Displaying drugs 51 - 75 of 2654 in total
Abatacept
Abatacept is a soluble fusion protein, which links the extracellular domain of human cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4) to the modified Fc (hinge, CH2, and CH3 domains) portion of human immunoglobulin G1 (IgG1).[L20504,L42715] Structurally, abatacept is a glycosylated fusion protein with a MALDI-MS molecular weight of 92,300 Da and it...
Approved
Matched Synonyms: … Abatacept recombinant …
Matched Description: … It is produced through recombinant DNA technology in mammalian CHO cells. ... antigen 4 (CTLA-4) to the modified Fc (hinge, CH2, and CH3 domains) portion of human immunoglobulin ... Abatacept is a soluble fusion protein, which links the extracellular domain of human cytotoxic T-lymphocyte-associated …
Matched Description: … It is produced through recombinant DNA technology in mammalian CHO cells. ... antigen 4 (CTLA-4) to the modified Fc (hinge, CH2, and CH3 domains) portion of human immunoglobulin ... Abatacept is a soluble fusion protein, which links the extracellular domain of human cytotoxic T-lymphocyte-associated …
Alfacalcidol
Alfacalcidol, or 1-alpha-hydroxycholecalciferol or 1-alpha-hydroxyvitamin D3, is a non-endogenous analogue of vitamin D. It plays an essential function in calcium homeostasis and bone metabolism. Alfacaldisol is activated by the enzyme 25-hydroxylase in the liver to mediate its effects in the body, or most importantly, the kidneys and bones. The pharmacological...
Approved
Nutraceutical
Matched Synonyms: … 9,10-secocholesta-5,7,10(19)-triene-1α,3β-diol ... (5Z,7E)-9,10-seco-5,7,10(19)-cholestatrien-1α,3β-diol …
Ergocalciferol
Ergocalciferol is an inactivated vitamin D analog. It is synthesized by some plants in the presence of UVB light. The production of ergocalciferol was prompted by the identification of dietary deficiency, more specifically vitamin D, as the main causative factor for the development of rickets. Ergocalciferol was isolated for the...
Approved
Nutraceutical
Matched Synonyms: … (3β,5Z,7E,22E)-9,10-secoergosta-5,7,10(19),22-tetraen-3-ol ... (5Z,7E,22E)-(3S)-9,10-seco-5,7,10(19),22-ergostatetraen-3-ol ... (5Z,7E,22E)-(3S)-9,10-secoergosta-5,7,10(19),22-tetraen-3-ol …
rhThrombin
rhThrombin (recombinant human thrombin) is being developed by ZymoGenetics, Inc. as a general aid to achieving hemostasis during surgery. ZymoGenetics is developing rhThrombin, a recombinant form of human thrombin that is not derived from animal or human blood, as an aid to controlling bleeding during surgery. Thrombin is used in...
Approved
Investigational
Matched Synonyms: … Recombinant thrombin …
Matched Description: … rhThrombin (recombinant human thrombin) is being developed by ZymoGenetics, Inc. as a general aid to ... ZymoGenetics is developing rhThrombin, a recombinant form of human thrombin that is not derived from ... The production of recombinant proteins is not dependent on the availability of blood from animals or …
Matched Description: … rhThrombin (recombinant human thrombin) is being developed by ZymoGenetics, Inc. as a general aid to ... ZymoGenetics is developing rhThrombin, a recombinant form of human thrombin that is not derived from ... The production of recombinant proteins is not dependent on the availability of blood from animals or …
Insulin glulisine
Insulin glulisine is a short-acting form of insulin used for the treatment of hyperglycemia caused by Type 1 and Type 2 Diabetes. Insulin is typically prescribed for the management of diabetes mellitus to mimic the activity of endogenously produced human insulin, a peptide hormone produced by beta cells of the...
