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Displaying drugs 851 - 875 of 14549 in total

Phenindione

An indandione that has been used as an anticoagulant. Phenindione has actions similar to warfarin, but it is now rarely employed because of its higher incidence of severe adverse effects. (From Martindale, The Extra Pharmacopoeia, 30th ed, p234)
Approved
Investigational
Matched Categories: … Blood and Blood Forming Organs …

Lactose

A disaccharide of glucose and galactose in human and cow milk. It is used in pharmacy for tablets, in medicine as a nutrient, and in industry.
Approved
Experimental
Investigational
Matched Description: … A disaccharide of glucose and galactose in human and cow milk. ... It is used in pharmacy for tablets, in medicine as a nutrient, and in industry. …
Matched Categories: … Diet, Food, and Nutrition …

Levocetirizine

Levocetirizine is a selective histamine H1 antagonist used to treat a variety of allergic symptoms.[A181748,A181790,L7694] It is the R enantiomer of cetirizine. Levocetirizine has greater affinity for the histamine H1 receptor than cetirizine. Levocetirizine was granted FDA approval in 1995.
Approved
Matched Categories: … Cetirizine and isomer …

Fosnetupitant

In April 2018, the U.S. Food and Drug Administration (FDA) and the Swiss company Helsinn approved the intravenous formulation of AKYNZEO® (NEPA, a fixed antiemetic combination of fosnetupitant, 235mg, and palonosetron, 0.25mg) as an alternative treatment option for patients experiencing chemotherapy-induced nausea and vomiting . Fosnetupitant is the pro-drug form...
Approved
Matched Description: … Food and Drug Administration (FDA) and the Swiss company Helsinn approved the intravenous formulation ... of AKYNZEO® (NEPA, a fixed antiemetic combination of fosnetupitant, 235mg, and palonosetron, 0.25mg) ... as an alternative treatment option for patients experiencing chemotherapy-induced nausea and vomiting …
Matched Categories: … Netupitant and prodrug …

Tezepelumab

Asthma is a heterogeneous chronic obstructive respiratory disease with both "type 2" (T2) and T2-low endotypes characterized by reduced airflow, chronic inflammation, and airway remodelling.[A243764, A243769] Thymic stromal lymphopoietin (TSLP), an innate pleiotropic IL-2-family cytokine, has emerged as a key upstream regulator of chronic inflammation across asthma endotypes. Blocking the...
Approved
Investigational
Matched Description: … including eosinophil counts and IgE, FeNO, IL-5, and IL-13 levels. ... endotypes characterized by reduced airflow, chronic inflammation, and airway remodelling. ... Asthma is a heterogeneous chronic obstructive respiratory disease with both "type 2" (T2) and T2-low …
Matched Categories: … Amino Acids, Peptides, and Proteins …

Prochlorperazine

Prochlorperazine, also known as compazine, is a piperazine phenothiazine and first-generation antipsychotic drug that is used for the treatment of severe nausea and vomiting, as well as short-term management of psychotic disorders such as generalized non-psychotic anxiety and schizophrenia.[label] It mainly works by depressing the chemoreceptor trigger zone and blocking...
Approved
Vet approved
Matched Description: … of psychotic disorders such as generalized non-psychotic anxiety and schizophrenia. ... It was shown to also block histaminergic, cholinergic and noradrenergic receptors. ... Prochlorperazine, also known as compazine, is a piperazine phenothiazine and first-generation antipsychotic …

Siltuximab

Siltuximab is a chimeric (human-mouse) monoclonal immunoglobulin G1-kappa antibody produced in a Chinese hamster ovary (CHO) cell line by recombinant DNA technology. Siltuximab prevents the binding of IL-6 to soluble and membrane-bound IL-6 receptors by forming high affinity complexes with human interleukin-6 (IL-6). Its use is indicated for the treatment...
Approved
Investigational
Matched Description: … Siltuximab prevents the binding of IL-6 to soluble and membrane-bound IL-6 receptors by forming high ... MCD is a rare blood disorder caused by dysregulated IL-6 production, proliferation of lymphocytes, and ... patients with multicentric Castleman's disease (MCD) who are human immunodeficiency virus (HIV) negative and …
Matched Categories: … Amino Acids, Peptides, and Proteins ... Antineoplastic and Immunomodulating Agents …

Leflunomide

Leflunomide is a pyrimidine synthesis inhibitor belonging to the DMARD (disease-modifying antirheumatic drug) class of drugs, which are chemically and pharmacologically very heterogeneous. Leflunomide was approved by FDA and in many other countries (e.g., Canada, Europe) in 1999.
Approved
Investigational
Matched Description: … Leflunomide was approved by FDA and in many other countries (e.g., Canada, Europe) in 1999. ... belonging to the DMARD (disease-modifying antirheumatic drug) class of drugs, which are chemically and …
Matched Categories: … Leflunomide and metabolite ... Antineoplastic and Immunomodulating Agents …

Flucytosine

A fluorinated cytosine analog that is used as an antifungal agent.
Approved
Investigational
Matched Categories: … Fluorouracil and prodrugs …

