Displaying drugs 1726 - 1750 of 2916 in total
Cilomilast
Cilomilast (Ariflo, SB-207,499) is a drug which was developed for the treatment of respiratory disorders such as asthma and Chronic Obstructive Pulmonary Disease (COPD). It is orally active and acts as a selective Phosphodiesterase-4 inhibitor. Following four clinical trials, the drug proved to be effective in treating COPD, however it...
Investigational
Matched Synonyms: … cis-4-cyano-4-(3-(cyclopentyloxy)-4-methoxyphenyl)cyclohexanecarboxylic acid …
Matched Iupac: … (1s,4s)-4-cyano-4-[3-(cyclopentyloxy)-4-methoxyphenyl]cyclohexane-1-carboxylic acid …
Matched Description: … SB-207,499) is a drug which was developed for the treatment of respiratory disorders such as asthma and ... It is orally active and acts as a selective Phosphodiesterase-4 inhibitor. ... proved to be effective in treating COPD, however it has never been marketed due to a poor side effect profile …
Matched Categories: … Carboxylic Acids ... Acids, Carbocyclic …
Matched Iupac: … (1s,4s)-4-cyano-4-[3-(cyclopentyloxy)-4-methoxyphenyl]cyclohexane-1-carboxylic acid …
Matched Description: … SB-207,499) is a drug which was developed for the treatment of respiratory disorders such as asthma and ... It is orally active and acts as a selective Phosphodiesterase-4 inhibitor. ... proved to be effective in treating COPD, however it has never been marketed due to a poor side effect profile …
Matched Categories: … Carboxylic Acids ... Acids, Carbocyclic …
Avalglucosidase alfa
Avalglucosidase alfa, or NeoGAA, is a drug for enzyme replacement therapy specifically designed for Pompe disease, a rare inherited neuromuscular disorder caused by the deficiency of the alpha-glucosidase (GAA) enzyme. GAA is an essential enzyme that hydrolyzes glycogen into free glucose for use in cellular functions. In Pompe disease, the...
Approved
Investigational
Matched Synonyms: … Neo-recombinant human acid alpha-glucosidase …
Matched Description: … , especially in smooth, cardiac, and skeletal muscle cells. ... In Pompe disease, the GAA enzyme is missing and patients are unable to properly break down glycogen, ... resulting in the accumulation of glycogen within lysosomes and progressive disruption of cellular function …
Matched Categories: … Alimentary Tract and Metabolism ... Enzymes and Coenzymes …
Matched Description: … , especially in smooth, cardiac, and skeletal muscle cells. ... In Pompe disease, the GAA enzyme is missing and patients are unable to properly break down glycogen, ... resulting in the accumulation of glycogen within lysosomes and progressive disruption of cellular function …
Matched Categories: … Alimentary Tract and Metabolism ... Enzymes and Coenzymes …
Lithium citrate
Approved
Matched Synonyms: … Citric acid, trilithium salt …
Matched Categories: … Acids, Acyclic ... Carboxylic Acids ... Tricarboxylic Acids …
Matched Categories: … Acids, Acyclic ... Carboxylic Acids ... Tricarboxylic Acids …
Aldesleukin
Aldesleukin, a lymphokine, is produced by recombinant DNA technology using a genetically engineered E. coli strain containing an analog of the human interleukin-2 gene. Genetic engineering techniques were used to modify the human IL-2 gene, and the resulting expression clone encodes a modified human interleukin-2. This recombinant form differs from...
