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Displaying drugs 476 - 500 of 15379 in total

Latanoprostene bunod

Latanoprostene Bunod has been used in trials studying the treatment of Glaucoma, Ocular Hypertension, Open-Angle Glaucoma, Open Angle Glaucoma, and Intraocular Pressure. As of November 2, 2017 the FDA approved Bausch + Lomb's Vyzulta (latanoprostene bunod opthalmic solution), 0.024% for the indication of reducing intraocular pressure in patients with open-angle...
Approved
Investigational
Matched Description: … In comparison, both latanoprost and latanoprostene bunod contain a latanoprost acid backbone. ... Open-Angle Glaucoma, Open Angle Glaucoma, and Intraocular Pressure. ... typically found in latanoprost. …
Matched Categories: … Antiglaucoma Preparations and Miotics …

Influenza A virus A/Switzerland/9715293/2013 (H3N2) live (attenuated) antigen

A seasonally-specific component of the influenza vaccine. The influenza vaccine, also known as the "flu shot", is a vaccine that protects against infection from the influenza viruses. Vaccines provide protection from influenza by exposing the immune system to the virus (or parts of the virus) which stimulates an immunological defence...
Approved
Matched Description: … Inactivated vaccines contain a virus particle that has been grown in media and then subsequently killed ... Inactivated virus cannot replicate, and therefore cannot cause disease from infection, even in immunocompromised ... In contrast, live vaccines are produced from "wild-type" or disease-causing viruses that have been attenuated …

Influenza A virus A/Brisbane/02/2018 (H1N1) recombinant hemagglutinin antigen

A seasonally-specific component of the influenza vaccine. The influenza vaccine, also known as the "flu shot", is a vaccine that protects against infection from the influenza viruses. Vaccines provide protection from influenza by exposing the immune system to the virus (or parts of the virus) which stimulates an immunological defence...
Approved
Matched Description: … Inactivated vaccines contain a virus particle that has been grown in media and then subsequently killed ... Inactivated virus cannot replicate, and therefore cannot cause disease from infection, even in immunocompromised ... In contrast, live vaccines are produced from "wild-type" or disease-causing viruses that have been attenuated …

Glucagon

Glucagon is a 29 amino acid hormone used as a diagnostic aid in radiologic exams to temporarily inhibit the movement of the gastrointestinal tract and to treat severe hypoglycemia.[L7634,L7637,L7640,L7643,L8519] Glucagon raises blood sugar through activation of hepatic glucagon receptors, stimulating glycogenolysis and the release of glucose.[L7640,L7643] Glucagon was granted FDA...
Approved
Matched Description: … Glucagon is a 29 amino acid hormone used as a diagnostic aid in radiologic exams to temporarily inhibit ... the movement of the gastrointestinal tract and to treat severe hypoglycemia. ... Glucagon raises blood sugar through activation of hepatic glucagon receptors, stimulating glycogenolysis and …
Matched Categories: … Sex Hormones and Insulins ... Amino Acids, Peptides, and Proteins ... Hormones, Hormone Substitutes, and Hormone Antagonists …

Cholesterol

The principal sterol of all higher animals, distributed in body tissues, especially the brain and spinal cord, and in animal fats and oils.
Approved
Investigational
Matched Description: … cord, and in animal fats and oils. ... The principal sterol of all higher animals, distributed in body tissues, especially the brain and spinal …

Rosuvastatin

Rosuvastatin, also known as the brand name product Crestor, is a lipid-lowering drug that belongs to the statin class of medications, which are used to lower the risk of cardiovascular disease and manage elevated lipid levels by inhibiting the endogenous production of cholesterol in the liver. More specifically, statin medications...
Approved
Matched Description: … stroke, has become a leading cause of death in high-income countries and a major cause of morbidity ... involved in lipid metabolism and transport including cholesterol, low-density lipoprotein (LDL) (sometimes ... [A181084] Elevated cholesterol levels, and in particular, elevated low-density lipoprotein (LDL) levels …
Matched Mixtures name: … Rosuvastatin and Ezetimibe ... Rosuvastatin and Ezetimibe ... Rosuvastatin and Ezetimibe …
Matched Categories: … Drugs Used in Diabetes ... Alimentary Tract and Metabolism ... rosuvastatin and ramipril ... rosuvastatin and valsartan ... rosuvastatin and ezetimibe …