Approved
Matched Synonyms: … Insulin glulisine recombinant ... Insulin Glulisine (recombinant DNA origin) …
Matched Description: … This recombinant hormone differs from native human insulin in that the amino acid asparagine at position ... Insulin glulisine is a biosynthetic, rapid-acting human insulin analogue produced in a non-pathogenic ... typically prescribed for the management of diabetes mellitus to mimic the activity of endogenously produced human …
Matched Description: … This recombinant hormone differs from native human insulin in that the amino acid asparagine at position ... Insulin glulisine is a biosynthetic, rapid-acting human insulin analogue produced in a non-pathogenic ... typically prescribed for the management of diabetes mellitus to mimic the activity of endogenously produced human …
Cholecalciferol
Vitamin D, in general, is a secosteroid generated in the skin when 7-dehydrocholesterol located there interacts with ultraviolet irradiation - like that commonly found in sunlight . Both the endogenous form of vitamin D (that results from 7-dehydrocholesterol transformation), vitamin D3 (cholecalciferol), and the plant-derived form, vitamin D2 (ergocalciferol), are...
Approved
Nutraceutical
Matched Synonyms: … (3β,5Z,7E)-9,10-secocholesta-5,7,10(19)-trien-3-ol ... (5Z,7E)-(3S)-9,10-secocholesta-5,7,10(19)-trien-3-ol …
Matched Mixtures name: … Se-Natal 19 ... Thrivite 19 ... Se-Natal 19 …
Matched Mixtures name: … Se-Natal 19 ... Thrivite 19 ... Se-Natal 19 …
Susoctocog alfa
Intravenous susoctocog alfa is a recombinant, B-domain deleted, porcine sequence antihaemophilic factor VIII (FVIII) product that has recently been approved for the treatment of bleeding episodes in adults with acquired haemophilia A (AHA). AHA is a rare bleeding disorder that results in a prolonged clotting time as measured by the...
Approved
Investigational
Matched Synonyms: … Antihemophilic factor (recombinant) porcine sequence ... ANTIHEMOPHILIC FACTOR (RECOMBINANT), PORCINE SEQUENCE ... Porcine recombinant factor VIII B-domain truncated …
Matched Description: … The recombinant porcine sequence allows less susceptibility to inactivation by circulating human factor ... These autoantibodies neutralize circulating human factor VIII and create a functional deficiency of this ... Intravenous susoctocog alfa is a recombinant, B-domain deleted, porcine sequence antihaemophilic factor …
Matched Description: … The recombinant porcine sequence allows less susceptibility to inactivation by circulating human factor ... These autoantibodies neutralize circulating human factor VIII and create a functional deficiency of this ... Intravenous susoctocog alfa is a recombinant, B-domain deleted, porcine sequence antihaemophilic factor …
Choriogonadotropin alfa
Recombinant human chorionic gonadotropin with 2 subunits, alpha = 92 residues, beta = 145 residues, each with N-and O-linked carbohydrate moieties linked to ASN-52 and ASN-78 (on alpha subunit) and ASN-13, ASN-30, SER-121, SER-127, SER-132 and SER-138 (on beta subunit). The primary structure of the alpha-chain of r-hCG is identical...
Approved
Matched Synonyms: … Chorionic gonadotropin (recombinant) …
Matched Description: … Recombinant human chorionic gonadotropin with 2 subunits, alpha = 92 residues, beta = 145 residues, each …
Matched Description: … Recombinant human chorionic gonadotropin with 2 subunits, alpha = 92 residues, beta = 145 residues, each …
Plasminogen
Plasminogen is a pro-enzyme (i.e. a zymogen) which is cleaved to form plasmin - also known as fibrinolysin - as part of the fibrinolytic pathway that breaks down fibrin blood clots. This pathway is activated when a clot is no longer needed or to prevent a clot from extending beyond...
Approved
Matched Synonyms: … Human plasminogen ... plasminogen, human-tvmh …
Matched Description: … [L34635] In June 2021, the FDA approved a plasma-derived plasminogen (Ryplazim, human plasminogen-tvmh …
Matched Description: … [L34635] In June 2021, the FDA approved a plasma-derived plasminogen (Ryplazim, human plasminogen-tvmh …
Ethynodiol diacetate
A synthetic progestational hormone used alone or in combination with estrogens as an oral contraceptive. Although etynodiol or ethynodiol are sometimes used as a synonym for ethynodiol diacetate, what is usually being referred to is actually ethynodiol diacetate and not ethynodiol (which is a separate drug that has never been...