Approved
Matched Synonyms: … 125-L-serine-2-133-interleukin 2 (human reduced) …
Matched Description: … has serine substituted for cysteine at amino acid position 125. ... Genetic engineering techniques were used to modify the human IL-2 gene, and the resulting expression ... ; the codon for this amino acid was deleted during the genetic engineering procedure; c) the molecule …
Matched Categories: … Amino Acids, Peptides, and Proteins ... Antineoplastic and Immunomodulating Agents ... Intercellular Signaling Peptides and Proteins …
Matched Description: … has serine substituted for cysteine at amino acid position 125. ... Genetic engineering techniques were used to modify the human IL-2 gene, and the resulting expression ... ; the codon for this amino acid was deleted during the genetic engineering procedure; c) the molecule …
Matched Categories: … Amino Acids, Peptides, and Proteins ... Antineoplastic and Immunomodulating Agents ... Intercellular Signaling Peptides and Proteins …
LM-030
Investigational
Matched Synonyms: … (S)-2-ISOBUTYRYLAMINO-PENTANEDIOIC ACID 5-AMIDE 1-{[(2S,5S,8S,11R,12S,15S,18S,21R)-2,8-BIS-((S)-SEC-BUTYL ... L-ISOLEUCINE, N2-(2-METHYL-1-OXOPROPYL)-L-GLUTAMINYL-L-THREONYL-L-LEUCYL-(.ALPHA.S,3S,6R)-3-AMINO-6-HYDROXY …
Abequolixron
Investigational
Matched Synonyms: … ((3r)-3-(((2-chloro-3-(trifluoromethyl)phenyl)methyl)(2,2- diphenylethyl)amino)butoxy)phenyl)acetic acid ... -((3r)-3-(((2-chloro-3-(trifluoromethyl)phenyl)methyl)(2,2-diphenylethyl)amino)butoxy)phenyl)acetic acid ... -[(3R)-3-({[2-chloro-3-(trifluoromethyl)phenyl]methyl}(2,2-diphenylethyl)amino)butoxy]phenyl}acetic acid …
Matched Iupac: … -[(3R)-3-({[2-chloro-3-(trifluoromethyl)phenyl]methyl}(2,2-diphenylethyl)amino)butoxy]phenyl}acetic acid …
Matched Categories: … Acids, Carbocyclic ... Carboxylic Acids …
Matched Iupac: … -[(3R)-3-({[2-chloro-3-(trifluoromethyl)phenyl]methyl}(2,2-diphenylethyl)amino)butoxy]phenyl}acetic acid …
Matched Categories: … Acids, Carbocyclic ... Carboxylic Acids …
Zomepirac
Zomepirac, formerly marketed as Zomax tablets, was associated with fatal and near-fatal anaphylactoid reactions. The manufacturer voluntarily removed Zomax tablets from the Canadian, US, and UK markets in March 1983.
Withdrawn
Matched Synonyms: … 5-(4-Chlorobenzoyl)-1,4-dimethyl-1H-pyrrole-2-acetic acid …
Matched Iupac: … 2-[5-(4-chlorobenzoyl)-1,4-dimethyl-1H-pyrrol-2-yl]acetic acid …
Matched Description: … Zomepirac, formerly marketed as Zomax tablets, was associated with fatal and near-fatal anaphylactoid ... The manufacturer voluntarily removed Zomax tablets from the Canadian, US, and UK markets in March 1983 …
Matched Categories: … Acetic Acid Derivatives and Related Substances ... Antiinflammatory and Antirheumatic Products ... Antiinflammatory and Antirheumatic Products, Non-Steroids …
Matched Iupac: … 2-[5-(4-chlorobenzoyl)-1,4-dimethyl-1H-pyrrol-2-yl]acetic acid …
Matched Description: … Zomepirac, formerly marketed as Zomax tablets, was associated with fatal and near-fatal anaphylactoid ... The manufacturer voluntarily removed Zomax tablets from the Canadian, US, and UK markets in March 1983 …
Matched Categories: … Acetic Acid Derivatives and Related Substances ... Antiinflammatory and Antirheumatic Products ... Antiinflammatory and Antirheumatic Products, Non-Steroids …
Glucarpidase
Glucarpidase is a recombinant carboxypeptidase G2 produced by genetically modified Escherichia coli bacteria. It is a 390-amino acid homodimer protein. High-dose methotrexate, an antifolate agent, has been widely and safely used for many decades in treating various cancers; however, even with aggressive hydration, urine alkalinization, and leucovorin rescue, some patients...