Gimeracil

Gimeracil is an adjunct to antineoplastic therapy, used to increase the concentration and effect of the main active componets within chemotherapy regimens. Approved by the European Medicines Agency (EMA) in March 2011, Gimeracil is available in combination with DB03209 and DB09256 within the commercially available product "Teysuno". The main active...
Approved
Matched Description: … Gimeracil is an adjunct to antineoplastic therapy, used to increase the concentration and effect of the ... European Medicines Agency (EMA) in March 2011, Gimeracil is available in combination with [DB03209] and ... By mimicking a class of compounds called "pyrimidines" that are essential components of RNA and DNA, …

Dabigatran etexilate

Dabigatran etexilate is an oral prodrug that is hydrolyzed to the competitive and reversible direct thrombin inhibitor dabigatran.[A177463, A6970, L34675, L34680] Dabigatran etexilate may be used to decrease the risk of venous thromboembolic events in patients in whom anticoagulation therapy is indicated. In contrast to warfarin, because its anticoagulant effects...
Approved
Matched Description: … Dabigatran etexilate is an oral prodrug that is hydrolyzed to the competitive and reversible direct thrombin …
Matched Categories: … Blood and Blood Forming Organs …

Mepolizumab

Eosinophils are involved in inflammatory immune responses, and prolonged hypereosinophilia (typically defined as absolute eosinophil levels of 1500/mm3 or more) is associated with a spectrum of diseases, including severe asthma, eosinophilic granulomatosis with polyangiitis (EGPA), and hypereosinophilic syndrome (HES). The pathogenesis of eosinophilia is complex, but IL-5 is recognized as...
Approved
Investigational
Matched Description: … Activated eosinophils further stimulate an inflammatory response and also induce tissue lesions and promote ... Eosinophils are involved in inflammatory immune responses, and prolonged hypereosinophilia (typically ... spectrum of diseases, including severe asthma, eosinophilic granulomatosis with polyangiitis (EGPA), and …
Matched Categories: … Amino Acids, Peptides, and Proteins …

Butobarbital

Butobarbital is a sedative and a hypnotic drug.
Approved
Illicit
Matched Description: … Butobarbital is a sedative and a hypnotic drug. …
Matched Categories: … Hypnotics and Sedatives …

Acipimox

Acipimox is a niacin derivative used as a hypolipidemic agent. It is used in low doses and may have less marked adverse effects, although it is unclear whether the recommended dose is as effective as are standard doses of nicotinic acid. Acipimox inhibits the production of triglycerides by the liver...
Approved
Investigational
Matched Description: … indirectly to a modest reduction in LDL and increase in HDL. ... It is used in low doses and may have less marked adverse effects, although it is unclear whether the ... High doses can cause disorders of liver function, impair glucose tolerance and precipitate gout. …
Matched Categories: … Nicotinic Acid and Derivatives …

Yeast

Yeast allergenic extract is used in allergenic testing.
Approved
Matched Categories: … Alimentary Tract and Metabolism …

Tozinameran

The Pfizer-BioNTech COVID-19 vaccine (also known as BNT162b2, Tozinameran, and Comirnaty), is one of four advanced mRNA-based vaccines developed through "Project Lightspeed," a joint program between Pfizer and BioNTech.[L15002,L15007,L36025] Comirnaty is a nucleoside modified mRNA (modRNA) vaccine encoding an optimized full-length version of the severe acute respiratory syndrome coronavirus 2...
Approved
Investigational
Matched Description: … The Pfizer-BioNTech COVID-19 vaccine (also known as BNT162b2, Tozinameran, and Comirnaty), is one of ... advanced mRNA-based vaccines developed through "Project Lightspeed," a joint program between Pfizer and ... [L26956] Fact sheets for caregivers, recipients, and healthcare providers are now available. …
Matched Categories: … Amino Acids, Peptides, and Proteins …

Odesivimab

Ebola virus (EBOV) remains an important human pathogen within the Ebolavirus genus, having been responsible for at least 17 known outbreaks with an average case fatality rate of 43.92%. Immune therapy using monoclonal antibodies (mAbs) is becoming an increasingly attractive therapeutic method to combat infectious diseases due to its rapid...
Approved
Matched Description: … neutralizing and Fc-mediated immune effector function against EBOV _in vitro_ and protection against ... INMAZEB™ is produced by Regeneron Pharmaceuticals and was granted FDA approval on October 14, 2020. ... attractive therapeutic method to combat infectious diseases due to its rapid development, low toxicity, and …
Matched Categories: … Amino Acids, Peptides, and Proteins …

