Displaying drugs 10276 - 10300 of 12422 in total
Aganirsen
Aganirsen is under investigation in clinical trial NCT02947867 (Trial of Aganirsen in iCRVO Patients at Risk of Developing NVG).
Investigational
Matched Description: … at Risk of Developing NVG). ... Aganirsen is under investigation in clinical trial NCT02947867 (Trial of Aganirsen in iCRVO Patients …
BacTRL-spike
BacTRL-Spike is composed of a bacterial medium with colony-forming-units of live Bifidobacterium longum engineered to deliver synthetic DNA encoding spike protein from SARS-CoV-2 contained by plasmids. The vaccine was developed by Symvivo Corporation. As of June, 2020, the company is pursuing a Phase 1, Randomized, Observer-Blind, Placebo-Controlled Trial (NCT04334980) to...
Investigational
Matched Description: … BacTRL-Spike is composed of a bacterial medium with colony-forming-units of live Bifidobacterium longum ... Trial (NCT04334980) to test the safety and immunogenicity of the vaccine. ... As of June, 2020, the company is pursuing a Phase 1, Randomized, Observer-Blind, Placebo-Controlled …
Proscillaridin
Proscillaridin is a cardiac glycoside that is derived from plants of the genus Scilla and in Drimia maritima (Scilla maritima). Studies suggest the potential cytotoxic and anticancer property of proscillaridin, based on evidence of the drug potently disrupting topoisomerase I and II activity at nanomolar drug concentrations and triggering cell...
Experimental
Matched Description: … ] and triggering cell death and blocking cell proliferation of glioblastoma cell lines [A27194]. ... Proscillaridin is a cardiac glycoside that is derived from plants of the genus Scilla and in Drimia maritima ... Studies suggest the potential cytotoxic and anticancer property of proscillaridin, based on evidence …
ORG-34517
ORG-34517 is currently under investigation by Organon for the treatment of depression. It has potential to treat a number of diseases such as Cushing’s disease, hypertension, diabetes, glaucoma etc, in which the activity of metabolites corticosterone and cortisol is high.
Investigational
Matched Description: … etc, in which the activity of metabolites corticosterone and cortisol is high. ... ORG-34517 is currently under investigation by Organon for the treatment of depression. ... It has potential to treat a number of diseases such as Cushing’s disease, hypertension, diabetes, glaucoma …
PI-0824
Pemphigus vulgaris (PV) is an autoimmune disease affecting approximately 40,000 people worldwide. People with PV produce antibodies that attack the cells of the skin, resulting in blisters which, if left untreated, can lead to devastating infections and discomfort. Currently, most doctors who treat patients with PV will prescribe high-dose steroids...
Investigational
Matched Description: … The goal of this therapy is to reduce the production of antibodies that cause PV blisters by acting only ... on the disease causing components of the immune system. ... Peptimmune, Inc. has developed a new therapy for the treatment of PV, PI-0824. …
GZ-389988
GZ-389988 is under investigation in clinical trial NCT02845271 (Proof-of-concept Study to Assess the Efficacy, Tolerability and Safety of a Single Intraarticular Dose of GZ389988 Versus Placebo in Patients With Painful Osteoarthritis of the Knee).
Investigational
Matched Description: … Efficacy, Tolerability and Safety of a Single Intraarticular Dose of GZ389988 Versus Placebo in Patients ... With Painful Osteoarthritis of the Knee). ... GZ-389988 is under investigation in clinical trial NCT02845271 (Proof-of-concept Study to Assess the …
Endothelin-1
Endothelin 1 is under investigation in clinical trial NCT00745693 (The Effects of Diesel Exhaust Inhalation on Vascular Function - the Role of Endothelin).
Investigational
Matched Description: … on Vascular Function - the Role of Endothelin). ... Endothelin 1 is under investigation in clinical trial NCT00745693 (The Effects of Diesel Exhaust Inhalation …
DLO6002
DLO6002 is developed by Summit Corporation and is in phase I of clinical trials for the treatment of Parkinson's disease.