Approved
Matched Synonyms: … 3β,17β-Diacetoxy-19-nor-17α-pregn-4-en-20-yne ... 19-Nor-17α-pregn-4-en-20-yne-3β,17-diol diacetate ... 17α-Ethynyl-19-norandrost-4-ene-3β,17-beta-diol diacetate …
Nonacog beta pegol
Nonacog beta pegol is a recombinant coagulation factor IX derivative. It is produced without animal-derived materials and with an attached 40kDa polyethylene glycol (PEG) molecule for peptide activation by a site-directed glycoPEGylation. Once activated, the activation molecule with PEG is cleaved to leave the activated factor IX (Factor IXa). Nonacog...
Approved
Investigational
Matched Synonyms: … Coagulation Factor IX (Recombinant), GlycoPEGylated …
Matched Description: … Nonacog beta pegol is a recombinant coagulation factor IX derivative. …
Matched Description: … Nonacog beta pegol is a recombinant coagulation factor IX derivative. …
Remestemcel-L
Remestemcel-L is a third-party, off-the-shelf suspension of ex-vivo cultured adult human mesenchymal stem cells intended for intravenous infusion. The mesenchymal stem cells are derived from the bone marrow of unrelated and human leukocyte antigen (HLA)–unmatched healthy adult donors and have the ability to differentiate into different tissue cells. It was...
Approved
Investigational
Matched Synonyms: … Adult human mesenchymal stem cells ... Allogeneic human mesenchymal stem cell …
Matched Description: … Remestemcel-L is a third-party, off-the-shelf suspension of ex-vivo cultured adult human mesenchymal ... The mesenchymal stem cells are derived from the bone marrow of unrelated and human leukocyte antigen ... Human mesenchymal stem cells (hMSCs) serve to down-regulate inflammatory responses and produce anti-inflammatory …
Matched Description: … Remestemcel-L is a third-party, off-the-shelf suspension of ex-vivo cultured adult human mesenchymal ... The mesenchymal stem cells are derived from the bone marrow of unrelated and human leukocyte antigen ... Human mesenchymal stem cells (hMSCs) serve to down-regulate inflammatory responses and produce anti-inflammatory …
Elotuzumab
Elotuzumab is a humanized IgG1 (Immunoglobulin G) monoclonal antibody indicated in combination with lenalidomide and dexamethasone for the treatment of patients with multiple myeloma who have received one to three prior therapies. Elotuzumab targets SLAMF7, also known as Signaling Lymphocytic Activation Molecule Family member 7, a cell surface glycoprotein. Elotuzumab...
Approved
Matched Synonyms: … Immunoglobulin G1, anti-(human protein CS1) (human-mouse HuLuc63 heavy chain), disulfide with human-mouse …
Matched Description: … Elotuzumab is produced in NS0 cells by recombinant DNA technology. ... consists of the complementary determining regions (CDR) of the mouse antibody, MuLuc63, grafted onto human …
Matched Description: … Elotuzumab is produced in NS0 cells by recombinant DNA technology. ... consists of the complementary determining regions (CDR) of the mouse antibody, MuLuc63, grafted onto human …
Hemoglobin
The respiratory protein of the red blood cells. It consists primarily of globin and heme.
Approved
Experimental
Investigational
Matched Synonyms: … Human hemoglobin …
rsPSMA Vaccine
Prostate-specific membrane antigen (PSMA) is an ∼100 kDa transmembrane glycoprotein that is abundantly and preferentially expressed in prostate cancer, including recurrent and hormone-refractory cases. rsPSMA Vaccine is a subunit vaccine based on a novel rsPSMA protein that represents the entire extracellular domain of PSMA (Schulke et al., PNAS 100:12590, 2003)....
