Displaying drugs 13176 - 13200 of 13944 in total
RUS 3108
RUS 3108 is being developed for the treatment of atherosclerosis, the major cause of cardiovascular disorders such as heart attacks and stroke by Dr. Reddy’s Laboratories.
The drug’s Phase I clinical trials have been initiated in Europe to assess safety of the drug compound in healthy volunteers.
Investigational
Sepofarsen
Sepofarsen is under investigation in clinical trial NCT03913143 (A Study to Evaluate Efficacy, Safety, Tolerability and Exposure After a Repeat-dose of Sepofarsen (QR-110) in LCA10 (ILLUMINATE)).
Investigational
Matched Description: … , Tolerability and Exposure After a Repeat-dose of Sepofarsen (QR-110) in LCA10 (ILLUMINATE)). ... Sepofarsen is under investigation in clinical trial NCT03913143 (A Study to Evaluate Efficacy, Safety …
Merbromin
Mercurochrome is a trade name of merbromin commonly used as a topical first-aid antiseptic agent. It is an organomercuric disodium salt compound and a fluorescein that is available in many countries, except Switzerland, France, Germany, and the United States where the drug was withdrawn from market due to the possibility...
Experimental
Matched Iupac: … disodium [2,7-dibromo-9-(2-carboxylatophenyl)-6-oxido-3-oxo-3H-xanthen-5-yl]mercurol …
Matched Description: … Mercurochrome is a trade name of merbromin commonly used as a topical first-aid antiseptic agent. ... It is an organomercuric disodium salt compound and a fluorescein that is available in many countries, …
Matched Categories: … Heterocyclic Compounds, 3-Ring …
Matched Description: … Mercurochrome is a trade name of merbromin commonly used as a topical first-aid antiseptic agent. ... It is an organomercuric disodium salt compound and a fluorescein that is available in many countries, …
Matched Categories: … Heterocyclic Compounds, 3-Ring …
MTL-CEBPA
MTL-CEBPA is a SMARTICLES liposomal formulation of MTL-501, a small activating RNA (saRNA) oligonucleotide.
Investigational
Matched Description: … MTL-CEBPA is a SMARTICLES liposomal formulation of MTL-501, a small activating RNA (saRNA) oligonucleotide …
Danoprevir
Danoprevir has been used in trials studying the treatment of Hepatitis C, Chronic.
Investigational
Matched Iupac: … ]-2,15-dioxo-3,16-diazatricyclo[14.3.0.0^{4,6}]nonadec-7-en-18-yl 4-fluoro-2,3-dihydro-1H-isoindole-2- …
Matched Categories: … Heterocyclic Compounds, 2-Ring …
Matched Categories: … Heterocyclic Compounds, 2-Ring …
Peptide YY (3-36)
Peptide YY (3-36), a synthetic human PYY 3-36, is a compound being evaluated for the treatment of obesity. It reduces appetite and increases satiety in obese patients.
Investigational
Matched Synonyms: … PYY 3-36 ... PYY(3-36) ... Pyy (3-36) peptide …
Matched Name: … Peptide YY (3-36) …
Matched Description: … Peptide YY (3-36), a synthetic human PYY 3-36, is a compound being evaluated for the treatment of obesity …
Matched Name: … Peptide YY (3-36) …
Matched Description: … Peptide YY (3-36), a synthetic human PYY 3-36, is a compound being evaluated for the treatment of obesity …
Lancovutide
Lancovutide, a peptide antibiotic, is in clinical development for the treatment of cystic fibrosis. Lancovutide is a 19-amino-acid tetracyclic peptide produced by Streptoverticillium cinnamoneus and is closely related to cinnamycin (Ro09-0198). It belongs to the lantibiotics. Lantibiotics are bacteriocins that are characterized by the presence of a high proportion of...
