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Displaying drugs 1976 - 2000 of 15145 in total

Plant-based virus-like particles, recombinant, adjuvanted COVID-19 vaccine

The Covifenz COVID-19 vaccine (plant-based virus-like particles (VLP), recombinant, adjuvanted) is a plant-based vaccine developed in partnership by Medicago and GlaxoSmithKline which is approved in Canada for the prevention of COVID-19. It is composed of VLPs expressing SARS-CoV-2 spike protein trimers (stabilized in a pre-fusion conformation) and is mixed with...
Approved
Matched Description: … nucleic acid vaccines (e.g. the [Moderna COVID-19 vaccine]). ... ease of manufacturing and increased immunogenicity. ... particles (VLP), recombinant, adjuvanted) is a plant-based vaccine developed in partnership by Medicago and …

Midazolam

Midazolam is a short-acting hypnotic-sedative drug with anxiolytic, muscle relaxant, anticonvulsant, sedative, hypnotic, and amnesic properties. It belongs to a class of drugs called benzodiazepines. This drug is unique from others in this class due to its rapid onset of effects and short duration of action. Midazolam is available by...
Approved
Illicit
Matched Description: … and endoscopic procedures as pre-anesthetic medication, and as an adjunct to local anesthesia. ... This drug is unique from others in this class due to its rapid onset of effects and short duration of ... short-acting hypnotic-sedative drug with anxiolytic, muscle relaxant, anticonvulsant, sedative, hypnotic, and …
Matched Categories: … Hypnotics and Sedatives ... Benzodiazepine hypnotics and sedatives ... Benzodiazepines and benzodiazepine derivatives …

Bromhexine

Bromhexine is mucolytic agent used for a variety of respiratory conditions associated with increased mucus secretion. It is derived from the Adhatoda vasica plant and aids in the clearance of excess mucus, improving breathing and reducing cough. It was introduced into the market in 1963, and is widely available as...
Approved
Matched Description: … and reducing cough. ... prevention and treatment of COVID-19 due to their interactions with cell receptors in the lungs. ... It was introduced into the market in 1963, and is widely available as an over-the-counter drug in many …
Matched Categories: … Cough and Cold Preparations …

Hydrocortisone butyrate

Approved
Vet approved
Matched Categories: … Hydrocortisone and derivatives ... hydrocortisone butyrate and antiseptics ... Hormones, Hormone Substitutes, and Hormone Antagonists …

Hydrocortisone phosphate

Approved
Vet approved
Matched Iupac: … 3H,3aH,3bH,4H,5H,7H,8H,9H,9aH,9bH,10H,11H,11aH-cyclopenta[a]phenanthren-1-yl]-2-oxoethoxy}phosphonic acid …
Matched Categories: … Hydrocortisone and derivatives ... Hormones, Hormone Substitutes, and Hormone Antagonists …

Hydrocortisone valerate

Approved
Vet approved
Matched Categories: … Hydrocortisone and derivatives ... Hormones, Hormone Substitutes, and Hormone Antagonists …

Rofecoxib

Rofecoxib is used for the treatment of osteoarthritis, rheumatoid arthritis, acute pain in adults, and primary dysmenorrhea, as well as acute treatment of migraine attacks with or without auras. Rofecoxib is a solid. This compound belongs to the stilbenes. These are organic compounds containing a 1,2-diphenylethylene moiety. Stilbenes (C6-C2-C6 )...
Approved
Investigational
Withdrawn
Matched Description: … doses of 125, 25, and 50 mg is approximately 93%. ... The proteins that rofecoxib target include elastin and prostaglandin G/H synthase 2. ... Rofecoxib is used for the treatment of osteoarthritis, rheumatoid arthritis, acute pain in adults, and …
Matched Categories: … Antiinflammatory and Antirheumatic Products ... Antiinflammatory and Antirheumatic Products, Non-Steroids …

