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Displaying drugs 701 - 725 of 1846 in total
An inhibitor of members of the Bcl‑2 family of apoptosis regulators.
Investigational
Matched Synonyms: … -1-((phenylthio)methyl)propyl)amino)-3-nitrophenyl)sulfonyl)- ... Benzamide, 4-(4-((4'-chloro(1,1'-biphenyl)-2-yl)methyl)-1-piperazinyl)-n-((4-(((1r)-3-(dimethylamino) …
Matched Iupac: … 4-[4-({4'-chloro-[1,1'-biphenyl]-2-yl}methyl)piperazin-1-yl]-N-(4-{[(2R)-4-(dimethylamino)-1-(phenylsulfanyl …
Rosiglitazone is an anti-diabetic drug in the thiazolidinedione class of drugs. It is marketed by the pharmaceutical company GlaxoSmithKline as a stand-alone drug (Avandia) and in combination with metformin (Avandamet) or with glimepiride (Avandaryl). Like other thiazolidinediones, the mechanism of action of rosiglitazone is by activation of the intracellular receptor...
Approved
Investigational
Matched Synonyms: … (±)-5-[p-[2-(methyl-2-pyridylamino)ethoxy]benzyl]-2,4-thiazolidinedione ... (RS)-5-{4-[2-(Methyl-2-pyridylamino)ethoxy]benzyl}-2,4-thiazolidinedion …
Matched Iupac: … 5-[(4-{2-[methyl(pyridin-2-yl)amino]ethoxy}phenyl)methyl]-1,3-thiazolidine-2,4-dione …
Matched Description: … Rosiglitazone is a selective ligand of PPARγ, and has no PPARα-binding action. ... It is marketed by the pharmaceutical company GlaxoSmithKline as a stand-alone drug (Avandia) and in combination ... resistance, it appears to have an anti-inflammatory effect: nuclear factor kappa-B (NFκB) levels fall and
Matched Salts cas: … 155141-29-0 …
Matched Categories: … Alimentary Tract and Metabolism ... metformin and rosiglitazone ... glimepiride and rosiglitazone …
Investigational
Matched Synonyms: … 1,3-benzenedisulfonic acid, 4-(((1,1-dimethylethyl)oxidoimino)methyl)- ... 4-(((1,1-dimethylethyl)imino)methyl)benzene-1,3-disulfonate n-oxide ... 4-(((1,1-dimethylethyl)imino)methyl)benzene-1,3-disulphonate n-oxide …
Experimental
Matched Name: … N-Methyl-Pyridoxal-5'-Phosphate …
Matched Iupac: … 4-formyl-3-hydroxy-1,2-dimethyl-5-[(phosphonooxy)methyl]pyridin-1-ium …
Experimental
Matched Name: … 3-Fluoro-2-Methyl-Aniline …
Experimental
Matched Synonyms: … S-Methyl-5'-thioadenosine ... 9-(5-S-methyl-5-thio-β-D-ribofuranosyl)-9H-purin-6-amine …
Matched Name: … 5'-S-methyl-5'-thioadenosine …
Matched Iupac: … (2R,3R,4S,5S)-2-(6-amino-9H-purin-9-yl)-5-[(methylsulfanyl)methyl]oxolane-3,4-diol …
Matched Categories: … Amino Acids, Peptides, and Proteins ... Nucleic Acids, Nucleotides, and Nucleosides …
Experimental
Matched Name: … 3,5,6,8-Tetramethyl-N-Methyl Phenanthrolinium …
Experimental
Matched Name: … [[N-(Benzyloxycarbonyl)Amino]Methyl]Phosphate …
Matched Iupac: … ({[(benzyloxy)carbonyl]amino}methyl)phosphonic acid …
Experimental
Matched Name: … 4-Methyl-5-Hydroxyethylthiazole Phosphate …
Matched Iupac: … [2-(4-methyl-1,3-thiazol-5-yl)ethoxy]phosphonic acid …
Experimental
Matched Name: … Pterin-6-Yl-Methyl-Monophosphate …
Experimental
Matched Name: … 3,4-Dihydro-5-Methyl-Isoquinolinone …
Matched Iupac: … 5-methyl-1,2,3,4-tetrahydroisoquinolin-1-one …
Experimental
Matched Name: … N-Methyl-N-(Methylbenzyl)Formamide …
Matched Iupac: … N-methyl-N-[(1S)-1-phenylethyl]formamide …
Experimental
Matched Name: … S-METHYL-4,5,6,7-TETRABROMO-BENZIMIDAZOLE …
Levomefolic acid (INN) is the metabolite of folic acid (Vitamin B9) and it is a predominant active form of folate found in foods and in the blood circulation, accounting for 98% of folates in human plasma . It is transported across the membranes including the blood-brain barrier into various tissues...