Ergosterol

A steroid of interest both because its biosynthesis in FUNGI is a target of ANTIFUNGAL AGENTS, notably AZOLES, and because when it is present in SKIN of animals, ULTRAVIOLET RAYS break a bond to result in ERGOCALCIFEROL.
Approved
Experimental
Matched Description: … AZOLES, and because when it is present in SKIN of animals, ULTRAVIOLET RAYS break a bond to result in ... A steroid of interest both because its biosynthesis in FUNGI is a target of ANTIFUNGAL AGENTS, notably …
Matched Categories: … Diet, Food, and Nutrition …

Pentoxifylline

Pentoxifylline (PTX) is a synthetic dimethylxanthine derivative that modulates the rheological properties of blood and also has both anti-oxidant and anti-inflammatory properties.[A226415, L30300] Although originally developed to treat intermittent claudication, a form of exertion-induced leg pain common in patients with peripheral arterial disease, PTX has been investigated for its possible...
Approved
Investigational
Matched Description: … originally developed to treat intermittent claudication, a form of exertion-induced leg pain common in ... patients with peripheral arterial disease, PTX has been investigated for its possible use in diverse ... [A226608] Pentoxifylline has been marketed in Europe since 1972; PTX extended-release tablets sold …
Matched Categories: … Compounds used in a research, industrial, or household setting …

Sotagliflozin

Sotagliflozin is a dual inhibitor of SGLT1 and SGLT2, the first of its kind, which is approved for use in the EU, in combination with insulin, to improve glycemic control in patients with type 1 diabetes mellitus (T1DM) and a BMI ≥27 kg/m2. Its potency in inhibiting SGLT2 is similar...
Approved
Investigational
Matched Description: … and heart failure in patients with high risk factors.[] ... ] and [dapagliflozin], but its potency in inhibiting SGLT1 is >10-fold higher than its predecessors. ... diabetes mellitus (T1DM) and a BMI ≥27 kg/m2. …
Matched Categories: … Alimentary Tract and Metabolism ... Drugs Used in Diabetes …

Influenza A virus A/Hong Kong/4801/2014 (H3N2) recombinant hemagglutinin antigen

A seasonally-specific component of the influenza vaccine. The influenza vaccine, also known as the "flu shot", is a vaccine that protects against infection from the influenza viruses. Vaccines provide protection from influenza by exposing the immune system to the virus (or parts of the virus) which stimulates an immunological defence...
Approved
Matched Description: … Inactivated vaccines contain a virus particle that has been grown in media and then subsequently killed ... Inactivated virus cannot replicate, and therefore cannot cause disease from infection, even in immunocompromised ... In contrast, live vaccines are produced from "wild-type" or disease-causing viruses that have been attenuated …

Influenza A virus A/Minnesota/41/2019 (H3N2) recombinant hemagglutinin antigen

A seasonally-specific component of the influenza vaccine. The influenza vaccine, also known as the "flu shot", is a vaccine that protects against infection from the influenza viruses. Vaccines provide protection from influenza by exposing the immune system to the virus (or parts of the virus) which stimulates an immunological defence...
Approved
Matched Description: … Inactivated vaccines contain a virus particle that has been grown in media and then subsequently killed ... Inactivated virus cannot replicate, and therefore cannot cause disease from infection, even in immunocompromised ... In contrast, live vaccines are produced from "wild-type" or disease-causing viruses that have been attenuated …

Influenza A virus A/West Virginia/30/2022 (H1N1) Recombinant Hemagglutinin Antigen

A seasonally-specific component of the influenza vaccine. The influenza vaccine, also known as the "flu shot", is a vaccine that helps to protect against infection from influenza viruses. These vaccines provide protection from influenza by exposing the immune system to the virus (or parts of the virus) which results in...
Approved
Matched Description: … Inactivated vaccines contain a virus particle that has been grown in media and then subsequently killed ... Inactivated viruses cannot replicate and thus cannot cause disease from infection, even in immunocompromised ... protection from influenza by exposing the immune system to the virus (or parts of the virus) which results in …