Investigational
Matched Iupac: … trithia-3,6,9,15,18,21,24,27,30,33,36,39,46,49,52,55,58,60,66-nonadecaazapentacyclo[38.18.9.3^{19,56}.3^ ... 25S,28R,31S,37S,40S,41S,44R,47S,50S,53S,56R,65S,70S)-44-amino-47-(4-aminobutyl)-4,16,22-tribenzyl-50-(2- ... hydroxy)methyl]-41,70-dimethyl-2,5,8,14,17,20,23,26,29,32,35,38,45,48,51,54,57,67-octadecaoxo-25-(propan-2- …
Matched Description: … Lancovutide, a peptide antibiotic, is in clinical development for the treatment of cystic fibrosis. ... Lancovutide is a 19-amino-acid tetracyclic peptide produced by Streptoverticillium cinnamoneus and is ... Lantibiotics are bacteriocins that are characterized by the presence of a high proportion of unusual …
Matched Description: … Lancovutide, a peptide antibiotic, is in clinical development for the treatment of cystic fibrosis. ... Lancovutide is a 19-amino-acid tetracyclic peptide produced by Streptoverticillium cinnamoneus and is ... Lantibiotics are bacteriocins that are characterized by the presence of a high proportion of unusual …
LU-31130
LU-31130 is a rapid acting therapy developed by H. Lundbeck A/S to treat Psychosis, Schizophrenia and Schizoaffective Disorders. It acts at the Dopamine D4 receptors in the cortex and has low affinity for D2 receptors, adrenoceptors, muscarinic and histaminergic receptors.
It provides anti-psychotic characteristic and a low incidence of extrapyramidal...
Investigational
Matched Description: … LU-31130 is a rapid acting therapy developed by H. ... Lundbeck A/S to treat Psychosis, Schizophrenia and Schizoaffective Disorders. ... It provides anti-psychotic characteristic and a low incidence of extrapyramidal and cardiovascular side …
Virginiamycin
Virginiamycin is a streptogramin antibiotic similar to pristinamycin and quinupristin/dalfopristin. It is a combination of pristinamycin IIA and virginiamycin S1. Virginiamycin is used in the fuel ethanol industry to prevent microbial contamination and in livestock to prevent and treat infections. According to a USDA study, antibiotics can save as much...
Vet approved
Matched Iupac: … [23.2.1.0^{3,7}]octacosa-1(27),6,12,17,19,25(28)-hexaene-2,8,14,23-tetrone; N-[(3S,6S,12R,15S,16R,19S ... [20.4.0.0^{6,10}]hexacosan-15-yl]-3-hydroxypyridine-2-carboxamide ... (10R,11R,12E,17E,19E,21S)-21-hydroxy-11,19-dimethyl-10-(propan-2-yl)-9,26-dioxa-3,15,28-triazatricyclo ... ,22S)-3-benzyl-12-ethyl-4,16-dimethyl-2,5,11,14,18,21,24-heptaoxo-19-phenyl-17-oxa-1,4,10,13,20-pentaazatricyclo …
Matched Description: … It is a combination of pristinamycin IIA and virginiamycin S1. ... Virginiamycin is a streptogramin antibiotic similar to pristinamycin and quinupristin/dalfopristin. ... According to a USDA study, antibiotics can save as much as 30% in feed costs among young swine. …
Matched Description: … It is a combination of pristinamycin IIA and virginiamycin S1. ... Virginiamycin is a streptogramin antibiotic similar to pristinamycin and quinupristin/dalfopristin. ... According to a USDA study, antibiotics can save as much as 30% in feed costs among young swine. …
Resiniferatoxin
Resiniferatoxin (RTX) is a naturally occurring, ultrapotent capsaicin analog that activates the vanilloid receptor in a subpopulation of primary afferent sensory neurons involved in nociception (the transmission of physiological pain).
Investigational
Matched Iupac: … [11.4.1.0^{1,10}.0^{2,6}.0^{11,15}]octadeca-3,8-dien-8-yl]methyl 2-(4-hydroxy-3-methoxyphenyl)acetate ... [(1R,2R,6R,10S,11R,15R,17R)-13-benzyl-6-hydroxy-4,17-dimethyl-5-oxo-15-(prop-1-en-2-yl)-12,14,18-trioxapentacyclo …
Matched Description: … Resiniferatoxin (RTX) is a naturally occurring, ultrapotent capsaicin analog that activates the vanilloid ... receptor in a subpopulation of primary afferent sensory neurons involved in nociception (the transmission …
Matched Description: … Resiniferatoxin (RTX) is a naturally occurring, ultrapotent capsaicin analog that activates the vanilloid ... receptor in a subpopulation of primary afferent sensory neurons involved in nociception (the transmission …
Tanaproget
Tanaproget (NSP-989) is an investigational non-steroidal progestin. It is a high affinity, high efficacy agonist of the progesterone receptor (PR) with a much more selective binding profile relative to most conventional progestins. Because of this tanaproget may prove to produce fewer side effects in comparison. It is currently in the...
