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Displaying drugs 1951 - 1975 of 15191 in total

Foslevodopa

Foslevodopa is under investigation in clinical trial NCT04750226 (Study to Assess Adverse Events and Change in Disease Activity of 24-hour Continuous Subcutaneous Infusion of ABBV-951 in Adult Participants With Advanced Parkinson's Disease).
Approved
Investigational
Matched Iupac: … (2S)-2-amino-3-[3-hydroxy-4-(phosphonooxy)phenyl]propanoic acid …
Matched Description: … Foslevodopa is under investigation in clinical trial NCT04750226 (Study to Assess Adverse Events and …
Matched Categories: … Dopa and Dopa Derivatives ... foslevodopa and decarboxylase inhibitor …

Grazoprevir

Grazoprevir is a direct acting antiviral medication used as part of combination therapy to treat chronic Hepatitis C, an infectious liver disease caused by infection with Hepatitis C Virus (HCV). HCV is a single-stranded RNA virus that is categorized into nine distinct genotypes, with genotype 1 being the most common...
Approved
Matched Description: … Subtitutions at amino acid positions 155, 156, or 168 are known to confer resistance. ... with or without [DB00811] depending on the the presence of resistance associated amino acid substitutions ... to achieve a SVR between 94% and 97% for genotype 1 and 97% and 100% for genotype 4 after 12 weeks of …
Matched Categories: … elbasvir and grazoprevir …

Ketotifen

Ketotifen is a benzocycloheptathiophene derivative with potent antihistaminic and mast cell stabilizing properties. It has a similar structure to some other first-generation antihistamines such as cyproheptadine and azatadine. Ketotifen was first developed in Switzerland in 1970 by Sandoz Pharmaceuticals and was initially marketed for the treatment of anaphylaxis. In the...
Approved
Matched Description: … allergic symptoms and disorders,[A231204] including urticaria, mastocytosis, and food allergy. ... Ketotifen is a benzocycloheptathiophene derivative[A231204] with potent antihistaminic and mast cell ... It has a similar structure to some other first-generation antihistamines such as [cyproheptadine] and …
Matched Categories: … Decongestants and Antiallergics …
Matched Products: … Up and Up Eye Itch Relief …

Netarsudil

A Rho kinase inhibitor with norepinephrine transport inhibitory activity that reduces production of aqueous As of December 18, 2017 the FDA approved Aerie Pharmaceutical's Rhopressa (netarsudil ophthalmic solution) 0.02% for the indication of reducing elevated intraocular pressure in patients with open-angle glaucoma or ocular hypertension. Acting as both a rho...
Approved
Matched Description: … Acting as both a rho kinase inhibitor and a norepinephrine transport inhibitor, Netarsudil is a novel ... conventional trabecular pathway of aqueous humour outflow to act as an inhibitor to the rho kinase and …
Matched Categories: … latanoprost and netarsudil ... Amino Acids, Peptides, and Proteins ... Antiglaucoma Preparations and Miotics …

Rifapentine

Rifapentine is an antibiotic drug used in the treatment of tuberculosis. It inhibits DNA-dependent RNA polymerase activity in susceptible cells. Specifically, it interacts with bacterial RNA polymerase but does not inhibit the mammalian enzyme.
Approved
Investigational

Atosiban

Atosiban is an inhibitor of the hormones oxytocin and vasopressin. It is used intravenously to halt premature labor. Although initial studies suggested it could be used as a nasal spray and hence would not require hospital admission, it is not used in that form. Atobisan was developed by the Swedish...
Approved
Investigational
Matched Description: … Atosiban is an inhibitor of the hormones oxytocin and vasopressin. ... Although initial studies suggested it could be used as a nasal spray and hence would not require hospital ... Atosiban is licensed in proprietary and generic forms for the delay of imminent pre-term birth in pregnant …
Matched Categories: … Amino Acids, Peptides, and Proteins ... Genito Urinary System and Sex Hormones ... Hormones, Hormone Substitutes, and Hormone Antagonists …

