Displaying drugs 13276 - 13300 of 13918 in total
DYNE-251
DYNE-251 is a phosphorodiamidate morpholino oligomer (PMO) conjugated to a fragment antibody (Fab) that binds to the transferrin receptor 1 (TfR1). It is being investigated for the treatment of Duchenne muscular dystrophy (DMD) in patients who are amenable to exon 51 skipping.
Investigational
Matched Description: … binds to the transferrin receptor 1 (TfR1). ... DYNE-251 is a phosphorodiamidate morpholino oligomer (PMO) conjugated to a fragment antibody (Fab) that …
Petesicatib
Petesicatib is under investigation in clinical trial NCT02295332 (A Study of RG7625 in Healthy Volunteers).
Investigational
Matched Iupac: … (2S,4R)-N-(1-cyanocyclopropyl)-4-[4-(1-methyl-1H-pyrazol-4-yl)-2-(trifluoromethyl)benzenesulfonyl]-1- ... [1-(trifluoromethyl)cyclopropanecarbonyl]pyrrolidine-2-carboxamide …
Matched Description: … Petesicatib is under investigation in clinical trial NCT02295332 (A Study of RG7625 in Healthy Volunteers …
Matched Categories: … Heterocyclic Compounds, 1-Ring …
Matched Description: … Petesicatib is under investigation in clinical trial NCT02295332 (A Study of RG7625 in Healthy Volunteers …
Matched Categories: … Heterocyclic Compounds, 1-Ring …
KW-6356
KW-6356 is a selective antagonist of adenosine A2A receptors developed by Kyowa Kirin.
Experimental
Matched Description: … KW-6356 is a selective antagonist of adenosine A2A receptors developed by Kyowa Kirin.[L43822] …
RP-L301
RP-L301 is a lentiviral vector containing the human liver and erythroid pyruvate kinase gene.
Investigational
Matched Description: … RP-L301 is a lentiviral vector containing the human liver and erythroid pyruvate kinase gene. …
KT-253
KT-253 is a selective heterobifunctional small molecule degrader of mouse double minute 2 (MDM2).
Investigational
Matched Description: … KT-253 is a selective heterobifunctional small molecule degrader of mouse double minute 2 (MDM2). …
STP-707
STP-707 is a small interfering RNA (siRNA) targeting TGF-Beta1 and COX-2 mRNA.
Investigational
Matched Description: … STP-707 is a small interfering RNA (siRNA) targeting TGF-Beta1 and COX-2 mRNA. …
Tonapofylline
Tonapofylline has been used in trials studying the treatment of Heart Failure, Renal Insufficiency, and Congestive Heart Failure.
Investigational
Matched Iupac: … 3-[4-(2,6-dioxo-1,3-dipropyl-2,3,6,7-tetrahydro-1H-purin-8-yl)bicyclo[2.2.2]octan-1-yl]propanoic acid …
Matched Categories: … Heterocyclic Compounds, 2-Ring …
Matched Categories: … Heterocyclic Compounds, 2-Ring …
TMP
Experimental
Matched Iupac: … {[(2R,3S,4R,5R)-3,4-dihydroxy-5-(4-hydroxy-5-methyl-2-oxo-1,2-dihydropyrimidin-1-yl)oxolan-2-yl]methoxy …
Matched Categories: … Heterocyclic Compounds, 1-Ring …
Matched Categories: … Heterocyclic Compounds, 1-Ring …
CAM-2029
CAM2029 is a new ready-to-use, long-acting octreotide formulation being developed for the long-term treatment of acromegaly, carcinoid syndrome and vasoactive intestinal peptide (VIP)-producing tumours. CAM2029 was found to provide long-acting release of octreotide resulting in a statistically significant suppression of a clinical biomarker insulin-like growth factor 1 (IGF-1) over the...
Investigational
Matched Description: … suppression of a clinical biomarker insulin-like growth factor 1 (IGF-1) over the target one-month therapeutic ... CAM2029 is a new ready-to-use, long-acting octreotide formulation being developed for the long-term treatment ... CAM2029 was found to provide long-acting release of octreotide resulting in a statistically significant …
Brifentanil
Brifentanil (also known as A-3331) is an analog of fentanyl, a potent opioid. This drug is classified as an opioid analgesic and was developed in the early 1990s. The effects of brifentanil are very similar to those of alfentanil, with strong but short lasting analgesia and sedation, and particularly notable...
Illicit
Matched Iupac: … N-[(3R,4S)-1-[2-(4-ethyl-5-oxo-4,5-dihydro-1H-1,2,3,4-tetrazol-1-yl)ethyl]-3-methylpiperidin-4-yl]-N- ... (2-fluorophenyl)-2-methoxyacetamide …
Matched Description: … Brifentanil (also known as A-3331) is an analog of fentanyl, a potent opioid. …
Matched Categories: … Heterocyclic Compounds, 1-Ring …
Matched Description: … Brifentanil (also known as A-3331) is an analog of fentanyl, a potent opioid. …
Matched Categories: … Heterocyclic Compounds, 1-Ring …
GSK-945237
GSK-945237 is under investigation in clinical trial NCT01039610 (A Single Center Four Part Study in Healthy Adult Subjects to Evaluate: the Safety, Tolerability and Pharmacokinetics of a Single Oral Dose and Repeat Escalating Oral Doses of GSK945237; the Effect of Linezolid on Hematology Safety Parameters; and the Effects of GSK945237...
