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Displaying drugs 1826 - 1850 of 1932 in total

Refametinib

Investigational

ABBV-011

ABBV-011 is an antibody-drug conjugate of humanized, cysteine-engineered IgG1 monoclonal antibody targeting seizure-related 6 homolog conjugated to N-acetyl-gamma-calicheamicin.
Investigational

Tabelecleucel

Tabelecleucel is an innovative therapy that uses Epstein-Barr virus (EBV)-specific allogeneic cytotoxic T cells (CTLs). It is produced by mixing T-cells with B-cells that have been infected with the Epstein-Barr virus (EBV). Both T-cells and B-cells are obtained from the same donor, and T-cells are grown to increase their numbers....
Investigational
Matched Description: … [A253292,A253297,L43557] In October 2022, the EMA's Committee for Medicinal Products for Human Use ... Both T-cells and B-cells are obtained from the same donor, and T-cells are grown to increase their numbers ... (CHMP) recommended tabelecleucel be granted marketing authorization for the treatment of adult and pediatric …
Matched Categories: … Antineoplastic cell and gene therapy ... Antineoplastic and Immunomodulating Agents …

Tandutinib

MLN518 is a novel, oral, small molecule designed to inhibit type III receptor tyrosine kinases, including FLT3, (platelet-derived growth-factor receptor) PDGFR and c-KIT. Tyrosine kinases are enzymes involved in several cellular processes and are known to be activated in cancer cells to drive tumor growth. AML patients with FLT3 mutations...
Investigational
Matched Description: … Food and Drug Administration. Phase I/II trials are underway. ... type III receptor tyrosine kinases, including FLT3, (platelet-derived growth-factor receptor) PDGFR and ... Tyrosine kinases are enzymes involved in several cellular processes and are known to be activated in …

Piboserod

Piboserod (SB 207266) is a selective 5-HT(4) receptor antagonist.
Investigational

XL019

XL019 is a selective inhibitor of the cytoplasmic tyrosine kinase JAK2. An IND for XL019 was filed by Exelixis in May 2007.
Investigational

Urelumab

Urelumab has been used in trials studying the treatment of Leukemia, Multiple Myeloma, Malignant Tumors, and Cancer - Solid Tumors and B-Cell Non-Hodgkin's Lymphoma. Urelumab is a fully human antibody that targets CD137. The antibody product was developed using Medarex's UltiMAb(R) technology and was the first UltiMAb- derived antibody in...
Investigational
Matched Description: … Urelumab is a fully human antibody that targets CD137. ... Cancer - Solid Tumors and B-Cell Non-Hodgkin's Lymphoma. ... Urelumab has been used in trials studying the treatment of Leukemia, Multiple Myeloma, Malignant Tumors, and …
Matched Categories: … Amino Acids, Peptides, and Proteins …

LV-SMENP Vaccine

LV-SMENP-DC is a vaccine candidate being developed by Shenzhen Geno-Immune Medical Institute that comprises dendritic cells that are modified with lentiviral vector-expressing synthetic minigene which are based on domains of selected viral proteins. This vaccine is also administered with antigen-specific cytotoxic T lymphocytes (CTLs). As of August 2020, this vaccine...
Investigational
Matched Description: … As of August 2020, this vaccine is being tested for prophylaxis against COVID-19 in human clinical trials …

ADU-S100

ADU-S100 (MIW815) is a synthetic cyclic dinucleotide (CDN) agonist (activator) of Stimulator of Interferon Genes (STING), a receptor crucial to activate the innate (endogenous) immune system. ADU-S100 (MIW815) activates all known human and mouse STINGs, and effectively induces the expression of cytokines and chemokines, leading to a robust and durable...
Investigational
Matched Description: … ADU-S100 (MIW815) activates all known human and mouse STINGs, and effectively induces the expression ... of cytokines and chemokines, leading to a robust and durable antigen-specific T-cell mediated immune …
Matched Categories: … Nucleic Acids, Nucleotides, and Nucleosides …

