Displaying drugs 501 - 525 of 8039 in total
Afatinib
Afatinib is a 4-anilinoquinazoline tyrosine kinase inhibitor in the form of a dimaleate salt available as Boehringer Ingelheim's brand name Gilotrif [FDA Label]. For oral use, afatinib tablets are a first-line (initial) treatment for patients with metastatic non-small cell lung cancer (NSCLC) with common epidermal growth factor receptor (EGFR) mutations...
Approved
Matched Description: … Afatinib is a 4-anilinoquinazoline tyrosine kinase inhibitor in the form of a dimaleate salt available …
Levobupivacaine
Levobupivacaine is an amino-amide local anaesthetic drug belonging to the family of n-alkylsubstituted
pipecoloxylidide. It is the S-enantiomer of bupivacaine. Levobupivacaine hydrochloride is commonly marketed by AstraZeneca under the trade name Chirocaine. In particular, the specific levobupivacaine enantiomer is a worthwhile pursuit because it demonstrates less vasodilation and possesses a...
Approved
Investigational
Matched Description: … It is the S-enantiomer of bupivacaine. ... Levobupivacaine is an amino-amide local anaesthetic drug belonging to the family of n-alkylsubstituted ... When administered appropriately, the occurrence of adverse effects is not anticipated much if at all. …
Triflusal
Triflusal is a 2-acetoxy-4-trifluoromethylbenzoic acid and it is an aspirin chemically-related molecule but not a derivative. The benefits of this agent are the lack of action over the arachidonic acid pathway, the driven production of nitric oxide and the increase of cyclic nucleotide concentration on endothelial cells. The latest translates...
Approved
Investigational
Matched Description: … of nitric oxide and the increase of cyclic nucleotide concentration on endothelial cells. ... The benefits of this agent are the lack of action over the arachidonic acid pathway, the driven production ... [A31675] It is very important as a secondary prevention of ischemic stroke by offering a lower risk of …
Sonidegib
Sonidegib is a Hedgehog signaling pathway inhibitor (via smoothened antagonism) developed as an anticancer agent by Novartis. It was FDA approved in 2015 for the treatment of basal cell carcinoma.
Approved
Investigational
Matched Description: … It was FDA approved in 2015 for the treatment of basal cell carcinoma. …
Bendazac
Bendazac is an oxyacetic acid [A39863, A39869]. Despite possessing anti-inflammatory, anti-necrotic, choleretic, and anti-lipidemic characteristics, most research has revolved around studying and demonstrating the agent's principal action in inhibiting the denaturation of proteins - an effect that has primarily proven useful in managing and delaying the progression of ocular cataracts...
Approved
Withdrawn
Matched Description: … revolved around studying and demonstrating the agent's principal action in inhibiting the denaturation of ... proteins - an effect that has primarily proven useful in managing and delaying the progression of ocular ... risk for eliciting hepatotoxicity [A39891, A39892, A39893, L4778] in patients although a small handful of …
Ferrous ascorbate
Approved
Ferrous glycine sulfate
Approved
Fosinopril
Fosinopril is a phosphinic acid-containing ester prodrug that belongs to the angiotensin-converting enzyme (ACE) inhibitor class of medications. It is rapidly hydrolyzed to fosinoprilat, its principle active metabolite. Fosinoprilat inhibits ACE, the enzyme responsible for the conversion of angiotensin I (ATI) to angiotensin II (ATII). ATII regulates blood pressure and...
Approved
Matched Description: … heart failure, and to slow the rate of progression of renal disease in hypertensive individuals with ... acid-containing ester prodrug that belongs to the angiotensin-converting enzyme (ACE) inhibitor class of ... ATII regulates blood pressure and is a key component of the renin-angiotensin-aldosterone system (RAAS …
Ferrous fumarate
Used in treatment of iron deficiency anemia.
Approved
Matched Description: … Used in treatment of iron deficiency anemia. …
Benznidazole
Benznidazole was granted accelerated approval for the treatment of Chagas disease in children 2-12 years of age by the FDA on August 29, 2017. It is the first treatment made available in the United States for Chagas disease.
Approved
Investigational
Matched Description: … of age by the FDA on August 29, 2017. ... Benznidazole was granted accelerated approval for the treatment of Chagas disease in children 2-12 years …
Cemiplimab
Cemiplimab is a fully human monoclonal antibody that works against programmed death receptor-1 (PD-1), which is a negative regulator of T cell function. By blocking PD-1, cemiplimab works to enhance T cell-mediated antitumour responses. Cemiplimab was first approved by the FDA on September 28, 2018, as the first FDA-approved treatment...
