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Displaying drugs 176 - 200 of 215 in total

Mavelertinib

Mavelertinib is under investigation in clinical trial NCT02349633 (Study for Patients With NSCLC EGFR Mutations (Del 19 or L858R +/- T790M)).
Investigational
Matched Synonyms: … Egfr t790m inhibitor pf-06747775 …
Matched Description: … under investigation in clinical trial NCT02349633 (Study for Patients With NSCLC EGFR Mutations (Del 19 or …

Agatolimod

Agatolimod is under investigation in clinical trial NCT00471471 (Vaccine Therapy in Treating Patients With Recurrent Stage III or Stage IV Melanoma That Cannot Be Removed by Surgery).
Investigational
Matched Synonyms: … PF-3512676 free acid …
Matched Description: … investigation in clinical trial NCT00471471 (Vaccine Therapy in Treating Patients With Recurrent Stage III or …

Marzeptacog alfa (activated)

Marzeptacog alfa (activated) is under investigation in clinical trial NCT01439971 (Phase 1 Safety, Pharmacokinetics And Pharmacodynamics Study Of Recombinant Factor VIIa Variant (813d) In Adult Subjects With Hemophilia).
Investigational
Matched Synonyms: … PF-05280602 …

Ponsegromab

Ponsegromab is under investigation in clinical trial NCT05492500 (A Study of Ponsegromab in People With Heart Failure).
Investigational
Matched Synonyms: … PF-06946860 ... -06946860 .gamma.1-chain), disulfide with human-mus musculus monoclonal pf-06946860 .kappa. ... -alanine,240-alanine), anti-(human growth differentiation factor 15) (human-mus musculus monoclonal pf …

Sasanlimab

Sasanlimab is under investigation in clinical trial NCT06218069 (Immuno-pet Imaging Responses Administered Immune Checkpoint Inhibitor).
Investigational
Matched Synonyms: … Anti-pd-1 checkpoint inhibitor pf-06801591 …

Giroctocogene fitelparvovec

Giroctocogene fitelparvovec is under investigation in clinical trial NCT04370054 (Study to Evaluate the Efficacy and Safety of PF-07055480 in Moderately Severe to Severe Hemophilia a Adults).
Investigational
Matched Synonyms: … PF 07055480 ... Dna (recombinant adeno-associated virus 6 vector pf-07055480 human b-domain-deleted blood-coagulation …
Matched Description: … is under investigation in clinical trial NCT04370054 (Study to Evaluate the Efficacy and Safety of PF …

Marstacimab

Marstacimab is a human Monoclonal Antibody Directed Against Tissue Factor Pathway Inhibitor currently being developed by Pfizer for the treatment of hemophilia A and hemophilia B.
Investigational
Matched Synonyms: … -chain), disulfide with human monoclonal pf-06741086 .lambda. ... Immunoglobulin g1, anti-(human tissue factor pathway inhibitor) (human monoclonal pf-06741086 .gamma.1 …

Dazukibart

Investigational
Matched Synonyms: … -06823859 γ1-chain), disulfide with human-Mus musculus monoclonal PF-06823859 κ-chain, dimer ... alanine,239-alanine,de-C-terminal-lysine], anti-(human interferon β) (human-Mus musculus monoclonal PF …

Fordadistrogene movaparvovec

Investigational
Matched Synonyms: … DNA (RECOMBINANT ADENO-ASSOCIATED VIRUS 9 VECTOR PF-06939926 HUMAN MUSCLE-SPECIFIC ENHANCER/PROMOTER …

Trichostatin A

Experimental

TSHA-118

TSHA-118 is a self-complementary AAV9 gene replacement therapy designed to express a human codon-optimized CLN1 transgene for the treatment of CLN1 disease.
Experimental

TSHA-105

TSHA-105 is an adeno-associated virus serotype 9 (AAV9) vector with an engineered transgene encoding the human SLC13A5 protein.
Investigational

TSN-084

Investigational

Mirdametinib

PD-0325901 has been used in trials studying the treatment and basic science of Melanoma, Solid Tumour, Solid Tumors, Advanced Cancer, and Breast Neoplasms, among others.
Investigational

TSHA-120

Investigational

AZD-0328

AZD0328 has been used in trials studying the treatment and basic science of Schizophrenia and Alzheimer's Disease.
Investigational

Thymectacin

Thymectacin, a phosphoramidate derivative of (E)-5-(2-bromovinyl)-2'-deoxyuridine, is a novel small molecule anticancer agent. Thymectacin is selectively active against tumor cells expressing high levels of thymidylate synthase (TS), a critical enzyme in DNA biosynthesis. Thymectacin was as efficacious as irinotecan, a drug recently approved for the treatment of 5-fluorouracil-resistant colon cancer.
Investigational
Matched Description: … Thymectacin is selectively active against tumor cells expressing high levels of thymidylate synthase (TS …

TSHA-104

Investigational

TSHA-101

Investigational

TSHA-102

TSHA-102 is a recombinant serotype 9 adeno-associated virus encoding a codon-optimized human MECP2 gene.
Investigational

OSI-7904L

OSI-7904L is a liposome encapsulated thymidylate synthase inhibitor, which is indicated for use in advanced gastric and/or gastroesophageal adenocarcinoma (A-G/GEJA). Current treatments also inhibit thymidylate synthase but the innovative lipid coating of OSI-7904L allows for more enduring results with administration of the TS inhibitor.
Investigational
Matched Description: … liposome encapsulated thymidylate synthase inhibitor, which is indicated for use in advanced gastric and/or ... the innovative lipid coating of OSI-7904L allows for more enduring results with administration of the TS …

Camellia japonica seed oil

Camellia japonica seed oil is a plant/plant extract used in some OTC (over-the-counter) products. It is not an approved drug.
Experimental

TST10088

TST10088 is a recombinant variant of a plant toxin belonging to the family of class II ribosome inactivating proteins. These molecules efficiently kill cells by activating preprogrammed death pathways known as apoptosis. TST10088 has been designed and engineered by Twinstrand to contain a peptide switch that is specifically cleaved by...
Investigational

Osemitamab

Investigational

ANX-510

ANX-510 (CoFactor) is a folate-based biomodulator drug being developed to enhance the activity and reduce associated toxicity of the widely used cancer chemotherapy, 5-fluorouracil (5-FU). CoFactor use with 5-FU is being evaluated in clinical trials in first line treatment of metastatic colorectal cancer.
Investigational
Displaying drugs 176 - 200 of 215 in total