Viomycin is a tuberactinomycin antibiotic that was used to treat Mycobacterium tuberculosis until it was replaced by the less toxic capreomycin. These drugs bind RNA in bacterial ribosomes and inhibit... Viomycin was derived from the actinomycete Streptomyces puniceus.
- Mechanism
- Curator reviewed
Viomycin binds to a site on the ribosome which lies at the interface between helix 44 of the small ribosomal subunit and helix 69 of the large ribosomal subunit. The structures of this complexes suggest that the viomycin inhibits translocation by stabilizing the tRNA in the A site in the pretranslocation state. This inhibits protein synthesis.
- Primary indication
- Viomycin is an essential component in the drug cocktail currently used to fight infections of Mycobacterium tuberculosis.Curator reviewed
- Formula / weight
- C25H43N13O10 · 685.69 g/mol (avg)
- Also known as
- Vinacetin A
Resolves to
GXFAIFRPOKBQRV-GHXCTMGLSA-NSMILES[H][C@@]1(C[C@H](O)NC(=N)N1)[C@]1([H])NC(=O)\C(NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@H](CNC1=O)NC(=O)C[C@@H](N)CCCN)=C\NC(N)=OWhat you can answer from here — as of September 16, 2026
Which drugs share a target with Viomycin, and which of those have an active Phase 3 trial?
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