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Displaying drugs 1151 - 1175 of 1625 in total

ABSK-012

Investigational
Matched Synonyms: … 3-(5-cyano-4-(cyclopropylamino)pyridin-2-yl)-1-(6-formyl-5-((4-methyl-2-oxopiperazin-1-yl)methyl)pyridin ... N′-[5-Cyano-4-(cyclopropylamino)-2-pyridinyl]-N-[6-formyl-5-[(4-methyl-2-oxo-1-piperazinyl)methyl]-2- ... Urea, N′-[5-cyano-4-(cyclopropylamino)-2-pyridinyl]-N-[6-formyl-5-[(4-methyl-2-oxo-1-piperazinyl)methyl …
Matched Iupac: … 3-[5-cyano-4-(cyclopropylamino)pyridin-2-yl]-1-{6-formyl-5-[(4-methyl-2-oxopiperazin-1-yl)methyl]pyridin …

Brentuximab vedotin

Brentuximab vedotin, also known as Adcetris®, is an antibody-drug conjugate that combines an anti-CD30 antibody with the drug monomethyl auristatin E (MMAE). It is an anti-neoplastic agent used in the treatment of Hodgkin's lymphoma and systemic anaplastic large-cell lymphoma. Brentuximab vedotin was initially approved in 2011. In January 2012, the...
Approved
Investigational
Matched Description: … This demonstrates meaningful progress in treatment for patients affected by this disease.[L1739] ... Lymphoma may begin anywhere in the body and can spread to nearby lymph nodes. ... It is an anti-neoplastic agent used in the treatment of Hodgkin's lymphoma and systemic anaplastic large-cell …
Matched Categories: … Amino Acids, Peptides, and Proteins ... Antineoplastic and Immunomodulating Agents ... MONOCLONAL ANTIBODIES AND ANTIBODY DRUG CONJUGATES …
Matched Products: … ADCETRIS 50 MG (POWDER FOR CONCENTRATE FOR SOLUTION FOR INFUSION) ... POWDER FOR CONCENTRATE FOR SOLUTION FOR INFUSION 50MG/VIAL ... Adcetris 50mg, powder for concentrate for solution for infusion …

Polyvinyl alcohol

Polyvinyl alcohol is a water-soluble synthetic polymer obtained by polymerization of vinyl alcohol. It has varying roles in commercial and industrial applications such as papermaking, textiles, and printing. Polyvinyl alcohol is found in ophthalmic solutions as a lubricant to prevent irritation or to relieve dryness of the eyes .
Approved
Matched Description: … It has varying roles in commercial and industrial applications such as papermaking, textiles, and printing …
Matched Mixtures name: … Murine Tears for Dry Eyes ... Murine Plus for Dry Eyes Redness Relief …
Matched Products: … Liquifilm Forte 3% ... Artificial Tears for Dry Eyes …

Simoctocog alfa

Simoctocog alfa is a recombinant B-domain deleted (BDD) rFVIII produced in genetically modified human embryonic kidney (HEK) 293F cells. The harvested product is concentrated and purified by a series of chromatography steps. It is an antihemorrhagic agent used as a replacement therapy in individuals with Haemophilia A who lack the...
Approved
Matched Description: … The harvested product is concentrated and purified by a series of chromatography steps. ... + A3-C1-C2 whereas the B-domain, present in the full-length plasma-derived FVIII, has been deleted and ... potentially immunogenic glycosylation patterns found in non-human cell lines led to decreased immunogenicity and …
Matched Categories: … Amino Acids, Peptides, and Proteins …
Matched Products: … Nuwiq 250IU Powder for Solution for Injection ... Nuwiq 500IU Powder for Solution for Injection ... Nuwiq 1000IU Powder for Solution for Injection …

Oxaliplatin

Oxaliplatin is a platinum-based chemotherapy drug in the same family as cisplatin and carboplatin. Compared to cisplatin the two amine groups are replaced by diamino cyclohexane (DACH) group to provide a greater antitumor effect. However, this leads to poorer water solubility, which was compensated by the addition of the chloride...
Approved
Investigational
Matched Description: … [A797] However, this leads to poorer water solubility, which was compensated by the addition of the chloride ... Oxaliplatin is a platinum-based chemotherapy drug in the same family as cisplatin and carboplatin. ... cancer, mesothelioma, and non-small cell lung cancer. …
Matched Categories: … Antineoplastic and Immunomodulating Agents …
Matched Products: … hovid Oxaliplatin 50mg Powder for Concentrate for Solution for Infusion ... HOVID OXALIPLATIN POWDER FOR CONCENTRATE FOR SOLUTION FOR INFUSION 50MG/VIAL ... hovid Oxaliplatin 100mg Powder for Concentrate for Solution for Infusion …