Investigational
Matched Description: … DLO6002 is developed by Summit Corporation and is in phase I of clinical trials for the treatment of …
Romilkimab
Romilkimab is under investigation in clinical trial NCT02345070 (Efficacy and Safety of SAR156597 in the Treatment of Idiopathic Pulmonary Fibrosis).
Investigational
Matched Description: … the Treatment of Idiopathic Pulmonary Fibrosis). ... Romilkimab is under investigation in clinical trial NCT02345070 (Efficacy and Safety of SAR156597 in …
Sibofimloc
Sibofimloc is under investigation in clinical trial NCT03943446 (TAK-018 for Prevention of the Recurrence of Postoperative Crohn's Disease (CD)).
Investigational
Matched Description: … of Postoperative Crohn's Disease (CD)). ... Sibofimloc is under investigation in clinical trial NCT03943446 (TAK-018 for Prevention of the Recurrence …
Ianalumab
Ianalumab is under investigation in clinical trial NCT01930175 (Study of Efficacy and Safety of VAY736 in Patients With Pemphigus Vulgaris).
Investigational
Matched Description: … Ianalumab is under investigation in clinical trial NCT01930175 (Study of Efficacy and Safety of VAY736 …
(1R,2S)-2-Phenylcyclopropanaminium
A propylamine formed from the cyclization of the side chain of amphetamine. This monoamine oxidase inhibitor is effective in the treatment of major depression, dysthymic disorder, and atypical depression. It also is useful in panic and phobic disorders. (From AMA Drug Evaluations Annual, 1994, p311)
Experimental
Matched Description: … A propylamine formed from the cyclization of the side chain of amphetamine. ... This monoamine oxidase inhibitor is effective in the treatment of major depression, dysthymic disorder …
VX-765
VX-765 is the orally available prodrug of a potent and selective competitive inhibitor of ICE/caspase-1 (VRT-043198). VX-765 is currently under clinical development for the treatment of inflammatory and autoimmune conditions, as it blocks the hypersensitive response to an inflammatory stimulus.
Investigational
Matched Description: … VX-765 is the orally available prodrug of a potent and selective competitive inhibitor of ICE/caspase ... VX-765 is currently under clinical development for the treatment of inflammatory and autoimmune conditions …
ALT-2074
An organoselenium drug previously studied by Oxis International in Phase-II clinical trials for ulcerative colitis patients. Some indications of efficacy were demonstrated. BXT-51072 has enthusiastic endorsement for treatment in cardiovascular indications, primarily because of its ability to mimic the function of glutathione peroxidase.
Investigational
Matched Description: … Some indications of efficacy were demonstrated. ... its ability to mimic the function of glutathione peroxidase. ... BXT-51072 has enthusiastic endorsement for treatment in cardiovascular indications, primarily because of …
AVE-1625
AVE-1625 is an oral selective and potent antagonist of cannabinoid 1 (CB1) receptors having the same mechanism of action as rimonabant. It is currently developed in obesity and its associated comorbidities. AVE-1625 is also being developed for the treatment of Alzheimer disease.
Investigational
Matched Description: … mechanism of action as rimonabant. ... AVE-1625 is also being developed for the treatment of Alzheimer disease. ... AVE-1625 is an oral selective and potent antagonist of cannabinoid 1 (CB1) receptors having the same …
Probiorinse
Probiorinse is an intranasal probiotic treatment composed of a pre-mixed and buffered sinus irrigation solution that contains the probiotic bacteria Lactococcus lactis W136. This strain of bacteria is said to have salubrious effects on the microbiome of the nasal cavity and sinuses.
Investigational
Matched Description: … [L16368] This strain of bacteria is said to have salubrious effects on the microbiome of the nasal cavity ... Probiorinse is an intranasal probiotic treatment composed of a pre-mixed and buffered sinus irrigation …
G4544
G4544 is an oral gallium compound that enables oral absorption of the active ingredient contained in Ganite™ (gallium nitrate injection). It targets bone tissue and is actively incorporated into bone mineral at sites where bone is metabolically active.