Pentaerythritol tetranitrate

Pentaerythritol tetranitrate is the nitrate ester of pentaerythritol that possesses explosive properties. When mixed with a plasticizer, this chemical forms a plastic explosive. It is recognized by the FDA to be a coronary vasodilator in the treatment of heart conditions such as angina . It is a pentaerythritol nitrate in...
Approved
Matched Description: … with nitric acid (HNO2). ... that is stored and shipped as a mixture with water and alcohol [L2394]. ... It is also one of the most powerful high explosives known and is a component of the plastic explosive …

Ox bile extract

Approved
Experimental
Investigational
Matched Mixtures name: … Pancreatin and Enzyme Formula - Tablet …
Matched Categories: … Bile Acids and Salts …

Dienogest

Dienogest is an orally-active semisynthetic progestogen which also possesses the properties of 17α-hydroxyprogesterone. It is a derivative of 19-nortestosterone and has antiandrogenic properties. It is primarily used as a contraceptive in combination with ethinylestradiol, or in other combination form pills approved in United States and Europe however it is not...
Approved
Matched Description: … Dienogest is commonly marketed as Visanne, Natazia and Qlaira. ... It is a derivative of 19-nortestosterone and has antiandrogenic properties. ... in combination with ethinylestradiol, or in other combination form pills approved in United States and …
Matched Mixtures name: … Estradiol Valerate and Estradiol Valerate/Dienogest ... Estradiol Valerate and Estradiol Valerate/Dienogest …
Matched Categories: … dienogest and estrogen ... dienogest and estradiol ... dienogest and ethinylestradiol ... Genito Urinary System and Sex Hormones ... Sex Hormones and Modulators of the Genital System …

Ximelagatran

Ximelagatran is an anticoagulant intended to become a replacement for warfarin by overcoming the dietary restrictions, drug interaction, and monitoring issues associated with the former. In 2006, its manufacturer AstraZeneca announced that it would not attempt to market ximelagatran after reports of hepatotoxicity (liver damage) during trials, and to discontinue...
Approved
Investigational
Withdrawn
Matched Description: … intended to become a replacement for warfarin by overcoming the dietary restrictions, drug interaction, and ... would not attempt to market ximelagatran after reports of hepatotoxicity (liver damage) during trials, and …
Matched Categories: … Blood and Blood Forming Organs …

Ganaxolone

Ganaxolone is the 3β-methylated synthetic analog of allopregnanolone, a metabolite of progesterone. Ganaxolone belongs to a class of compounds referred to as neurosteroids. Endogenous neurosteroids, which comprise certain metabolites of progesterone and deoxycorticosterone, bind potently and specifically to GABAA receptors to enhance their inhibitory effects, and are thus known to...
Approved
Investigational
Matched Description: … , bind potently and specifically to GABAA receptors to enhance their inhibitory effects, and ... [A3197] Endogenous neurosteroids, which comprise certain metabolites of progesterone and deoxycorticosterone ... are thus known to have anxiolytic, analgesic, anticonvulsant, sedative, hypnotic, and anesthetic properties …
Matched Categories: … Neuroactive Steroid Gamma-Aminobutyric Acid A Receptor Positive Modulator …

Lorlatinib

Lorlatinib is a third-generation ALK tyrosine kinase inhibitor (TKI) for patients with ALK-positive metastatic non-small cell lung cancer which was first approved by the US FDA in November of 2018. It was subsequently approved by the EMA in 2019 for the treatment of select patients with previously treated advanced ALK-positive...
Approved
Investigational
Matched Categories: … Antineoplastic and Immunomodulating Agents …

Abciximab

Abciximab is a Fab fragment of the chimeric human-murine monoclonal antibody 7E3. Abciximab binds to the glycoprotein (GP) IIb/IIIa receptor of human platelets and inhibits platelet aggregation by preventing the binding of fibrinogen, von Willebrand factor, and other adhesive molecules. It also binds to vitronectin (αvβ3) receptor found on platelets...
Approved
Matched Description: … It also binds to vitronectin (αvβ3) receptor found on platelets and vessel wall endothelial and smooth ... by preventing the binding of fibrinogen, von Willebrand factor, and other adhesive molecules. ... Abciximab binds to the glycoprotein (GP) IIb/IIIa receptor of human platelets and inhibits platelet aggregation …
Matched Categories: … Amino Acids, Peptides, and Proteins ... Blood and Blood Forming Organs …