Zidovudine

A dideoxynucleoside compound in which the 3'-hydroxy group on the sugar moiety has been replaced by an azido group. This modification prevents the formation of phosphodiester linkages which are needed for the completion of nucleic acid chains. The compound is a potent inhibitor of HIV replication, acting as a chain-terminator...
Approved
Matched Description: … Its principal toxic effect is dose-dependent suppression of bone marrow, resulting in anemia and leukopenia ... A dideoxynucleoside compound in which the 3'-hydroxy group on the sugar moiety has been replaced ... It improves immunologic function, partially reverses the HIV-induced neurological dysfunction, and improves …
Matched Mixtures name: … Lamivudine and Zidovudine ... Lamivudine and Zidovudine ... Lamivudine and Zidovudine …
Matched Categories: … Antivirals used in combination for the treatment of HIV infections ... zidovudine and lamivudine ... zidovudine, lamivudine and abacavir ... zidovudine, lamivudine and nevirapine ... Nucleic Acids, Nucleotides, and Nucleosides …

Ursodeoxycholic acid

Ursodeoxycholic acid (UDCA), also known as ursodiol, is a naturally-occurring bile acid that constitutes a minor fraction of the human bile acid pool.[A256272,A256277] UDCA has been used to treat liver disease for decades: its first use in traditional medicine dates back more than a hundred years.[A256267,A256463] UDCA was first characterized...
Approved
Investigational
Matched Description: … [A256267,A256463] UDCA was first characterized in the bile of the Chinese black bear and is formed by ... [A256272] UDCA was first approved by the FDA in 1987 for dissolution of gallstones and for primary ... biliary cirrhosis in 1996. …
Matched Categories: … Bile Acids and Salts ... Bile and Liver Therapy ... Bile acids and derivatives ... Alimentary Tract and Metabolism ... Cholagogues and Choleretics …

Deferasirox

Deferasirox is an iron chelator and the first oral medication FDA approved for chronic iron overload in patients receiving long term blood transfusions.
Approved
Investigational
Matched Description: … in patients receiving long term blood transfusions. ... Deferasirox is an iron chelator and the first oral medication FDA approved for chronic iron overload …
Matched Categories: … Compounds used in a research, industrial, or household setting …

Influenza A virus A/Switzerland/9715293/2013 (H3N2) recombinant hemagglutinin antigen

A seasonally-specific component of the influenza vaccine. The influenza vaccine, also known as the "flu shot", is a vaccine that protects against infection from the influenza viruses. Vaccines provide protection from influenza by exposing the immune system to the virus (or parts of the virus) which stimulates an immunological defence...
Approved
Matched Description: … Inactivated vaccines contain a virus particle that has been grown in media and then subsequently killed ... Inactivated virus cannot replicate, and therefore cannot cause disease from infection, even in immunocompromised ... In contrast, live vaccines are produced from "wild-type" or disease-causing viruses that have been attenuated …

Trandolapril

Trandolapril is a non-sulhydryl prodrug that belongs to the angiotensin-converting enzyme (ACE) inhibitor class of medications. It is metabolized to its biologically active diacid form, trandolaprilat, in the liver. Trandolaprilat inhibits ACE, the enzyme responsible for the conversion of angiotensin I (ATI) to angiotensin II (ATII). ATII regulates blood pressure...
Approved
Matched Description: … and microalbuminuria or overt nephropathy. ... It is metabolized to its biologically active diacid form, trandolaprilat, in the liver. ... ATII regulates blood pressure and is a key component of the renin-angiotensin-aldosterone system (RAAS …
Matched Mixtures name: … Trandolapril and Verapamil Hydrochloride ... Trandolapril and Verapamil Hydrochloride ... Trandolapril and Verapamil Hydrochloride …
Matched Categories: … trandolapril and verapamil ... ACE Inhibitors and Calcium Channel Blockers …

Methadone

Methadone is a potent synthetic analgesic that works as a full µ-opioid receptor (MOR) agonist and N-methyl-d-aspartate (NMDA) receptor antagonist. As a full MOR agonist, methadone mimics the natural effects of the body's opioids, endorphins, and enkephalins through the release of neurotransmitters involved in pain transmission. It also has a...
Approved
Matched Description: … At higher doses, methadone use can result in respiratory depression, overdose, and death. ... through the release of neurotransmitters involved in pain transmission. ... ; in particular, methadone has a lower risk of neuropsychiatric toxicity compared to other opioids (due …
Matched Categories: … Drugs Used in Opioid Dependence ... Drugs Used in Addictive Disorders …