(3-Formyl-but-3-Enyl)-Phosphonic Acid

Experimental
Matched Name: … (3-Formyl-but-3-Enyl)-Phosphonic Acid …

5-Formyl-2'-deoxy-cytidine-5'-monophosphate

Experimental
Matched Name: … 5-Formyl-2'-deoxy-cytidine-5'-monophosphate …
Matched Iupac: … {[(2R,3S,5R)-5-(4-amino-5-formyl-2-oxo-1,2-dihydropyrimidin-1-yl)-3-hydroxyoxolan-2-yl]methoxy}phosphonic …

Ceftaroline fosamil

Ceftaroline fosamil is a cephalosporin antibacterial indicated for the treatment of the following infections caused by designated susceptible bacteria: Acute bacterial skin and skin structure infections. Community-acquired bacterial pneumonia.
Approved
Investigational
Matched Description: … caused by designated susceptible bacteria: Acute bacterial skin and skin structure infections. ... Ceftaroline fosamil is a cephalosporin antibacterial indicated for the treatment of the following infections …
Matched Salts name: … Ceftaroline fosamil acetate ... Ceftaroline fosamil acetate monohydrate …
Matched Categories: … Antibacterials for Systemic Use ... Antiinfectives for Systemic Use …
Matched Products: … Zinforo 600mg Powder for Concentrate for Solution for Infusion ... Zinforo Powder for Concentrate for Solution for Infusion 600mg/vial …

Gemcitabine

Gemcitabine is a nucleoside analog and a chemotherapeutic agent. It was originally investigated for its antiviral effects, but it is now used as an anticancer therapy for various cancers. Gemcitabine is a cytidine analog with two fluorine atoms replacing the hydroxyl on the ribose. As a prodrug, gemcitabine is transformed...
Approved
Matched Description: … for various cancers. ... Gemcitabine is a nucleoside analog and a chemotherapeutic agent. ... [L32950] It is also being investigated in other cancer and tumour types. …
Matched Categories: … Antineoplastic and Immunomodulating Agents ... Nucleic Acids, Nucleotides, and Nucleosides …
Matched Products: … GEMZAR 1gm POWDER FOR SOLUTION FOR INFUSION ... GEMZAR 200mg Powder for Solution for Infusion ... DBL Gemcitabine Powder for Solution for Injection 1g …

Daratumumab

Daratumumab is an immunoglobulin G1 kappa monoclonal antibody developed by Janssen and Genmab. It was first described in the literature in 2010 as a monoclonal antibody that targets CD38+ multiple myeloma cells; the first of its kind. Daratumumab was granted FDA approval on 16 November 2015. It is approved for...
Approved
Matched Description: … [L13290] It is approved for the treatment of multiple myeloma as monotherapy or combination therapy and ... Daratumumab is an immunoglobulin G1 kappa monoclonal antibody developed by Janssen and Genmab. …
Matched Categories: … Amino Acids, Peptides, and Proteins ... Antineoplastic and Immunomodulating Agents ... MONOCLONAL ANTIBODIES AND ANTIBODY DRUG CONJUGATES …
Matched Products: … DARZALEX CONCENTRATE FOR SOLUTION FOR INFUSION 400MG/20ML ... DARZALEX CONCENTRATE FOR SOLUTION FOR INFUSION 100MG/5ML ... Darzalex 20mg/mL Concentrate for Solution for Infusion …

Vedolizumab

Vedolizumab is a recombinant humanized IgG1 monoclonal antibody directed against the human lymphocyte α4β7 integrin, a key mediator of gastrointestinal inflammation implicated in diseases like ulcerative colitis or Crohn's disease. α4β7 integrin facilitates the interaction between lymphocytes and gut endothelial cells through the α4β7 integrin-MAdCAM1 interaction, leading to the mobilization...
Approved
Matched Description: … for the maintenance therapy of moderately to severely active Ulcerative Colitis and Crohn’s Disease in ... April and September 2023, respectively. ... six weeks and then every 8 weeks thereafter. …
Matched Categories: … Amino Acids, Peptides, and Proteins ... Antineoplastic and Immunomodulating Agents …
Matched Products: … Entyvio 300mg Powder for Concentrate for Solution for Infusion ... ENTYVIO POWDER FOR CONCENTRATE FOR SOLUTION FOR INFUSION 300MG/VIAL …