Atenolol

Atenolol is a cardioselective beta-blocker used in a variety of cardiovascular conditions. Sir James Black, a Scottish pharmacologist, pioneered the use of beta-blockers for the management of angina pectoris in 1958 for which he received the Nobel Prize. Beta-blockers quickly became popular in clinical use and where subsequently investigated for...
Approved
Matched Description: … use in myocardial infarction, arrhythmias, and hypertension during the 1960s. ... [A178429] Beta-blockers quickly became popular in clinical use and where subsequently investigated for ... widely prescribed beta blockers, evidence suggests atenolol may not significantly reduce mortality, and …
Matched Mixtures name: … Atenolol and Chlorthalidone ... Atenolol and Chlorthalidone ... Atenolol and Chlorthalidone …
Matched Categories: … atenolol and thiazides ... atenolol and nifedipine ... atenolol and other diuretics ... Beta Blocking Agents and Thiazides ... atenolol, thiazides and other diuretics …

Dinoprost

Dinoprost has been investigated in Headache.
Approved
Investigational
Matched Iupac: … (5Z)-7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(1E,3S)-3-hydroxyoct-1-en-1-yl]cyclopentyl]hept-5-enoic acid …
Matched Categories: … Genito Urinary System and Sex Hormones …

Abarelix

Synthetic decapeptide antagonist to gonadotropin releasing hormone (GnRH). It is marketed by Praecis Pharmaceuticals as Plenaxis. Praecis announced in June 2006 that it was voluntarily withdrawing the drug from the market.
Approved
Investigational
Withdrawn
Matched Categories: … Amino Acids, Peptides, and Proteins ... Hormone Antagonists and Related Agents ... Antineoplastic and Immunomodulating Agents ... Hormones, Hormone Substitutes, and Hormone Antagonists …

Capreomycin

Cyclic peptide antibiotic similar to viomycin. It is produced by Streptomyces capreolus.
Approved
Matched Categories: … Amino Acids, Peptides, and Proteins …

Rifampin

Rifampin, also known as rifampicin, is a broad-spectrum antimicrobial that was first discovered in 1965 and clinically used in 1968. Rifampin is used to treat tuberculosis and works by inhibiting the microbial DNA-dependent RNA polymerase (RNAP).
Approved
Matched Description: … rifampicin, is a broad-spectrum antimicrobial [A263748] that was first discovered in 1965 [A263753] and ... [A263768] Rifampin is used to treat tuberculosis and works by inhibiting the microbial DNA-dependent …
Matched Categories: … Nucleic Acid Synthesis Inhibitors ... dapsone and rifampicin ... rifampicin and isoniazid ... dapsone, rifampicin and clofazimine ... rifampicin, ethambutol and isoniazid …

Pilocarpine

A naturally occurring alkaloid derived from the Pilocarpus plants, pilocarpine is a muscarinic acetylcholine agonist.[A262016, A262036] Pilocarpine is associated with parasympathomimetic effects by selectively working on muscarinic receptors. Pilocarpine is used to treat dry mouth and various ophthalmic conditions, including elevated intraocular pressure and glaucoma. The usage of glaucoma by...
Approved
Investigational
Matched Description: … intraocular pressure and glaucoma. ... [A262036] Pilocarpine is used to treat dry mouth and various ophthalmic conditions, including elevated …
Matched Categories: … Antiglaucoma Preparations and Miotics …

Macitentan

Macitentan is a dual endothelin receptor antagonist used in the treatment of pulmonary arterial hypertension (PAH). It was first approved by the FDA in 2013. Macitentan differs from its predecessor bosentan in part due to its lower risk of hepatotoxicity. A combination product (Opsynvi) comprising macitentan and tadalafil was approved...
Approved
Matched Description: … A combination product (Opsynvi) comprising macitentan and [tadalafil] was approved in Canada in October …
Matched Categories: … macitentan and tadalafil …

