Displaying drugs 10751 - 10775 of 11800 in total
Rocaglamide
Rocaglamide, also referred to as rocaglamide-A, is the eponymous member of a class of anti-cancer phytochemicals known as rocaglamides. Rocaglamides are secondary metabolites of the plant genus Aglaia, and extracts of the plant have traditionally been used as a form of insect repellant due to its natural insecticidal properties. Reports...
Experimental
Matched Description: … Rocaglamide, also referred to as rocaglamide-A, is the eponymous member of a class of anti-cancer phytochemicals ... [A186760] Rocaglamide and a number of its derivatives (e.g. ... metabolites of the plant genus _Aglaia_, and extracts of the plant have traditionally been used as a …
αAβ–Gas6
αAβ–Gas6 is a chimeric fusion protein being investigated in preclinical studies as an immunotherapeutic agent for Alzheimer's disease (AD). It is made of a single chain variable fragment (scFv) of an Amyloid β (Aβ)-targeting monoclonal antibody fused with a truncated receptor binding domain of growth arrest-specific 6 (Gas6), which is...
Experimental
Matched Description: … fused with a truncated receptor binding domain of growth arrest-specific 6 (Gas6), which is a ligand ... αAβ–Gas6 is a chimeric fusion protein being investigated in preclinical studies as an immunotherapeutic ... It is made of a single chain variable fragment (scFv) of an Amyloid β (Aβ)-targeting monoclonal antibody …
JNJ-27390467
JNJ-27390467 is a potent, nonpeptide inhibitor of human mast cell tryptase.
Experimental
Matched Description: … JNJ-27390467 is a potent, nonpeptide inhibitor of human mast cell tryptase. …
Kebuzone
Kebuzone (also known as ketophenylbutazone ) is a non-steroidal anti-inflammatory drug.
Experimental
Matched Description: … Kebuzone (also known as ketophenylbutazone ) is a non-steroidal anti-inflammatory drug. …
Cloperastine
Cloperastine is a cough suppressant that acts on the central nervous system.
Experimental
Matched Description: … Cloperastine is a cough suppressant that acts on the central nervous system. …
Biomodulin T
Biomodulin T is a polypeptide fraction from bovine thymus with immunomodulatory effects.
Investigational
Matched Description: … Biomodulin T is a polypeptide fraction from bovine thymus with immunomodulatory effects. …
KT-333
KT-333 is a small molecule targeted protein degrader of STAT3.
Investigational
Matched Description: … KT-333 is a small molecule targeted protein degrader of STAT3.[L44086] …
MPB-1523
MPB-1523 is a contrast agent comprising PEGylated iron oxide nanoparticles.
Investigational
Matched Description: … MPB-1523 is a contrast agent comprising PEGylated iron oxide nanoparticles.[L48161] …
rAAV9-hNAGLU
rAAV9-hNAGLU consists of a recombinant AAV9 expressing human alpha-N-acetylglucosaminidase.
Investigational
Matched Description: … rAAV9-hNAGLU consists of a recombinant AAV9 expressing human alpha-N-acetylglucosaminidase. …
ZVS101e
ZVS101e is a recombinant adeno-associated virus vector carrying human CYP4V2 gene.
Investigational
Matched Description: … ZVS101e is a recombinant adeno-associated virus vector carrying human CYP4V2 gene. …
EI-1071
EI-1071 is a selective Colony Stimulating Factor-1 Receptor kinase inhibitor.
Investigational
Matched Description: … EI-1071 is a selective Colony Stimulating Factor-1 Receptor kinase inhibitor. …
Thymidine
Thymidine is a pyrimidine deoxynucleoside. Thymidine is the DNA nucleoside T, which pairs with deoxyadenosine (A) in double-stranded DNA. In cell biology it is used to synchronize the cells in S phase.
Experimental
Investigational
Matched Description: … Thymidine is a pyrimidine deoxynucleoside. ... Thymidine is the DNA nucleoside T, which pairs with deoxyadenosine (A) in double-stranded DNA. …
beta-Naphthoflavone
β-Naphthoflavone, also known as 5,6-benzoflavone, is a potent agonist of the aryl hydrocarbon receptor and induces cytochromes P450 (CYPs) and uridine 5'-diphospho-glucuronosyltransferases (UGTs). It may be a chemopreventive agent.
Experimental
Matched Description: … It may be a chemopreventive agent. ... β-Naphthoflavone, also known as 5,6-benzoflavone, is a potent agonist of the aryl hydrocarbon receptor …
Idraparinux
Idraparinux, a synthetic pentasaccharide is an antithrombin-dependent inhibitor of activated factor X. It was developed for the treatment and prevention of thromboembolic events. However, clinical trials have revealed that idraparinux had lead to bleeding. As a result, Sanofi stopped the development of the drug.