Investigational
Matched Iupac: … (3R)-3-({4-[({6H,7H-[1,4]dioxino[2,3-c]pyridazin-3-yl}methyl)amino]piperidin-1-yl}methyl)-5-fluoro-1- …
Matched Description: … GSK-945237 is under investigation in clinical trial NCT01039610 (A Single Center Four Part Study in Healthy ... Adult Subjects to Evaluate: the Safety, Tolerability and Pharmacokinetics of a Single Oral Dose and …
Matched Description: … GSK-945237 is under investigation in clinical trial NCT01039610 (A Single Center Four Part Study in Healthy ... Adult Subjects to Evaluate: the Safety, Tolerability and Pharmacokinetics of a Single Oral Dose and …
MK-0731
MK-0731 is a kinesin spindle protein inhibitor and antineoplastic agent.
Experimental
Matched Iupac: … (2S)-4-(2,5-difluorophenyl)-N-[(3R,4S)-3-fluoro-1-methylpiperidin-4-yl]-2-(hydroxymethyl)-N-methyl-2- ... phenyl-2,5-dihydro-1H-pyrrole-1-carboxamide …
Matched Description: … MK-0731 is a kinesin spindle protein inhibitor and antineoplastic agent. …
Matched Categories: … Heterocyclic Compounds, 1-Ring …
Matched Description: … MK-0731 is a kinesin spindle protein inhibitor and antineoplastic agent. …
Matched Categories: … Heterocyclic Compounds, 1-Ring …
LAVA-051
LAVA-051 is a humanized Vγ9Vδ2-T cell-engaging bispecific antibody.
Investigational
Matched Description: … LAVA-051 is a humanized Vγ9Vδ2-T cell-engaging bispecific antibody. …
Rovazolac
Rovazolac is under investigation in clinical trial NCT03175354 (A Study in Subjects With Moderate Atopic Dermatitis).
Investigational
Matched Iupac: … ethyl 2-(5-{3'-methanesulfonyl-[1,1'-biphenyl]-4-yl}-3-(trifluoromethyl)-1H-pyrazol-1-yl)acetate …
Matched Description: … Rovazolac is under investigation in clinical trial NCT03175354 (A Study in Subjects With Moderate Atopic …
Matched Description: … Rovazolac is under investigation in clinical trial NCT03175354 (A Study in Subjects With Moderate Atopic …
LB-P8
LB-P8 is an investigational live biotherapeutic product consisting of a single bacterial strain (Leuconostoc citreum).
Investigational
Matched Description: … LB-P8 is an investigational live biotherapeutic product consisting of a single bacterial strain (_Leuconostoc …
Ertiprotafib
Ertiprotafib belongs to a novel class of insulin sensitizers developed for treatment of type 2 diabetes. In insulin-resistant rodent models, ertiprotafib and a close analog lowered both fasting blood glucose and insulin levels and improved glycemic excursion during an oral glucose tolerance test.
Investigational
Matched Iupac: … (2R)-2-(4-{9-bromo-2,3-dimethylnaphtho[2,3-b]thiophen-4-yl}-2,6-dimethylphenoxy)-3-phenylpropanoic acid …
Matched Description: … Ertiprotafib belongs to a novel class of insulin sensitizers developed for treatment of type 2 diabetes ... In insulin-resistant rodent models, ertiprotafib and a close analog lowered both fasting blood glucose …
Matched Categories: … Heterocyclic Compounds, 1-Ring …
Matched Description: … Ertiprotafib belongs to a novel class of insulin sensitizers developed for treatment of type 2 diabetes ... In insulin-resistant rodent models, ertiprotafib and a close analog lowered both fasting blood glucose …
Matched Categories: … Heterocyclic Compounds, 1-Ring …
Gemogenovatucel-T
Gemogenovatucel-T is a bi-shRNA furin/Granulocyte Macrophage Colony Stimulating Factor (GMCSF) Augmented autologous tumour cell vaccine. Furin is a convertase involved in the activation of TGFβ-1 and TGFβ-2. Gemogenovatucel-T is being investigated in the treatment of various cancers.
Investigational
Matched Description: … Furin is a convertase involved in the activation of TGFβ-1 and TGFβ-2. ... Gemogenovatucel-T is a bi-shRNA furin/Granulocyte Macrophage Colony Stimulating Factor (GMCSF) Augmented …
Daxdilimab
Daxdilimab is under investigation in clinical trial NCT04526912 (Treatment and Prevention of Acute Lung Injury (ALI) in Patients With COVID-19 Infection).
Investigational
Thymidine
Thymidine is a pyrimidine deoxynucleoside. Thymidine is the DNA nucleoside T, which pairs with deoxyadenosine (A) in double-stranded DNA. In cell biology it is used to synchronize the cells in S phase.