Approved
Investigational
Matched Description: … monoclonal antibody that works against programmed death receptor-1 (PD-1), which is a negative regulator of ... Products for Human Use (CHMP) recommended cemiplimab be granted marketing authorization for the treatment of …
Tropicamide
Tropicamide is an alkaloid atropine‐derived anticholinergic drug and a non‐selective antagonist of muscarinic acetylcholine (mACh) receptors. Usually available in ophthalmic formulations, tropicamide is used to cause mydriasis and cycloplegia for eye exams or ocular procedures. It is also used in combination with hydroxyamphetamine for the same indication. Oral tropicamide has...
Approved
Investigational
Matched Description: … Tropicamide is an alkaloid atropine‐derived anticholinergic drug and a non‐selective antagonist of muscarinic …
Gelatin
Gelatin is a multifunctional ingredient that is used in foods, pharmaceuticals, cosmetics, and photographic films as a gelling agent, stabilizer, thickener, emulsifier, as well as film former. As a thermoreversible hydrocolloid with a small gap between its melting and gelling temperatures, gelatin provides unique advantages over carbohydrate-based gelling agents. Gelatin...
Approved
Vet approved
Withdrawn
Matched Description: … [L2121]
Fish skins from a number of fish species a type of substance that has been comprehensively ... Gelatin continues to be approved for other routes of administration.[L43942] ... An increasing number of novel applications have been found for collagen and gelatin. …
Dimenhydrinate
Dimehydrinate was first described in the literature in 1949, and patented in 1950. Early research into dimenhydrinate focused on its role as an antihistamine for urticaria; the treatment of motion sickness was an accidental discovery. Dimenhydrinate, also known as B-dimethylaminoethyl benzohydrol ether 8-chlorotheophyllinate, is indicated to prevent nausea, vomiting, and...
Approved
Matched Description: … Early research into dimenhydrinate focused on its role as an antihistamine for urticaria; the treatment of ... [L32980,L32985,L32995] Dimenhydrinate is a combination of [Diphenhydramine] and [8-chlorotheophylline ... antagonism of H1 histamine receptors in the vestibular system[A1540] while the excitatory effects are …
Penciclovir
Penciclovir is a synthetic acyclic guanine derivative with antiviral activity used for the treatment of various herpes simplex virus (HSV) infections. Displaying low toxicity and good selectivity, penciclovir is a nucleoside analogue.
Approved
Matched Description: … Penciclovir is a synthetic acyclic guanine derivative with antiviral activity used for the treatment of …
Dequalinium
Dequalinium is an antibacterial agent with multi-targeted actions. It also possesses antifungal, antiparasitic, antiviral, anticancer, and neuroprotective properties. It is a quaternary ammonium compound, as it consists of an amphipathic cation with two aminoquinaldinium rings at both ends of a long hydrophobic hydrocarbon chain. Due to its flexible structure, dequalinium...
Approved
Investigational
Matched Description: … two aminoquinaldinium rings at both ends of a long hydrophobic hydrocarbon chain. ... [A249255] It is a quaternary ammonium compound,[L42190] as it consists of an amphipathic cation with ... and disinfectant in the 1950s, dequalinium is still found in various OTC products to treat conditions of …
Artenimol
Artenimol is an artemisinin derivative and antimalarial agent used in the treatment of uncomplicated Plasmodium falciparum infections [FDA Label]. It was first authorized for market by the European Medicines Agency in October 2011 in combination with DB13941 as the product Eurartesim. Artemisinin combination therapy is highly effective against malaria and...
Approved
Experimental
Investigational
Matched Description: … Artenimol is an artemisinin derivative and antimalarial agent used in the treatment of uncomplicated …
Anifrolumab
Anifrolumab, or MEDI-546, is a type 1 interferon receptor (IFNAR) inhibiting IgG1κ monoclonal antibody indicated in the treatment of adults with moderate to severe systemic lupus erythematosus.[A237074,L34929] The standard therapy for systemic lupus erythematosus consists of antimalarials like hydroxychloroquine, glucocorticoids like dexamethasone, and disease modifying antirheumatic drugs like methotrexate.[A237079,L34929]
Three...
Approved
Investigational
Matched Description: … success of the trial. ... [A237054] The design of the clinical trials use different definitions of autoantibody positivity, making ... [A237054]
The design of early clinical trials of anti-interferon treatments such as anifrolumab, rontalizumab …
Casimersen
Duchenne muscular dystrophy (DMD) is an X-linked recessive allelic disorder characterized by a lack of functional dystrophin protein, which leads to progressive impairment of ambulatory, pulmonary, and cardiac function and is invariably fatal. A related, albeit a less severe, form of muscular dystrophy known as Becker muscular dystrophy (BMD) is...
