Displaying drugs 526 - 550 of 13915 in total
Elapegademase
Elapegademase is a PEGylated recombinant adenosine deaminase. It can be defined molecularly as a genetically modified bovine adenosine deaminase with a modification in cysteine 74 for serine and with about 13 methoxy polyethylene glycol chains bound via carbonyl group in alanine and lysine residues. Elapegademase is generated in E. coli,...
Approved
Matched Synonyms: … (74-SERINE (C>S),245-THREONINE (A>T))BOS TAURUS ADENOSINE DEAMINASE (BOVINE ADENOSINE AMINOHYDROLASE, …
Matched Description: … It can be defined molecularly as a genetically modified bovine adenosine deaminase with a modification ... Elapegademase is a PEGylated recombinant adenosine deaminase. …
Matched Description: … It can be defined molecularly as a genetically modified bovine adenosine deaminase with a modification ... Elapegademase is a PEGylated recombinant adenosine deaminase. …
Azatadine
Antihistamines such as azatadine appear to compete with histamine for histamine H1- receptor sites on effector cells. The antihistamines antagonize those pharmacological effects of histamine which are mediated through activation of H1- receptor sites and thereby reduce the intensity of allergic reactions and tissue injury response involving histamine release.
Approved
Matched Iupac: … 2-(1-methylpiperidin-4-ylidene)-4-azatricyclo[9.4.0.0^{3,8}]pentadeca-1(15),3(8),4,6,11,13-hexaene …
Choriogonadotropin alfa
Recombinant human chorionic gonadotropin with 2 subunits, alpha = 92 residues, beta = 145 residues, each with N-and O-linked carbohydrate moieties linked to ASN-52 and ASN-78 (on alpha subunit) and ASN-13, ASN-30, SER-121, SER-127, SER-132 and SER-138 (on beta subunit). The primary structure of the alpha-chain of r-hCG is identical...
Approved
Matched Description: … Recombinant human chorionic gonadotropin with 2 subunits, alpha = 92 residues, beta = 145 residues, each …
Nilutamide
Nilutamide is an antineoplastic hormonal agent primarily used in the treatment of prostate cancer. Nilutamide is a pure, nonsteroidal anti-androgen with affinity for androgen receptors (but not for progestogen, estrogen, or glucocorticoid receptors). Consequently, Nilutamide blocks the action of androgens of adrenal and testicular origin that stimulate the growth of...
Approved
Investigational
Matched Description: … Nilutamide is a pure, nonsteroidal anti-androgen with affinity for androgen receptors (but not for progestogen …
Propantheline
A muscarinic antagonist used as an antispasmodic, in rhinitis, in urinary incontinence, and in the treatment of ulcers. At high doses it has nicotinic effects resulting in neuromuscular blocking.
Approved
Matched Iupac: … methylbis(propan-2-yl)[2-(9H-xanthene-9-carbonyloxy)ethyl]azanium …
Matched Description: … A muscarinic antagonist used as an antispasmodic, in rhinitis, in urinary incontinence, and in the treatment …
Matched Description: … A muscarinic antagonist used as an antispasmodic, in rhinitis, in urinary incontinence, and in the treatment …
Conestat alfa
C1 Esterase Inhibitor (Recombinant) is a recombinant analogue of endogenous complement component-1 esterase inhibitor (rhC1INH), purified from the milk of transgenic rabbits. The primary function of endogenous C1INH is to regulate the activation of the complement and contact system pathways. It does this through inhibition of several target proteases within...
Approved
Investigational
Matched Description: … C1 Esterase Inhibitor (Recombinant) is a recombinant analogue of endogenous complement component-1 esterase …
Varenicline
Varenicline is a prescription medication used to treat smoking addiction. This medication is the first approved nicotinic receptor partial agonist. Specifically, varenicline is a partial agonist of the alpha4/beta2 subtype of the nicotinic acetylcholine receptor. In addition it acts on alpha3/beta4 and weakly on alpha3beta2 and alpha6-containing receptors. A full...
