Displaying drugs 10576 - 10600 of 12589 in total
MPI-674
MPI-674 is an aromatase inhibitor (AI) with a well-established, multi-year chronic safety and tolerability profile. AIs are a class of drugs that reduce the amount of estrogen circulating in the body by binding to and inhibiting the enzyme aromatase, which is responsible for converting certain hormones to estrogen. It is...
Investigational
Matched Description: … AIs are a class of drugs that reduce the amount of estrogen circulating in the body by binding to and ... It is developed for the treatment of several serious women’s health conditions including endometrial …
Pipequaline
Pipequaline is an anticonflict & anticonvulsant quinoline derivative. It is an anxiolytic drug that was never marketed. It presents a unique chemical structure that does not follow the structural properties of other drugs of its class. Pipequaline has a similar pharmacological profile to the reported for the benzodiazepines. However, it...
Experimental
Matched Description: … of its class. ... It presents a unique chemical structure that does not follow the structural properties of other drugs ... However, it presents a significant set of anxiolytic properties with a very little sedative, amnestic …
LNP-nCoVsaRNA Vaccine
LNP-nCoVsaRNA is a purified, synthetic mRNA vaccine candidate encoding the S glycoprotein of SARS-CoV-2, which is used primarily by the virus to attach to and invade human cells. The vaccine was developed in and tested by the Medical Research Council Clinical Trials Unit at UCL in the UK, and jointly...
Investigational
Matched Description: … of the vaccine. ... LNP-nCoVsaRNA is a purified, synthetic mRNA vaccine candidate encoding the S glycoprotein of SARS-CoV ... As of July 2020, a clinical trial (COVAC1) is underway (ISRCTN17072692) to test the safety and immunogenicity …
IMA901
IMA901 is a vaccine consists of tumor-associated peptides (TUMAPs).
Investigational
Matched Description: … IMA901 is a vaccine consists of tumor-associated peptides (TUMAPs). …
Napabucasin
Napabucasin has been investigated for the treatment of Colorectal Carcinoma.
Investigational
Matched Description: … Napabucasin has been investigated for the treatment of Colorectal Carcinoma. …
Cerlapirdine
Cerlapirdine has been investigated for the treatment of Alzheimer Disease.
Investigational
Matched Description: … Cerlapirdine has been investigated for the treatment of Alzheimer Disease. …
Puerarin
Puerarin has been investigated for the treatment of Alcohol Abuse.
Investigational
Matched Description: … Puerarin has been investigated for the treatment of Alcohol Abuse. …
AC-430
AC430 has been investigated for the treatment of Rheumatoid Arthritis.
Investigational
Matched Description: … AC430 has been investigated for the treatment of Rheumatoid Arthritis. …
Vamifeport
Vamifeport is being investigated for the treatment of beta-thalassemia.
Investigational
Matched Description: … Vamifeport is being investigated for the treatment of beta-thalassemia. …
TZ-101
TZ-101 composes of GDP-L-fucose and fucosyltransferase VI
Investigational
Matched Description: … TZ-101 composes of [GDP-L-fucose] and fucosyltransferase VI …
G4544
G4544 is an oral gallium compound that enables oral absorption of the active ingredient contained in Ganite™ (gallium nitrate injection). It targets bone tissue and is actively incorporated into bone mineral at sites where bone is metabolically active.
Investigational
Matched Description: … G4544 is an oral gallium compound that enables oral absorption of the active ingredient contained in …
Sar9, Met (O2)11-Substance P
Sar9, Met (O2)11-Substance P is a neurokinin-1 receptor agonist. It is an analog of the naturally occurring human neuropeptide Substance P, which can be found throughout the body, including in the airways of humans and many other species.
Investigational
Matched Description: … the body, including in the airways of humans and many other species. ... It is an analog of the naturally occurring human neuropeptide Substance P, which can be found throughout …
MK-4721
MK-4721 is a fully human monoclonal antibody directed to Agensys’ proprietary target Prostate Stem Cell Antigen (PSCA), an antigen expressed at significant levels on tumor cells from the majority of patients with all stages of prostate, pancreatic and bladder cancers.
Investigational
Matched Description: … patients with all stages of prostate, pancreatic and bladder cancers. ... Stem Cell Antigen (PSCA), an antigen expressed at significant levels on tumor cells from the majority of …
BBM-H803
BBM-H803 is a recombinant adeno-associated virus (AAV) based gene therapy drug for hemophilia A developed and manufactured by Belief BioMed. It consists of an adeno-associated virus vector containing an expression cassette of the human Factor VIII transgene.
Investigational
Matched Description: … It consists of an adeno-associated virus vector containing an expression cassette of the human Factor …
Besifovir dipivoxil
Besifovir dipivoxil is a small-molecule orally available inhibitor of the HBV polymerase. The HBV polymerase is the enzyme that catalyzes the production of new RNA from the existing strand of RNA. Besifovir dipivoxil is believed to inhibit viral proliferation by interrupting the replicating machinery of the virus.
Investigational
Matched Description: … The HBV polymerase is the enzyme that catalyzes the production of new RNA from the existing strand of ... Besifovir dipivoxil is a small-molecule orally available inhibitor of the HBV polymerase. ... Besifovir dipivoxil is believed to inhibit viral proliferation by interrupting the replicating machinery of …
Nebicapone
Nebicapone is under investigation in clinical trial NCT03097211 (Effect of BIA 6-512 at Steady-state on the Levodopa Pharmacokinetics With a Single-dose of Levodopa/Benserazide 200/50 mg or With a Single-dose of Levodopa/Benserazide 200/50 mg Plus a Single-dose of Nebicapone 150 mg).