Edoxaban

Edoxaban is a member of the Novel Oral Anti-Coagulants (NOACs) class of drugs, and is a rapidly acting, oral, selective factor Xa inhibitor. By inhibiting factor Xa, a key protein in the coagulation cascade, edoxaban prevents the stepwise amplification of protein factors needed to form blood clots. It is indicated...
Approved
Matched Description: … INR testing, and numerous drug-drug and drug-food interactions. ... atrial fibrillation (NVAF) and for the treatment of deep vein thrombosis (DVT) and pulmonary embolism ... Edoxaban is a member of the Novel Oral Anti-Coagulants (NOACs) class of drugs, and is a rapidly acting …
Matched Categories: … Blood and Blood Forming Organs …

Rolapitant

Rolapitant is a potent, highly selective, long-acting Neurokinin-1 (NK-1) receptor antagonist approved for the prevention of delayed chemotherapy-induced nausea and vomiting (CINV) in adults. Delayed-phase CINV typically occurs >24 hours after chemotherapy treatment and is principally mediated by Neurokinin-1 and its ligand Substance P, which is released in the gut...
Approved
Investigational
Matched Description: … Delayed-phase CINV typically occurs >24 hours after chemotherapy treatment and is principally mediated ... Neurokinin-1 (NK-1) receptor antagonist approved for the prevention of delayed chemotherapy-induced nausea and ... By blocking Substance P from interacting with NK-1 receptors in the gut and the central nervous system …
Matched Categories: … Antiemetics and Antinauseants ... Alimentary Tract and Metabolism …

Atogepant

Atogepant is an oral antagonist of calcitonin gene-related peptide (CGRP) receptors indicated for the prevention of episodic migraine headaches. It was developed by AbbVie and received FDA approval under the brand name Qulipta in September 2021. While its approval was predated by two other members of the same drug family,...
Approved
Investigational
Matched Description: … [valproic acid] or [topiramate]) or beta-blockers (e.g. ... It was developed by AbbVie and received FDA approval under the brand name Qulipta in September 2021. ... ] While its approval was predated by two other members of the same drug family, namely [ubrogepant] and …

Colfosceril palmitate

Colfosceril palmitate is a synthetic pulmonary surfactant administered in infants with respiratory distress syndrome. It was part of the first generation of commercially available artificial surfactants. It was developed by Burroughs Wellcome and it was FDA approved on August 6, 1990. Nowadays colfosceril palmitate is under the state of canceled...
Approved
Investigational
Withdrawn
Matched Description: … [T70] It was developed by Burroughs Wellcome and it was FDA approved on August 6, 1990. …

DL-dimyristoylphosphatidylcholine

A synthetic phospholipid used in liposomes and lipid bilayers for the study of biological membranes. It is used in commercial drug preparations to solubilize drugs for injection
Approved
Matched Description: … A synthetic phospholipid used in liposomes and lipid bilayers for the study of biological membranes. …
Matched Categories: … Indicators and Reagents …

Voxilaprevir

Voxilaprevir is a Direct-Acting Antiviral (DAA) medication used as part of combination therapy to treat chronic Hepatitis C, an infectious liver disease caused by infection with Hepatitis C Virus (HCV). HCV is a single-stranded RNA virus that is categorized into nine distinct genotypes, with genotype 1 being the most common...
Approved
Investigational
Matched Description: … mature virus: NS3, NS4A, NS4B, NS5A, and NS5B [A19643]. ... categorized into nine distinct genotypes, with genotype 1 being the most common in the United States, and ... genetic material into the following structural and nonstructural proteins required for assembly into …
Matched Categories: … Amino Acids, Peptides, and Proteins ... sofosbuvir, velpatasvir and voxilaprevir …

Ferric cation

Iron is a transition metal with a symbol Fe and atomic number 26. By mass, it is the most common element on Earth. Iron is an essential element involved in various metabolic processes, including oxygen transport, deoxyribonucleic acid (DNA) synthesis, and energy production in electron transport . Resulting from inadequate...
Approved
Matched Description: … essential element involved in various metabolic processes, including oxygen transport, deoxyribonucleic acid ... Iron is a transition metal with a symbol Fe and atomic number 26. ... (DNA) synthesis, and energy production in electron transport [A32514]. …