Dronabinol

Dronabinol (marketed as Marinol) is a synthetic form of delta-9-tetrahydrocannabinol (Δ⁹-THC), the primary psychoactive component of cannabis (marijuana). THC demonstrates its effects through weak partial agonist activity at Cannabinoid-1 (CB1R) and Cannabinoid-2 (CB2R) receptors, which results in the well-known effects of smoking cannabis such as increased appetite, reduced pain, and...
Approved
Illicit
Matched Description: … CBD are obtained through conversion from their precursors, tetrahydrocannabinolic acid-A (THCA-A) and ... cannabidiolic acid (CBDA), through decarboxylation reactions. ... and emotional regulation. …
Matched Categories: … Cannabinoids and similars ... Alimentary Tract and Metabolism ... Antiemetics and Antinauseants ... Hormones, Hormone Substitutes, and Hormone Antagonists …

Netilmicin

Netilmicin is a semisynthetic 1-N-ethyl derivative of sisomycin, an aminoglycoside antibiotic with action similar to gentamicin, but less ear and kidney toxicity. Netilmicin inhibits protein synthesis in susceptible organisms by binding to the bacterial 30S ribosomal subunit and interfering with mRNA binding and the acceptor tRNA site. The bactericidal effect...
Approved
Investigational
Matched Description: … interfering with mRNA binding and the acceptor tRNA site. ... derivative of sisomycin, an aminoglycoside antibiotic with action similar to gentamicin, but less ear and ... inhibits protein synthesis in susceptible organisms by binding to the bacterial 30S ribosomal subunit and …

Fingolimod

Multiple sclerosis, or MS, is a devastating inflammatory disease that often progresses and causes severe neurological, physical, and cognitive effects. Fingolimod is a sphingosine 1-phosphate receptor modulator for the treatment of relapsing-remitting multiple sclerosis. It was developed by Novartis and initially approved by the FDA in 2010. Fingolimod was also...
Approved
Investigational
Matched Description: … neurological, physical, and cognitive effects. ... It was developed by Novartis and initially approved by the FDA in 2010. ... Multiple sclerosis, or MS, is a devastating inflammatory disease that often progresses and causes severe …
Matched Categories: … Antineoplastic and Immunomodulating Agents …

Perhexiline

Perhexiline is a coronary vasodilator used especially for angina of effort. It may cause neuropathy and hepatitis.
Approved
Investigational
Matched Description: … It may cause neuropathy and hepatitis. …
Matched Categories: … Calcium-Regulating Hormones and Agents …

Fluticasone furoate

Fluticasone furoate is a synthetic glucocorticoid available as an inhaler and nasal spray for various inflammatory indications[FDA Label] . Fluticasone furoate was first approved in 2007 .
Approved
Matched Description: … Fluticasone furoate is a synthetic glucocorticoid available as an inhaler and nasal spray for various …
Matched Mixtures name: … Fluticasone Furoate and Vilanterol ... Fluticasone Furoate and Vilanterol …
Matched Categories: … vilanterol and fluticasone furoate ... vilanterol, umeclidinium bromide and fluticasone furoate …

Pancrelipase lipase

Pancrelipase, in general, is composed of a mixture of pancreatic enzymes which include amylases, lipases, and proteases. These enzymes are extracted from porcine pancreatic glands. The pancrelipase lipase is an enzyme secreted by the pancreas that is responsible for the hydrolysis of dietary fat molecules in the human digestive system....
Approved
Matched Description: … Pancrelipase, in general, is composed of a mixture of pancreatic enzymes which include amylases, lipases, and ... mixture, including pancrelipase lipase, was developed by Ortho-McNeil-Janssen Pharmaceuticals, Inc and …
Matched Mixtures name: … Pancreatin and Enzyme Formula - Tablet …
Matched Categories: … Enzymes and Coenzymes …