Approved
Investigational
Matched Synonyms: … Pteroylmonoglutamic acid hydrolase G2 …
Matched Description: … It is a 390-amino acid homodimer protein. ... [L39855] High-dose [methotrexate], an antifolate agent, has been widely and safely used for many decades ... in treating various cancers; however, even with aggressive hydration, urine alkalinization, and leucovorin …
Matched Categories: … Amino Acids, Peptides, and Proteins ... Enzymes and Coenzymes ... gamma-Glutamyl Hydrolase, antagonists & inhibitors …
Matched Description: … It is a 390-amino acid homodimer protein. ... [L39855] High-dose [methotrexate], an antifolate agent, has been widely and safely used for many decades ... in treating various cancers; however, even with aggressive hydration, urine alkalinization, and leucovorin …
Matched Categories: … Amino Acids, Peptides, and Proteins ... Enzymes and Coenzymes ... gamma-Glutamyl Hydrolase, antagonists & inhibitors …
Indium In-111 pentetate
Indium In-111 pentetate disodium is a radioactive diagnostic indicated for use in radionuclide cisternography. Decay of In-111 by electron capture allows for detection with a gamma camera for visualization of the brain and spinal column.
Approved
Matched Synonyms: … Indium (111In) pentetic acid …
Matched Iupac: … (111In)indium(3+) ion 2-[bis({2-[bis(carboxymethyl)amino]ethyl})amino]acetate …
Matched Description: … In-111 by electron capture allows for detection with a gamma camera for visualization of the brain and …
Matched Categories: … indium (111In) pentetic acid …
Matched Iupac: … (111In)indium(3+) ion 2-[bis({2-[bis(carboxymethyl)amino]ethyl})amino]acetate …
Matched Description: … In-111 by electron capture allows for detection with a gamma camera for visualization of the brain and …
Matched Categories: … indium (111In) pentetic acid …
Zanamivir
A guanido-neuraminic acid that is used to inhibit neuraminidase.
Approved
Investigational
Matched Synonyms: … 4-guanidino-2,4-dideoxy-2,3-dehydro-N-acetylneuraminic acid ... 5-acetamido-2,6-anhydro-3,4,5-trideoxy-4-guanidino-D-glycero-D-galacto-non-2-enonic acid ... acetylamino)-4-carbamimidamido-2-[(1R,2R)-1,2,3-trihydroxypropyl]-3,4-dihydro-2H-pyran-6-carboxylic acid …
Matched Iupac: … diaminomethylidene)amino]-3-acetamido-2-[(1R,2R)-1,2,3-trihydroxypropyl]-3,4-dihydro-2H-pyran-6-carboxylic acid …
Matched Description: … A guanido-neuraminic acid that is used to inhibit neuraminidase. …
Matched Categories: … Acids, Acyclic ... Sugar Acids ... Carboxylic Acids ... Sialic Acids ... Hydroxy Acids …
Matched Iupac: … diaminomethylidene)amino]-3-acetamido-2-[(1R,2R)-1,2,3-trihydroxypropyl]-3,4-dihydro-2H-pyran-6-carboxylic acid …
Matched Description: … A guanido-neuraminic acid that is used to inhibit neuraminidase. …
Matched Categories: … Acids, Acyclic ... Sugar Acids ... Carboxylic Acids ... Sialic Acids ... Hydroxy Acids …
Treprostinil palmitil
Investigational
Matched Synonyms: … Acetic acid, 2-(((1r,2r,3as,9as)-2,3,3a,4,9,9a-hexahydro-2-hydroxy-1-((3s)- 3-hydroxyoctyl)-1h-benz(f ... 3as,9as)-2-hydroxy-1-((s)-3-hydroxyoctyl)-2,3,3a,4,9,9a-hexahydro-1h-cyclopenta(b)naphthalen-5-yl)oxy)acetate …
Acamprosate
Alcohol use disorder is responsible for a large worldwide burden of morbidity, premature mortality, and economic consequences resulting from accidents, violence, incarceration, decreased productivity, and increased healthcare spending. Acamprosate, also known by the brand name Campral, is a drug used for the maintenance of alcohol abstinence. It is a structural...