Camazepam

Camazepam is a benzodiazepine which is a dimethyl carbamate ester of tamzepam, a metabolite of diazepam. Similarly to other drugs in its class, it has antxiolytic, anticonvulsant, hypnotic, and skeletal muscle relaxant properties. However, unlike other benzodiapeines camazepam is predominantly anxiolytic and is relatively weak as an anticonvulsant, hypnotic and...
Experimental
Illicit
Matched Description: … an anticonvulsant, hypnotic and skeletal muscle relaxant. ... Camazepam is also believed to increase attention, and is associated with skin disorders. ... Similarly to other drugs in its class, it has antxiolytic, anticonvulsant, hypnotic, and skeletal muscle …
Matched Categories: … Benzodiazepines and benzodiazepine derivatives …

AGRO100

AGRO100 is an oligonucleotide that functions as an aptamer and binds to nucleolin, a protein found intranuclear in all cells, but uniquely expressed on the surface of tumor cells. Such binding leads to internalization of the complex, and a strong anti-proliferative response in the tumor cell. Pre-clinical testing demonstrates that...
Investigational
Matched Description: … colon cancer, as well as malignant melanoma and leukemia. ... Such binding leads to internalization of the complex, and a strong anti-proliferative response in the ... AGRO100 is an oligonucleotide that functions as an aptamer and binds to nucleolin, a protein found intranuclear …
Matched Categories: … Nucleic Acids, Nucleotides, and Nucleosides …

Tomaralimab

Tomaralimab is under investigation in clinical trial NCT01794663 (Placebo-Controlled Study to Evaluate the Safety and Efficacy of OPN-305 in Preventing Delayed Renal Graft Function).
Investigational
Matched Description: … under investigation in clinical trial NCT01794663 (Placebo-Controlled Study to Evaluate the Safety and …
Matched Categories: … Amino Acids, Peptides, and Proteins …

Tegoprubart

Investigational

Allogeneic Cardiosphere-Derived Cells

Cardiosphere-derived cells (CDCs) are derived from human neonatal heart tissue with a distinct antigenic profile (CD105+, CD45-, and CD90low). They exert their effects by secreting exosomes: nanometer-sized, membrane-bound vesicles used for the purpose of cell-cell communication. CDCs target multiple cytokine pathways associated with poor outcomes (e.g. TNFa, IFN-y, IL-1B, and...
Investigational
Matched Description: … Cardiosphere-derived cells (CDCs) are derived from human neonatal heart tissue with a distinct antigenic ... TNFa, IFN-y, IL-1B, and IL-15). ... profile (CD105+, CD45-, and CD90low). …

KB001

KB001 is a Humaneered™ PEGylated monoclonal antibody fragment for the treatment of life-threatening Pseudomonas aeruginosa infections, a common problem of cystic fibrosis and mechanically ventilated patients.
Investigational
Matched Description: … treatment of life-threatening Pseudomonas aeruginosa infections, a common problem of cystic fibrosis and …

Uric acid

Uric acid is the last product of purine metabolism in humans. The formation of uric acid is through the enzyme xanthine oxidase, which oxidizes oxypurines. Normally a small amount of uric acid is present in the body, but when there is an excess amount in the blood, called hyperuricemia, this...
Investigational
Matched Description: … body, but when there is an excess amount in the blood, called hyperuricemia, this can lead to gout and ... As a therapeutic agent, it is known that uric acid is increased in response to oxidative stress, and …

PRO-542

PRO 542 belongs to a new class of drugs, viral-entry inhibitor, which is intended to prevent HIV from entering and infecting cells. PRO 542 (CD4-immunoglobulin G2) is a tetravalent CD4-immunoglobulin fusion protein that broadly neutralizes primary HIV-1 isolates.
Investigational
Matched Description: … belongs to a new class of drugs, viral-entry inhibitor, which is intended to prevent HIV from entering and …
Matched Categories: … Amino Acids, Peptides, and Proteins …

Interferon alfa

Natural interferon alpha or Multiferon is obtained from the leukocyte fraction of human blood following induction with Sendai virus. Interferon alfa contains several naturally occurring IFN-α subtypes and is purified by affinity chromatography. Interferon alpha proteins are mainly involved in innate immune response against viral infection. They come in 13...
Investigational
Matched Description: … Natural interferon alpha or Multiferon is obtained from the leukocyte fraction of human blood following ... Of these, IFN-α2 and IFN-α14 are glycosylated. ... Multiferon consists of the 6 major subtypes are IFN-α1, IFN-α2, IFN-α8, IFN-α10, IFN-α14 and IFN-α21. …
Matched Categories: … Amino Acids, Peptides, and Proteins ... Intercellular Signaling Peptides and Proteins …