Drostanolone propionate

Approved
Illicit
Matched Categories: … Testosterone and derivatives …

Vaborbactam

Vaborbactam is a β-lactamase inhibitor based on a cyclic boronic acid pharmacophore. It has been used in trials investigating the treatment of bacterial infections in subjects with varying degrees of renal insufficiency. In August 2017, a combination antibacterial therapy under the market name Vabomere was approved by the FDA for...
Approved
Investigational
Matched Description: … [A32053] It has been used in trials investigating the treatment of bacterial infections in subjects with ... Vabomere consists of vaborbactam and [Meropenem] for intravenous administration. ... [Label] The treatment aims to resolve infection-related symptoms of cUTI and achieve negative urine culture …
Matched Categories: … meropenem and vaborbactam …

Valoctocogene roxaparvovec

Valoctocogene roxaparvovec is an adeno-associated virus serotype 5 (AAV5) based gene therapy vector that expresses the B-domain deleted SQ form of human coagulation factor VIII (hFVIII-SQ). The expression of hFVIII-SQ is driven by a liver-specific promoter, which enables hepatocytes to produce factor VIII protein and increase the levels of active...
Approved
Investigational
Matched Description: … [L43282,A252807] Valoctocogene roxaparvovec was approved by EMA in September 2022 and is indicated for ... It is not approved for use in the United States. ... increase the levels of active factor VIII in blood. …
Matched Categories: … Cellular and Gene Therapy ... Blood and Blood Forming Organs ... Amino Acids, Peptides, and Proteins …

Plazomicin

Developed by Achaogen biopharmaceuticals, plazomicin is a next-generation aminoglycoside synthetically derived from DB12604. The structure of plazomicin was established via appending hydroxylaminobutyric acid to DB12604 at position 1 and 2-hydroxyethyl group at position 6' . It was designed to evade all clinically relevant aminoglycoside-modifying enzymes, which contribute to the main...
Approved
Investigational
Matched Description: … On June 28th, 2018, plazomicin sulfate was approved by the FDA for use in adult patients for the treatment ... It is marketed as Zemdri and is administered via once-daily intravenous infusion. ... However, acquired resistance of aminoglycosides may arise through over expression of efflux pumps and …

Troglitazone

Troglitazone was withdrawn in 2000 due to risk of hepatotoxicity. It was superseded by pioglitazone and rosiglitazone.
Approved
Investigational
Withdrawn
Matched Description: … It was superseded by [pioglitazone] and [rosiglitazone]. ... Troglitazone was withdrawn in 2000 due to risk of hepatotoxicity. …
Matched Categories: … Alimentary Tract and Metabolism ... Drugs Used in Diabetes …

Terconazole

Terconazole is an anti-fungal drug that is mainly used to treat vaginal yeast infections (or vaginal candidiasis). It is classified as a triazole ketal derivative. Terconazole was initially approved by the FDA in 1987.[FDA label] This drug is available in cream and suppository forms and both have demonstrated high levels...
Approved
Matched Description: … of safety, efficacy, and tolerability in clinical trials. ... [FDA label] This drug is available in cream and suppository forms and both have demonstrated high levels ... [A178096] Terconazole was initially approved by the FDA in 1987. …
Matched Categories: … Genito Urinary System and Sex Hormones ... Gynecological Antiinfectives and Antiseptics …

Vardenafil

Vardenafil is a selective inhibitor of cyclic guanosine monophosphate (cGMP)-specific phosphodiesterase type 5 (PDE5) and an oral therapy for the treatment of erectile dysfunction.[L45563,L45568] During sexual stimulation, nitric oxide (NO) is released from nerve endings and endothelial cells in the corpus cavernosum, activating the enzyme guanylate cyclase and increasing the...
Approved
Matched Description: … cells in the corpus cavernosum, activating the enzyme guanylate cyclase and increasing the synthesis ... the penis, resulting in an erection. ... of cGMP in the smooth muscle cells of the corpus cavernosum. …
Matched Categories: … Drugs Used in Erectile Dysfunction ... Genito Urinary System and Sex Hormones …
Displaying drugs 476 - 500 of 15379 in total