxide …
Matched Name: … Titanium dioxide …
Matched Description: … Titanium dioxide, also known as titanium(IV) oxide or titania, is the naturally occurring oxide of titanium ... It is used as a pigment under the names titanium white, Pigment White 6 (PW6), or CI 77891. …
Matched Mixtures name: … Zinc Oxide, Titanium Dioxide ... SPF 30 With Titanium Dioxide ... Avobenzone, Octinoxate, Titanium Dioxide …
Matched Products: … Titanium Dioxide ... Men's Titanium 4 - Crm 2% ... Titanium Plus Natures Sunblock 16spf …
Matched Name: … Titanium dioxide …
Matched Description: … Titanium dioxide, also known as titanium(IV) oxide or titania, is the naturally occurring oxide of titanium ... It is used as a pigment under the names titanium white, Pigment White 6 (PW6), or CI 77891. …
Matched Mixtures name: … Zinc Oxide, Titanium Dioxide ... SPF 30 With Titanium Dioxide ... Avobenzone, Octinoxate, Titanium Dioxide …
Matched Products: … Titanium Dioxide ... Men's Titanium 4 - Crm 2% ... Titanium Plus Natures Sunblock 16spf …
Dipentamethylenethiuram disulfide
Approved
Experimental
Matched Synonyms: … 1-Piperidinethiocarbonyl disulfide ... Bis(pentamethylene)thiuram disulfide ... Bis(1-piperidylthiocarbonyl) disulfide …
Matched Name: … Dipentamethylenethiuram disulfide …
Matched Name: … Dipentamethylenethiuram disulfide …
2,2'-Dibenzothiazyl disulfide
2,2'-Dibenzothiazyl disulfide is an accelerator used in the processing process for natural and synthetic rubber and plastic regeneration. It is also a known allergen and dermatological sensitizer.
Sensitivity to 2,2'-Dibenzothiazyl disulfide may be identified with a clinical patch test.
Approved
Experimental
Matched Synonyms: … 2-Benzothiazolyl disulfide ... Benzothiazole disulfide ... Benzothiazolyl disulfide …
Matched Name: … 2,2'-Dibenzothiazyl disulfide …
Matched Description: … Sensitivity to 2,2'-Dibenzothiazyl disulfide may be identified with a clinical patch test. ... 2,2'-Dibenzothiazyl disulfide is an accelerator used in the processing process for natural and synthetic …
Matched Name: … 2,2'-Dibenzothiazyl disulfide …
Matched Description: … Sensitivity to 2,2'-Dibenzothiazyl disulfide may be identified with a clinical patch test. ... 2,2'-Dibenzothiazyl disulfide is an accelerator used in the processing process for natural and synthetic …
Thiram
Thiram may be used in dermatology as a scabicide . Thiram is mainly used as a fungicide for plants and treatment for seeds, however, this use is being investigated for safety in many markets including Canada .
Approved
Experimental
Matched Synonyms: … Tetramethylthiuram disulfide …
Zinc dibutyldithiocarbamate
Zinc dibutyldithiocarbamate is a dermatological sensitizer and allergen. Sensitivity to zinc dibutyldithiocarbamate may be identified with a clinical patch test.
Approved
Experimental
Matched Synonyms: … zinc bis(dibutylthiocarbamoyl)disulfide ... zinc bis(dibutyldithiocarbamoyl)disulfide …
Spesolimab
Spesolimab is an interleukin-36 (IL-36) receptor antagonist. It is a humanized monoclonal immunoglobulin G1 antibody that was produced in Chinese hamster ovary (CHO) cells by recombinant DNA technology. The biosimilar of the drug, spesolimab-sbzo, was first approved by the FDA in September 2022 to treat generalized pustular psoriasis flares. Spesolimab...
Approved
Investigational
Matched Synonyms: … Immunoglobulin G1, anti-(human interleukin 36 receptor) (humanized monoclonal BI 655130 gamma1-chain), disulfide …
Pucotenlimab
Pucotenlimab is a recombinant humanized anti-PD-1 monoclonal antibody. It received its first global approval in China in July 2022 for the treatment of solid tumours. It is being investigated in other cancers.
Approved
Investigational
Matched Synonyms: … alanine), anti-(human programmed cell death 1) (human-mus musculus monoclonal hx008 .gamma.4-chain), disulfide …
Natalizumab
Natalizumab is a recombinant humanized IgG4κ monoclonal antibody that binds to α4-integrin. While natalizumab was originally approved by the FDA to treat multiple sclerosis in 2004, it was withdrawn from the market following multiple reports of fatal progressive multifocal leukoencephalopathy (PML). In 2006, the FDA reintroduced the drug to the...
Approved
Investigational
Matched Synonyms: … IMMUNOGLOBULIN G4 (HUMAN-MOUSE MONOCLONAL AN100226 4-CHAIN ANTI-HUMAN INTEGRIN 4), DISULFIDE WITH HUMAN-MOUSE …
Captopril
Captopril is a potent, competitive inhibitor of angiotensin-converting enzyme (ACE), the enzyme responsible for the conversion of angiotensin I (ATI) to angiotensin II (ATII). ATII regulates blood pressure and is a key component of the renin-angiotensin-aldosterone system (RAAS). Captopril may be used in the treatment of hypertension.