Approved
Investigational
Matched Iupac: … 5,8,14-triazatetracyclo[10.3.1.0^{2,11}.0^{4,9}]hexadeca-2(11),3,5,7,9-pentaene …
Matched Description: … Varenicline is a prescription medication used to treat smoking addiction. ... A full agonism was displayed on alpha7-receptors. On March 9, 2015, the U.S. ... Specifically, varenicline is a partial agonist of the alpha4/beta2 subtype of the nicotinic acetylcholine …
Matched Categories: … Heterocyclic Compounds, 2-Ring …
Matched Description: … Varenicline is a prescription medication used to treat smoking addiction. ... A full agonism was displayed on alpha7-receptors. On March 9, 2015, the U.S. ... Specifically, varenicline is a partial agonist of the alpha4/beta2 subtype of the nicotinic acetylcholine …
Matched Categories: … Heterocyclic Compounds, 2-Ring …
Acetyldigitoxin
Cardioactive derivative of lanatoside A or of digitoxin used for fast digitalization in congestive heart failure.
Approved
Matched Synonyms: … Desglucolanatoside A …
Matched Iupac: … 9aS,9bS,11aR)-3a-hydroxy-9a,11a-dimethyl-1-(5-oxo-2,5-dihydrofuran-3-yl)-hexadecahydro-1H-cyclopenta[a] ... phenanthren-7-yl]oxy}-4-hydroxy-2-methyloxan-3-yl]oxy}-4-hydroxy-2-methyloxan-3-yl]oxy}-3-hydroxy-2-methyloxan …
Matched Description: … Cardioactive derivative of lanatoside A or of digitoxin used for fast digitalization in congestive heart …
Matched Categories: … Compounds used in a research, industrial, or household setting …
Matched Iupac: … 9aS,9bS,11aR)-3a-hydroxy-9a,11a-dimethyl-1-(5-oxo-2,5-dihydrofuran-3-yl)-hexadecahydro-1H-cyclopenta[a] ... phenanthren-7-yl]oxy}-4-hydroxy-2-methyloxan-3-yl]oxy}-4-hydroxy-2-methyloxan-3-yl]oxy}-3-hydroxy-2-methyloxan …
Matched Description: … Cardioactive derivative of lanatoside A or of digitoxin used for fast digitalization in congestive heart …
Matched Categories: … Compounds used in a research, industrial, or household setting …
Lesinurad
Lesinurad is an oral uric acid transporter 1 (URAT1) inhibitor indicated for the treatment of hyperuricemia associated with gout. It reduces serum uric acid concentration through the inhibition of URAT1, an enzyme responsible for reuptake of uric acid from the renal tubule, and OAT4, another uric acid transporter associated with...
Approved
Investigational
Matched Iupac: … 2-{[5-bromo-4-(4-cyclopropylnaphthalen-1-yl)-4H-1,2,4-triazol-3-yl]sulfanyl}acetic acid …
Matched Description: … In August 2017, a combination oral therapy consisting of lesinurad and [DB00437] was FDA-approved under ... Marketed as the product Zurampic, it is indicated for use in combination with a xanthine oxidase inhibitor ... hyperuricemia associated with gout in patients who have not achieved target serum uric acid levels with a …
Matched Description: … In August 2017, a combination oral therapy consisting of lesinurad and [DB00437] was FDA-approved under ... Marketed as the product Zurampic, it is indicated for use in combination with a xanthine oxidase inhibitor ... hyperuricemia associated with gout in patients who have not achieved target serum uric acid levels with a …
Influenza A virus A/California/7/2009 X-179A (H1N1) antigen (formaldehyde inactivated)
A seasonally-specific component of the influenza vaccine. The influenza vaccine, also known as the "flu shot", is a vaccine that protects against infection from the influenza viruses. Vaccines provide protection from influenza by exposing the immune system to the virus (or parts of the virus) which stimulates an immunological defence...
Approved
Investigational
Matched Name: … Influenza A virus A/California/7/2009 X-179A (H1N1) antigen (formaldehyde inactivated) …
Matched Description: … A seasonally-specific component of the influenza vaccine. ... The influenza vaccine, also known as the "flu shot", is a vaccine that protects against infection from ... Inactivated vaccines contain a virus particle that has been grown in media and then subsequently killed …
Matched Description: … A seasonally-specific component of the influenza vaccine. ... The influenza vaccine, also known as the "flu shot", is a vaccine that protects against infection from ... Inactivated vaccines contain a virus particle that has been grown in media and then subsequently killed …
Methacholine
Asthma is a complex condition associated with phenomena such as airway hyperresponsiveness (AHR), in which the smooth muscle in the airways (ASM) excessively contracts in response to stimuli, reducing pulmonary function and causing symptoms such as difficulty breathing.[A229598, A229603] Although the underlying pathology of AHR is complex, ASM contraction can...