Approved
Investigational
Matched Synonyms: … 3-Acetamido-1-propanesulfonic acid …
Matched Iupac: … 3-acetamidopropane-1-sulfonic acid …
Matched Description: … It is a structural analogue of the neurotransmitter γ-aminobutyric acid (GABA). ... Alcohol use disorder is responsible for a large worldwide burden of morbidity, premature mortality, and ... economic consequences resulting from accidents, violence, incarceration, decreased productivity, and …
Matched Categories: … Sulfur Acids ... Sulfonic Acids …
Matched Iupac: … 3-acetamidopropane-1-sulfonic acid …
Matched Description: … It is a structural analogue of the neurotransmitter γ-aminobutyric acid (GABA). ... Alcohol use disorder is responsible for a large worldwide burden of morbidity, premature mortality, and ... economic consequences resulting from accidents, violence, incarceration, decreased productivity, and …
Matched Categories: … Sulfur Acids ... Sulfonic Acids …
Oleoyl-estrone
Oleoyl-estrone (OE) is a fatty acid ester of estrone. This hormone occurs naturally and is found circulating in various animal species and humans. It has been shown in animal studies to promote the loss of body fat while maintaining body protein storage, maintaining nitrogen balance. Body protein loss is an...
Investigational
Matched Synonyms: … Estrone oleic acid ester …
Matched Description: … Oleoyl-estrone (OE) is a fatty acid ester of estrone. ... This hormone occurs naturally and is found circulating in various animal species and humans. ... Body protein loss is an unpleasant effect of fat loss by the restriction of calories, and studies show …
Matched Categories: … Hormones, Hormone Substitutes, and Hormone Antagonists ... Fatty Acids ... Fatty Acids, Unsaturated ... Fatty Acids, Monounsaturated …
Matched Description: … Oleoyl-estrone (OE) is a fatty acid ester of estrone. ... This hormone occurs naturally and is found circulating in various animal species and humans. ... Body protein loss is an unpleasant effect of fat loss by the restriction of calories, and studies show …
Matched Categories: … Hormones, Hormone Substitutes, and Hormone Antagonists ... Fatty Acids ... Fatty Acids, Unsaturated ... Fatty Acids, Monounsaturated …
Bicyclol
Bicyclol is under investigation in clinical trial NCT02944552 (The Multi Center, Randomized, Double-blind, Positive Controlled Study of Bicyclol in the Treatment of Acute DILI).
Investigational
Matched Synonyms: … 4,4'-bi-1,3-benzodioxole)-5-carboxylic acid, 5'-(hydroxymethyl)-7,7'-dimethoxy-, methyl ester …
Vonafexor
Investigational
Matched Synonyms: … 2-benzofurancarboxylic acid, 4-chloro-5-(4-((2,6-dichlorophenyl)sulfonyl)-1-piperazinyl)- …
Adapalene
Acne vulgaris is a multifactorial disorder of the pilosebaceous unit involving increased sebum production, inflammation, and hyperproliferation/hyperkeratinization of the follicular infundibulum. It is also associated with Cutibacterium acnes (also known as Propionibacterium acnes). Adapalene is a third-generation topical retinoid used for the treatment of acne vulgaris. Adapalene has similar efficacy...