Prednisolone acetate

Prednisolone acetate is a prednisolone molecule bound to an acetate functional group by an ester bond. Prednisolone acetate was granted FDA approval in 1955.
Approved
Vet approved

Cyclothiazide

As a diuretic, cyclothiazide inhibits active chloride reabsorption at the early distal tubule via the Na-Cl cotransporter, resulting in an increase in the excretion of sodium, chloride, and water. Thiazides like cyclothiazide also inhibit sodium ion transport across the renal tubular epithelium through binding to the thiazide sensitive sodium-chloride transporter....
Approved
Matched Description: … corticosteroid and estrogen therapy. ... tubule via the Na-Cl cotransporter, resulting in an increase in the excretion of sodium, chloride, and ... indicated as adjunctive therapy in edema associated with congestive heart failure, hepatic cirrhosis, and …
Matched Categories: … cyclothiazide and potassium ... Genito Urinary System and Sex Hormones ... Gynecological Antiinfectives and Antiseptics …

Benzydamine

Benzydamine (also known as Tantum Verde or Difflam), available as the hydrochloride salt, is a locally-acting nonsteroidal anti-inflammatory drug (NSAID) with local anaesthetic and analgesic properties. It is used topically for pain relief and anti-inflammatory treatment of the mouth, throat, or muscoskeletal system. Although the indazole analogue benzydamine is a...
Approved
Matched Description: … hydrochloride salt, is a locally-acting nonsteroidal anti-inflammatory drug (NSAID) with local anaesthetic and ... It is used topically for pain relief and anti-inflammatory treatment of the mouth, throat, or muscoskeletal ... benzydamine is a non-steroidal anti-inflammatory drug (NSAID), it has various physicochemical properties and …
Matched Mixtures name: … Anti-inflammatory Lozenge (with antibacterial) (Eucalyptus and Menthol) ... Difflam plus ANAESTHETIC Sore Throat Lozenges (Sugar Free) Menthol and Eucalyptus Flavour …
Matched Categories: … Mouthwashes and Gargles ... Alimentary Tract and Metabolism ... Genito Urinary System and Sex Hormones ... Antiinflammatory and Antirheumatic Products ... Topical Products for Joint and Muscular Pain …

Ceruletide

Caerulein is a specific decapeptide similar in action and composition to the natural gastrointestinal peptide hormone cholecystokinin. It exerts stimulatory effects on the gastric, biliary, and pancreatic secretion, as well as on certain smooth muscles.
Approved
Matched Iupac: … 3-hydroxybutanamido]acetamido}-3-(1H-indol-3-yl)propanamido]-4-(methylsulfanyl)butanamido]propanoic acid …
Matched Description: … Caerulein is a specific decapeptide similar in action and composition to the natural gastrointestinal ... It exerts stimulatory effects on the gastric, biliary, and pancreatic secretion, as well as on certain …
Matched Categories: … Amino Acids, Peptides, and Proteins …

Insulin glargine

Insulin glargine is a long-acting form of insulin used for the treatment of hyperglycemia caused by Type 1 and Type 2 Diabetes. Insulin is typically prescribed for the management of diabetes mellitus to mimic the activity of endogenously produced human insulin, a peptide hormone produced by beta cells of the...
Approved
Matched Description: … and proteolysis. ... tissues such as the liver, fat cells, and skeletal muscle. ... addition of two arginines to the C-terminus (positions B31 and 32) of the B-chain. …
Matched Categories: … Alimentary Tract and Metabolism ... Amino Acids, Peptides, and Proteins ... insulin glargine and lixisenatide ... Hormones, Hormone Substitutes, and Hormone Antagonists …
Displaying drugs 1976 - 2000 of 15145 in total