Investigational
Matched Iupac: … 5-(4,4-dimethyl-2-sulfanylidene-2,4-dihydro-1H-3,1-benzoxazin-6-yl)-1-methyl-1H-pyrrole-2-carbonitrile …
Matched Description: … It is a high affinity, high efficacy agonist of the progesterone receptor (PR) with a much more selective ... An analog of tanaproget, 4-fluoropropyltanaproget (18F), has been developed as a radiotracer for imaging ... It is currently in the process of being developed for clinical use as a contraceptive by Ligand Pharmaceuticals …
Matched Categories: … Heterocyclic Compounds, 1-Ring ... Heterocyclic Compounds, 2-Ring …
Matched Description: … It is a high affinity, high efficacy agonist of the progesterone receptor (PR) with a much more selective ... An analog of tanaproget, 4-fluoropropyltanaproget (18F), has been developed as a radiotracer for imaging ... It is currently in the process of being developed for clinical use as a contraceptive by Ligand Pharmaceuticals …
Matched Categories: … Heterocyclic Compounds, 1-Ring ... Heterocyclic Compounds, 2-Ring …
XEN-2174
XEN-2174 is a synthetic drug modeled on a peptide from the venom of a cone shell found on Australia's Great Barrier Reef. XEN-2174 represents a new class of molecules, called the chi conopeptides that selectively inhibit the Norepinephrine Transporter (NET). NET is the primary mechanism regulating the biological effects of...
Investigational
Matched Description: … XEN-2174 is a synthetic drug modeled on a peptide from the venom of a cone shell found on Australia's ... XEN-2174 represents a new class of molecules, called the chi conopeptides that selectively inhibit the …
RGX-202
RGX-202 is a recombinant AAV8 that contains a vector genome encoding a miniaturized dystrophin protein (microdystrophin).
Investigational
Matched Description: … RGX-202 is a recombinant AAV8 that contains a vector genome encoding a miniaturized dystrophin protein …
Stem-cell derived exosome vesicle products
Mesenchymal stem cells (MSCs) exert their therapeutic effects through multiple modalities, including paracrine factors such as exosomes. Exosomes are nanometer-sized, membrane-bound vesicles secreted for the purpose of cell-cell communication. Once secreted into extracellular fluid, exosomes are taken up by their target cells or carried to distant target sites. Various bioactive...
Investigational
Matched Description: … While many contain a conserved set of proteins, they also carry unique tissue type-specific proteins. …
Liatermin
Investigational
Caroxazone
Caroxazone is an antidepressant that has been withdrawn from the market. It is a reversible monoamine oxidase inhibitor (MAOI) of both A and B monoamine oxidase subtypes. However, it presents a five-fold preference for the MAO-B subtype.
Withdrawn
Matched Iupac: … 2-(2-oxo-3,4-dihydro-2H-1,3-benzoxazin-3-yl)acetamide …
Matched Description: … It is a reversible monoamine oxidase inhibitor (MAOI) of both A and B monoamine oxidase subtypes. ... However, it presents a five-fold preference for the MAO-B subtype. …
Matched Categories: … Heterocyclic Compounds, 1-Ring …
Matched Description: … It is a reversible monoamine oxidase inhibitor (MAOI) of both A and B monoamine oxidase subtypes. ... However, it presents a five-fold preference for the MAO-B subtype. …
Matched Categories: … Heterocyclic Compounds, 1-Ring …
Mongersen
Mongersen is under investigation in clinical trial NCT02957474 (A Study to Evaluate the Effect of Food, Formulation Strength, and a Proton Pump Inhibitor on GED 0301 Pharmacokinetics in Healthy Adult Subjects).
Investigational
Matched Description: … Mongersen is under investigation in clinical trial NCT02957474 (A Study to Evaluate the Effect of Food ... , Formulation Strength, and a Proton Pump Inhibitor on GED 0301 Pharmacokinetics in Healthy Adult Subjects …
Diclazuril
Diclazuril is a coccidiostat.