Bevacizumab

There is a great deal of evidence indicating that vascular endothelial growth factor (VEGF) is important for the survival and proliferation of cancer cells.[A192939,A192837,A192891,A193275] VEGF plays an important role in angiogenesis, lymphangiogenesis, and tumor growth, which are all factors that contribute to its attractiveness as a therapeutic target for anti-cancer...
Approved
Investigational
Matched Description: … the survival and proliferation of cancer cells. ... [A193272,A193275] It is a humanized monoclonal IgG antibody, and inhibits angiogenesis by binding and ... regimens which are specific to the type, severity, and stage of cancer. …
Matched Categories: … Amino Acids, Peptides, and Proteins ... Antineoplastic and Immunomodulating Agents ... MONOCLONAL ANTIBODIES AND ANTIBODY DRUG CONJUGATES ... Experimental Unapproved Treatments for COVID-19 …
Matched Products: … ZIRABEV CONCENTRATE FOR SOLUTION FOR INFUSION 100 MG/4 ML ... ZIRABEV CONCENTRATE FOR SOLUTION FOR INFUSION 400 MG/16 ML ... MVASI CONCENTRATE FOR SOLUTION FOR INFUSION 25 MG/ML …

Bendamustine

Bendamustine is a nitrogen mustard drug which has been used in the treatment of chronic lymphocytic leukemia (CLL) and indolent B-cell non-Hodgkin lymphoma (NHL). Bendamustine is a bifunctional mechlorethamine derivative capable of forming electrophilic alkyl groups that covalently bond to other molecules. Through this function as an alkylating agent, bendamustine...
Approved
Investigational
Matched Description: … a nitrogen mustard drug which has been used in the treatment of chronic lymphocytic leukemia (CLL) and ... Through this function as an alkylating agent, bendamustine causes intra- and inter-strand crosslinks ... It is active against both active and quiescent cells, although the exact mechanism of action is unknown …
Matched Categories: … Antineoplastic and Immunomodulating Agents …
Matched Products: … BEMUNAT POWDER FOR CONCENTRATE FOR SOLUTION FOR INFUSION 25 MG/VIAL USP ... BEMUNAT POWDER FOR CONCENTRATE FOR SOLUTION FOR INFUSION 100 MG/VIAL USP ... RIBOMUSTIN 25MG/VIAL POWDER FOR CONCENTRATE FOR SOLUTION FOR INFUSION …

Erenumab

Erenumab (AMG-334) (INN; trade name Aimovig) is a human monoclonal antibody designed specifically to bind and antagonize the calcitonin gene-related peptide receptor (CGRPR) as a means to prevent migraines. Aimovig, as released and marketed by Novartis and Amgen, is in fact a novel therapeutic approach as the first and only...
Approved
Investigational
Matched Description: … Aimovig, as released and marketed by Novartis and Amgen, is in fact a novel therapeutic approach as the ... Erenumab (AMG-334) (INN; trade name Aimovig) is a human monoclonal antibody designed specifically to bind and ... first and only FDA approved treatment specifically developed to prevent migraine by blocking the CGRP …
Matched Categories: … Amino Acids, Peptides, and Proteins …
Matched Products: … AIMOVIG (140 MG/ML SOLUTION FOR INJECTION) ... AIMOVIG (70 MG/ML SOLUTION FOR INJECTION) ... AIMOVIG SOLUTION FOR INJECTION IN PRE-FILLED PEN 70MG/ML …

Formoterol

Formoterol is an inhaled beta2-agonist used in the management of COPD and asthma that was first approved for use in the United States in 2001. It acts on bronchial smooth muscle to dilate and relax airways, and is administered as a racemic mixture of its active (R;R)- and inactive (S;S)-enantiomers....
Approved
Investigational
Matched Description: … this reason, treatment guidelines for asthma recommend its use as both a reliever and maintenance medication ... [L10986] It acts on bronchial smooth muscle to dilate and relax airways, and is administered as a racemic ... first approved for use in the United States in 2001. …
Matched Mixtures name: … Budesonide and Formoterol Fumarate Dihydrate ... Budesonide and Formoterol Fumarate Dihydrate ... Budesonide and Formoterol Fumarate Dihydrate …
Matched Categories: … Adrenergics for Systemic Use ... Drugs for Obstructive Airway Diseases ... formoterol and mometasone ... formoterol and budesonide ... formoterol and fluticasone …
Matched Products: … FORMO-ARISTO 12UG ... Foradil Dry Powder Capsules for Inhalation ... FORADIL CAPSULE FOR INHALATION 12 mcg/capsule …