Investigational
Matched Description: … As a result, Sanofi stopped the development of the drug. ... Idraparinux, a synthetic pentasaccharide is an antithrombin-dependent inhibitor of activated factor X …
XL784
XL784 is a potent inhibitor of the ADAM-10 metalloprotease enzyme, a target of significant interest because of its important role in blood vessel formation and cell proliferation. XL784 was specifically optimized to be MMP-1 sparing, thus potentially enhancing its safety profile and enabling higher dosing compared with other previously studied...
Investigational
Matched Description: … XL784 is a potent inhibitor of the ADAM-10 metalloprotease enzyme, a target of significant interest because …
G207
G207 is cancer-killing viruses, so-called oncolytic viruses, for the treatment of various forms of cancer developed by MediGene AG. These viruses are specific herpes simplex viruses, or HSVs, generally known as the cause of cold sores. MediGene uses these viruses, however, in a modified and "disarmed" form in order to...
Investigational
Matched Description: … as a therapeutic agent in humans. ... MediGene uses these viruses, however, in a modified and "disarmed" form in order to make them utilizable …
Vasomera
Investigational
IDD-1
Lipids promote the fusion of liposomes to cells. Eladem (IDD-1) is a therapeutic vaccine consisting of dendritophages that are loaded in vitro with tumor antigens and then reinjected into the subject. As with other monoclonal antibodies, this process stimulates an immune response to a particular disease-related antigen.
Investigational
Matched Description: … Eladem (IDD-1) is a therapeutic vaccine consisting of dendritophages that are loaded in vitro with tumor ... As with other monoclonal antibodies, this process stimulates an immune response to a particular disease-related …
OSI-7904L
OSI-7904L is a liposome encapsulated thymidylate synthase inhibitor, which is indicated for use in advanced gastric and/or gastroesophageal adenocarcinoma (A-G/GEJA). Current treatments also inhibit thymidylate synthase but the innovative lipid coating of OSI-7904L allows for more enduring results with administration of the TS inhibitor.
Investigational
Matched Description: … gastric and/or gastroesophageal adenocarcinoma (A-G/GEJA). ... OSI-7904L is a liposome encapsulated thymidylate synthase inhibitor, which is indicated for use in advanced …
Nisoxetine
Nisoxetine is a selective norepinephrine reuptake inhibitor (SNRI) developed in the 1970s. It was originally investigated as an antidepressant but has no current clinical applications aside from being a research standard SNRI. It has been used to research obesity and energy balance, and exerts some local analgesia effects.
Experimental
Matched Description: … Nisoxetine is a selective norepinephrine reuptake inhibitor (SNRI) developed in the 1970s. ... originally investigated as an antidepressant but has no current clinical applications aside from being a …
Tipapkinogene sovacivec
Investigational
SD118
SD118 was previously under investigation in Japan for a different indication and now, following re-profiling and evaluation in experimental animal models, has demonstrated its potential as a new oral therapy for neuropathic pain.
Investigational
Matched Description: … SD118 was previously under investigation in Japan for a different indication and now, following re-profiling ... and evaluation in experimental animal models, has demonstrated its potential as a new oral therapy for …
CTCE-0214
CTCE-0214 is a stable peptide agonist of stromal cell-derived factor-1 (SDF-1), a key signaling molecule in the proliferation, homing, engraftment and expansion of hematopoietic stem cells and white blood cells.
Investigational
Matched Description: … CTCE-0214 is a stable peptide agonist of stromal cell-derived factor-1 (SDF-1), a key signaling molecule …
MW33
MW33 is a recombinant fully human antibody to SARS-CoV-2. This antibody injection is currently being investigated against COVID-19 in the clinical trial NCT04533048 (A Clinical Study to Evaluate MW33 Injection).
Investigational
Matched Description: … MW33 is a recombinant fully human antibody to SARS-CoV-2. ... antibody injection is currently being investigated against COVID-19 in the clinical trial NCT04533048 (A …
Zofin
Zofin, previously known as Organicell Flow, is a nanoparticle-based therapeutic derived from perinatal sources which is manufactured in a way that retains the naturally occurring microRNAs without the addition of other substances .
Investigational
Matched Description: … Zofin, previously known as Organicell Flow, is a nanoparticle-based therapeutic derived from perinatal ... sources which is manufactured in a way that retains the naturally occurring microRNAs without the addition …
Displaying drugs 10751 - 10775 of 11800 in total