Approved
Investigational
Matched Synonyms: … 5-methyl-(6S)-tetrahydrofolic acid ... N-[4-[[[(6S)-2-Amino-3,4,5,6,7,8-hexahydro-5-methyl-4-oxo-6-pteridinyl]methyl]amino]benzoyl]-L-glutamic …
Matched Iupac: … (2S)-2-{[4-({[(6S)-2-amino-5-methyl-4-oxo-1,4,5,6,7,8-hexahydropteridin-6-yl]methyl}amino)phenyl]formamido …
Matched Description: … regulation of homocysteine, where it methylates homocysteine and forms methionine and tetrahydrofolate ... Levomefolic acid (INN) is the metabolite of folic acid (Vitamin B9) and it is a predominant active form ... of folate found in foods and in the blood circulation, accounting for 98% of folates in human plasma …
Matched Mixtures name: … L-Methyl-B6-B12 ... L-Methyl MC ... L-Methyl MC NAC …
Matched Categories: … Enzymes and Coenzymes ... Folic Acid and Derivatives ... Amino Acids, Peptides, and Proteins …
Fimepinostat (CUDC-907) has been used in trials studying the treatment of lymphoma, solid tumors, breast cancer, multiple myeloma, and NUT midline carcinoma, among others.
Investigational
Matched Synonyms: … N-hydroxy-2-(((2-(6-methoxypyridin-3-yl)-4-morpholinothieno[3,2-d]pyrimidin-6-yl)methyl)(methyl)amino ... pyrimidinecarboxamide, N-hydroxy-2-[[[2-(6-methoxy-3-pyridinyl)-4-(4-morpholinyl)thieno[3,2-d]pyrimidin-6-yl]methyl
Matched Iupac: … N-hydroxy-2-({[2-(6-methoxypyridin-3-yl)-4-(morpholin-4-yl)thieno[3,2-d]pyrimidin-6-yl]methyl}(methyl
Matched Description: … been used in trials studying the treatment of lymphoma, solid tumors, breast cancer, multiple myeloma, and
Sulindac is a nonsteroidal anti-inflammatory drug (NSAID) of the arylalkanoic acid class that is marketed by Merck under the brand name Clinoril. Like other NSAIDs, it may be used in the treatment of acute or chronic inflammatory conditions. Sulindac is a prodrug, derived from sulfinylindene, that is converted in vivo...
Approved
Investigational
Matched Synonyms: … cis-5-Fluoro-2-methyl-1-((p-methylsulfinyl)benzylidene)indene-3-acetic acid ... (Z)-5-Fluoro-2-methyl-1-((p-(methylsulfinyl)phenyl)methylene)-1H-indene-3-acetic acid ... cis-5-Fluoro-2-methyl-1-((4-(methylsulfinyl)phenyl)methylene)-1H-indene-3-acetic acid …
Matched Iupac: … 2-[(1Z)-5-fluoro-1-[(4-methanesulfinylphenyl)methylidene]-2-methyl-1H-inden-3-yl]acetic acid …
Matched Description: … is thought to primarily mediate its action by inhibiting prostaglandin synthesis by inhibiting COX-1 and ... levels of the compound without inducing gastrointestinal effects, where the drug is excreted in the bile and
Matched Categories: … Acetic Acid Derivatives and Related Substances ... Antiinflammatory and Antirheumatic Products ... Antiinflammatory and Antirheumatic Products, Non-Steroids …
Indopan (alpha-methyltryptamine) is a stimulant and psychoactive drug which produces effects similar to 3,4-methylenedioxy-N-methylamphetamine (MDMA), despite being structurally dissimilar. It was developed in the 1960's by Upjohn with the intention for use as an antidepressant. In the 1990's, indopan became regulated as a Schedule I controlled substance in the United...
Experimental
Illicit
Matched Synonyms: … α-Methyl-3-indoleethanamine ... alpha-Methyl-1H-indole-3-ethanamine ... alpha-Methyl-beta-indoleethylamine …
Matched Description: … Indopan (alpha-methyltryptamine) is a stimulant and psychoactive drug which produces effects similar …
At low concentrations, this compound inhibits reduction of conventional hydrophilic electron acceptors, probably acting as a plastoquinone antagonist. At higher concentrations, it acts as an electron acceptor, intercepting electrons either before or at the site of its inhibitory activity. [PubChem]
Experimental
Matched Synonyms: … 2,5-dibromo-3-isopropyl-6-methyl-1,4-benzoquinone ... 2,5-dibromo-3-methyl-6-(1-methylethyl)-2,5-cyclohexadiene-1,4-dione ... 2,5-dibromo-3-methyl-6-(1-methylethyl)cyclohexa-2,5-diene-1,4-dione …
Matched Iupac: … 2,5-dibromo-3-methyl-6-(propan-2-yl)cyclohexa-2,5-diene-1,4-dione …
Rivanicline (TC-2403, RJR-2403, (E)-metanicotine) is a partial agonist at neuronal nicotinic acetylcholine receptors, binding primarily to the α4β2 subtype. It was originally developed as a potential treatment for Alzheimer's disease for its nootropic effects but has also been found to inhibit the production of Interleukin-8. It has subsequently been developed...