Approved
Matched Synonyms: … 6-(3-(1-Adamantyl)-4-methoxyphenyl)-2-naphthoic acid …
Matched Iupac: … 6-[3-(adamantan-1-yl)-4-methoxyphenyl]naphthalene-2-carboxylic acid …
Matched Description: … multifactorial disorder of the pilosebaceous unit involving increased sebum production, inflammation, and ... [A193521] [Tazarotene] is more efficacious than adapalene but is designated as pregnancy category X and ... can also be combined with benzoyl peroxide (BPO), which possesses bactericidal properties[A193524], and …
Matched Mixtures name: … Adapalene and Benzoyl Peroxide ... ADAPALENE and BENZOYL PEROXIDE ... Adapalene and Benzoyl Peroxide …
Matched Categories: … Skin and Mucous Membrane Agents …
Matched Iupac: … 6-[3-(adamantan-1-yl)-4-methoxyphenyl]naphthalene-2-carboxylic acid …
Matched Description: … multifactorial disorder of the pilosebaceous unit involving increased sebum production, inflammation, and ... [A193521] [Tazarotene] is more efficacious than adapalene but is designated as pregnancy category X and ... can also be combined with benzoyl peroxide (BPO), which possesses bactericidal properties[A193524], and …
Matched Mixtures name: … Adapalene and Benzoyl Peroxide ... ADAPALENE and BENZOYL PEROXIDE ... Adapalene and Benzoyl Peroxide …
Matched Categories: … Skin and Mucous Membrane Agents …
Ambrisentan
Ambrisentan is an orally active selective type A endothelin receptor antagonist indicated for the treatment of pulmonary arterial hypertension. It is approved in Europe, Canada and the United States for use as a single agent to improve exercise ability and delay clinical worsening. In addition, it is approved in the...
Approved
Investigational
Matched Synonyms: … (2S)-2-[(4,6-dimethylpyrimidin-2-yl)oxy]-3-methoxy- 3,3-diphenylpropanoic acid …
Matched Iupac: … (2S)-2-[(4,6-dimethylpyrimidin-2-yl)oxy]-3-methoxy-3,3-diphenylpropanoic acid …
Matched Description: … ability and delay clinical worsening. ... It is approved in Europe, Canada and the United States for use as a single agent to improve exercise ... States for use in combination with tadalafil to reduce the risks of disease progression, hospitalization and …
Matched Categories: … ambrisentan and tadalafil ... Acids, Carbocyclic ... Carboxylic Acids …
Matched Iupac: … (2S)-2-[(4,6-dimethylpyrimidin-2-yl)oxy]-3-methoxy-3,3-diphenylpropanoic acid …
Matched Description: … ability and delay clinical worsening. ... It is approved in Europe, Canada and the United States for use as a single agent to improve exercise ... States for use in combination with tadalafil to reduce the risks of disease progression, hospitalization and …
Matched Categories: … ambrisentan and tadalafil ... Acids, Carbocyclic ... Carboxylic Acids …
VMD-928
Investigational
Matched Synonyms: … 4-((4-AMINO-3-(4-CYCLOHEXYLPIPERAZIN-1-YL)-9,10-DIOXO-9,10-DIHYDROANTHRACEN-1-YL)AMINO)BENZOIC ACID ... 4-{[4-Amino-3-(4-cyclohexylpiperazin-1-yl)-9,10-dioxo-9,10-dihydroanthracen-1-yl]amino}benzoic acid ... BENZOIC ACID, 4-((4-AMINO-3-(4-CYCLOHEXYL-1-PIPERAZINYL)-9,10-DIHYDRO-9,10-DIOXO-1-ANTHRACENYL)AMINO) …
Matched Iupac: … 4-{[4-amino-3-(4-cyclohexylpiperazin-1-yl)-9,10-dioxo-9,10-dihydroanthracen-1-yl]amino}benzoic acid …
Matched Iupac: … 4-{[4-amino-3-(4-cyclohexylpiperazin-1-yl)-9,10-dioxo-9,10-dihydroanthracen-1-yl]amino}benzoic acid …
Cinoxacin
Synthetic antimicrobial related to oxolinic acid and nalidixic acid and used in urinary tract infections.