Approved
Investigational
Matched Iupac: … [2-(acetyloxy)propyl]trimethylazanium …
Matched Description: … Asthma is a complex condition associated with phenomena such as airway hyperresponsiveness (AHR), in ... [A229603, A229618, A229643] Methacholine is a non-specific cholinergic agonist (parasympathomimetic) ... [L31763] In patients with AHR, a lower dose of methacholine is required to induce bronchoconstriction …
Matched Description: … Asthma is a complex condition associated with phenomena such as airway hyperresponsiveness (AHR), in ... [A229603, A229618, A229643] Methacholine is a non-specific cholinergic agonist (parasympathomimetic) ... [L31763] In patients with AHR, a lower dose of methacholine is required to induce bronchoconstriction …
Troglitazone
Troglitazone was withdrawn in 2000 due to risk of hepatotoxicity. It was superseded by pioglitazone and rosiglitazone.
Approved
Investigational
Withdrawn
Matched Iupac: … 5-({4-[(6-hydroxy-2,5,7,8-tetramethyl-3,4-dihydro-2H-1-benzopyran-2-yl)methoxy]phenyl}methyl)-1,3-thiazolidine …
Matched Categories: … Heterocyclic Compounds, 2-Ring …
Matched Categories: … Heterocyclic Compounds, 2-Ring …
Influenza A virus A/Switzerland/9715293/2013 NIB-88 (H3N2) hemagglutinin antigen (UV, formaldehyde inactivated)
A seasonally-specific component of the influenza vaccine. The influenza vaccine, also known as the "flu shot", is a vaccine that protects against infection from the influenza viruses. Vaccines provide protection from influenza by exposing the immune system to the virus (or parts of the virus) which stimulates an immunological defence...
Approved
Matched Name: … Influenza A virus A/Switzerland/9715293/2013 NIB-88 (H3N2) hemagglutinin antigen (UV, formaldehyde inactivated …
Matched Description: … A seasonally-specific component of the influenza vaccine. ... The influenza vaccine, also known as the "flu shot", is a vaccine that protects against infection from ... Inactivated vaccines contain a virus particle that has been grown in media and then subsequently killed …
Matched Description: … A seasonally-specific component of the influenza vaccine. ... The influenza vaccine, also known as the "flu shot", is a vaccine that protects against infection from ... Inactivated vaccines contain a virus particle that has been grown in media and then subsequently killed …
Fruquintinib
Fruquintinib is a novel small-molecule anti-VEGFR that targets VEGFR-1,-2, and -3 to inhibit angiogenesis. Tumor angiogenesis is one of the most critical biological processes for increasing oxygen and nutrient supply to cancer cells, and the VEGF/VEGFR pathway is one of the most critical pathways for this phenomenon.[A262102,A262107] Indeed, oncogenic activation,...
Approved
Investigational
Matched Iupac: … 6-[(6,7-dimethoxyquinazolin-4-yl)oxy]-N,2-dimethyl-1-benzofuran-3-carboxamide …
Matched Description: … Fruquintinib is a novel small-molecule anti-VEGFR that targets VEGFR-1,-2, and -3 to inhibit angiogenesis ... The first approach can be exemplified by [bevacizumab], a VEGF-A trap antibody. ... Therefore, the advent of fruquintinib, a new generation of VEGFR inhibitors with a high kinome selectivity …
Matched Categories: … Heterocyclic Compounds, 2-Ring …
Matched Description: … Fruquintinib is a novel small-molecule anti-VEGFR that targets VEGFR-1,-2, and -3 to inhibit angiogenesis ... The first approach can be exemplified by [bevacizumab], a VEGF-A trap antibody. ... Therefore, the advent of fruquintinib, a new generation of VEGFR inhibitors with a high kinome selectivity …
Matched Categories: … Heterocyclic Compounds, 2-Ring …
Chikungunya vaccine (live, attenuated)
Chikungunya virus (CHIKV) is a member of the Alphavirus genus that was first identified in Tanzania in 1952. It is spread primarily by the bite of infected mosquitos of the Aedes genus. Infection with CHIKV causes chikungunya fever, an illness characterized by acute fever and severe, persistent arthralgia. Prior to...