Viomycin

Viomycin is a tuberactinomycin antibiotic that was used to treat Mycobacterium tuberculosis until it was replaced by the less toxic capreomycin. These drugs bind RNA in bacterial ribosomes and inhibit protein synthesis. Viomycin was derived from the actinomycete Streptomyces puniceus.
Approved
Matched Description: … These drugs bind RNA in bacterial ribosomes and inhibit protein synthesis. …
Matched Categories: … Amino Acids, Peptides, and Proteins …

Trametinib

Trametinib is an orally bioavailable mitogen-activated extracellular signal-regulated kinase 1 (MEK1) and MEK2 inhibitor.[A258298,A258293] It was first approved by the FDA in May 2013 for the treatment of melanoma. It was later approved by Health Canada on July 18, 2013 and by the European Commission on June 30, 2014. Trametinib...
Approved
Matched Description: … Trametinib is an orally bioavailable mitogen-activated extracellular signal-regulated kinase 1 (MEK1) and ... [A258298] It was later approved by Health Canada on July 18, 2013 [L45588] and by the European Commission ... currently approved to treat a variety of cancers with BRAF mutations, such as non-small cell lung cancer and …
Matched Categories: … Antineoplastic and Immunomodulating Agents …

Glutathione

A tripeptide with many roles in cells. It conjugates to drugs to make them more soluble for excretion, is a cofactor for some enzymes, is involved in protein disulfide bond rearrangement and reduces peroxides.
Approved
Investigational
Nutraceutical
Matched Iupac: … (2S)-2-amino-4-{[(1R)-1-[(carboxymethyl)carbamoyl]-2-sulfanylethyl]carbamoyl}butanoic acid …
Matched Description: … for excretion, is a cofactor for some enzymes, is involved in protein disulfide bond rearrangement and …
Matched Categories: … Amino Acids, Peptides, and Proteins …

Levothyroxine

Levothyroxine is a synthetically produced form of thyroxine, a major endogenous hormone secreted by the thyroid gland. Also known as L-thyroxine or the brand name product Synthroid, levothyroxine is used primarily to treat hypothyroidism, a condition where the thyroid gland is no longer able to produce sufficient quantities of the...
Approved
Matched Iupac: … (2S)-2-amino-3-[4-(4-hydroxy-3,5-diiodophenoxy)-3,5-diiodophenyl]propanoic acid …
Matched Description: … produce sufficient quantities of the thyroid hormones T4 (tetraiodothyronine or thyroxine) and ... hypothyroidism begin to develop such as fatigue, increased heart rate, depression[A179620], dry skin and ... [F4633] T4 and T3 act on nearly every cell of the body, but have a particularly …
Matched Mixtures name: … Levothyroxine and Liothyronine Thyroid ... Levothyroxine and Liothyronine Thyroid ... Levothyroxine and Liothyronine Thyroid …
Matched Categories: … Sex Hormones and Insulins ... Amino Acids, Peptides, and Proteins ... levothyroxine sodium and iodine compounds ... Hormones, Hormone Substitutes, and Hormone Antagonists …

Simoctocog alfa

Simoctocog alfa is a recombinant B-domain deleted (BDD) rFVIII produced in genetically modified human embryonic kidney (HEK) 293F cells. The harvested product is concentrated and purified by a series of chromatography steps. It is an antihemorrhagic agent used as a replacement therapy in individuals with Haemophilia A who lack the...
Approved
Matched Description: … replaced by a 16 amino acid linker. ... The harvested product is concentrated and purified by a series of chromatography steps. ... + A3-C1-C2 whereas the B-domain, present in the full-length plasma-derived FVIII, has been deleted and …
Matched Categories: … Amino Acids, Peptides, and Proteins …
Displaying drugs 1951 - 1975 of 15191 in total