Investigational
Matched Description: … G4544 is an oral gallium compound that enables oral absorption of the active ingredient contained in …
Methaqualone
Methaqualone is a sedative-hypnotic drug that is similar in effect to barbiturates, a general central nervous system depressant. The sedative-hypnotic activity was first noted by Indian researchers in the 1950s and in 1962 methaqualone itself was patented in the US by Wallace and Tiernan. Its use peaked in the early...
Illicit
Withdrawn
IN01
The IN01 Vaccine, sponsored by the Instituto Oncologico Dr Rosell, IN3BIO, and PANGAEA, is a compound containing recombinant bacteria . These cultures contain EGF-4-EGF with the cholera toxin B-subunit domain G33D sequence . Administration of the vaccine stimulates the production of anti-epidermal growth factor (anti-EGF) neutralizing antibodies . Of note,...
Investigational
Matched Description: … The study will explore the effect of this vaccine on pulmonary function, oxygen saturation, quality of ... Administration of the vaccine stimulates the production of anti-epidermal growth factor (anti-EGF) neutralizing ... life, and fibrosing status in addition to biomarkers and molecular markers of the vaccine. …
XL784
XL784 is a potent inhibitor of the ADAM-10 metalloprotease enzyme, a target of significant interest because of its important role in blood vessel formation and cell proliferation. XL784 was specifically optimized to be MMP-1 sparing, thus potentially enhancing its safety profile and enabling higher dosing compared with other previously studied...
Investigational
Matched Description: … XL784 is a potent inhibitor of the ADAM-10 metalloprotease enzyme, a target of significant interest because ... Results of single dose Phase I clinical trials of XL784 administered orally to 96 healthy volunteers ... of its important role in blood vessel formation and cell proliferation. …
ARC183
ARC183 is a DNA aptamer, which is a single-stranded DNA molecule consisting of 15 deoxynucleotides that forms well-defined three-dimensional configuration, allowing it to bind to thrombin with high affinity and specificity. The key
advantage of ARC183 compared to other thrombin inhibitors is its rapid onset of action and short half-life,...
Investigational
Matched Description: … The key
advantage of ARC183 compared to other thrombin inhibitors is its rapid onset of action and short ... ARC183 is a DNA aptamer, which is a single-stranded DNA molecule consisting of 15 deoxynucleotides that ... , giving it the potential to be an ideal agent for medical procedures that require rapid resolution of …
ANA971
ANA971, an orally administered prodrug of isatoribine. Isatoribine is a nucleoside analog in development for the treatment of chronic hepatitis C virus (HCV) infection. ANA971 is a prodrug designed to improve the oral bioavailability of isatoribine. ANA971 resulted in higher levels of isatoribine in the blood than were present after...
Investigational
Matched Description: … of isatoribine itself. ... ANA971, an orally administered prodrug of isatoribine. ... ANA971 is a prodrug designed to improve the oral bioavailability of isatoribine. …
PRTX-100
PRTX-100 is a highly-purified form of Staphylococcal Protein A that binds directly to monocytes and a subset of B-cells that are involved in the development and progression of various autoimmune diseases. These binding interactions enable the compound to modulate the function of these cells and restore the balance of the...
Investigational
Matched Description: … balance of the immune system. ... subset of B-cells that are involved in the development and progression of various autoimmune diseases ... PRTX-100 is a highly-purified form of Staphylococcal Protein A that binds directly to monocytes and a …
DTX-101
DTX-101 is an investigational gene therapy consisting of an adeno-associated virus serotype Rh10 vector encoding the human Factor Ix gene. It was previously investigated for the treatment of hemophilia B; however, the clinical development of DTX-101 was discontinued.
Investigational
Matched Description: … It was previously investigated for the treatment of hemophilia B; however, the clinical development of ... DTX-101 is an investigational gene therapy consisting of an adeno-associated virus serotype Rh10 vector …
VLTS-589
VLTS-589 consists of plasmid encoding the angiomatrix protein Del-1 in conjunction with poloxamer 188 for the treatment of peripheral vascular disease.
Investigational
Matched Description: … for the treatment of peripheral vascular disease. ... VLTS-589 consists of plasmid encoding the angiomatrix protein Del-1 in conjunction with poloxamer 188 …
Displaying drugs 10276 - 10300 of 12422 in total