Displaying drugs 10951 - 10975 of 12071 in total
Trefoil Factor 2
The trefoil factor 2 (TFF2) peptide is a low-molecular weight protein and one of the three trefoil-motif-containing proteins. They are expressed predominantly in gastric tissues with the source for them being predominantly stromal cells, although expression of TFF2 mRNA transcripts also occurs with tissue macrophages. The peptides themselves are most...
Investigational
Matched Description: … The trefoil factor 2 (TFF2) peptide is a low-molecular weight protein and one of the three trefoil-motif-containing …
Guanosine tetraphosphate
Guanosine tetraphosphate is a guanine nucleotide containing four phosphate groups. Two phosphate groups are esterified to the sugar moiety in the 5' position and the other two in the 2' or 3' position. This nucleotide serves as a messenger to turn off the synthesis of ribosomal RNA when amino acids...
Experimental
Matched Description: … Guanosine tetraphosphate is a guanine nucleotide containing four phosphate groups. ... This nucleotide serves as a messenger to turn off the synthesis of ribosomal RNA when amino acids are …
ReN001
ReN001 is a clonal human neural stem cell line developed for clinical use in the treatment of stable disability after stroke. ReN001 a strong candidate for one of the first cell-based IND applications to be submitted to the Food and Drug Administration in the United States for consideration for the...
Investigational
Matched Description: … ReN001 is a clonal human neural stem cell line developed for clinical use in the treatment of stable ... ReN001 a strong candidate for one of the first cell-based IND applications to be submitted to the Food …
R411
R411 is a non-steroid oral medicine for the treatment of asthma. It is not immunosuppressive, but blocks the activation and recruitment of cells involved in respiratory inflammation. It is a dual-acting competitive integrin antagonist (as compared to previously developed single integrin antagonists or SIAs) that prevents binding of V-CAM1 to...
Investigational
Matched Description: … R411 is a non-steroid oral medicine for the treatment of asthma. ... It is a dual-acting competitive integrin antagonist (as compared to previously developed single integrin …
GnRH pharmaccine
The GnRH pharmaccine consists of synthetic peptides (constructed to "look like" GnRH), which are bound chemically to a carrier and suspended in a proprietary "delivery vehicle". The pharmaccine is administered intramuscularly to the patient by injection and induces an immune response or production of antibodies in the patient, which neutralize...
Investigational
Matched Description: … carrier and suspended in a proprietary "delivery vehicle". ... pharmaccine consists of synthetic peptides (constructed to "look like" GnRH), which are bound chemically to a …
5-(5-(2,6-dichloro-4-(4,5-dihydro-2-oxazolyl)phenoxy)pentyl)-3-(hydroxyethyl oxymethyleneoxymethyl) isoxazole
5-(5-(2,6-dichloro-4-(4,5-dihydro-2-oxazolyl)phenoxy)pentyl)-3-(hydroxyethyl oxymethyleneoxymethyl) isoxazole is a solid. This compound belongs to the phenol ethers. These are aromatic compounds containing an ether group substituted with a benzene ring. 5-(5-(2,6-dichloro-4-(4,5-dihydro-2-oxazolyl)phenoxy)pentyl)-3-(hydroxyethyl oxymethyleneoxymethyl) isoxazole targets the protein genome polyprotein.
Experimental
Matched Description: … dichloro-4-(4,5-dihydro-2-oxazolyl)phenoxy)pentyl)-3-(hydroxyethyl oxymethyleneoxymethyl) isoxazole is a ... These are aromatic compounds containing an ether group substituted with a benzene ring. 5-(5-(2,6-dichloro …
CIGB 2020 Vaccine
CIGB 2020 is a vaccine candidate administered nasally and sublingually, working to strengthen immunity in the areas administered. The vaccine was developed and tested by the Center for Genetic Engineering and Biotechnology (CIGB), in Havana Cuba. As of July, 2020, a Randomized control clinical trial (RPCEC00000306) is underway to evaluate...