Ergoloid mesylate

Ergoloid Mesylate is an equiproportional preparation of three different ergotamantriones: dihydroergocornine, dihydroergocristine, and dihydroergocryptine. All these components are produced by the fungus Claviceps purpurea and are all derivatives of the tetracyclic compound 6-methylergonovine. The derivatives of this fungus are identified to be about 350 different substances from which the components...
Approved
Matched Description: … [A32912] All these components are produced by the fungus _Claviceps purpurea_ and are all derivatives ... equiproportional preparation of three different ergotamantriones: dihydroergocornine, dihydroergocristine, and ... [A32914] The mixture of ergoloid mesylate was first developed by Novartis and FDA approved on November …
Matched Categories: … Ergot Alkaloids and Derivatives …

Erdafitinib

In early April of 2019, the US FDA approved Janssen Pharmaceutical Companies' brand name Balversa (erdafitinib) as the first-ever fibroblast growth factor receptor (FGFR) kinase inhibitor indicated for patients with locally advanced or metastatic urothelial carcinoma, with susceptible FGFR3 or FGFR2 genetic alterations, that has progressed during or following platinum-containing...
Approved
Investigational
Matched Description: … for patients with metastatic bladder cancer, which demonstrates the development of more personalized and …
Matched Categories: … Antineoplastic and Immunomodulating Agents …

Medium-chain triglycerides

Medium-chain triglycerides (MCTs) are triglycerides made up of a glycerol backbone and three fatty acids with an aliphatic tail of six to 12 carbon atoms. MCTs are found in natural foods, such as coconut oil, palm kernel oil, and raw coconut meat. In the body, MCTs are broken down into...
Approved
Matched Description: … the blood stream and transported to the target organs to exert a range of biological and metabolic effects ... fatty acids in conditions associated with malnutrition and malabsorption. ... MCTs are found in natural foods, such as coconut oil, palm kernel oil, and raw coconut meat. …

Brentuximab vedotin

Brentuximab vedotin, also known as Adcetris®, is an antibody-drug conjugate that combines an anti-CD30 antibody with the drug monomethyl auristatin E (MMAE). It is an anti-neoplastic agent used in the treatment of Hodgkin's lymphoma and systemic anaplastic large-cell lymphoma. Brentuximab vedotin was initially approved in 2011. In January 2012, the...
Approved
Investigational
Matched Description: … Lymphoma may begin anywhere in the body and can spread to nearby lymph nodes. ... Food and Drug Administration approved Adcetris in March 2018 to treat adult patients with previously ... was revised with a boxed warning of a condition known as progressive multifocal leukoencephalopathy and …
Matched Categories: … Amino Acids, Peptides, and Proteins ... Antineoplastic and Immunomodulating Agents ... MONOCLONAL ANTIBODIES AND ANTIBODY DRUG CONJUGATES …

Paritaprevir

Paritaprevir is a direct acting antiviral medication used as part of combination therapy to treat chronic Hepatitis C, an infectious liver disease caused by infection with Hepatitis C Virus (HCV). HCV is a single-stranded RNA virus that is categorized into nine distinct genotypes, with genotype 1 being the most common...
Approved
Investigational
Matched Description: … : Viekira Pak (FDA), Technivie (FDA and Health Canada), and Holkira Pak (Health Canada). ... FDA- and Health Canada-approved product Technivie. ... mature virus: NS3, NS4A, NS4B, NS5A, and NS5B [A19643]. …
Matched Categories: … Amino Acids, Peptides, and Proteins ... ombitasvir, paritaprevir and ritonavir ... dasabuvir, ombitasvir, paritaprevir and ritonavir …

Lumateperone

Schizophrenia is a complex mental illness and impacts approximately 1% of the population. Although there are several antipsychotics including aripiprazole, paliperidone and clozapine available for clinical use, they are generally accompanied by significant metabolic and/or neurological adverse effects. Lumateperone is a newly approved 2nd generation antipsychotic currently indicated for the...
Approved
Investigational
Matched Description: … Schizophrenia is a complex mental illness and impacts approximately 1% of the population. ... [L10902] Although there are several antipsychotics including [aripiprazole], [paliperidone] and [clozapine ... ] available for clinical use, they are generally accompanied by significant metabolic and/or neurological …

Butamben

Butamben is a local anesthetic in the form of n-butyl-p-aminobenzoate. Its structure corresponds to the standard molecule of a hydrophilic and hydrophobic domain separated by an intermediate ester found in most of the local anesthetics. Due to its very low water solubility, butamben is considered to be suitable only for...
Approved
Withdrawn
Matched Description: … [A27147] Its structure corresponds to the standard molecule of a hydrophilic and hydrophobic domain separated …

Aprocitentan

Aprocitentan is a dual antagonist of endothelin receptors A and B used for treatment-resistant hypertension. It is the active metabolite of macitentan. Approximately 10-15% of patients with hypertension have resistant hypertension, defined as uncontrolled high blood pressure despite the combined use of a renin-angiotensin system blocker, a calcium channel blocker,...
Approved
Investigational
Matched Description: … [A263386] and have traditionally had limited additional treatment options. ... Aprocitentan is a dual antagonist of endothelin receptors A and B used for treatment-resistant hypertension ... pressure despite the combined use of a renin-angiotensin system blocker, a calcium channel blocker, and …
Displaying drugs 851 - 875 of 14549 in total