Approved
Investigational
Matched Description: … Duchenne muscular dystrophy (DMD) is an X-linked recessive allelic disorder characterized by a lack of ... A related, albeit a less severe, form of muscular dystrophy known as Becker muscular dystrophy (BMD) ... functional dystrophin protein, which leads to progressive impairment of ambulatory, pulmonary, and cardiac …
Evinacumab
Evinacumab is a recombinant human IgG4 monoclonal antibody targeted against angiopoietin-like protein 3 (ANGPTL3) and the first drug of its kind. The ANGPTL family of proteins serve a number of physiologic functions - including involvement in the regulation of lipid metabolism - which have made them desirable therapeutic targets in...
Approved
Investigational
Matched Description: … The ANGPTL family of proteins serve a number of physiologic functions - including involvement in the ... provides a unique and synergistic therapeutic option in the treatment of HoFH. ... IgG4 monoclonal antibody targeted against angiopoietin-like protein 3 (ANGPTL3) and the first drug of …
Hydroxychloroquine
Hydroxychloroquine is a racemic mixture consisting of an R and S enantiomer. Hydroxychloroquine is an aminoquinoline like chloroquine. It is a commonly prescribed medication in the treatment of uncomplicated malaria, rheumatoid arthritis, chronic discoid lupus erythematosus, and systemic lupus erythematosus. Hydroxychloroquine is also used for the prophylaxis of malaria in...
Approved
Matched Description: … Hydroxychloroquine is a racemic mixture consisting of an R and S enantiomer. ... [L8072] It is a commonly prescribed medication in the treatment of uncomplicated malaria, rheumatoid ... [A183092] Chloroquine and hydroxychloroquine are both being investigated for the treatment of SARS-CoV …
Gemcitabine
Gemcitabine is a nucleoside analog and a chemotherapeutic agent. It was originally investigated for its antiviral effects, but it is now used as an anticancer therapy for various cancers. Gemcitabine is a cytidine analog with two fluorine atoms replacing the hydroxyl on the ribose. As a prodrug, gemcitabine is transformed...
Approved
Matched Description: … [L32960] The structure, metabolism, and mechanism of action of gemcitabine are similar to [cytarabine ... ], but gemcitabine has a wider spectrum of antitumour activity. ... , gemcitabine is transformed into its active metabolites that work by replacing the building blocks of …
Cefdinir
Cefdinir, also known as Omnicef, is a semi-synthetic, broad-spectrum antibiotic belonging to the third generation of the cephalosporin class. It has been proven to be effective for the treatment of common bacterial infections in the ear, sinus, throat, lungs, and skin. Cefdinir was approved by the FDA in 1997 to...
Approved
Matched Description: … first-line cephalosporin therapy due to the production of beta-lactamase enzymes. ... known as Omnicef, is a semi-synthetic, broad-spectrum antibiotic belonging to the third generation of ... It has been proven to be effective for the treatment of common bacterial infections in the ear, sinus …
Mecasermin
Mecasermin contains recombinant-DNA-engineered human insulin-like growth factor-1 (rhIGF-1)[FDA Label]. IGF-1 consists of 70 amino acids in a single chain with three intramolecular disulfide bridges and a molecular weight of 7649 daltons. The amino acid sequence of the product is identical to that of endogenous human IGF-1. The rhIGF-1 protein is...
Approved
Investigational
Matched Description: … The amino acid sequence of the product is identical to that of endogenous human IGF-1. ... molecular weight of 7649 daltons. ... IGF-1 consists of 70 amino acids in a single chain with three intramolecular disulfide bridges and a …
Calfactant
Calfactant is a sterile, non-pyrogenic lung surfactant intended for intratracheal instillation. It is an off-white suspension of an extract of natural surfactant from calf lungs suspended in 0.9% saline. Each milliliter of calfactant contains 35mg of phospholipids (including 26 mg phosphatidylcholine of which 16 mg is disaturated phosphatidylcholine) and 0.65mg...
Approved
Matched Description: … Each milliliter of calfactant contains 35mg of phospholipids (including 26 mg phosphatidylcholine of ... It is an off-white suspension of an extract of natural surfactant from calf lungs suspended in 0.9% saline ... Calfactant is approved for use in the United States of America. …
Displaying drugs 501 - 525 of 8039 in total