Cintredekin besudotox

Cintredekin besudotox has been developed as a specific tumor-targeting agent, which is administered by positive-pressure convection-enhanced delivery (CED) directly to brain tissue at risk for residual infiltrating glioblastoma multiforme (GBM) after tumor resection. Cintredekin besudotox is made from a human protein, Interleukin 13 (IL13), linked to a bacterial toxin, Pseudomonas...
Investigational
Matched Description: … Cintredekin besudotox is made from a human protein, Interleukin 13 (IL13), linked to a bacterial toxin …
Matched Categories: … Amino Acids, Peptides, and Proteins ... Intercellular Signaling Peptides and Proteins …

Tridolgosir

An indolizidine alkaloid from the plant Swainsona canescens that is a potent alpha-mannosidase inhibitor. Swainsonine also exhibits antimetastatic, antiproliferative, and immunomodulatory activity.
Experimental
Matched Description: … Swainsonine also exhibits antimetastatic, antiproliferative, and immunomodulatory activity. …

Fasinumab

Fasinumab is a human IgG1k monoclonal antibody targeted against nerve growth factor (NGF). It is currently under investigation for the treatment osteoarthritic pain and has demonstrated significantly greater pain relief and functional improvement as compared to standard therapy (i.e. NSAIDs and/or opioids) in this patient population. NGF was first discovered...
Investigational
Matched Description: … Fasinumab is a human IgG1k monoclonal antibody targeted against nerve growth factor (NGF). ... be identified and biochemically characterized. ... NSAIDs and/or opioids) in this patient population. …
Matched Categories: … Amino Acids, Peptides, and Proteins …

D-Tryptophan

Tryptophan is one of the 20 standard amino acids, as well as an essential amino acid in the human diet. It is encoded in the standard genetic code as the codon UGG. The D-stereoisomer is occasionally found in naturally produced peptides (for example, the marine venom peptide contryphan). The distinguishing...
Experimental
Matched Description: … Tryptophan is one of the 20 standard amino acids, as well as an essential amino acid in the human diet …

CA4P

CA4P has been shown in the laboratory to shut down the blood supply to tumours. It is one of the first vascular targeting drugs to be tested in patients. This drug was originally isolated from the African Bush Willow. The first studies in patients with this drug were aimed at...
Investigational
Matched Description: … whether it can actually shut down the blood supply to human tumours. ... were aimed at finding out whether it can be safely given to patients, what side effects it produces and …

Dendritic cells vaccine

The recombinant chimeric DC vaccine is a subunit-based vaccine candidate investigated for safety and effectiveness against SARS-CoV-2-induced pneumonia. With a better safety profile than inactivated and live-attenuated virus and virus-vector vaccines, the recombinant chimeric DC vaccine reduces the risk of virulence recovery, pre-existing anti-vector immunity, and incomplete viral inactivation. As...
Investigational
Matched Description: … As of August 2020, this vaccine is being tested for prophylaxis against COVID-19 in human clinical trials ... With a better safety profile than inactivated and live-attenuated virus and virus-vector vaccines, the ... The recombinant chimeric DC vaccine is a subunit-based vaccine candidate investigated for safety and …

MM-093

MM-093 is a recombinant version of human alpha-fetoprotein (hAFP), an immunomodulatory serum protein normally produced at very high levels by the fetus and present in low levels in the blood of adults and children. Research on AFP suggests that it may play a role in modulating the immune system of...
Investigational
Matched Description: … MM-093 is a recombinant version of human alpha-fetoprotein (hAFP), an immunomodulatory serum protein ... normally produced at very high levels by the fetus and present in low levels in the blood of adults and ... been associated with remission of many autoimmune diseases, including rheumatoid arthritis, psoriasis and …
Displaying drugs 1826 - 1850 of 1932 in total