Experimental
Investigational
Matched Synonyms: … 2'-thymidine ... 2'-deoxythymidine ... 2'-deoxy-5-methyluridine …
Matched Iupac: … 1-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-methyl-1,2,3,4-tetrahydropyrimidine-2,4-dione …
Matched Description: … Thymidine is a pyrimidine deoxynucleoside. ... Thymidine is the DNA nucleoside T, which pairs with deoxyadenosine (A) in double-stranded DNA. …
Matched Categories: … Heterocyclic Compounds, 1-Ring …
Matched Iupac: … 1-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-methyl-1,2,3,4-tetrahydropyrimidine-2,4-dione …
Matched Description: … Thymidine is a pyrimidine deoxynucleoside. ... Thymidine is the DNA nucleoside T, which pairs with deoxyadenosine (A) in double-stranded DNA. …
Matched Categories: … Heterocyclic Compounds, 1-Ring …
VLTS-589
VLTS-589 consists of plasmid encoding the angiomatrix protein Del-1 in conjunction with poloxamer 188 for the treatment of peripheral vascular disease.
Investigational
Matched Description: … VLTS-589 consists of plasmid encoding the angiomatrix protein Del-1 in conjunction with poloxamer 188 …
MW33
MW33 is a recombinant fully human antibody to SARS-CoV-2. This antibody injection is currently being investigated against COVID-19 in the clinical trial NCT04533048 (A Clinical Study to Evaluate MW33 Injection).
Investigational
Matched Description: … MW33 is a recombinant fully human antibody to SARS-CoV-2. ... antibody injection is currently being investigated against COVID-19 in the clinical trial NCT04533048 (A …
Zofin
Zofin, previously known as Organicell Flow, is a nanoparticle-based therapeutic derived from perinatal sources which is manufactured in a way that retains the naturally occurring microRNAs without the addition of other substances .
Investigational
Matched Description: … Zofin, previously known as Organicell Flow, is a nanoparticle-based therapeutic derived from perinatal ... sources which is manufactured in a way that retains the naturally occurring microRNAs without the addition …
Guanosine tetraphosphate
Guanosine tetraphosphate is a guanine nucleotide containing four phosphate groups. Two phosphate groups are esterified to the sugar moiety in the 5' position and the other two in the 2' or 3' position. This nucleotide serves as a messenger to turn off the synthesis of ribosomal RNA when amino acids...
Experimental
Matched Synonyms: … Guanosine-5',3'-tetraphosphate …
Matched Iupac: … {[hydroxy({[(2R,3S,4R,5R)-4-hydroxy-3-{[hydroxy(phosphonooxy)phosphoryl]oxy}-5-(6-hydroxy-2-imino-3,9 ... -dihydro-2H-purin-9-yl)oxolan-2-yl]methoxy})phosphoryl]oxy}phosphonic acid …
Matched Description: … or 3' position. ... Two phosphate groups are esterified to the sugar moiety in the 5' position and the other two in the 2' ... Guanosine tetraphosphate is a guanine nucleotide containing four phosphate groups. …
Matched Categories: … Heterocyclic Compounds, 2-Ring …
Matched Iupac: … {[hydroxy({[(2R,3S,4R,5R)-4-hydroxy-3-{[hydroxy(phosphonooxy)phosphoryl]oxy}-5-(6-hydroxy-2-imino-3,9 ... -dihydro-2H-purin-9-yl)oxolan-2-yl]methoxy})phosphoryl]oxy}phosphonic acid …
Matched Description: … or 3' position. ... Two phosphate groups are esterified to the sugar moiety in the 5' position and the other two in the 2' ... Guanosine tetraphosphate is a guanine nucleotide containing four phosphate groups. …
Matched Categories: … Heterocyclic Compounds, 2-Ring …
GnRH pharmaccine
The GnRH pharmaccine consists of synthetic peptides (constructed to "look like" GnRH), which are bound chemically to a carrier and suspended in a proprietary "delivery vehicle". The pharmaccine is administered intramuscularly to the patient by injection and induces an immune response or production of antibodies in the patient, which neutralize...
Investigational
Matched Description: … carrier and suspended in a proprietary "delivery vehicle". ... pharmaccine consists of synthetic peptides (constructed to "look like" GnRH), which are bound chemically to a …
CIGB 2020 Vaccine
CIGB 2020 is a vaccine candidate administered nasally and sublingually, working to strengthen immunity in the areas administered. The vaccine was developed and tested by the Center for Genetic Engineering and Biotechnology (CIGB), in Havana Cuba. As of July, 2020, a Randomized control clinical trial (RPCEC00000306) is underway to evaluate...
Investigational
Matched Description: … CIGB 2020 is a vaccine candidate administered nasally and sublingually, working to strengthen immunity ... As of July, 2020, a Randomized control clinical trial (RPCEC00000306) is underway to evaluate prophylaxis …
Displaying drugs 13276 - 13300 of 13918 in total