Investigational
Matched Synonyms: … (3E)-N-methyl-4-(pyridin-3-yl)but-3-en-1-amine ... (E)-N-Methyl-4-(3-pyridinyl)-3-butene-1-amine ... N-methyl-4-(3-pyridinyl)-(3E)-3-buten-1-amine …
Matched Iupac: … methyl[(3E)-4-(pyridin-3-yl)but-3-en-1-yl]amine …
Matched Description: … Rivanicline also has stimulant and analgesic actions which are thought due to increased noradrenaline …
Docetaxel is a clinically well established anti-mitotic chemotherapy medication used for the treatment of different types of cancer, including breast, ovarian, and non-small cell lung cancer. Docetaxel is a complex diterpenoid molecule and a semisynthetic analogue of paclitaxel.[A259676,L46466] Docetaxel reversibly binds to microtubulin with high affinity in a 1:1 stoichiometric...
Approved
Investigational
Matched Description: … Docetaxel is a complex diterpenoid molecule and a semisynthetic analogue of [paclitaxel]. ... chemotherapy medication used for the treatment of different types of cancer, including breast, ovarian, and ... microtubulin with high affinity in a 1:1 stoichiometric ratio, allowing it to prevent cell division and
Matched Categories: … Antineoplastic and Immunomodulating Agents …
Matched Products: … Oncotaxel Concentrate and solvent for solution for infusion 40 mg/ ml …
Investigational
Matched Synonyms: … 2'-Fluoro-5-methyl-beta-L-arabinofuranosyluracil …
Matched Iupac: … 1-[(2S,3R,4S,5S)-3-fluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-methyl-1,2,3,4-tetrahydropyrimidine …
Matched Categories: … Nucleic Acids, Nucleotides, and Nucleosides ... Nucleoside and Nucleotide Reverse Transcriptase Inhibitors …
Despite the introduction of using cocaine injections for regional anesthesia in 1884, non-addictive substitutes were sought after immediately . Finally, in 1903 the world's first synthetic and non-addictive local anesthetic, amylocaine, was synthesized and patented under the name Forneaucaine by Ernest Fourneau at the Pasteur Institute . Elsewhere in English...
Approved
Withdrawn
Matched Synonyms: … 1-(Dimethylamino)-2-methyl-2-butanol benzoate …
Matched Description: … and prilocaine in the 1940s and 1950s superseded and made the use of amylocaine obsolete. ... and patented under the name Forneaucaine by Ernest Fourneau at the Pasteur Institute [L1882]. ... Finally, in 1903 the world's first synthetic and non-addictive local anesthetic, amylocaine, was synthesized …
Nintedanib is a small molecule kinase inhibitor used in the treatment of pulmonary fibrosis, systemic sclerosis-associated interstitial lung disease, and non-small cell lung cancer (NSCLC).[L8453,L8459] It was first approved for use in the United States in 2014. Within the spectrum of idiopathic pulmonary fibrosis treatment options, nintedanib is currently one...
Approved
Matched Synonyms: … methyl (3Z)-3-[(4-{methyl[(4-methylpiperazin-1-yl)acetyl]amino}anilino)(phenyl)methylidene]-2-oxo-2,3 …
Matched Iupac: … methyl (3Z)-3-[({4-[N-methyl-2-(4-methylpiperazin-1-yl)acetamido]phenyl}amino)(phenyl)methylidene]-2- …
Matched Description: … used in the treatment of pulmonary fibrosis, systemic sclerosis-associated interstitial lung disease, and ... indicated for the condition (the other being [Pirfenidone]) and as such is used as a first-line treatment ... fibrosis treatment options, nintedanib is currently one of only two disease-modifying therapies available and
Matched Categories: … Antineoplastic and Immunomodulating Agents …
Investigational
Matched Synonyms: … 2-propenethioamide, 3-(2-bromo-3,4-dihydroxyphenyl)-n-((3,4,5-trihydroxyphenyl)methyl)- ... 2-propenethioamide, 3-(2-bromo-3,4-dihydroxyphenyl)-n-((3,4,5-trihydroxyphenyl)methyl)-, (2e)- …
Matched Iupac: … (2E)-3-(2-bromo-3,4-dihydroxyphenyl)-N-[(3,4,5-trihydroxyphenyl)methyl]prop-2-enethioamide …
Investigational
Matched Synonyms: … 2-{2,6-Dichloro-3-[(2,2-dimethyl-propionylamino)-methyl]-phenylamino}-6-(2,2-difluoroethoxy)-1-methyl
Matched Iupac: … 2-({2,6-dichloro-3-[(2,2-dimethylpropanamido)methyl]phenyl}amino)-6-(2,2-difluoroethoxy)-1-methyl-N-[ …
Displaying drugs 701 - 725 of 1846 in total