Pertuzumab

Pertuzumab is a recombinant humanized monoclonal antibody that targets the extracellular dimerization domain (subdomain II) of the human epidermal growth factor receptor 2 protein (HER2). It consists of two heavy chains and two lights chains that have 448 and 214 residues respectively. It was first approved by the FDA in...
Approved
Matched Description: … It was first approved by the FDA in 2012 for use with [docetaxel] and another HER2-targeted monoclonal ... It consists of two heavy chains and two lights chains that have 448 and 214 residues respectively. ... Its indicated conditions have since expanded to include use as both a neoadjuvant therapy and an adjuvant …
Matched Categories: … Amino Acids, Peptides, and Proteins ... pertuzumab and trastuzumab ... Antineoplastic and Immunomodulating Agents ... MONOCLONAL ANTIBODIES AND ANTIBODY DRUG CONJUGATES …
Matched Products: … Perjeta 420 mg concentrate for solution for infusion ... PERJETA CONCENTRATE FOR SOLUTION FOR INFUSION 420MG/14ML ... PHESGO SOLUTION FOR SUBCUTANEOUS INJECTION 600 MG/600 MG / 10 ML …

Azacitidine

Azacitidine is a pyrimidine nucleoside analogue with anti-neoplastic activity. It differs from cytosine by the presence of nitrogen in the C5-position, key in its hypomethylating activity.[A1406,A1413,A1415] Two main mechanisms of action have been proposed for azacitidine. One of them is the induction of cytotoxicity. As an analogue of cytidine, it...
Approved
Investigational
Matched Description: … As an analogue of cytidine, it is able to incorporate into RNA and DNA, disrupting RNA metabolism and ... inhibiting protein and DNA synthesis. ... [A1407] Due to its anti-neoplastic activity and its ability to inhibit methylation in replicating DNA …
Matched Categories: … Antineoplastic and Immunomodulating Agents ... Nucleic Acids, Nucleotides, and Nucleosides …
Matched Products: … Azacitidine For ... Vidaza powder for suspension for injection 100mg/vial ... AZADINE POWDER FOR SUSPENSION FOR INJECTION 100MG/VIAL …

Mepolizumab

Eosinophils are involved in inflammatory immune responses, and prolonged hypereosinophilia (typically defined as absolute eosinophil levels of 1500/mm3 or more) is associated with a spectrum of diseases, including severe asthma, eosinophilic granulomatosis with polyangiitis (EGPA), and hypereosinophilic syndrome (HES). The pathogenesis of eosinophilia is complex, but IL-5 is recognized as...
Approved
Investigational
Matched Description: … Mepolizumab was first approved by the FDA on November 4, 2015, as an add-on therapy for severe asthma ... Activated eosinophils further stimulate an inflammatory response and also induce tissue lesions and promote ... Eosinophils are involved in inflammatory immune responses, and prolonged hypereosinophilia (typically …
Matched Categories: … Amino Acids, Peptides, and Proteins ... Drugs for Obstructive Airway Diseases …
Matched Products: … NUCALA POWDER FOR SOLUTION FOR INJECTION 100mg ... Nucala 100mg Powder for Solution for Injection ... NUCALA SOLUTION FOR INJECTION IN PRE-FILLED PEN 100MG/ML …

Atezolizumab

Atezolizumab is a humanized monoclonal antibody used to prevent the interaction of PD-L1 and PD-1, removing inhibition of immune responses seen in some cancers.[A18493,L7489] This medication is reserved for patients whose tumors express PD-L1, cannot receive platinum-based chemotherapy, or whose tumors do not respond to platinum-based chemotherapy. Atezolizumab was granted...
Approved
Investigational
Matched Description: … Atezolizumab is a humanized monoclonal antibody used to prevent the interaction of PD-L1 and PD-1, removing ... [L7489] In November 2022, the manufacturer (Genentech) voluntarily withdrew the use of atezolizumab for ... [A18493,L7489] This medication is reserved for patients whose tumors express PD-L1, cannot receive platinum-based …
Matched Categories: … Amino Acids, Peptides, and Proteins ... Antineoplastic and Immunomodulating Agents ... MONOCLONAL ANTIBODIES AND ANTIBODY DRUG CONJUGATES …
Matched Products: … TECENTRIQ CONCENTRATE FOR SOLUTION FOR INFUSION 840MG/14ML ... Tecentriq 60mg/ml Concentrate for Solution for Infusion ... TECENTRIQ CONCENTRATE FOR SOLUTION FOR INFUSION 1200 MG/ 20 ML …