Approved
Matched Description: … Chikungunya virus (CHIKV) is a member of the Alphavirus genus that was first identified in Tanzania in …
Hydralazine
Originally developed in the 1950s as a malaria treatment, hydralazine showed antihypertensive ability and was soon repurposed. Hydralazine is a hydrazine derivative vasodilator used alone or as adjunct therapy in the treatment of hypertension and only as adjunct therapy in the treatment of heart failure.[A186820,L8782,L8785] Hydralazine is no longer a...
Approved
Matched Description: … Originally developed in the 1950s as a malaria treatment, hydralazine showed antihypertensive ability ... [A186841] Hydralazine is a hydrazine derivative vasodilator used alone or as adjunct therapy in the treatment ... [A186820,L8782,L8785] Hydralazine is no longer a first line therapy for these indications since the development …
Nabilone
Nabilone (marketed as Cesamet) is a synthetic form of delta-9-tetrahydrocannabinol (Δ⁹-THC), the primary psychoactive component of cannabis (marijuana). Although structurally distinct from THC, nabilone mimics THC's structure and pharmacological activity through weak partial agonist activity at Cannabinoid-1 (CB1R) and Cannabinoid-2 (CB2R) receptors, however it is considered to be twice as...
Approved
Investigational
Matched Iupac: … (6aR,10aR)-1-hydroxy-6,6-dimethyl-3-(2-methyloctan-2-yl)-6H,6aH,7H,8H,9H,10H,10aH-benzo[c]isochromen- …
Matched Description: … pharmacological activity through weak partial agonist activity at Cannabinoid-1 (CB1R) and Cannabinoid-2 ... for such a wide variety of medical conditions. ... Nabilone is a racemate consisting of the (S,S) and the (R,R) isomers. …
Matched Description: … pharmacological activity through weak partial agonist activity at Cannabinoid-1 (CB1R) and Cannabinoid-2 ... for such a wide variety of medical conditions. ... Nabilone is a racemate consisting of the (S,S) and the (R,R) isomers. …
Laropiprant
Laropiprant is an ingredient in the EMA-withdrawn product Pelzont.
Approved
Investigational
Withdrawn
Matched Iupac: … 2-[(3R)-4-[(4-chlorophenyl)methyl]-7-fluoro-5-methanesulfonyl-1H,2H,3H,4H-cyclopenta[b]indol-3-yl]acetic …
Matched Categories: … Heterocyclic Compounds, 2-Ring …
Matched Categories: … Heterocyclic Compounds, 2-Ring …
Masoprocol
A potent lipoxygenase inhibitor that interferes with arachidonic acid metabolism. The compound also inhibits formyltetrahydrofolate synthetase, carboxylesterase, and cyclooxygenase to a lesser extent. It also serves as an antioxidant in fats and oils. [PubChem]
Approved
Investigational
Matched Description: … A potent lipoxygenase inhibitor that interferes with arachidonic acid metabolism. ... The compound also inhibits formyltetrahydrofolate synthetase, carboxylesterase, and cyclooxygenase to a …
Matched Categories: … Compounds used in a research, industrial, or household setting …
Matched Categories: … Compounds used in a research, industrial, or household setting …
Bisphenol A diglycidyl ether
Approved
Experimental
Matched Synonyms: … Diglycidyl bisphenol A ether …
Matched Name: … Bisphenol A diglycidyl ether …
Matched Iupac: … 2-{[4-(2-{4-[(oxiran-2-yl)methoxy]phenyl}propan-2-yl)phenoxy]methyl}oxirane …
Matched Name: … Bisphenol A diglycidyl ether …
Matched Iupac: … 2-{[4-(2-{4-[(oxiran-2-yl)methoxy]phenyl}propan-2-yl)phenoxy]methyl}oxirane …
Desonide
A nonfluorinated corticosteroid anti-inflammatory agent used topically for dermatoses.
Approved
Investigational
Matched Iupac: … (1S,2S,4R,8S,9S,11S,12S,13R)-11-hydroxy-8-(2-hydroxyacetyl)-6,6,9,13-tetramethyl-5,7-dioxapentacyclo[ …
Matched Description: … A nonfluorinated corticosteroid anti-inflammatory agent used topically for dermatoses. …
Matched Mixtures name: … PRECORT-A KREM ... PRECORT-A POMAD ... PREDNOL-A 30 GR KREM …
Matched Description: … A nonfluorinated corticosteroid anti-inflammatory agent used topically for dermatoses. …
Matched Mixtures name: … PRECORT-A KREM ... PRECORT-A POMAD ... PREDNOL-A 30 GR KREM …
Magnesium trisilicate
Magnesium trisilicate is an inorganic compound that is used as an antacid in the treatment of peptic ulcers.