Approved
Investigational
Matched Synonyms: … Recombinant soluble prostate-specific membrane antigen (rsPSMA) vaccine …
Neisseria meningitidis serogroup b nhba fusion protein antigen
Approved
Matched Synonyms: … Neisseria meningitidis serogroup B recombinant NHBA fusion protein antigen …
Neisseria meningitidis serogroup b nada protein antigen
Approved
Matched Synonyms: … Neisseria meningitidis serogroup B recombinant NADA fusion protein antigen …
Calcitriol
Calcitriol is an active metabolite of vitamin D with 3 hydroxyl (OH) groups and is commonly referred to as 1,25-dihydroxycholecalciferol, or 1alpha,25-dihydroxyvitamin D3, 1,25-dihydroxyvitamin D3. It is produced in the body after series of conversion steps of 7-dehydrocholesterol from exposure to UV light. 7-dehydrocholesterol is converted to DB00169 (vitamin D3)...
Approved
Nutraceutical
Matched Synonyms: … (1α,3β,5Z,7E)-9,10-secocholesta-5,7,10(19)-triene-1,3,25-triol ... (5Z,7E)-(1S,3R)-9,10-secocholesta-5,7,10(19)-triene-1,3,25-triol …
Nirsevimab
Nirsevimab (MEDI8897) is a recombinant human immunoglobulin G1 kappa (IgG1ĸ) monoclonal antibody used to prevent respiratory syncytial virus (RSV) lower respiratory tract disease in neonates and infants. It binds to the prefusion conformation of the RSV F protein, a glycoprotein involved in the membrane fusion step of the viral entry...
Approved
Investigational
Matched Synonyms: … Immunoglobulin g1-kappa, anti-(human respiratory syncytial virus fusion glycoprotein f0 (protein f))human ... Immunoglobulin g1, anti-(human respiratory syncytial virus fusion protein)(human monoclonal med18897 ... monoclonal antibody.gamma.1 heavy chain (1-456) (human vh (homo sapiens ighv1-69*01(ighd)-ighj4*01 ( …
Matched Description: … Nirsevimab (MEDI8897) is a recombinant human immunoglobulin G1 kappa (IgG1ĸ) monoclonal antibody used ... [L44146] Nirsevimab was also approved by Health Canada on April 19, 2023 and by the FDA in July 17, 2023 …
Matched Description: … Nirsevimab (MEDI8897) is a recombinant human immunoglobulin G1 kappa (IgG1ĸ) monoclonal antibody used ... [L44146] Nirsevimab was also approved by Health Canada on April 19, 2023 and by the FDA in July 17, 2023 …
Lenograstim
Lenograstim is a recombinant granulocyte colony-stimulating factor used as an immunostimulating agent.
Approved
Investigational
Matched Synonyms: … Glycosylated recombinant G-CSF ... Glycosylated recombinant granulocyte colony stimulating factor …
Matched Description: … Lenograstim is a recombinant granulocyte colony-stimulating factor used as an immunostimulating agent …
Matched Description: … Lenograstim is a recombinant granulocyte colony-stimulating factor used as an immunostimulating agent …
Turoctocog alfa pegol
Turoctocog alfa pegol is a pegylated version of turoctocog alfa. Novo Nordisk's brand name Esperoct (turoctocog alfa pegol, N8-GP) was approved by the US FDA on February 19, 2019.
Fundamentally, the N8-GP moiety is identical to turoctocog alfa, a recombinant human clotting factor VIII (rFVIII) with a truncated B-domain made...
Approved
Matched Synonyms: … Antihemophilic factor (recombinant), glycopegylated-exei …
Matched Description: … Fundamentally, the N8-GP moiety is identical to [turoctocog alfa], a recombinant human clotting factor ... Nordisk's brand name Esperoct (turoctocog alfa pegol, N8-GP) was approved by the US FDA on February 19 ... Turoctocog alfa is produced in Chinese hamster ovary (CHO) cells without addition of any human or animal-derived …
Matched Categories: … Recombinant Proteins …
Matched Description: … Fundamentally, the N8-GP moiety is identical to [turoctocog alfa], a recombinant human clotting factor ... Nordisk's brand name Esperoct (turoctocog alfa pegol, N8-GP) was approved by the US FDA on February 19 ... Turoctocog alfa is produced in Chinese hamster ovary (CHO) cells without addition of any human or animal-derived …
Matched Categories: … Recombinant Proteins …
Becaplermin
Becaplermin is produced by recombinant DNA technology by insertion of the gene for the B chain of platelet derived growth factor (PDGF) into the yeast, Saccharomyces cerevisiae. Becaplermin has a molecular weight of approximately 25 KD and is a homodimer composed of two identical polypeptide chains that are bound together...