Approved
Investigational
Withdrawn
Matched Synonyms: … 1-ethyl-6,7-methylenedioxy-4(1H)-oxocinnoline-3-carboxylic acid ... 5-Ethyl-8-oxo-5,8-dihydro-1,3-dioxa-5,6-diaza-cyclopenta[b]naphthalene-7-carboxylic acid …
Matched Iupac: … 1-ethyl-4-oxo-1H,4H,7H-[1,3]dioxolo[4,5-g]cinnoline-3-carboxylic acid …
Matched Description: … Synthetic antimicrobial related to oxolinic acid and nalidixic acid and used in urinary tract infections …
Matched Categories: … Acids, Heterocyclic …
Matched Iupac: … 1-ethyl-4-oxo-1H,4H,7H-[1,3]dioxolo[4,5-g]cinnoline-3-carboxylic acid …
Matched Description: … Synthetic antimicrobial related to oxolinic acid and nalidixic acid and used in urinary tract infections …
Matched Categories: … Acids, Heterocyclic …
Thiopental
A barbiturate that is administered intravenously for the induction of general anesthesia or for the production of complete anesthesia of short duration. It is also used for hypnosis and for the control of convulsive states. It has been used in neurosurgical patients to reduce increased intracranial pressure. It does not...
Approved
Vet approved
Matched Synonyms: … Thiopentobarbituric acid ... 2-Thio-5-ethyl-5-sec-pentylbarbituric acid …
Matched Description: … It is also used for hypnosis and for the control of convulsive states. ... Small doses have been shown to be anti-analgesic and lower the pain threshold. ... It does not produce any excitation but has poor analgesic and muscle relaxant properties. …
Matched Categories: … Hypnotics and Sedatives …
Matched Description: … It is also used for hypnosis and for the control of convulsive states. ... Small doses have been shown to be anti-analgesic and lower the pain threshold. ... It does not produce any excitation but has poor analgesic and muscle relaxant properties. …
Matched Categories: … Hypnotics and Sedatives …
2-(3,4-Dihydroxyphenyl)Acetic Acid
A deaminated metabolite of levodopa. [PubChem]
Experimental
Matched Name: … 2-(3,4-Dihydroxyphenyl)Acetic Acid …
Matched Iupac: … 2-(3,4-dihydroxyphenyl)acetic acid …
Matched Iupac: … 2-(3,4-dihydroxyphenyl)acetic acid …
2-Oxo-3-Pentenoic Acid
Experimental
Matched Name: … 2-Oxo-3-Pentenoic Acid …
Matched Iupac: … (3Z)-2-oxopent-3-enoic acid …
Matched Iupac: … (3Z)-2-oxopent-3-enoic acid …
6-phospho-D-gluconic acid
Experimental
Matched Name: … 6-phospho-D-gluconic acid …
Matched Iupac: … (2R,3S,4R,5R)-2,3,4,5-tetrahydroxy-6-(phosphonooxy)hexanoic acid …
Matched Categories: … Acids, Acyclic ... Sugar Acids ... Hydroxy Acids ... Carboxylic Acids …
Matched Iupac: … (2R,3S,4R,5R)-2,3,4,5-tetrahydroxy-6-(phosphonooxy)hexanoic acid …
Matched Categories: … Acids, Acyclic ... Sugar Acids ... Hydroxy Acids ... Carboxylic Acids …
4-iodo-acetamido phenylboronic acid
Experimental
Matched Name: … 4-iodo-acetamido phenylboronic acid …
Matched Iupac: … [3-(2-iodoacetamido)phenyl]boronic acid …
Matched Iupac: … [3-(2-iodoacetamido)phenyl]boronic acid …
1-Hydroxyamine-2-Isobutylmalonic Acid
Experimental
Matched Name: … 1-Hydroxyamine-2-Isobutylmalonic Acid …
Matched Iupac: … (2R)-2-(hydroxycarbamoyl)-4-methylpentanoic acid …
Matched Iupac: … (2R)-2-(hydroxycarbamoyl)-4-methylpentanoic acid …
Displaying drugs 1726 - 1750 of 2916 in total