Approved
Matched Iupac: … dimagnesium(2+) ion {[dioxido({[oxido(oxo)silyl]oxy})silyl]oxy}silanoylolate …
Matched Salts cas: … 39365-87-2 …
Matched Mixtures name: … แม๊ก 2 ... Mag-A-folic Tab …
Matched Salts cas: … 39365-87-2 …
Matched Mixtures name: … แม๊ก 2 ... Mag-A-folic Tab …
Abemaciclib
Abemaciclib is an antitumor agent and dual inhibitor of cyclin-dependent kinases 4 (CDK4) and 6 (CDK6) that are involved in the cell cycle and promotion of cancer cell growth in case of unregulated activity. On September 28, 2017, FDA granted approval of abemaciclib treatment under the market name Verzenio for...
Approved
Investigational
Matched Iupac: … N-{5-[(4-ethylpiperazin-1-yl)methyl]pyridin-2-yl}-5-fluoro-4-[4-fluoro-2-methyl-1-(propan-2-yl)-1H-1,3 ... -benzodiazol-6-yl]pyrimidin-2-amine …
Matched Categories: … MATE 2 Inhibitors ... Heterocyclic Compounds, 2-Ring ... MATE 1 Substrates with a Narrow Therapeutic Index ... P-glycoprotein substrates with a Narrow Therapeutic Index ... Cytochrome P-450 CYP3A4 Substrates with a Narrow Therapeutic Index …
Matched Categories: … MATE 2 Inhibitors ... Heterocyclic Compounds, 2-Ring ... MATE 1 Substrates with a Narrow Therapeutic Index ... P-glycoprotein substrates with a Narrow Therapeutic Index ... Cytochrome P-450 CYP3A4 Substrates with a Narrow Therapeutic Index …
Nebivolol
Nebivolol is a racemic mixture of 2 enantiomers where one is a beta adrenergic antagonist and the other acts as a cardiac stimulant without beta adrenergic activity. Treatment with nebivolol leads to a greater decrease in systolic and diastolic blood pressure than atenolol, propranolol, or pindolol. Nebivolol and other beta...
Approved
Investigational
Matched Iupac: … 1-(6-fluoro-3,4-dihydro-2H-1-benzopyran-2-yl)-2-{[2-(6-fluoro-3,4-dihydro-2H-1-benzopyran-2-yl)-2-hydroxyethyl …
Matched Description: … Nebivolol is a racemic mixture of 2 enantiomers where one is a beta adrenergic antagonist and the other ... acts as a cardiac stimulant without beta adrenergic activity. ... [A182579] Treatment with nebivolol leads to a greater decrease in systolic and diastolic blood pressure …
Matched Categories: … Heterocyclic Compounds, 2-Ring …
Matched Description: … Nebivolol is a racemic mixture of 2 enantiomers where one is a beta adrenergic antagonist and the other ... acts as a cardiac stimulant without beta adrenergic activity. ... [A182579] Treatment with nebivolol leads to a greater decrease in systolic and diastolic blood pressure …
Matched Categories: … Heterocyclic Compounds, 2-Ring …
Influenza A virus A/Brisbane/02/2018 (H1N1) recombinant hemagglutinin antigen
A seasonally-specific component of the influenza vaccine. The influenza vaccine, also known as the "flu shot", is a vaccine that protects against infection from the influenza viruses. Vaccines provide protection from influenza by exposing the immune system to the virus (or parts of the virus) which stimulates an immunological defence...
Approved
Matched Name: … Influenza A virus A/Brisbane/02/2018 (H1N1) recombinant hemagglutinin antigen …
Matched Description: … A seasonally-specific component of the influenza vaccine. ... The influenza vaccine, also known as the "flu shot", is a vaccine that protects against infection from ... Inactivated vaccines contain a virus particle that has been grown in media and then subsequently killed …
Matched Description: … A seasonally-specific component of the influenza vaccine. ... The influenza vaccine, also known as the "flu shot", is a vaccine that protects against infection from ... Inactivated vaccines contain a virus particle that has been grown in media and then subsequently killed …
Displaying drugs 526 - 550 of 13915 in total