Approved
Investigational
Matched Synonyms: … Platelet-derived growth factor BB, recombinant ... Recombinant platelet-derived growth factor BB …
Matched Description: … Becaplermin is produced by recombinant DNA technology by insertion of the gene for the B chain of platelet …
Matched Categories: … Human Platelet-derived Growth Factor …
Matched Description: … Becaplermin is produced by recombinant DNA technology by insertion of the gene for the B chain of platelet …
Matched Categories: … Human Platelet-derived Growth Factor …
Asparaginase Erwinia chrysanthemi
Asparaginase Erwinia chrysanthemi is an asparaginase-specific enzyme derived from Erwinia chrysanthemi used as an anticancer agent. It works by depleting the stores of an important amino acid called asparagine, which is involved in DNA synthesis and cell survival of malignant cells, leading to cell death. L-asparaginase was first identified in...
Approved
Investigational
Matched Synonyms: … Asparaginase Erwinia chrysanthemi (recombinant) ... asparaginase erwinia chrysanthemi (recombinant)-rywn …
Matched Description: … [L149] In June 2021, the recombinant form of asparaginase _Erwinia chrysanthemi_ was approved by the …
Matched Description: … [L149] In June 2021, the recombinant form of asparaginase _Erwinia chrysanthemi_ was approved by the …
Dinutuximab
Dinutuximab is an IgG1 monoclonal human/mouse chimeric antibody against GD2, a disialoganglioside expressed on tumors of neuroectodermal origin, including human neuroblastoma and melanoma, with highly restricted expression on normal tissues. It is composed of the variable heavy- and light-chain regions of the murine anti-GD2 mAb 14.18 and the constant regions...
Approved
Investigational
Matched Synonyms: … WITH HUMAN-MUS MUSCULUS MONOCLONAL CH14.18 LIGHT CHAIN, DIMER ... WITH HUMAN-MUS MUSCULUS MONOCLONAL CH14.18/CHO LIGHT CHAIN, DIMER ... IMMUNOGLOBULIN G1, ANTI-(GANGLIOSIDE GD2) (HUMAN-MUS MUSCULUS MONOCLONAL CH14.18 HEAVY CHAIN), DISULFIDE …
Matched Description: … It is indicated, in combination with granulocyte-macrophage colony-stimulating factor (GM-CSF), interleukin ... Dinutuximab is an IgG1 monoclonal human/mouse chimeric antibody against GD2, a disialoganglioside expressed ... on tumors of neuroectodermal origin, including human neuroblastoma and melanoma, with highly restricted …
Matched Description: … It is indicated, in combination with granulocyte-macrophage colony-stimulating factor (GM-CSF), interleukin ... Dinutuximab is an IgG1 monoclonal human/mouse chimeric antibody against GD2, a disialoganglioside expressed ... on tumors of neuroectodermal origin, including human neuroblastoma and melanoma, with highly restricted …
Antithymocyte immunoglobulin (rabbit)
Rabbit anti-thymocyte globulin. Thymoglobulin is a polyclonal antibody that suppresses certain types of immune cells responsible for acute organ rejection in transplant patients. Thymoglobulin is a mixture of antibodies intended to bind to various cell surface antigens. The most common mode of action of Thymoglobulin is via selective depletion of...
Approved
Matched Synonyms: … Rabbit anti-human thymocyte globulin ... Anti-human thymocyte immunoglobulin, rabbit ... Rabbit anti-human thymocyte immunoglobulin …
Displaying drugs 51 - 75 of 2654 in total