Aflibercept

Aflibercept is a recombinant protein composed of the binding domains of two human vascular endothelial growth factor (VEGF) receptors, VEGFR1 and VEGFR2, fused with the Fc region of human immunoglobulin gamma 1 (IgG1). Structurally, Aflibercept is a dimeric glycoprotein with a protein molecular weight of 96.9 kilo Daltons (kDa). It...
Approved
Matched Description: … the treatment of retinopathy of prematurity in preterm infants in February 2023 and for the treatment ... and February 2013, respectively. ... the treatment of metastatic colorectal cancer, and it was approved by the FDA and EMA in August 2012 …
Matched Categories: … Amino Acids, Peptides, and Proteins ... Enzymes and Coenzymes ... Antineoplastic and Immunomodulating Agents …
Matched Products: … Zaltrap 25mg/ml Concentrate for Solution for Infusion ... ZALTRAP CONCENTRATE FOR SOLUTION FOR INFUSION 25 MG/ML ... EYLEA SOLUTION FOR INJECTION IN VIAL 2MG …

{(2S)-1-[N-(tert-butoxycarbonyl)glycyl]pyrrolidin-2-yl}methyl (3-chlorophenyl)acetate

Experimental
Matched Name: … {(2S)-1-[N-(tert-butoxycarbonyl)glycyl]pyrrolidin-2-yl}methyl (3-chlorophenyl)acetate …
Matched Iupac: … [(2S)-1-(2-{[(tert-butoxy)carbonyl]amino}acetyl)pyrrolidin-2-yl]methyl 2-(3-chlorophenyl)acetate …

Burosumab

Burosumab (KRN23) is an entirely human monoclonal IgG1 antibody that binds excess fibroblast growth factor 23 (FGF23) and has been successfully tested in clinical trials in children with X-linked hypophosphatemic rickets . The U.S. Food and Drug Administration approved Crysvita (burosumab) in April 2018. This is the first drug approved...
Approved
Investigational
Matched Description: … (XLH), which is a rare, inherited form of rickets. ... It causes impaired bone growth and development in children and adolescents and issues with bone mineralization ... This is the first drug approved to treat adults and children ages 1 year and older with X-linked hypophosphatemia …
Matched Categories: … Amino Acids, Peptides, and Proteins ... Drugs Affecting Bone Structure and Mineralization ... Drugs for Treatment of Bone Diseases …
Matched Products: … CRYSVITA 10 MG SOLUTION FOR INJECTION ... CRYSVITA 20 MG SOLUTION FOR INJECTION ... CRYSVITA 30 MG SOLUTION FOR INJECTION …

Levodropropizine

Levodropropizine is under investigation in clinical trial NCT01573663 (A Drug-Drug Interaction Study of Ambroxol and Levodropropizine).
Investigational
Matched Description: … Levodropropizine is under investigation in clinical trial NCT01573663 (A Drug-Drug Interaction Study of Ambroxol and …
Matched Categories: … Cough and Cold Preparations …
Matched Products: … LEVOZOPIN FORT 60MG/5ML ŞURUP, 75 ML ... LEVOPRONT FORT 60 MG/5 ML ŞURUP, 75 ML ... LEVOSOL FORT 60 MG / 5 ML ŞURUP, 75 ML …

Tirzepatide

Tirzepatide is a novel dual glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptor agonist. Dual GIP/GLP-1 agonists gained increasing attention as new therapeutic agents for glycemic and weight control as they demonstrated better glucose control and weight loss compared to selective GLP-1 receptor agonists in preclinical and clinical trials....
Approved
Investigational
Matched Description: … Dual GIP/GLP-1 agonists gained increasing attention as new therapeutic agents for glycemic and weight ... agonists in preclinical and clinical trials. ... the treatment of adults with type 2 diabetes, making it the first and only GIP and GLP-1 receptor agonist …
Matched Categories: … Alimentary Tract and Metabolism ... Amino Acids, Peptides, and Proteins ... Hormones, Hormone Substitutes, and Hormone Antagonists …
Matched Products: … Mounjaro 2.5 mg solution for injection in pre-filled pen ... Mounjaro 5 mg solution for injection in pre-filled pen ... Mounjaro 7.5 mg solution for injection in pre-filled pen …

(10R)-10-formyl-5,8,10-trideazafolic acid

Experimental
Matched Name: … (10R)-10-formyl-5,8,10-trideazafolic acid …
Displaying drugs 1151 - 1175 of 1625 in total