Investigational
Vet approved
Matched Iupac: … 2-(4-chlorophenyl)-2-[2,6-dichloro-4-(3,5-dioxo-2,3,4,5-tetrahydro-1,2,4-triazin-2-yl)phenyl]acetonitrile …
Matched Description: … Diclazuril is a coccidiostat. …
Matched Categories: … Heterocyclic Compounds, 1-Ring …
Matched Description: … Diclazuril is a coccidiostat. …
Matched Categories: … Heterocyclic Compounds, 1-Ring …
2,4-Diamino-5-Methyl-6-[(3,4,5-Trimethoxy-N-Methylanilino)Methyl]Pyrido[2,3-D]Pyrimidine
Experimental
Matched Name: … 2,4-Diamino-5-Methyl-6-[(3,4,5-Trimethoxy-N-Methylanilino)Methyl]Pyrido[2,3-D]Pyrimidine …
BENZYL N-({(2S,3S)-3-[(PROPYLAMINO)CARBONYL]OXIRAN-2-YL}CARBONYL)-L-ISOLEUCYL-L-PROLINATE
Experimental
Matched Name: … BENZYL N-({(2S,3S)-3-[(PROPYLAMINO)CARBONYL]OXIRAN-2-YL}CARBONYL)-L-ISOLEUCYL-L-PROLINATE …
Matched Iupac: … benzyl (2S)-1-[(2S,3S)-3-methyl-2-{[(2S,3S)-3-(propylcarbamoyl)oxiran-2-yl]formamido}pentanoyl]pyrrolidine ... -2-carboxylate …
Matched Iupac: … benzyl (2S)-1-[(2S,3S)-3-methyl-2-{[(2S,3S)-3-(propylcarbamoyl)oxiran-2-yl]formamido}pentanoyl]pyrrolidine ... -2-carboxylate …
Tonapofylline
Tonapofylline has been used in trials studying the treatment of Heart Failure, Renal Insufficiency, and Congestive Heart Failure.
Investigational
Matched Iupac: … 3-[4-(2,6-dioxo-1,3-dipropyl-2,3,6,7-tetrahydro-1H-purin-8-yl)bicyclo[2.2.2]octan-1-yl]propanoic acid …
Matched Categories: … Heterocyclic Compounds, 2-Ring …
Matched Categories: … Heterocyclic Compounds, 2-Ring …
MT-0169
MT-0169 is a usion protein comprised of an enzymatically active Shiga-like toxin-I A1 subunit fused to a human single chain variable fragment with affinity for human CD38 cell surface protein.
Investigational
Matched Description: … a human single chain variable fragment with affinity for human CD38 cell surface protein. ... MT-0169 is a usion protein comprised of an enzymatically active Shiga-like toxin-I A1 subunit fused to …
Uridine diphosphate glucose
A key intermediate in carbohydrate metabolism. Serves as a precursor of glycogen, can be metabolized into UDPgalactose and UDPglucuronic acid which can then be incorporated into polysaccharides as galactose and glucuronic acid. Also serves as a precursor of sucrose lipopolysaccharides, and glycosphingolipids.
Experimental
Matched Iupac: … {[(2R,3S,4R,5R)-5-(2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}({[hydroxy ... ({[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy})phosphoryl]oxy})phosphinic acid …
Matched Description: … A key intermediate in carbohydrate metabolism. ... Also serves as a precursor of sucrose lipopolysaccharides, and glycosphingolipids. ... Serves as a precursor of glycogen, can be metabolized into UDPgalactose and UDPglucuronic acid which …
Matched Categories: … Heterocyclic Compounds, 1-Ring …
Matched Description: … A key intermediate in carbohydrate metabolism. ... Also serves as a precursor of sucrose lipopolysaccharides, and glycosphingolipids. ... Serves as a precursor of glycogen, can be metabolized into UDPgalactose and UDPglucuronic acid which …
Matched Categories: … Heterocyclic Compounds, 1-Ring …
SB-559448
SB-559448 is a small-molecule drug that mimics the activity of thrombopoietin (TPO), a protein factor that promotes growth and production of blood platelets. This drug is developed by GlaxoSmithKline and used to treat Thrombocytopenia.Thrombocytopenia (decreased platelet count) is a common side effect of many chemotherapies and can lead to uncontrolled...
Investigational
Matched Description: … SB-559448 is a small-molecule drug that mimics the activity of thrombopoietin (TPO), a protein factor ... common side effect of many chemotherapies and can lead to uncontrolled bleeding, thus representing a ... by GlaxoSmithKline and used to treat Thrombocytopenia.Thrombocytopenia (decreased platelet count) is a …
Displaying drugs 13176 - 13200 of 13944 in total