Camazepam is a benzodiazepine which is a dimethyl carbamate ester of tamzepam, a metabolite of diazepam. Similarly to other drugs in its class, it has antxiolytic, anticonvulsant, hypnotic, and skeletal... However, unlike other benzodiapeines camazepam is predominantly anxiolytic and is relatively weak as an anticonvulsant, hypnotic and skeletal muscle relaxant.
- Mechanism
- Curator reviewed
Camazepam has been shown to bind competitively to benzodiazepine receptors in the brain with a relatively low affinity in animal models. This binding of benzodiazepine receptors by camazepam and its active metabolites is responsible for its anticonvulsant effects. Notably, only three metabolites were shown to exert anticonvulsant activity, temazepam, oxazepam, and hydroxy camazepam.
The anxiolytic properties of camazepam are also attributed to their ability to bind benzodiazepine receptors, also known as GABA receptors. When benzodiazepines bind to GABA receptors they increase the efficiency with which the inhibitory neurotransmitter GABA binds.
- Primary indication
- Camazepam has been used in placebo controlled studies for the treatment of patients suffering from anxiety and depression.Curator reviewed
- Formula / weight
- C19H18ClN3O3 · 371.818 g/mol (avg)
Resolves to
PXBVEXGRHZFEOF-UHFFFAOYSA-NSMILESCN(C)C(=O)OC1N=C(C2=CC=CC=C2)C2=C(C=CC(Cl)=C2)N(C)C1=OWhat you can answer from here — as of September 16, 2026
Which companies are running trials of Camazepam, in which indications and phases, and which of those programs are still active?
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