Investigational
Matched Description: … CIGB 2020 is a vaccine candidate administered nasally and sublingually, working to strengthen immunity ... As of July, 2020, a Randomized control clinical trial (RPCEC00000306) is underway to evaluate prophylaxis …
PF-04418948
Pf 04418948 is under investigation in clinical trial NCT01002963 (A Study To Investigate The Safety And Toleration Of A Single Dose Of PF-04418948 In Healthy Volunteers).
Investigational
Matched Description: … Toleration Of A Single Dose Of PF-04418948 In Healthy Volunteers). ... Pf 04418948 is under investigation in clinical trial NCT01002963 (A Study To Investigate The Safety And …
MRK-003
MRK-003 is a potent and selective γ-secretase inhibitor developed by Merck. It is the preclinical analog of MK-0752, a drug in clinical development.
Investigational
Matched Description: … MRK-003 is a potent and selective γ-secretase inhibitor developed by Merck. ... It is the preclinical analog of [MK-0752], a drug in clinical development.[A252682] …
XL281
XL281 is a novel anticancer compound designed to potently inhibit the RAS/RAF/MEK/ERK signaling pathway. Mutational activation of RAS occurs in about 30 percent of all human tumors, including non-small cell lung, pancreatic, and colon cancer. XL281 is a specific inhibitor of RAF kinases, including the mutant form of B-RAF, which...
Investigational
Matched Description: … XL281 is a novel anticancer compound designed to potently inhibit the RAS/RAF/MEK/ERK signaling pathway ... XL281 is a specific inhibitor of RAF kinases, including the mutant form of B-RAF, which is activated …
Renzapride
Renzapride is currently in Phase III clinical development in the United States for the treatment of constipation-predominant irritable bowel syndrome (IBS-C). It has been suggested that renzapride is effective in the treatment of irritable bowel syndrome with alternating stool pattern. It is being developed by Alizyme of the UK.
Investigational
VB10.16
VB10.16 is a novel therapeutic antigen-presenting cell-targeting DNA vaccine developed to treat HPV16-positive cancers. It is composed of three parts, one encodes the E6/E7 fusion protein of human papillomavirus (HPV) type 16 (HPV16), a dimerization entity, and the part encoding a protein that specifically binds to antigen-presenting cells (APCs).
Investigational
Matched Description: … VB10.16 is a novel therapeutic antigen-presenting cell-targeting DNA vaccine developed to treat HPV16 ... of three parts, one encodes the E6/E7 fusion protein of human papillomavirus (HPV) type 16 (HPV16), a ... dimerization entity, and the part encoding a protein that specifically binds to antigen-presenting cells …
GS030-DP
GS030-DP is an optogenetic gene therapy being investigated for the treatment of retinitis pigmentosa. It targets retinal ganglion cells that encodes a light-sensitive channelrhodopsin, ChrimsonR-tdTomato (ChR-tdT), delivered by an AAV2.7m8 vector. It is a component of GS030, an investigational optogenetic treatment, in combination with a medical device GS030-MD.[A259816, L46701]
Investigational
Matched Description: … It is a component of GS030, an investigational optogenetic treatment, in combination with a medical device ... It targets retinal ganglion cells that encodes a light-sensitive channelrhodopsin, ChrimsonR-tdTomato …
IGN301
IGN301 is a cancer vaccine based on an anti-idiotypic antibody which provokes an immune response to Lewis Y. Lewis Y is a carbohydrate molecule expressed on the surface of tumor cells of epithelial origin (e.g. lung, intestinal, breast, prostate or ovarian cancers).
Investigational
Matched Description: … IGN301 is a cancer vaccine based on an anti-idiotypic antibody which provokes an immune response to Lewis ... Lewis Y is a carbohydrate molecule expressed on the surface of tumor cells of epithelial origin (e.g. …
YKP-1358
YKP1358 is a novel serotonin (5-HT2A) and dopamine (D2) antagonist that has demonstrated potent activity in animals that relates to both positive and negative symptoms of schizophrenia. In addition, the YKP1358 pharmacological profile suggests a very low potential for extrapyramidal side effects.