Approved
Tiopronin
Tiopronin is a prescription thiol drug used primarily in the treatment of severe homozygous cystinuria. Patients with cystinuria excrete high levels of cystine in their urine and are at risk for kidney stone formation. Tiopronin is used as a second-line therapy to control the rate of cystine precipitation and excretion,...
Approved
Investigational
Matched Categories: … Cystine Disulfide Reduction …
Cystine
A covalently linked dimeric nonessential amino acid formed by the oxidation of cysteine. Two molecules of cysteine are joined together by a disulfide bridge to form cystine.
Approved
Nutraceutical
Matched Description: … Two molecules of cysteine are joined together by a disulfide bridge to form cystine. …
Glutathione
A tripeptide with many roles in cells. It conjugates to drugs to make them more soluble for excretion, is a cofactor for some enzymes, is involved in protein disulfide bond rearrangement and reduces peroxides.
Approved
Investigational
Nutraceutical
Matched Description: … drugs to make them more soluble for excretion, is a cofactor for some enzymes, is involved in protein disulfide …
Mecasermin
Mecasermin contains recombinant-DNA-engineered human insulin-like growth factor-1 (rhIGF-1)[FDA Label]. IGF-1 consists of 70 amino acids in a single chain with three intramolecular disulfide bridges and a molecular weight of 7649 daltons. The amino acid sequence of the product is identical to that of endogenous human IGF-1. The rhIGF-1 protein is...
Approved
Investigational
Matched Description: … IGF-1 consists of 70 amino acids in a single chain with three intramolecular disulfide bridges and a …
Pantoprazole
Pantoprazole is a first-generation proton pump inhibitor (PPI) used for the management of gastroesophageal reflux disease (GERD), for gastric protection to prevent recurrence of stomach ulcers or gastric damage from chronic use of NSAIDs, and for the treatment of pathological hypersecretory conditions including Zollinger-Ellison (ZE) Syndrome. It can also be...
Approved
Atosiban
Atosiban is an inhibitor of the hormones oxytocin and vasopressin. It is used intravenously to halt premature labor. Although initial studies suggested it could be used as a nasal spray and hence would not require hospital admission, it is not used in that form. Atobisan was developed by the Swedish...
Approved
Investigational
Odesivimab
Ebola virus (EBOV) remains an important human pathogen within the Ebolavirus genus, having been responsible for at least 17 known outbreaks with an average case fatality rate of 43.92%. Immune therapy using monoclonal antibodies (mAbs) is becoming an increasingly attractive therapeutic method to combat infectious diseases due to its rapid...
Approved
Omeprazole
Originally approved by the FDA in 1989, omeprazole is a proton-pump inhibitor, used to treat gastric acid-related disorders. These disorders may include gastroesophageal reflux disease (GERD), peptic ulcer disease, and other diseases characterized by the oversecretion of gastric acid. This drug was the first clinical useful drug in its class,...
Approved
Investigational
Vet approved
Pentetreotide
Pentetreotide has been used in trials studying the diagnosis of Cushing's syndrome.
Approved
Investigational
Moxetumomab pasudotox
CD22 is a lineage-restricted B-cell antigen that is expressed solely in on B-chronic lymphocytic leukemia, hairy cell leukemia, acute lymphocytic leukemiathe and Burkitt's lymphoma. The predecessor of Moxetumab pasudotox (MxP), named BL22, was first created based on the antibody RFB4 which specifically binds to CD22. This antibody was used to...
Approved
Investigational
Matched Description: … This antibody was used to generate a recombinant immunotoxin in which a stabilized Fv segment by a disulfide …
Dibotermin alfa
Dibotermin alfa is a recombinant human bone morphogenetic protein-2 (rhBMP-2) derived from a recombinant Chinese Hamster Ovary (CHO) cell line [FDA Label]. It is implanted in patients undergoing bone surgeries or those with fractures. BMPs are subfamily of the transforming growth factor-β (TGF-β) superfamily that have different actions on the...
Approved
Investigational
Matched Description: … In Infuse, rhBMP is a disulfide-linked dimeric protein molecule with two major subunit species of 114 …
Ecallantide
Ecallantide is a potent and selective human plasma kallikrein inhibitor that is indicated for the symptomatic treatment of hereditary angioedema. Ecallantide is a recombinant 60-amino-acid protein produced in Pichia pastoris yeast cells that contains three intramolecular disulfide bonds [FDA Label]. It was discovered by phage display technology . It shares...
Approved
Investigational
Matched Description: … 60-amino-acid protein produced in _Pichia pastoris_ yeast cells that contains three intramolecular disulfide …
Insulin human
Human Insulin, also known as Regular Insulin, is a short-acting form of insulin used for the treatment of hyperglycemia caused by Type 1 and Type 2 Diabetes. Human insulin is produced by recombinant DNA technology and is identical to endogenously produced insulin. Typically prescribed for the management of diabetes mellitus,...
Approved
Investigational
Matched Description: … The structure is identical to native human insulin, with two amino acid chains covalently linked by disulfide …
Displaying drugs 26 - 50 of 258 in total