Investigational
Matched Description: … of Levodopa/Benserazide 200/50 mg Plus a Single-dose of Nebicapone 150 mg). ... Nebicapone is under investigation in clinical trial NCT03097211 (Effect of BIA 6-512 at Steady-state ... on the Levodopa Pharmacokinetics With a Single-dose of Levodopa/Benserazide 200/50 mg or With a Single-dose …
CNS-5161
CNS 5161 is a blocker of the NMDA ion channel and has completed Phase IIa proof of concept clinical trials as a novel compound for the treatment of neuropathic pain.
Investigational
Matched Description: … CNS 5161 is a blocker of the NMDA ion channel and has completed Phase IIa proof of concept clinical trials ... as a novel compound for the treatment of neuropathic pain. …
MUC1 Dendritic Cell Vaccine
Dendritic Cell (DC) Therapy is a newly emerging and potent form of immune therapy that amplifies the actions of the body's own immune system to help fight cancer, AIDS and other serious conditions. The Dendritic Cell is an immune cell whose role is the recognition, processing and presentation of foreign...
Investigational
Matched Description: … Dendritic Cell (DC) Therapy is a newly emerging and potent form of immune therapy that amplifies the ... actions of the body's own immune system to help fight cancer, AIDS and other serious conditions. ... antigens to the T-cells to initiate a primary response in the effector arm of the immune system. …
RG2417
RG2417 is a proprietary formulation of uridine, a biological compound essential for the synthesis of DNA and RNA, the basic hereditary material found in all cells, and numerous other factors essential for cell metabolism. Uridine is synthesized by the mitochondria, the power plant of the human cell responsible for energy...
Investigational
Matched Description: … metabolism of the brain. ... RG2417 is a proprietary formulation of uridine, a biological compound essential for the synthesis of ... This new insight suggests that the symptoms of bipolar disorder may be linked to dysregulation of energy …
MM-093
MM-093 is a recombinant version of human alpha-fetoprotein (hAFP), an immunomodulatory serum protein normally produced at very high levels by the fetus and present in low levels in the blood of adults and children. Research on AFP suggests that it may play a role in modulating the immune system of...
Investigational
Matched Description: … The presence of hAFP in the pregnant mother’s blood has long been associated with remission of many autoimmune ... MM-093 is a recombinant version of human alpha-fetoprotein (hAFP), an immunomodulatory serum protein ... normally produced at very high levels by the fetus and present in low levels in the blood of adults and …
PYM50018
PYM50018 is a patented, orally active, neuroprotective and neuroregenerative compound. It is developed for the treatment of amyotrophic lateral sclerosis (ALS, also known as Lou Gehrig's disease). In pre-clinical models, PYM50018 has been observed to protect against neuronal damage, increase neurite outgrowth, reverse oxidative damage and reverse neuronal apoptosis in...
Investigational
Matched Description: … When administered orally to a transgenic pre-clinical model of ALS, PYM50018 delays the loss of muscle ... It is developed for the treatment of amyotrophic lateral sclerosis (ALS, also known as Lou Gehrig's disease …
Technetium Tc-99m ciprofloxacin
99mTc-Ciprofloxacin is a new formulation of ciprofloxacin (INFECTON), being investigated as a radioimaging agent for the potential diagnosis of infection, including fever of unknown origin, osteomyelitis, wound infection, abdominal abscess, pneumonia, appendicitis and tuberculosis. INFECTON combines the widely used antibiotic, ciprofloxacin, with Technetium ((99m)Tc), the most commonly used radioisotope in...
Investigational
Matched Description: … agent for the potential diagnosis of infection, including fever of unknown origin, osteomyelitis, wound ... 99mTc-Ciprofloxacin is a new formulation of ciprofloxacin (INFECTON), being investigated as a radioimaging …
GS-441524
GS-441524 is an adenosine nucleotide analog antiviral, similar to remdesivir.[A203057,L13239] This molecule was patented in 2009. In vitro studies of GS-441524 have determined it has a higher EC50 than remdesivir against a number of viruses, meaning GS-441524 is less potent.[A203057,A203057] GS-441524 continues to be studied in the treatment of Feline...
Experimental
Matched Description: … against a number of viruses, meaning GS-441524 is less potent. ... [L13775] _In vitro_ studies of GS-441524 have determined it has a higher EC50 than remdesivir ... [A203057,A203057] GS-441524 continues to be studied in the treatment of Feline Infectious Peritonitis …
APG-157
APG-157 consists of zinflavonoids being investigated for the treatment of cancers.
Investigational
Nutraceutical
Matched Description: … APG-157 consists of zinflavonoids being investigated for the treatment of cancers. …
iCo-007
iCo-007 (formerly known as ISIS 13650) is a second generation antisense compound being developed by iCo for the treatment of various eye diseases caused by the formation of new blood vessels (angiogenesis) such as age-related macular degeneration (AMD) and diabetic retinopathy(DR).
Investigational
Matched Description: … known as ISIS 13650) is a second generation antisense compound being developed by iCo for the treatment of ... various eye diseases caused by the formation of new blood vessels (angiogenesis) such as age-related …
Displaying drugs 10576 - 10600 of 12589 in total