Investigational
Matched Description: … YKP1358 is a novel serotonin (5-HT2A) and dopamine (D2) antagonist that has demonstrated potent activity ... In addition, the YKP1358 pharmacological profile suggests a very low potential for extrapyramidal side …
5-(5-(4-(4,5-dihydro-2-oxazoly)phenoxy)pentyl)-3-methyl osoxazole
5-(5-(4-(4,5-dihydro-2-oxazoly)phenoxy)pentyl)-3-methyl osoxazole is a solid. This compound belongs to the phenol ethers. These are aromatic compounds containing an ether group substituted with a benzene ring. This drug is known to target genome polyprotein.
Experimental
Matched Description: … 5-(5-(4-(4,5-dihydro-2-oxazoly)phenoxy)pentyl)-3-methyl osoxazole is a solid. ... These are aromatic compounds containing an ether group substituted with a benzene ring. …
Thalagen
Thalagen is a branded product developed by San Rocco Therapeutics. It consists of autologous CD34-positive hematopoietic progenitor cells transduced with TNS9.3.55, a lentiviral vector encoding the normal human beta-globin gene. It is being investigated for the treatment of beta-thalassemia.
Investigational
Matched Description: … Thalagen is a branded product developed by San Rocco Therapeutics. ... It consists of autologous CD34-positive hematopoietic progenitor cells transduced with TNS9.3.55, a lentiviral …
DYNE-251
DYNE-251 is a phosphorodiamidate morpholino oligomer (PMO) conjugated to a fragment antibody (Fab) that binds to the transferrin receptor 1 (TfR1). It is being investigated for the treatment of Duchenne muscular dystrophy (DMD) in patients who are amenable to exon 51 skipping.
Investigational
Matched Description: … DYNE-251 is a phosphorodiamidate morpholino oligomer (PMO) conjugated to a fragment antibody (Fab) that …
Gallium maltolate
Gallium maltolate is Titan’s novel oral agent in development for the potential treatment of chronic bacterial infections, bone disease and cancer.
Investigational
D-Treitol
A four-carbon sugar that is found in algae, fungi, and lichens. It is twice as sweet as sucrose and can be used as a coronary vasodilator. [PubChem]
Experimental
Matched Description: … A four-carbon sugar that is found in algae, fungi, and lichens. ... It is twice as sweet as sucrose and can be used as a coronary vasodilator. [PubChem] …
(S)-propane-1,2-diol
(S)-propane-1,2-diol is a clear, colorless, viscous organic solvent and diluent used in pharmaceutical preparations.
Experimental
Matched Description: … (S)-propane-1,2-diol is a clear, colorless, viscous organic solvent and diluent used in pharmaceutical …
Etozoline
Etozoline is marketed in Europe under the names Diulozin, Elkapin, and Etopinil. Etozoline is a loop diuretic.
Experimental
Matched Description: … Etozoline is a loop diuretic. …
Levodropropizine
Levodropropizine is under investigation in clinical trial NCT01573663 (A Drug-Drug Interaction Study of Ambroxol and Levodropropizine).
Investigational
Matched Description: … Levodropropizine is under investigation in clinical trial NCT01573663 (A Drug-Drug Interaction Study …
ST101 peptide
ST101 is a cell-penetrating peptide that disrupts the protein-protein interactions driving ATF5-regulated gene transcription.
Investigational
Matched Description: … ST101 is a cell-penetrating peptide that disrupts the protein-protein interactions driving ATF5-regulated …
tgAAG-76
tgAAG-76 consists of a recombinant adeno-associated virus (serotype 2) (rAAV2) gene transfer agent expressing RPE65.
Investigational
Matched Description: … tgAAG-76 consists of a recombinant adeno-associated virus (serotype 2) (rAAV2) gene transfer agent expressing …
Displaying drugs 10951 - 10975 of 12071 in total